Welcome to the Wang Lab! 

U of M Researchers Awarded Grant to Study the Development of Esophageal Cancer 

Wang Lab has been renewed for funding by the Divisions of Cancer Prevention (DCP) and Cancer Biology (DCB) at the National Institutes of Health (NIH) to support a Research Center in the Barrett’s Esophagus Translational Research Network (BETRNet).  The overarching goal of this Center is to advance new methods of imaging to visualize the effects of spatial distribution of genetic alterations in Barrett's Esophagus by evaluating tumor heterogeneity and their impact on the progression toward esophageal adenocarcinoma.  We will build on our previous results in genomic characterization, peptide biochemistry, and clinical translation to achieve our ultimate goal to perform early cancer detection at the stage of high-grade dysplasia where therapeutic intervention can be most effective.  

Abrams JA, Appelman HD, Beer DG, Berry LD, Chak A, Falk GW, Fitzgerald RC, Ginsberg GG, Grady WM, Joshi BP, Lynch JP, Markowitz S, Richmond ES, Rustgi AK, Seibel EJ, Shaheen NJ, Shyr Y, Umar A, Wang KK, Wang TC, Wang TD, Yassin R. Barrett's Esophagus Translational Research Network (BETRNet): the pivotal role of multi-institutional collaboration in esophageal adenocarcinoma research. Gastroenterology 2014;146:1586-90. PubMed


Wang Lab publishes ground breaking work on use of molecular imaging to assess risk for rupture of atherosclerotic plaques from increased presence of matrix-metalloproteinases.  We demonstrate a novel endoscope that collects multi-modal images of vulnerable plaques by targeting proteolytic activity with a fluorescent probe activated by these enzymes.  This cutting edge technology can be used to identify subtle thrombogenic lesions and define the risk for plaque rupture.  Multimodal laser-based angioscopy may be a platform for future diagnosis, prognosis, and image-guided therapy of atherosclerosis.

Savastano LE, Zhou Q, Smith A, Vega K, Murga-Zamalloa C, Gordon D, McHugh J, Zhao L, Wang M, Pandey A, Thompson BG, Xu J, Zhang J, Chen YE, Seibel EJ, Wang TD.  Multimodal laser-based angioscopy for structural, chemical, and biological imaging of atherosclerosis. Nature Biomedical Engineering 2017;1:0023. PubMed


Research in the Wang Lab focuses on molecular imaging in the digestive tract, and emphasizes the evelopment and validation of novel molecular imaging methods and systems for early cancer detection. Molecular probes are developed to visualize cell surface targets that are over-expressed in a number of human diseases. With the instrument and peptides developed in the Wang lab, cancer diagnoses can be made based on the expression of molecular targets specific to certain diseases, rather than on the gross visible appearance of mass lesions. 

Lee JH, Wang TD. Molecular endoscopy for targeted imaging in the digestive tract. Lancet Gastroenterology and Hepatology 2016;1:147-55. PubMed 

Dr. Wang, Xiyu Duan, and Gaoming Li, PhD, pictured left to right, are working with a microendoscopic instrument that can be used for in vivo imaging of epithelial diseases, such as colon and esophagus cancer. 

Located on the Medical School campus near the main hospital, in between the Engineering and Science campuses, the Wang Lab focuses on cutting edge translational research that bridges the College of Engineering with the School of Medicine at the University of Michigan. Collaborative efforts between investigators from these two separate campuses accelerate biomedical research performed to advance high resolution imaging methods to investigate the molecular properties of biology and disease within the native tissue microenvironment in living animals and human subjects.

Biomedical Science Research Building

Bridging Medicine with Engineering

Biomedical Science Research Bldg

Subpages (1): BETRnET