Publications
*The following publications were made possible through the support of CRNA’s NIH NIAID grant #U54 AI170660-01:
2022
Bevilacqua PC, Tolbert BS. Regulatory Mechanisms through RNA Conformational Switching and Dynamics. J Mol Biol. 2022 Sep 30;434(18):167794. doi: 10.1016/j.jmb.2022.167794. Epub 2022 Aug 18. PubMed PMID: 35988750; PubMed Link
Cai Z, Zafferani M, Akande OM, Hargrove AE. Quantitative Structure-Activity Relationship (QSAR) Study Predicts Small-Molecule Binding to RNA Structure. J Med Chem. 2022 May 26;65(10):7262-7277. doi: 10.1021/acs.jmedchem.2c00254. Epub 2022 May 6. PubMed Link
Chiu LY, Emery A, Jain N, Sugarman A, Kendrick N, Luo L, Ford W, Swanstrom R, Tolbert BS. Encoded Conformational Dynamics of the HIV Splice Site A3 Regulatory Locus: Implications for Differential Binding of hnRNP Splicing Auxiliary Factors.
J Mol Biol. 2022 Sep 30;434(18):167728. doi: 10.1016/j.jmb.2022.167728. Epub 2022 Jul 21.
Donlic A, Swanson EG, Chiu LY, Wicks SL, Juru AU, Cai Z, Kassam K, Laudeman C, Sanaba BG, Sugarman A, Han E, Tolbert BS, Hargrove AE. R-BIND 2.0: An Updated Database of Bioactive RNATargeting Small Molecules and Associated RNA Secondary Structures. ACS Chem Biol. 2022 Jun 17;17(6):1556-1566. doi: 10.1021/acschembio.2c00224. Epub 2022 May 20. PubMed Link
Gonçalves-Carneiro D, Mastrocola E, Lei X, DaSilva J, Chan YF, Bieniasz PD. Rational attenuation of RNA viruses with zinc finger antiviral protein. Nat Microbiol. 2022 Oct;7(10):1558-1567. doi: 10.1038/s41564-022-01223-8. Epub 2022 Sep 8. PubMed Link
Shema Mugisha C, Dinh T, Kumar A, Tenneti K, Eschbach JE, Davis K, Gifford R, Kvaratskhelia M, Kutluay SB. Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA. mBio. 2022 Oct 26;13(5):e0043122. doi: 10.1128/mbio.00431-22. Epub 2022 Aug 17. PubMed Link
2023
Jin D, Zhu Y, Schubert HL, Goff SP, Musier-Forsyth K. HIV-1 Gag Binds the Multi-Aminoacyl-tRNA Synthetase Complex via the EPRS Subunit.
Viruses. 2023 Feb 8;15(2):474. doi: 10.3390/v15020474. PubMed Link
Kharytonchyk S, Burnett C, Gc K, Telesnitsky A. Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements. bioRxiv. 2023 May 22:2023.05.22.541776. doi: 10.1101/2023.05.22.541776. Preprint.
Lei X, Gonçalves-Carneiro D, Zang TM, Bieniasz PD. Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal. Elife. 2023 Jan 23;12:e83548. doi: 10.7554/eLife.83548. PubMed Link