PUBLICATIONS

Selected Publications

1. Tamkus G, Uchida K, Lopatin AN. T-tubule recovery after detubulation in isolated mouse cardiomyocytes. Physiol Rep. 2023 Aug;11(15):e15779. doi: 10.14814/phy2.15779. PMID: 37537144.

2. Bouza AA, Edokobi N, Hodges SL, Pinsky AM, Offord J, Piao L, Zhao Y, Lopatin AN, Lopez-Santiago LF, Isom LL: Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling JCI Insight 6(3): e141776; 1-17, 2021. 33411695.

3. Uchida K, Nikouee A, Moench I, Tamkus G, Elghoul Y and Lopatin AN: The mechanism of osmotically induced sealing of cardiac t tubules Am J Physiol Heart Circ Physiol 319(2): H410-H421, 2020. PMC7473921.

4. Nikouee A, Uchida K, Moench I and Lopatin AN: Cholesterol Protects Against Acute Stress-Induced T-Tubule Remodeling in Mouse Ventricular Myocytes Front Physiol. 9: 1516-, 2018. PMC6240595.

5. Uchida K and Lopatin AN: Diffusional and Electrical Properties of T-Tubules Are Governed by Their Constrictions and Dilations Biophys J 114(2): 437-449, 2018. PMC5984979.

6. Uchida K, Moench I, Tamkus G, and Lopatin AN. Small membrane permeable molecules protect against osmotically-induced sealing of t-tubules in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2016; 311(1): H229-238. (Pubmed)

7. Moench I, Lopatin AN. Ca2+ homeostasis in sealed t-tubules of mouse ventricular myocytes. J Mol Cell Cardiol. 2014 Jul; 72:374-83.(Pubmed)

8. Moench I, Meekhof KE, Cheng LF, Lopatin AN. Resolution of hypo-osmotic stress in isolated mouse ventricular myocytes causes sealing of t-tubules. Exp Physiol. 2013; 98(7):1164-77. (Pubmed)

9. Cheng LF, Wang F, Lopatin AN. Metabolic stress in isolated mouse ventricular myocytes leads to remodeling of t-tubules. Am J Physiol Heart Circ Physiol. 2011; 301(5):H1984-95. (Pubmed)

10. Panama BK, McLerie M and Lopatin AN. Functional Consequences of Kir2.1/Kir2.2 Subunit Heteromerization. Pflugers Archiv-European Journal of Physiology 2010; 460(5): 839. (Pubmed)

11. Chen J, Hessler JA, Putchakayala K, Panama BK, Khan DP, Hong S, Mullen DG, Dimaggio SC, Som A, Tew GN, Lopatin AN, Baker JR, Holl MM, and Orr BG. Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes. J Phys Chem B. 2009; 113: 11179-11185. (Pubmed)

12. Day SM, Coutu P, Wang W, Herron TJ, Turner I, Shillingford M, Lacross NC, Converso KL, Piao L, Li J, Lopatin AN, Metzger JM. Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca2+ buffering action. Physiological Genomics. 2008; 33: 312-322. (Pubmed)

13. Panama BK, McLerie M and Lopatin AN. Heterogeneity of IK1 in the mouse heart. American Journal of Physiology. Heart and Circulation Physiology. 2007; 293(6):H3558-67. (Pubmed)

14. Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. Journal of Molecular and Cellular Cardiology. 2007; 43: 636-47. (Pubmed)

15. Piao L, Li J, McLerie M and Lopatin AN. Cardiac IK1 channels underlie early action potential shortening during hypoxia in the mouse heart. Journal of Molecular and Cellular Cardiology, 2007; 43(1): 27-38. (Pubmed)

16. Piao L, Li J, McLerie M and Lopatin AN. Transgenic upregulation of IK1 in the mouse heart is proarrhythmic. Basic Research in Cardiology, 2007; 102(5): 416-428. (Pubmed)

17. Flagg TP, Patton B, Masia R, Mansfield C, Lopatin AN, Yamada KA and Nichols CG. Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[ΔN30,K185Q] in the heart. American Journal of Physiology. Heart and Circulation Physiology, 2007; 293(1): H836-845. (Pubmed)

18. Fu Y, Huang X, Piao L, Lopatin AN, and Neubig RR. Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block. American Journal of Physiology. Heart and Circulation Physiology, 2007; 292: H2532-H2539. (Pubmed)

19. Noujaim SF, Pandit SV, Berenfeld O, Vikstrom K, Cerrone M, Mironov S, Zugermayr M, Lopatin AN and Jalife J. Up-regulation of the inward rectifier K+ current (IK1) in the mouse heart accelerates and stabilizes rotors. Journal of Physiology, 2007; 578: 315-326. (Pubmed)

20. Dobrzynski H, Billeter R, Greener ID, Tellez JO, Chandler NJ, Flagg TP, Nichols CG, Lopatin AN and Boyett MR. Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice. Journal of Molecular and Cellular Cardiology, 2006; 41: 855-867. (Pubmed)

21. Panama BK and Lopatin AN. Differential polyamine sensitivity in Kir2 channels. Journal of Physiology, 2006; 571(2): 287-302. (Pubmed)

22. Flagg TP, Remedi MS, Masia R, Gomes J, McLerie M, Lopatin AN and Nichols CG. Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal KATP. Journal of Molecular and Cellular Cardiology, 2005; 39(4): 647-656. (Pubmed)

23. Li J, McLerie M and Lopatin AN. Transgenic up-regulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability. American Journal of Physiology. Heart and Circulation Physiology, 2004; 287(6): H2790-H2802. (Pubmed)

24. Flagg TP, Charpentier F, Manning-Fox J, Remedi MS, Enkvetchakul D, Lopatin A, Koster J and Nichols C. Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels. American Journal of Physiology. Heart and Circulation Physiology, 2004; 286(4): H1361-H1369. (Pubmed)

25. McLerie M and Lopatin AN. Dominant negative suppression of IK1 in the mouse heart leads to altered cardiac excitability. Journal of Molecular and Cellular Cardiology, 2003; 35(4): 367-378. (Pubmed)

Reviews (including peer reviewed)

1. Anumonwo JM and Lopatin AN. Cardiac strong inward rectifier potassium channels. J Mol Cell Cardiol. 2010; 48(1): 45-54. (Pubmed)

2. Lopatin AN Inward rectification and cardiac excitability. Biological Membranes (Russ), 2002; 19(1): 57-65. (Pubmed)

3. Lopatin AN and Nichols CG. Inward rectifiers in the heart: An update on IK1. Journal of Molecular and Cellular Cardiology, 2001; 33(4): 625-638. (Pubmed)

Book Chapters

1. Lopatin AN and Anumonwo JMB. Structural and molecular bases of cardiac inward rectifier potassium channel function. In “Cardiac Electrophysiology: From Cell to Bedside”, Eds. Zipes DP and Jalife J: 6th Edition. 2013.

2. Lopatin AN and Nichols CG. Inward rectifier potassium channels. In “Encyclopedic Reference of Molecular Pharmacology”, Eds. S. Offermanns and W. Rosenthal. Springer Verlag, Berlin, Germany. 2nd Ed. 2007

3. Lopatin AN and Nichols CG. Inward rectifier potassium channels. In “Encyclopedic Reference of Molecular Pharmacology”, Eds. S. Offermanns and W. Rosenthal. Springer Verlag, Berlin, Germany. 1st Ed. 2002

4. Lopatin AN, Makhina EN and Nichols CG. Ch. 17. Crystallization technique for localizing ion channels in living cells. In: “Ion Channel Localization: Methods and Protocols.” Eds. Lopatin AN and Nichols CG. Humana Press Inc. Totowa, New Jersey. 2001

Books Edited

1. Lopatin AN and Nichols CG. “Ion Channel Localization Methods and Protocols” in series of “Methods in Pharmacology and Toxicology”. Humana Press. ISBN: 0-89603-8333-5. 2001