Publications

Satin LS, Butler PC, Ha J, Sherman AS. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. 2015 Jan 28. [Epub ahead of print] Review.

Benninger RK, Hutchens T, Head WS, McCaughey MJ, Zhang M, Le Marchand SJ, Satin LS, Piston DW. Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamics. Biophys J. 2014 Dec 2;107(11):2723-33.

Johnson JS, Kono T, Tong X, Yamamoto WR, Zarain-Herzberg A, Merrins MJ, Satin LS, Gilon P, Evans-Molina C. Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell. J Biol Chem. 2014 Nov 21;289(47):32798-810.

Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E. Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring. J Clin Invest. 2014 Oct 1;124(10):4395-410.

Paulette B. Goforth, Gina M. Leinninger, Christa M. Patterson, Leslie S. Satin, and Martin G. Myers Jr. (2014). Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms. Journal of Neuroscience. 2014; 34(34):11405-11415.

Craig S. Nunemaker and Leslie S. Satin (2014). Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH. Endocrine. 2014; 47(1):49-63.

Matthew J. Merrins, Aaron R. Van Dyke, Anna K. Mapp, Mark A. Rizzo and Leslie S. Satin (2013). Direct Measurements of Oscillatory Glycolysis in Pancreatic Islet-Cells Using Novel Fluorescence Resonance Energy Transfer (FRET) Biosensors for Pyruvate Kinase M2 Activity. J. Biol. Chem. 2013, 288:33312-33322.

Jianhua Ren, Arthur Sherman, Richard Bertram, Paulette B. Goforth, Craig S. Nunemaker, Christopher D. Waters, and Leslie S. Satin (2013). Slow oscillations of KATP conductance in mouse pancreatic islets provide support for electrical bursting driven by metabolic oscillations American Journal of Physiology - Endocrinology and Metabolism. 2013; 305(7):E805-E817.

Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, Rolph MS, Mackay CR. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. PLoS One. 2012;7(6):e39462.

Merrins MJ, Bertram R, Sherman A, Satin LS.

• Phosphofructo-2-kinase/fructose-2,6-bisphosphatase modulates oscillations of pancreatic islet metabolism. PLoS One. 2012;7(4):e34036.

Satin LS. Synapsins I and II are not required for β-cell insulin secretion: granules must pool their own weight. Endocrinology. 2012 May;153(5):2059-61.

Head WS, Orseth ML, Nunemaker CS, Satin LS, Piston DW, Benninger RK. Connexin-36 gap junctions regulate in vivo first- and second-phase insulin secretion dynamics and glucose tolerance in the conscious mouse. Diabetes. 2012 Jul;61(7):1700-7.

Benninger RK, Head WS, Zhang M, Satin LS, Piston DW. Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet. J Physiol. 2011 Nov 15;589(Pt 22):5453-66.

Cai T, Hirai H, Zhang G, Zhang M, Takahashi N, Kasai H, Satin LS, Leapman RD, Notkins AL. Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles. Diabetologia. 2011 Sep;54(9):2347-57.

Merrins MJ, Fendler B, Zhang M, Sherman A, Bertram R, Satin LS. Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations. Biophys J. 2010 Jul 7;99(1):76-84.

Richard Bertram, Arthur Sherman, and Leslie S. Satin (2010). Electrical bursting, calcium oscillations, and synchronization of pancreatic islets. Advances in Experimental Medicine and Biology. 2010; 654:261-279.

Houamed KM, Sweet IR, Satin LS. BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells. J Physiol. 2010 Sep 15;588(Pt 18):3511-23.

Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, Satin LS, Nelson P, Omenn GS, Trucco M, Becker DJ, Pietropaolo M.

• Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology. 2010 Jun;151(6):2528-37.

Benninger RK, Zhang M, Head WS, Satin LS and Piston DW. (2008). Gap junction coupling and calcium waves in the pancreatic islet. Biophys. J. Sept. 19 [epub ahead of print].

Zhang M, Fendler B, Peercy B, Goel P, Bertram R, Sherman A, and Satin LS. (2008). Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets. Biophys. J. Aug. 15 [epub ahead of print].

Tian Y, Corkey RF, Yaney GC, Goforth PB, Satin LS and Moitoso de Vargas L. (2008). Differential modulation of L-type Ca channel subunits by oleate. Am. J. Physiol-Endocrinol. Metab. 294: E1178-86.

Bertram R, Satin LS, Pedersen MG, Luciani DS and Sherman A. (2007). Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Biophys. J. 92: 1544-55.

Cohen A, Pfister BJ, Schwarzbach E, Grady S, Goforth PB and Satin LS (2007). Injury-induced alterations in CNS electrophysiology. Prog. Brain Res. 161: 143-69.

Amr S, Heisey C, Zhang M, Xia X-J, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H & Shiang R (2007). A novel zinc finger protein, ERIS, is responsible for Wolfram's Syndrome. Am. J. Human Genetics, 81:673-83.

Bertram R, Sherman A, and Satin LS. (2007). Metabolic and electrical oscillations: partners in controlling islet insulin secretion, Am J Physiol.-Endocrinol. Metab. 293:E890-900.