Household Influenza Vaccine Effectiveness (HIVE Study)

Principal Investigator

Arnold Monto

Co-Principal Investigator

Suzanne Ohmit

Funding Sources

Centers for Disease Control and Prevention (CDC)

About this Project

The HIVE Study is a community-based cohort of households designed to further evaluate the effectiveness of influenza vaccine. 328 Households (1440 individuals) with at least 4 members, of which at least 2 are children, were recruited from persons who receive their health care from the University of Michigan Health System in the summer/fall of 2010. The households are followed during periods when influenza viruses may be circulating (e.g. October - May) with weekly study contact to identify onset of acute respiratory illnesses. Those with illnesses meeting a case definition for respiratory illness will have specimens collected for virus identification and be interviewed about the characteristics of their illness. Laboratory confirmed influenza outcomes and self-reported and validated (by electronic medical record and administrative data sources) vaccination status will be used to estimate vaccine effectiveness. Influenza vaccine effectiveness estimates will be compared with estimates of vaccine effectiveness in preventing medically-attended illness obtained from the MFIVE study. Data will also be made available for modeling of transmission to determine probability of infection in the household and community. Additionally, adult household members will complete two surveys to assess their perception of influenza risk, and their knowledge, attitudes, and practices regarding influenza prevention strategies, including vaccination. Surveys will be completed prior to and following the influenza season and changes in responses across time evaluated.