PUBLICATIONS
Decheng Ren, Minghua Li, Chaojun Duan, Liangyou Rui. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metabolism, 2:95-104, 2005. PMID:16098827.
Decheng Ren, Yingjiang Zhou, David Morris, Minghau Li, Zhiqin Li, Liangyou Rui. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. Journal of Clinical Investigation, 117:397-406, 2007. PMC1765516.
Wei Song, Decheng Ren, Wenjun Li, Lin Jiang, Kae Won Cho, Ping Huang, Chen Fan, Yiyun Song, Yong Liu, Liangyou Rui. SH2B regulation of growth, metabolism and longevity in both insects and mammals. Cell Metabolism, 11:427-437, 2010. PMC 2881875.
Liang Sheng, Yingjiang Zhou, Zheng Chen, Decheng Ren, Kae Won Cho, Lin Jiang, Yoshiteru Sasaki, Liangyou Rui. NF-kB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nature Medicine, 18 (6):943-949, 2012. PMC3766969.
Hong Shen, Liang Sheng, Lin Jiang, Haoran Su, Zheng Chen, Lei Yin, M. Bishr Omary, Liangyou Rui. Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers a fatal macrophage-dependent liver injury and fibrosis. Hepatology, 60(6):2065-76, 2014. PMC4245385.
Bijie Jiang, Hong Shen, Zheng Chen, Lei Yin, Linsen Zan, Liangyou Rui. Carboxyl Terminus of HSC70-interacting Protein (CHIP) Downregulates NF-κB-inducing Kinase (NIK) and Suppresses NIK-induced Liver Injury. Journal of Biological Chemistry, 290(18):11704-14, 2015. PMC4416871.
Zheng Chen, Mark J. Canet, Liang Sheng, Lin Jiang, Yi Xiong, Lei Yin, Liangyou Rui. Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity. Molecular Metabolism, 4(12):951-60, 2015. PMC4731737.
Chengxin Sun, Lin Jiang, Yan Liu, Hong Shen, Stephen J. Weiss, Yifa Zhou, Liangyou Rui. Adipose Snail1 Governs Lipolysis and Lipid Partitioning by Epigenetically Suppressing Adipose Triacylglycerol Lipase expression. Cell Reports, 17(8) :2015-2027, 2016. PMC5131732
Yan Liu, Liang Sheng, Yi Xiong, Hong Shen, Yong Liu, Liangyou Rui. Liver NF-κB-inducing kinase (NIK) promotes liver steatosis and glucose counterregulation in male mice with obesity. Endocrinology, 158:1207-1216, 2017. PMC5460833.
Hong Shen, Liang Sheng, Yi Xiong, Yeunghyen Kim, Lin Jiang, Zheng Chen, Yong Liu, Cheong-Hee Chang, Liangyou Rui. NF-κB-inducing kinase (NIK) deficiency induces CD4+ T cell-elicited liver injury and fibrosis in mice. Journal of Hepatology, 67(1):100-109, 2017. PMC5476485.
Yan Liu, Lin Jiang, Chengxin Sun, Nicole Ireland, Yatrik M. Shah, Yong Liu, Liangyou Rui. Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. Nature Communications, 9(1):2751, 2018. PMC6048127.
Yi Xiong, Adriana Souza Torsoni, Feihua Wu, Hong Shen, Yan Liu, Mark J Canet, Lei Yin, M. Bishr Omary, Liangyou Rui. Hepatic NF-κB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. Elife, Aug 2;7.pii:e34152, 2018. PMC6078493.
Hong Shen, Lin Jiang, Jiandie D. Lin, M. Bishr Omary, Liangyou Rui. Brown fat protects against alcoholic liver disease. Journal of Clinical Investigation, 130:2305-2317, 2019. PMC6546460.
Hong Shen, Yewei Ji, Yi Xiong, Hana Kim, Michelle G. Jin, Yatrik M. Shah, M. Bishr Omary, Yong Liu, Ling Qi, Liangyou Rui. Medullary thymic epithelial NF-κB-inducing kinase (NIK)/IKKα pathway shapes lung and liver homeostasis. Proceedings of the National Academy of Sciences of USA, 116(38):19090-19097, 2019. PMC6754592.
Lin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min-Hyun Kim, Martin G. Myers Jr, Chung Owyang, Liangyou Rui. Hypothalamic Sh2b1 protects against obesity and metabolic diseases by activating sympathetic nerve-brown fat axis. Nature Communications, 11(1):1517, 2020. PMC7089966.
Yan Liu, Haiyan Lin, Lin Jiang, Qingsen Shang, Yin Lei, Jiandie D. Lin, Wen-Shu Wu, Liangyou Rui. Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. Journal of Clinical Investigation, 130 (6):2992-3004, 2020. PMC7260003.
Xiao Zhong, Zhiguo Zhang, Hong Shen, Yi Xiong, Yatrik M. Shah, Yong Liu, Xue-Gong Fan, Liangyou Rui. Hepatic NIK and IKKα promote liver oxidative stress, ferroptosis, and liver injury. Hepatology Communications, 5(10):1704-1720, 2021. PMC8485893.
Zhiguo Zhang, Xiao Zhong, Hong Shen, Liang Sheng, Anna S. Lok, M Bishr Omary, Shaomeng Wang, Liangyou Rui. Biliary NIK promotes ductular reaction, liver injury, inflammation, and fibrosis in mice. Nature Communications, 13(1):5111, 2022. PMC9427946.
Liangyou Rui, Jiandie Lin. Nonalcoholic steatohepatitis: from hepatic steatosis to the liver microenvironment. Annual Review of Nutrition, 42:91-113, 2022. PMC10122183.
Min-Hyun Kim, Lin Liang, Yuan Li, Martin G. Myers Jr, Wen-Shu Wu, Liangyou Rui. LepRb cell-specific deletion of Slug mitigates obesity and NAFLD. Journal of Clinical Investigation, 133(4):e156722, 2023. PMC9927931.
Qianqian Kang, Xiaorong Zhu, Decheng Ren, Alexander Ky, Ormond A. MacDougald, Robert W. O’Rourke, Liangyou Rui. Adipose METTL14-elicited N6-methyladenosine promotes obesity, insulin resistance, and NAFLD through suppressing β adrenergic signaling and lipolysis. Advanced Science, e2301645, 2023. PMID: 37526326.
Pingping Wang, Qianqian Kang, Wen-Shu Wu, Liangyou Rui. Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice. Cell Reports, 43(3)113875, 2024. PMID: 38451818.