Publications

  1. Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis. Circ Res. 2022 Jan 21;130(2):234-248. doi: 10.1161/CIRCRESAHA.121.318898. Epub 2021 Dec 8.

  2. Vigil TM, Frieler RA, Kilpatrick KL, Wang MM, Mortensen RM. Aconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice. Exp Neurol. 2022 Jan;347:113902. doi: 10.1016/j.expneurol.2021.113902. Epub 2021 Oct 23.

  3. Frieler RA, Vigil TM, Song J, Leung C, Lumeng CN, Mortensen RM. High-fat and high-sodium diet induces metabolic dysfunction in the absence of obesity. Obesity (Silver Spring). 2021 Nov;29(11):1868-1881. doi: 10.1002/oby.23264. Epub 2021 Sep 21.

  4. Lei I, Huang W, Ward PA, Pober JS, Tellides G, Ailawadi G, Pagani FD, Landstrom AP, Wang Z, Mortensen RM, Cascalho M, Platt J, Eugene Chen Y, Lam HYK, Tang PC. Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation. Physiol Rep. 2021 Sep;9(17):e15004. doi: 10.14814/phy2.15004.

  5. Song J, Frieler RA, Vigil TM, Ma J, Brombacher F, Goonewardena SN, Goldstein DR, Mortensen RM. Inactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling. J Am Heart Assoc. 2021 Jul 6;10(13):e017329. doi: 10.1161/JAHA.120.017329. Epub 2021 Jun 16.

  6. Song J, Frieler RA, Whitesall SE, Chung Y, Vigil TM, Muir LA, Ma J, Brombacher F, Goonewardena SN, Lumeng CN, Goldstein DR, Mortensen RM. Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling. Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H323-H337. doi: 10.1152/ajpheart.00251.2020. Epub 2020 Nov 8.

  7. Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM. Intestinal non-canonical NFκB signaling shapes the local and systemic immune response. Nat Commun. 2019 Feb 8;10(1):660.

  8. Triner D, Devenport SN, Ramakrishnan SK, Ma X, Frieler RA, Greenson JK, Inohara N, Nunez G, Colacino JA, Mortensen RM, Shah YM. Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice. Gastroenterology. 2019 Apr;156(5):1467-1482.

  9. Frieler RA, Chung Y, Ahlers CG, Gheordunescu G, Song J, Vigil TM, Shah YM, Mortensen RM. Genetic neutrophil deficiency ameliorates cerebral ischemia-reperfusion injury. Exp Neurol. 2017 Dec;298(Pt A):104-111.

  10. O'Donnell PE, Ye XZ, DeChellis MA, Davis VM, Duan SZ, Mortensen RM, Milstone DS. Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice. PLoS One. 2016 Aug 9;11(8):e0160636.

  11. Frieler RA, Nadimpalli S, Boland LK, Xie A, Kooistra LJ, Song J, Chung Y, Cho KW, Lumeng CN, Wang MM, Mortensen RM. Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury. Brain Res. 2015 Oct 22;1624:103-112.

  12. Frieler RA, Mortensen RM. Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling. Circulation. 2015;131:1019-1030.

  13. Li C, Zhang YY, Frieler RA, Zheng XJ, Zhang WC, Sun XN, YangQZ, Ma SM, Huang B, Berger S, Wang W, Wu Y, Yu Y, Duan SZ, Mortensen RM.Myeloid mineralocorticoid receptor deficiency inhibits aorticconstriction-induced cardiac hypertrophy in mice. PloS one. 2014;9:e110950

  14. He H, Tao H, Xiong H, Duan SZ, McGowan FX, Jr., Mortensen RM, Balschi JA. Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor gamma-independent mitochondrial oxidative stress in mouse hearts. Toxicological sciences : an official journal of the Society of Toxicology. 2014;138:468-481

  15. Yang G, Jia Z, Aoyagi T, McClain D, Mortensen RM, Yang T. Systemic ppargamma deletion impairs circadian rhythms of behavior and metabolism. PloS one. 2012;7:e38117

  16. Shen Z, Li C, Frieler RA, Gerasimva AS, Lee SJ, Wu J, Wang MM, Lumeng CN, Brosius FC, 3rd, Duan SZ, Mortensen RM. Smooth muscle protein 22 alpha-cre is expressed in myeloid cells in mice. Biochemical and biophysical research communications. 2012;422:639-642

  17. Mortensen RM. Immune cell modulation of cardiac remodeling. Circulation. 2012;125:1597-1600

  18. Frieler RA, Ray JJ, Meng H, Ramnarayanan SP, Usher MG, Su EJ, Berger S, Pinsky DJ, Lawrence DA, Wang MM, Mortensen RM. Myeloid mineralocorticoid receptor during experimental ischemic stroke: Effects of model and sex. Journal of the American Heart Association. 2012;1:e002584

  19. Frieler RA, Ramnarayanan S, Mortensen RM. Nuclear receptor control of opposing macrophage phenotypes in cardiovascular disease. Frontiers in bioscience. 2012;17:1917-1930

  20. Barbieri M, Di Filippo C, Esposito A, Marfella R, Rizzo MR, D'Amico M, Ferraraccio F, Di Ronza C, Duan SZ, Mortensen RM, Rossi F, Paolisso G. Effects of ppars agonists on cardiac metabolism in littermate and cardiomyocyte-specific ppar-gamma-knockout (cm-pgko) mice. PloS one. 2012;7:e35999

  21. Lamberts JT, Jutkiewicz EM, Mortensen RM, Traynor JR. Mu-opioid receptor coupling to galpha(o) plays an important role in opioid antinociception. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011;36:2041-2053

  22. Frieler RA, Meng H, Duan SZ, Berger S, Schutz G, He Y, Xi G, Wang MM, Mortensen RM. Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke; a journal of cerebral circulation. 2011;42:179-185

  23. Usher MG, Duan SZ, Ivaschenko CY, Frieler RA, Berger S, Schutz G, Lumeng CN, Mortensen RM. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. The Journal of clinical investigation. 2010;120:3350-3364

  24. Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. Rgs inhibition at g(alpha)i2 selectively potentiates 5-ht1a-mediated antidepressant effects. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:11086-11091

  25. Duan SZ, Usher MG, Foley ELt, Milstone DS, Brosius FC, 3rd, Mortensen RM. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (ppar-gamma)-deficient mice. Diabetologia. 2010;53:1493-1505

  26. Mortensen RM, Kingston RE. Selection of transfected mammalian cells. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]. 2009;Chapter 9:Unit9 5

  27. Duan SZ, Usher MG, Mortensen RM. PPARs: The vasculature, inflammation and hypertension. Current opinion in nephrology and hypertension. 2009;18:128-133

  28. Ye CP, Duan SZ, Milstone DS, Mortensen RM. G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes. American journal of physiology. Heart and circulatory physiology. 2008;294:H979-985

  29. Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL. In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter. The Journal of biological chemistry. 2008;283:32462-32470

  30. Duan SZ, Usher MG, Mortensen RM. Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circulation research. 2008;102:283-294

  31. Duan SZ, Ivashchenko CY, Usher MG, Mortensen RM. Ppar-gamma in the cardiovascular system. PPAR research. 2008;2008:745804

  32. Ivashchenko CY, Duan SZ, Usher MG, Mortensen RM. Ppar-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis. American journal of physiology. Gastrointestinal and liver physiology. 2007;293:G319-326

  33. Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Mortensen RM. Direct monitoring pressure overload predicts cardiac hypertrophy in mice. Physiological measurement. 2007;28:1329-1339

  34. Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, 3rd, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized ppargamma-deficient mice rescued from embryonic lethality. The Journal of clinical investigation. 2007;117:812-822

  35. Duan SZ, Christe M, Milstone DS, Mortensen RM. Go but not gi2 or gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochemical and biophysical research communications. 2007;357:139-143

  36. Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. Endogenous rgs proteins and galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects. Circulation research. 2006;98:659-666

  37. Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circulation research. 2005;97:372-379

  38. Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR. Rgs-insensitive g-protein mutations to study the role of endogenous rgs proteins. Methods in enzymology. 2004;389:229-243

  39. Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, Conley PB, Parise LV. Identification of p2y12-dependent and -independent mechanisms of glycoprotein vi-mediated rap1 activation in platelets. Blood. 2003;101:1409-1415

  40. Kosachunhanun N, Hunt SC, Hopkins PN, Williams RR, Jeunemaitre X, Corvol P, Ferri C, Mortensen RM, Hollenberg NK, Williams GH. Genetic determinants of nonmodulating hypertension. Hypertension. 2003;42:901-908

  41. Vernochet C, Milstone DS, Iehle C, Belmonte N, Phillips B, Wdziekonski B, Villageois P, Amri EZ, O'Donnell PE, Mortensen RM, Ailhaud G, Dani C. Ppargamma-dependent and ppargamma-independent effects on the development of adipose cells from embryonic stem cells. FEBS letters. 2002;510:94-98

  42. Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-specific overexpression of glut1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 2002;106:2125-2131

  43. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacology & toxicology. 2002;91:327-332

  44. Svetkey LP, Moore TJ, Simons-Morton DG, Appel LJ, Bray GA, Sacks FM, Ard JD, Mortensen RM, Mitchell SR, Conlin PR, Kesari M, group Dcr. Angiotensinogen genotype and blood pressure response in the dietary approaches to stop hypertension (dash) study. Journal of hypertension. 2001;19:1949-1956

  45. Palakurthi SS, Aktas H, Grubissich LM, Mortensen RM, Halperin JA. Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation. Cancer research. 2001;61:6213-6218

  46. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of ppar-gamma in macrophage differentiation and cholesterol uptake. Nature medicine. 2001;7:41-47

  47. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells lack functional responses to cholecystokinin and gastrin. Gastroenterology. 2001;121:1380-1390

  48. Jantzen HM, Milstone DS, Gousset L, Conley PB, Mortensen RM. Impaired activation of murine platelets lacking g alpha(i2). The Journal of clinical investigation. 2001;108:477-483

  49. Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM. Targeted inactivation of galpha(i) does not alter cardiac function or beta-adrenergic sensitivity. American journal of physiology. Heart and circulatory physiology. 2001;280:H569-575

  50. Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM. Galpha(i2) but not galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes. Circulation research. 2000;87:903-909

  51. Milstone DS, O'Donnell PE, Stavrakis G, Mortensen RM, Davis VM. E-selectin expression and stimulation by inflammatory mediators are developmentally regulated during embryogenesis. Laboratory investigation; a journal of technical methods and pathology. 2000;80:943-954

  52. Ye C, Sowell MO, Vassilev PM, Milstone DS, Mortensen RM. Galpha(i2), galpha(i3)and galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes. Journal of molecular and cellular cardiology. 1999;31:1771-1781

  53. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. Ppar gamma is required for the differentiation of adipose tissue in vivo and in vitro. Molecular cell. 1999;4:611-617

  54. Milstone DS, Bradwin G, Mortensen RM. Simultaneous cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations. Nucleic acids research. 1999;27:e10