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I have carried out a variety of consulting projects for industry and government, privately and through a statistical consulting corporation, Datametrics Research Inc., which I formed with Don Rubin. Topics include survey sampling in auditing and other applications, survey analysis, statistical modeling, test equating, and methods for handling missing data adjustment in clinical trials (e.g. Little et al. 2016, .
My early collaborative research focused on the environmental statistics (e.g. Little 1982), demography, specifically my work for the World Fertility Survey (e.g. Hobcraft & Little 1984), and economics, in particular missing-data adjustments for economic surveys such as the Income Supplement of the Current Population Survey (Little 1985; David, Little, Samuhel & Triest 1986).
While at UCLA I collaborated with Janet Sinsheimer and Jim Lake on Bayesian analyses of the structure of evolutionary trees using DNA sequences, based on the method of evolutionary parsimony and extensions (Sinsheimer, Lake & Little 1996, 1997).
At Michigan, I have collaborated in psychiatric epidemiology studies with Ronald Kessler at the University of Michigan Institute for Social Research (Little et al. 1997). I have also collaborated with Richard Price at ISR on intervention studies concerned with job training, Maryfran Sowers on the Study of Women’s Health Across the Nation, Sioban Harlow on ReStage, a study of markers of menopausal transition, and Noreen Clark at the Center for Managing Chronic Disease.
I have also directed biostatistics cores for the University of Michigan Alzheimer's Disease Research Center, the Michigan Center for Health Intervention in the School of Nursing, the Michigan Center for Health Communications Research, and most recently on a grant on Lifestage Exposures and Adult Disease. Some references associated with these collaborations are given below. I am a member of the University of Michigan Comprehensive Cancer Center, and have served as Interim Director of the Biostatistics Core for that Center
I have an interest in Federal Statistical Issues. I have served as a member of the Committee on National Statistics, the Federal Advisory Committee of the National Children's Study, and a number of other National Research Council committees. I recently chaired a National Academy Committee on the treatment of missing data in clinical trials. I spent a year as an ASA/Census/NSF Fellow at the Census Bureau, and am currently serving a three year appointment as Associate Director for Research and Methodology and Chief Scientist at the U.S. Census Bureau.
Selected References
Selected References
Bozoki, Andrea, An*, Hyonggin, Bozoki, E. & Little, R. (2009). The Existence of Cognitive Plateaus in Alzheimer Disease. Alzheimer's and Dementia, 5, 6, 470-478.
Bozoki, Andrea, An*, Hyonggin, Bozoki, E. & Little, R. (2009). The Existence of Cognitive Plateaus in Alzheimer Disease. Alzheimer's and Dementia, 5, 6, 470-478.
Chen, Q., Garabrant, D., Hedgeman, E., Little, R.J., Elliott, M. R., Gillespie, B., Lee, S-Y., Lepkowski, J., Franzblau, A., Adriaens, P., Demond, A. & Patterson Jr., D.G. (2010). Estimation of Background Serum 2,3,7,8-TCDD Concentrations by Using Quantile Regression in the UMDES and NHANES Populations. Epidemiology, 21, 4, S51-57. DOI: 10.1097/EDE.0b013e3181ce9550
Chen, Q., Garabrant, D., Hedgeman, E., Little, R.J., Elliott, M. R., Gillespie, B., Lee, S-Y., Lepkowski, J., Franzblau, A., Adriaens, P., Demond, A. & Patterson Jr., D.G. (2010). Estimation of Background Serum 2,3,7,8-TCDD Concentrations by Using Quantile Regression in the UMDES and NHANES Populations. Epidemiology, 21, 4, S51-57. DOI: 10.1097/EDE.0b013e3181ce9550
Consens, F.B., Chervin, R.D., Koeppe, R.A., Little, R.J., Liu*, S., Angell, K., Heumann, M., & Gilman, S. (2005). Validation of a Polysomnographic Score for REM Sleep Behavior Disorder (RBD). Sleep, 28(8), 993-997.
Consens, F.B., Chervin, R.D., Koeppe, R.A., Little, R.J., Liu*, S., Angell, K., Heumann, M., & Gilman, S. (2005). Validation of a Polysomnographic Score for REM Sleep Behavior Disorder (RBD). Sleep, 28(8), 993-997.
David, M., Little, R.J.A., Samuhel, M.E. and Triest, R.K. (1986). Alternative methods for CPS income imputation. Journal of the American Statistical Association, 81, 29-41.
David, M., Little, R.J.A., Samuhel, M.E. and Triest, R.K. (1986). Alternative methods for CPS income imputation. Journal of the American Statistical Association, 81, 29-41.
Di Carli, M., Davidson, M., Little, R. Khanna, S., Mody, F.V., Brunken, R.C., Czernin, J., Rokhsar, S., Stevenson, L.W., Laks, H., Hawkins, R., Schelbert, H.R., Phelps, M.E. & Maddahi, J. (1994). Value of Metabolic Imaging with Positron Emission Tomography for Evaluating Prognosis in patients with Coronary Artery Disease and Left Ventricular Dysfunction. American Journal of Cardiology 73, 8, 527-533.
Di Carli, M., Davidson, M., Little, R. Khanna, S., Mody, F.V., Brunken, R.C., Czernin, J., Rokhsar, S., Stevenson, L.W., Laks, H., Hawkins, R., Schelbert, H.R., Phelps, M.E. & Maddahi, J. (1994). Value of Metabolic Imaging with Positron Emission Tomography for Evaluating Prognosis in patients with Coronary Artery Disease and Left Ventricular Dysfunction. American Journal of Cardiology 73, 8, 527-533.
Fitten, L.J., Perryman, K.M., Wilkinson, C.J., Little, R.J., Burns, M.M., Pachana, N., Mervis, J.R. & Ganzell, S. (1995). Alzheimer's Disease and Driving: a Prospective Road and Laboratory study. Journal of the American Medical Association 273, 1360-1365.
Fitten, L.J., Perryman, K.M., Wilkinson, C.J., Little, R.J., Burns, M.M., Pachana, N., Mervis, J.R. & Ganzell, S. (1995). Alzheimer's Disease and Driving: a Prospective Road and Laboratory study. Journal of the American Medical Association 273, 1360-1365.
Gilman, S., Koeppe, R.A., Chervin, R., Consens, F., Little, R.J., An*, H., Junck, L., Heumann, M. (2003). REM Sleep Behavior Disorder Is Related to Striatal Mono-aminergic Deficit in MSA. Neurology, 61, 29-34.
Gilman, S., Koeppe, R.A., Chervin, R., Consens, F., Little, R.J., An*, H., Junck, L., Heumann, M. (2003). REM Sleep Behavior Disorder Is Related to Striatal Mono-aminergic Deficit in MSA. Neurology, 61, 29-34.
Gilman, S., Little, R.J.A., Johanns, J., Heumann, M., Kluin, K.J., Junck, L., Koeppe, R. A. & An*, H. (2000). Evolution of Sporadic Olivopontocerebellar Atrophy into Multiple System Atrophy. Neurology 55, 527-532.
Gilman, S., Little, R.J.A., Johanns, J., Heumann, M., Kluin, K.J., Junck, L., Koeppe, R. A. & An*, H. (2000). Evolution of Sporadic Olivopontocerebellar Atrophy into Multiple System Atrophy. Neurology 55, 527-532.
Gilman, S., Sima, A.A.F., Junck, L., Kluin, K.J., Koeppe, R.A., Lohman, M.E. & Little, R.J.A. (1996). Spinocerebellar Ataxia Type 1 with Multiple System Degeneration and Glial Cytoplasmic Inclusions. Annals of Neurology, 39, 2, 241-254.
Gilman, S., Sima, A.A.F., Junck, L., Kluin, K.J., Koeppe, R.A., Lohman, M.E. & Little, R.J.A. (1996). Spinocerebellar Ataxia Type 1 with Multiple System Degeneration and Glial Cytoplasmic Inclusions. Annals of Neurology, 39, 2, 241-254.
Harlow S.D. (in alphabetical order) Cain K., Crawford S., Dennerstein L., Little R., Mitchell E.S., Nan B., Randolph J., Taffe J., Yosef M. (2006). Evaluation of Four Proposed Bleeding Criteria for the Onset of Late Menopausal Transition. Journal of Clinical Endocrinology and Metabolism, 91(9), 3432-8.
Harlow S.D. (in alphabetical order) Cain K., Crawford S., Dennerstein L., Little R., Mitchell E.S., Nan B., Randolph J., Taffe J., Yosef M. (2006). Evaluation of Four Proposed Bleeding Criteria for the Onset of Late Menopausal Transition. Journal of Clinical Endocrinology and Metabolism, 91(9), 3432-8.
Hobcraft, J. and Little, R.J.A. (1984). Fertility exposure analysis: a new method for assessing the contribution of proximate determinants to fertility differentials. Population Studies, 38, 21-46.
Hobcraft, J. and Little, R.J.A. (1984). Fertility exposure analysis: a new method for assessing the contribution of proximate determinants to fertility differentials. Population Studies, 38, 21-46.
Koeppe, R.A., Gilman, S., Joshi, A., Liu*, S., Little, R., Junck, L., Heumann, M., Frey, K.A., Albin, R. L. (2005). {11C]DTBZ and [18F]FDG PET Measures in Differentiating Dementias. Journal of Nuclear Medicine 46, 936-944.
Koeppe, R.A., Gilman, S., Joshi, A., Liu*, S., Little, R., Junck, L., Heumann, M., Frey, K.A., Albin, R. L. (2005). {11C]DTBZ and [18F]FDG PET Measures in Differentiating Dementias. Journal of Nuclear Medicine 46, 936-944.
Little, R.J.A. (1982). The statistical analysis of low-level radioactivity in the presence of background counts. Health Physics, 43, 693-703.
Little, R.J.A. (1982). The statistical analysis of low-level radioactivity in the presence of background counts. Health Physics, 43, 693-703.
Little, R.J.A., Lewitzky, S. Heeringa, S., Lepkowski, J. and Kessler, R.C. (1997). An Assessment of Weighting Methodology for the National Comorbidity Study. American Journal of Epidemiology, 146, 439-449.
Little, R.J.A., Lewitzky, S. Heeringa, S., Lepkowski, J. and Kessler, R.C. (1997). An Assessment of Weighting Methodology for the National Comorbidity Study. American Journal of Epidemiology, 146, 439-449.
Little, R.J., Wang, J., Sun, X., Tian, H., Suh, E-Y., Lee, M., Sarich, T., Oppenheimer, L., Plotnikov, A., Wittes, J., Cook-Bruns, N., Burton, P., Gibson, M., and Mohanty, S. (2016). The treatment of missing data in a large cardiovascular clinical outcomes study. Clinical Trials, 13(3) 344–351.
Little, R.J., Wang, J., Sun, X., Tian, H., Suh, E-Y., Lee, M., Sarich, T., Oppenheimer, L., Plotnikov, A., Wittes, J., Cook-Bruns, N., Burton, P., Gibson, M., and Mohanty, S. (2016). The treatment of missing data in a large cardiovascular clinical outcomes study. Clinical Trials, 13(3) 344–351.
Little, R.J.A. and Yau, L. (1998). Statistical Techniques for Analyzing Data from Prevention Trials: Treatment of No-Shows Using Rubin's Causal Model. Psychological Methods, 3, 2, 147-159.
Little, R.J.A. and Yau, L. (1998). Statistical Techniques for Analyzing Data from Prevention Trials: Treatment of No-Shows Using Rubin's Causal Model. Psychological Methods, 3, 2, 147-159.
Randolph, J., Sowers, M.F., Bondarenko, I.V., Harlow, S.D., Luborsky, J.L., & Little, R.J. (2004). Change in Estradiol and Follicle-Stimulating Hormone across the Early Menopausal Transition: Effects of Ethnicity and Age. Journal of Clinical Endocrinology and Metabolism, 89, 1555-1561. Sinsheimer, J., Lake, J. and Little, R.J.A. (1996). Bayesian hypothesis testing for four-taxon topologies using molecular sequence data. Biometrics, 52, 193-210.
Randolph, J., Sowers, M.F., Bondarenko, I.V., Harlow, S.D., Luborsky, J.L., & Little, R.J. (2004). Change in Estradiol and Follicle-Stimulating Hormone across the Early Menopausal Transition: Effects of Ethnicity and Age. Journal of Clinical Endocrinology and Metabolism, 89, 1555-1561. Sinsheimer, J., Lake, J. and Little, R.J.A. (1996). Bayesian hypothesis testing for four-taxon topologies using molecular sequence data. Biometrics, 52, 193-210.
Sinsheimer, J., Lake, J. and Little, R.J.A. (1997). Inference for Phylogenies Under a Hybrid Parsimony Method: Evolutionary/Symmetric Transversion Parsimony. Biometrics, 53, 23-38.
Sinsheimer, J., Lake, J. and Little, R.J.A. (1997). Inference for Phylogenies Under a Hybrid Parsimony Method: Evolutionary/Symmetric Transversion Parsimony. Biometrics, 53, 23-38.
Sowers M.R., Jannausch M., McConnell D., Little R., Greendale G.A., Finkelstein J.S., Neer R.M., Johnston J., Ettinger B. (2006). Hormone Predictors of Bone Mineral Density Changes During the Menopausal Transition. Journal of Clinical Endocrinology and Metabolism, 91(4), 1261-7.
Sowers M.R., Jannausch M., McConnell D., Little R., Greendale G.A., Finkelstein J.S., Neer R.M., Johnston J., Ettinger B. (2006). Hormone Predictors of Bone Mineral Density Changes During the Menopausal Transition. Journal of Clinical Endocrinology and Metabolism, 91(4), 1261-7.
Strecher, V., McClure, J., Alexander, G., Chakraborty, B., Nair, V., Konkel, J., Greene, S., Collins, L., Carlier, C., Wiese, C., Little, R., Pomerleau, C, Pomerleau, O. (2008). Web-Based Smoking Cessation Components and Tailoring Depth: Results of A Randomized Trial. American Journal of Preventive Medicine, 34(5), 373-381.
Strecher, V., McClure, J., Alexander, G., Chakraborty, B., Nair, V., Konkel, J., Greene, S., Collins, L., Carlier, C., Wiese, C., Little, R., Pomerleau, C, Pomerleau, O. (2008). Web-Based Smoking Cessation Components and Tailoring Depth: Results of A Randomized Trial. American Journal of Preventive Medicine, 34(5), 373-381.
(revised December 7, 2011)
(revised December 7, 2011)
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