Publications

Pubmed search for Lumeng C

2024

Macrophage and T cell networks in adipose tissue

Jacks RD, Lumeng CN.

Nat Rev Endocrinol. 2024 Jan;20(1):50-61. doi: 10.1038/s41574-023-00908-2. Epub 2023 Oct 23. PMID: 37872302 Review.

2023

Matrix density regulates adipocyte phenotype

Ky A, McCoy AJ, Flesher CG, Friend NE, Li J, Akinleye K, Patsalis C, Lumeng CN, Putnam AJ, O'Rourke RW.

Adipocyte. 2023 Dec;12(1):2268261. doi: 10.1080/21623945.2023.2268261. Epub 2023 Oct 10. PMID: 37815174 

Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a Healthy Environment and Endocrine Disruptors Strategies Workshop

Heindel JJ, Alvarez JA, Atlas E, Cave MC, Chatzi VL, Collier D, Corkey B, Fischer D, Goran MI, Howard S, Kahan S, Kayhoe M, Koliwad S, Kotz CM, La Merrill M, Lobstein T, Lumeng C, Ludwig DS, Lustig RH, Myers P, Nadal A, Trasande L, Redman LM, Rodeheffer MS, Sargis RM, Stephens JM, Ziegler TR, Blumberg B.

Am J Clin Nutr. 2023 Jul;118(1):329-337. doi: 10.1016/j.ajcnut.2023.05.024. Epub 2023 May 23. PMID: 37230178

 MSR1 is not required for obesity-associated inflammation and insulin resistance in mice 

Nance SA, Muir L, Delproprosto J, Lumeng CN. 

Sci Rep. 2023 Feb 14;13(1):2651. doi: 10.1038/s41598-023-29736-0. PMID: 36788340; PMCID: PMC9927046. 

2022

Lumican modulates adipocyte function in obesity-associated type 2 diabetes 

Strieder-Barboza C, Flesher CG, Geletka LM, Eichler T, Akinleye O, Ky A, Ehlers AP, Lumeng CN, O'Rourke RW. 

Adipocyte. 2022 Dec;11(1):665-675. doi: 10.1080/21623945.2022.2154112. PMID: 36457256; PMCID: PMC9728465. 

Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity 

Nance SA, Muir L, Lumeng C. 

Mol Metab. 2022 Dec;66:101642. doi: 10.1016/j.molmet.2022.101642. Epub 2022 Nov 17. PMID: 36402403; PMCID: PMC9703629. 

TBK1-mTOR Signaling Attenuates Obesity-Linked Hyperglycemia and Insulin Resistance 

Bodur C, Kazyken D, Huang K, Tooley AS, Cho KW, Barnes TM, Lumeng CN, Myers MG, Fingar DC. 

2022 Nov 1;71(11):2297-2312. doi: 10.2337/db22-0256. PMID: 35983955; PMCID: PMC9630091. 

Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment 

Zhang P, Chen Z, Kuang H, Liu T, Zhu J, Zhou L, Wang Q, Xiong X, Meng Z, Qiu X, Jacks R, Liu L, Li S, Lumeng CN, Li Q, Zhou X, Lin JD. 

Cell Metab. 2022 Sep 6;34(9):1359-1376.e7. doi: 10.1016/j.cmet.2022.07.010. Epub 2022 Aug 15. PMID: 35973424; PMCID: PMC9458631. 

Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice. 

Frieler RA, Vigil TM, Song J, Leung C, Goldstein DR, Lumeng CN, Mortensen RM. 

Obesity (Silver Spring). 2022 Sep;30(9):1818-1830. doi: 10.1002/oby.23509. Epub 2022 Aug 4. PMID: 35927796; PMCID: PMC9541899. 

Microbiome, Metabolism, and Immunoregulation of Asthma: An American Thoracic Society and National Institute of Allergy and Infectious Diseases Workshop Report 

Kozik AJ, Holguin F, Segal LN, Chatila TA, Dixon AE, Gern JE, Lozupone C, Lukacs N, Lumeng C, Molyneaux PL, Reisdorph N, Vujkovic-Cvijin I, Togias A, Huang YJ. 

Am J Respir Cell Mol Biol. 2022 Aug;67(2):155-163. doi: 10.1165/rcmb.2022-0216ST. PMID: 35914321; PMCID: PMC9348558. 

Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters.

Muir LA, Cho KW, Geletka LM, Baker NA, Flesher CG, Ehlers AP, Kaciroti N, Lindsly S, Ronquist S, Rajapakse I, O'Rourke RW, Lumeng CN.

JCI Insight. 2022 Feb 8;7(3):e146563. doi: 10.1172/jci.insight.146563.

PMID: 34990410 

2021

 Maternal High-Fat Diet During Pre-Conception and Gestation Predisposes Adult Female Offspring to Metabolic Dysfunction in Mice.

  Akhaphong B, Gregg B, Kumusoglu D, Jo S, Singer K, Scheys J, DelProposto J, Lumeng C, Bernal-Mizrachi E, Alejandro EU.

  Front Endocrinol (Lausanne). 2022 Jan 17;12:780300. doi: 10.3389/fendo.2021.780300. eCollection 2021.

  PMID: 35111136 

High-fat and high-sodium diet induces metabolic dysfunction in the absence of obesity.

Frieler RA, Vigil TM, Song J, Leung C, Lumeng CN, Mortensen RM.

Obesity (Silver Spring). 2021 Nov;29(11):1868-1881. doi: 10.1002/oby.23264. Epub 2021 Sep 21.

PMID: 34549547

The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity.

Carruthers NJ, Strieder-Barboza C, Caruso JA, Flesher CG, Baker NA, Kerk SA, Ky A, Ehlers AP, Varban OA, Lyssiotis CA, Lumeng CN, Stemmer PM, O'Rourke RW.

Sci Rep. 2021 Aug 30;11(1):17394. doi: 10.1038/s41598-021-96995-0.

PMID: 34462518

Obesity results in adipose tissue T cell exhaustion.

Porsche CE, Delproposto JB, Geletka L, O'Rourke R, Lumeng CN.

JCI Insight. 2021 Apr 22;6(8):e139793. doi: 10.1172/jci.insight.139793.

PMID: 33724954

Pathways to Severe COVID-19 for People with Obesity.

O'Rourke RW, Lumeng CN.

Obesity (Silver Spring). 2021 Apr;29(4):645-653. doi: 10.1002/oby.23099.

PMID: 33270351 

A Bayesian Mixture Model for Predicting the COVID-19 Related Mortality in the United States.

Kaciroti NA, Lumeng C, Parekh V, Boulton ML.

Am J Trop Med Hyg. 2021 Feb 19;104(4):1484-1492. doi: 10.4269/ajtmh.20-1147.

PMID: 33606666 

Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling.

Song J, Frieler RA, Whitesall SE, Chung Y, Vigil TM, Muir LA, Ma J, Brombacher F, Goonewardena SN, Lumeng CN, Goldstein DR, Mortensen RM.

Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H323-H337. doi: 10.1152/ajpheart.00251.2020. Epub 2020 Nov 8.

PMID: 33164548

2020

Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells.

Bagchi DP, Nishii A, Li Z, DelProposto JB, Corsa CA, Mori H, Hardij J, Learman BS, Lumeng CN, MacDougald OA.

Mol Metab. 2020 Dec;42:101078. doi: 10.1016/j.molmet.2020.101078. Epub 2020 Sep 9.

PMID: 32919095

Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin-4.

Youngblood R, Flesher CG, Delproposto J, Baker NA, Neeley CK, Li F, Lumeng CN, Shea LD, O'Rourke RW.

Biotechnol Bioeng. 2020 Dec;117(12):3891-3901. doi: 10.1002/bit.27523. Epub 2020 Aug 18.

PMID: 32729936

Depot-specific adipocyte-extracellular matrix metabolic crosstalk in murine obesity.

Strieder-Barboza C, Baker NA, Flesher CG, Karmakar M, Patel A, Lumeng CN, O'Rourke RW.

Adipocyte. 2020 Dec;9(1):189-196. doi: 10.1080/21623945.2020.1749500.

PMID: 32272860

Elucidating nanoscale mechanical properties of diabetic human adipose tissue using atomic force microscopy.

Wenderott JK, Flesher CG, Baker NA, Neeley CK, Varban OA, Lumeng CN, Muhammad LN, Yeh C, Green PF, O'Rourke RW.

Sci Rep. 2020 Nov 24;10(1):20423. doi: 10.1038/s41598-020-77498-w.

PMID: 33235234

Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.

Russo L, Muir L, Geletka L, Delproposto J, Baker N, Flesher C, O'Rourke R, Lumeng CN.

Mol Metab. 2020 Sep;39:100983. doi: 10.1016/j.molmet.2020.100983. Epub 2020 Mar 27.

PMID: 32229247

Acute Aerobic Exercise Remodels the Adipose Tissue Progenitor Cell Phenotype in Obese Adults.

Ludzki AC, Krueger EM, Baldwin TC, Schleh MW, Porsche CE, Ryan BJ, Muir LA, Singer K, Lumeng CN, Horowitz JF.

Front Physiol. 2020 Jul 28;11:903. doi: 10.3389/fphys.2020.00903. eCollection 2020.

PMID: 32848853

  Weight Regain in Formerly Obese Mice Hastens Development of Hepatic Steatosis Due to Impaired Adipose Tissue Function.

  Zamarron BF, Porsche CE, Luan D, Lucas HR, Mergian TA, Martinez-Santibanez G, Cho KW, DelProposto JL, Geletka LM, Muir LA, Singer K, Lumeng CN.

  Obesity (Silver Spring). 2020 Jun;28(6):1086-1097. doi: 10.1002/oby.22788. Epub 2020 Apr 13.

  PMID: 32281747 

Enhanced Myeloid Leukocytes in Obese Children and Adolescents at Risk for Metabolic Impairment.

Gállego-Suárez C, Bulan A, Hirschfeld E, Wachowiak P, Abrishami S, Griffin C, Sturza J, Tzau A, Hayes T, Woolford SJ, Lumeng CN, Lee JM, Singer K.

Front Endocrinol (Lausanne). 2020 May 27;11:327. doi: 10.3389/fendo.2020.00327. eCollection 2020.

PMID: 32528415

  Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.

  Porsche CE, Delproposto JB, Patrick E, Zamarron BF, Lumeng CN.

  Mol Cell Endocrinol. 2020 Apr 5;505:110740. doi: 10.1016/j.mce.2020.110740. Epub 2020 Jan 24.

  PMID: 31987897

  Viscoelastic characterization of diabetic and non-diabetic human adipose tissue.

  Juliar BA, Strieder-Barboza C, Karmakar M, Flesher CG, Baker NA, Varban OA, Lumeng CN, Putnam AJ, O'Rourke RW.

  Biorheology. 2020;57(1):15-26. doi: 10.3233/BIR-190234.

  PMID: 32083565

2019

Advanced glycation end-products regulate extracellular matrix-adipocyte metabolic crosstalk in diabetes.

Strieder-Barboza C, Baker NA, Flesher CG, Karmakar M, Neeley CK, Polsinelli D, Dimick JB, Finks JF, Ghaferi AA, Varban OA, Lumeng CN, O'Rourke RW.

Sci Rep. 2019 Dec 24;9(1):19748. doi: 10.1038/s41598-019-56242-z.

PMID: 31875018 

A Human 3D Extracellular Matrix-Adipocyte Culture Model for Studying Matrix-Cell Metabolic Crosstalk.

Flesher CG, Baker NA, Strieder-Barboza C, Polsinelli D, Webster PJ, Varban OA, Lumeng CN, O'Rourke RW.

J Vis Exp. 2019 Nov 7;(153). doi: 10.3791/60486.

PMID: 31762470

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.

Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY, Ji Y, Li C, Guo L, Zhou L, Chen Z, Leon-Mimila P, Chung MT, Kurabayashi K, Opp J, Campos-Pérez F, Villamil-Ramírez H, Canizales-Quinteros S, Lyons R, Lumeng CN, Zhou B, Qi L, Huertas-Vazquez A, Lusis AJ, Xu XZS, Li S, Yu Y, Li JZ, Lin JD.

Mol Cell. 2019 Aug 8;75(3):644-660.e5. doi: 10.1016/j.molcel.2019.07.028.

PMID: 31398325 

GM-CSF Administration Improves Defects in Innate Immunity and Sepsis Survival in Obese Diabetic Mice.

Frydrych LM, Bian G, Fattahi F, Morris SB, O'Rourke RW, Lumeng CN, Kunkel SL, Ward PA, Delano MJ.

J Immunol. 2019 Feb 1;202(3):931-942. doi: 10.4049/jimmunol.1800713. Epub 2018 Dec 21.

PMID: 30578307

2018

Properties and functions of adipose tissue macrophages in obesity.

Russo L, Lumeng CN.

Immunology. 2018 Dec;155(4):407-417. doi: 10.1111/imm.13002. Epub 2018 Oct 19.

PMID: 30229891 

The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health.

Zhao XY, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD.

Mol Metab. 2018 Aug;14:60-70. doi: 10.1016/j.molmet.2018.06.005. Epub 2018 Jun 8.

PMID: 29934059

TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice.

Griffin C, Eter L, Lanzetta N, Abrishami S, Varghese M, McKernan K, Muir L, Lane J, Lumeng CN, Singer K.

J Biol Chem. 2018 Jun 8;293(23):8775-8786. doi: 10.1074/jbc.RA117.001526. Epub 2018 Apr 10.

PMID: 29636416 

Water-fat magnetic resonance imaging quantifies relative proportions of brown and white adipose tissues: ex-vivo experiments.

Stojanovska J, Lumeng CN, Griffin C, Hernando D, Hoffmann U, Haft JW, Kim KM, Burant CF, Singer K, Tsodikov A, Long BD, Romano MA, Tang PC, Yang B, Chenevert TL.

J Med Imaging (Bellingham). 2018 Apr;5(2):024007. doi: 10.1117/1.JMI.5.2.024007. Epub 2018 Jun 29.

PMID: 30137870

Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages.

Muir LA, Kiridena S, Griffin C, DelProposto JB, Geletka L, Martinez-Santibañez G, Zamarron BF, Lucas H, Singer K, O' Rourke RW, Lumeng CN.

J Leukoc Biol. 2018 Apr;103(4):615-628. doi: 10.1002/JLB.3HI1017-422R. Epub 2018 Mar 1.

PMID: 29493813

The IKK-related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists.

Bodur C, Kazyken D, Huang K, Ekim Ustunel B, Siroky KA, Tooley AS, Gonzalez IE, Foley DH, Acosta-Jaquez HA, Barnes TM, Steinl GK, Cho KW, Lumeng CN, Riddle SM, Myers MG Jr, Fingar DC.

EMBO J. 2018 Jan 4;37(1):19-38. doi: 10.15252/embj.201696164. Epub 2017 Nov 17.

PMID: 29150432

2017

Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery.

Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka LM, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O'Rourke RW.

Adipocyte. 2017 Apr 3;6(2):134-140. doi: 10.1080/21623945.2017.1287639. Epub 2017 Jan 27.

PMID: 28425841 

Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

Frikke-Schmidt H, Zamarron BF, O'Rourke RW, Sandoval DA, Lumeng CN, Seeley RJ.

Mol Metab. 2017 Feb 16;6(4):317-326. doi: 10.1016/j.molmet.2017.02.004. eCollection 2017 Apr.

PMID: 28377871

Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix.

Baker NA, Muir LA, Washabaugh AR, Neeley CK, Chen SY, Flesher CG, Vorwald J, Finks JF, Ghaferi AA, Mulholland MW, Varban OA, Lumeng CN, O'Rourke RW.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):1032-1043. doi: 10.1210/jc.2016-2915.

PMID: 28359093 

Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice.

Zamarron BF, Mergian TA, Cho KW, Martinez-Santibanez G, Luan D, Singer K, DelProposto JL, Geletka LM, Muir LA, Lumeng CN.

Diabetes. 2017 Feb;66(2):392-406. doi: 10.2337/db16-0500. Epub 2016 Nov 8.

PMID: 28108608 

Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer.

Zhang Y, Yu J, Grachtchouk V, Qin T, Lumeng CN, Sartor MA, Koenig RJ.

Oncotarget. 2017 Jan 24;8(4):5761-5773. doi: 10.18632/oncotarget.14050.

PMID: 28008156

The initiation of metabolic inflammation in childhood obesity.

Singer K, Lumeng CN.

J Clin Invest. 2017 Jan 3;127(1):65-73. doi: 10.1172/JCI88882. Epub 2017 Jan 3.

PMID: 28045405 

Differentiation and Metabolic Interrogation of Human Adipocytes.

Baker NA, Muir LA, Lumeng CN, O'Rourke RW.

Methods Mol Biol. 2017;1566:61-76. doi: 10.1007/978-1-4939-6820-6_7.

PMID: 28244041

2016

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance.

Cho KW, Zamarron BF, Muir LA, Singer K, Porsche CE, DelProposto JB, Geletka L, Meyer KA, O'Rourke RW, Lumeng CN.

J Immunol. 2016 Nov 1;197(9):3650-3661. doi: 10.4049/jimmunol.1600820. Epub 2016 Sep 28.

PMID: 27683748 

Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.

Meyer KA, Neeley CK, Baker NA, Washabaugh AR, Flesher CG, Nelson BS, Frankel TL, Lumeng CN, Lyssiotis CA, Wynn ML, Rhim AD, O'Rourke RW.

Biochem Biophys Rep. 2016 Sep;7:144-149. doi: 10.1016/j.bbrep.2016.06.004. Epub 2016 Jun 7.

PMID: 27617308

CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity.

Morris DL, Oatmen KE, Mergian TA, Cho KW, DelProposto JL, Singer K, Evans-Molina C, O'Rourke RW, Lumeng CN.

J Leukoc Biol. 2016 Jun;99(6):1107-19. doi: 10.1189/jlb.3A0115-009R. Epub 2015 Dec 11.

PMID: 26658005.

Lung Macrophage Diversity and Asthma.

Lumeng CN.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1(Suppl 1):S31-4. doi: 10.1513/AnnalsATS.201506-384MG.

PMID: 27027949 

Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity.

Muir LA, Neeley CK, Meyer KA, Baker NA, Brosius AM, Washabaugh AR, Varban OA, Finks JF, Zamarron BF, Flesher CG, Chang JS, DelProposto JB, Geletka L, Martinez-Santibanez G, Kaciroti N, Lumeng CN, O'Rourke RW.

Obesity (Silver Spring). 2016 Mar;24(3):597-605. doi: 10.1002/oby.21377.

PMID: 26916240 

Developmental programming: interaction between prenatal BPA exposure and postnatal adiposity on metabolic variables in female sheep.

Veiga-Lopez A, Moeller J, Sreedharan R, Singer K, Lumeng C, Ye W, Pease A, Padmanabhan V.

Am J Physiol Endocrinol Metab. 2016 Feb 1;310(3):E238-47. doi: 10.1152/ajpendo.00425.2015. Epub 2015 Dec 8.

PMID: 26646100

 Does bariatric surgery improve adipose tissue function?

 Frikke-Schmidt H, O'Rourke RW, Lumeng CN, Sandoval DA, Seeley RJ.

 Obes Rev. 2016 Sep;17(9):795-809. doi: 10.1111/obr.12429. Epub 2016 Jun 8.

 PMID: 27272117 

2015

Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury.

Frieler RA, Nadimpalli S, Boland LK, Xie A, Kooistra LJ, Song J, Chung Y, Cho KW, Lumeng CN, Wang MM, Mortensen RM.

Brain Res. 2015 Oct 22;1624:103-112. doi: 10.1016/j.brainres.2015.07.011. Epub 2015 Jul 21.

PMID: 26208897 

Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12.

Martinez-Santibanez G, Singer K, Cho KW, DelProposto JL, Mergian T, Lumeng CN.

Adipocyte. 2015 Apr 20;4(4):264-72. doi: 10.1080/21623945.2015.1027848. eCollection 2015 Oct-Dec.

PMID: 26451282

Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity.

Singer K, Maley N, Mergian T, DelProposto J, Cho KW, Zamarron BF, Martinez-Santibanez G, Geletka L, Muir L, Wachowiak P, Demirjian C, Lumeng CN.

J Biol Chem. 2015 May 22;290(21):13250-62. doi: 10.1074/jbc.M114.634568. Epub 2015 Apr 13.

PMID: 25869128

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.

Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR.

Nat Commun. 2015 Jan 12;6:6047. doi: 10.1038/ncomms7047.

PMID: 25581158 

Child body shape measurement using depth cameras and a statistical body shape model.

Park BK, Lumeng JC, Lumeng CN, Ebert SM, Reed MP.

Ergonomics. 2015;58(2):301-9. doi: 10.1080/00140139.2014.965754. Epub 2014 Oct 17.

PMID: 25323820

2014

An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation.

Cho KW, Morris DL, DelProposto JL, Geletka L, Zamarron B, Martinez-Santibanez G, Meyer KA, Singer K, O'Rourke RW, Lumeng CN.

Cell Rep. 2014 Oct 23;9(2):605-17. doi: 10.1016/j.celrep.2014.09.004. Epub 2014 Oct 9.

PMID: 25310975 

Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity.

O'Rourke RW, Meyer KA, Neeley CK, Gaston GD, Sekhri P, Szumowski M, Zamarron B, Lumeng CN, Marks DL.

Obesity (Silver Spring). 2014 Oct;22(10):2109-14. doi: 10.1002/oby.20823. Epub 2014 Jun 24.

PMID: 24962029 

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.

Singer K, DelProposto J, Morris DL, Zamarron B, Mergian T, Maley N, Cho KW, Geletka L, Subbaiah P, Muir L, Martinez-Santibanez G, Lumeng CN.

Mol Metab. 2014 Jul 10;3(6):664-75. doi: 10.1016/j.molmet.2014.06.005. eCollection 2014 Sep.

PMID: 25161889 

Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.

Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Fazeli PK, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA.

Cell Metab. 2014 Aug 5;20(2):368-375. doi: 10.1016/j.cmet.2014.06.003. Epub 2014 Jul 3.

PMID: 24998914 

Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man.

Jais A, Einwallner E, Sharif O, Gossens K, Lu TT, Soyal SM, Medgyesi D, Neureiter D, Paier-Pourani J, Dalgaard K, Duvigneau JC, Lindroos-Christensen J, Zapf TC, Amann S, Saluzzo S, Jantscher F, Stiedl P, Todoric J, Martins R, Oberkofler H, Müller S, Hauser-Kronberger C, Kenner L, Casanova E, Sutterlüty-Fall H, Bilban M, Miller K, Kozlov AV, Krempler F, Knapp S, Lumeng CN, Patsch W, Wagner O, Pospisilik JA, Esterbauer H.

Cell. 2014 Jul 3;158(1):25-40. doi: 10.1016/j.cell.2014.04.043.

PMID: 24995976

The relationship between body fat mass percentiles and inflammation in children.

Singer K, Eng DS, Lumeng CN, Gebremariam A, M Lee J.

Obesity (Silver Spring). 2014 May;22(5):1332-6. doi: 10.1002/oby.20710. Epub 2014 Feb 18.

PMID: 24464763

Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation.

Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD.

Diabetes. 2014 Apr;63(4):1340-52. doi: 10.2337/db13-1139. Epub 2013 Dec 30.

PMID: 24379350 

Fractalkine signaling in regulation of insulin secretion.

Gregg B, Lumeng CN, Bernal-Mizrachi E.

Islets. 2014;6(1):e27861. doi: 10.4161/isl.27861.

PMID: 25483879 

Macrophages and the regulation of adipose tissue remodeling.

Martinez-Santibañez G, Lumeng CN.

Annu Rev Nutr. 2014;34:57-76. doi: 10.1146/annurev-nutr-071812-161113. Epub 2014 May 14.

PMID: 24850386

Flow cytometry analyses of adipose tissue macrophages.

Cho KW, Morris DL, Lumeng CN.

Methods Enzymol. 2014;537:297-314. doi: 10.1016/B978-0-12-411619-1.00016-1.

PMID: 24480353 

Imaging white adipose tissue with confocal microscopy.

Martinez-Santibañez G, Cho KW, Lumeng CN.

Methods Enzymol. 2014;537:17-30. doi: 10.1016/B978-0-12-411619-1.00002-1.

PMID: 24480339 

2013

Obesity-Related Hormones in Low-Income Preschool-Age Children: Implications for School Readiness.

Miller AL, Lumeng CN, Delproposto J, Florek B, Wendorf K, Lumeng JC.

Mind Brain Educ. 2013 Dec;7(4):246-255. doi: 10.1111/mbe.12034.

PMID: 25302075

Thrombospondin 1 mediates high-fat diet-induced muscle fibrosis and insulin resistance in male mice.

Inoue M, Jiang Y, Barnes RH 2nd, Tokunaga M, Martinez-Santibañez G, Geletka L, Lumeng CN, Buchner DA, Chun TH.

Endocrinology. 2013 Dec;154(12):4548-59. doi: 10.1210/en.2013-1587. Epub 2013 Oct 18.

PMID: 24140711

Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes.

O'Rourke RW, Meyer KA, Gaston G, White AE, Lumeng CN, Marks DL.

PLoS One. 2013 Aug 14;8(8):e71165. doi: 10.1371/journal.pone.0071165. eCollection 2013.

PMID: 23967162

Obesity heats up adipose tissue lymphocytes.

O'Rourke RW, Lumeng CN.

Gastroenterology. 2013 Aug;145(2):282-5. doi: 10.1053/j.gastro.2013.06.026. Epub 2013 Jun 24.

PMID: 23806542 

Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice.

Morris DL, Cho KW, Delproposto JL, Oatmen KE, Geletka LM, Martinez-Santibanez G, Singer K, Lumeng CN.

Diabetes. 2013 Aug;62(8):2762-72. doi: 10.2337/db12-1404. Epub 2013 Mar 14.

PMID: 23493569

Targeted deletion of growth hormone (GH) receptor in macrophage reveals novel osteopontin-mediated effects of GH on glucose homeostasis and insulin sensitivity in diet-induced obesity.

Lu C, Kumar PA, Sun J, Aggarwal A, Fan Y, Sperling MA, Lumeng CN, Menon RK.

J Biol Chem. 2013 May 31;288(22):15725-35. doi: 10.1074/jbc.M113.460212. Epub 2013 Apr 17.

PMID: 23595986 

Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motility.

Su HW, Lanning NJ, Morris DL, Argetsinger LS, Lumeng CN, Carter-Su C.

J Cell Sci. 2013 Apr 15;126(Pt 8):1733-43. doi: 10.1242/jcs.113050. Epub 2013 Feb 26.

PMID: 23444381

Innate immune activation in obesity.

Lumeng CN.

Mol Aspects Med. 2013 Feb;34(1):12-29. doi: 10.1016/j.mam.2012.10.002. Epub 2012 Oct 13.

PMID: 23068074 

Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation.

Singer K, Morris DL, Oatmen KE, Wang T, DelProposto J, Mergian T, Cho KW, Lumeng CN.

PLoS One. 2013;8(3):e57929. doi: 10.1371/journal.pone.0057929. Epub 2013 Mar 5.

PMID: 23472120 

2012

Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages.

Orr JS, Puglisi MJ, Ellacott KL, Lumeng CN, Wasserman DH, Hasty AH.

Diabetes. 2012 Nov;61(11):2718-27. doi: 10.2337/db11-1595. Epub 2012 Jun 29.

PMID: 22751700 

Smooth muscle protein 22 alpha-Cre is expressed in myeloid cells in mice.

Shen Z, Li C, Frieler RA, Gerasimova AS, Lee SJ, Wu J, Wang MM, Lumeng CN, Brosius FC 3rd, Duan SZ, Mortensen RM.

Biochem Biophys Res Commun. 2012 Jun 15;422(4):639-42. doi: 10.1016/j.bbrc.2012.05.041. Epub 2012 May 16.

PMID: 22609406

CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity.

Morris DL, Oatmen KE, Wang T, DelProposto JL, Lumeng CN.

Obesity (Silver Spring). 2012 Jun;20(6):1189-99. doi: 10.1038/oby.2012.7. Epub 2012 Jan 17.

PMID: 22252034

Daily and intermittent corticosteroids have similar impact on recurrent wheezing in young children.

Ramirez I, Lumeng CN.

J Pediatr. 2012 May;160(5):881. doi: 10.1016/j.jpeds.2012.01.060.

PMID: 22516330 No abstract available.

2011

Aging is associated with an increase in T cells and inflammatory macrophages in visceral adipose tissue.

Lumeng CN, Liu J, Geletka L, Delaney C, Delproposto J, Desai A, Oatmen K, Martinez-Santibanez G, Julius A, Garg S, Yung RL.

J Immunol. 2011 Dec 15;187(12):6208-16. doi: 10.4049/jimmunol.1102188. Epub 2011 Nov 9.

PMID: 22075699

SirT1: a guardian at the gates of adipose tissue inflammation.

Cho KW, Lumeng CN.

Diabetes. 2011 Dec;60(12):3100-2. doi: 10.2337/db11-1308.

PMID: 22110091 

Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states.

Morris DL, Singer K, Lumeng CN.

Curr Opin Clin Nutr Metab Care. 2011 Jul;14(4):341-6. doi: 10.1097/MCO.0b013e328347970b.

PMID: 21587064 

Inflammatory links between obesity and metabolic disease.

Lumeng CN, Saltiel AR.

J Clin Invest. 2011 Jun;121(6):2111-7. doi: 10.1172/JCI57132. Epub 2011 Jun 1.

PMID: 21633179

Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers.

Deiuliis J, Shah Z, Shah N, Needleman B, Mikami D, Narula V, Perry K, Hazey J, Kampfrath T, Kollengode M, Sun Q, Satoskar AR, Lumeng C, Moffatt-Bruce S, Rajagopalan S.

PLoS One. 2011 Jan 26;6(1):e16376. doi: 10.1371/journal.pone.0016376.

PMID: 21298111 

2010

The role of pediatricians in the coordinated national effort to address childhood obesity.

Lumeng JC, Castle VP, Lumeng CN.

Pediatrics. 2010 Sep;126(3):574-5. doi: 10.1542/peds.2010-1873. Epub 2010 Aug 16.

PMID: 20713481 No abstract available.

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.

Usher MG, Duan SZ, Ivaschenko CY, Frieler RA, Berger S, Schütz G, Lumeng CN, Mortensen RM.

J Clin Invest. 2010 Sep;120(9):3350-64. doi: 10.1172/JCI41080. Epub 2010 Aug 9.

PMID: 20697155

Adipose tissue macrophages: a piece of the PAI of metabolic syndrome.

Lumeng CN.

Sci Transl Med. 2010 Feb 24;2(20):20ps7. doi: 10.1126/scitranslmed.3000850.

PMID: 20371488

2008

Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.

Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR.

Diabetes. 2008 Dec;57(12):3239-46. doi: 10.2337/db08-0872. Epub 2008 Oct 1.

PMID: 18829989