Gnegy Lab Publications

Recent publications. For a complete list of publications see: http://www.ncbi.nlm.nih.gov/pubmed/?term=Gnegy+ME

Luderman, K.D., Chen, R., Ferris, M.J., Jones, S.R., and Gnegy, M.E.: Protein Kinase Cb Regulates the D2-Like Dopamine Autoreceptor. Neuropharmacology, 89:335-341, 2015 PMCID In progress.

Fraser, R., Chen, Y., Guptaroy, B., Luderman, K.D., Stokes, S.L., Beg, A., DeFelice, L.J., and Gnegy, M.E., An N-Terminal Threonine Mutation Produces an Efflux-flavorable, Sodium-primed Conformation of the Human Dopamine Transporter. Mol Pharmacol., 2014 86(1):76-85. PMC4053999

Bosse KE, Jutkiewicz EM, Schultz-Kuszak KN, Mabrouk OS, Kennedy RT, Gnegy ME, Traynor JR: Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism. Neuropharmacology, 77:19-27, 2014. PMC3970824

Mabrouk, O.S., Semaan, D.Z., Mikelman, S., Gnegy, M.E., Kennedy, R.T.: Amphetamine stimulates movement through thalamocortical glutamate release. J. Neurochem, 128: 152-161, 2014. PMC3932332

Chen, R., Daining, C.P., Sun, H., Fraser, R., Stokes, S.L., Leitges, M., Gnegy, M.E.: Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J. Neurochem., 2013 125(5):663-72. PMC3660534

Guptaroy, B., Fraser, R., Desai, A., Zhang, M., Gnegy, M.E.: Site directed mutations near transmembrane domain 1 (TM1) alter conformation and function of norepinephrine and dopamine transporters. Molecular Pharmacology, 79(3):520-532, 2011. PMCID: 3061360

Kim, M., Jutkiewicz, E., Gnegy, M.E.: The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of β2 subunit-containing nicotinic acetylcholine receptors and glutamate N-methyl-D-aspartate receptors. Neuropharmacology, 60:1126, 2011 PMCID 3051040.

O’Malley, H., Park, Y., Isom, L., Gnegy, M.E.: PKCβ co-localizes with the dopamine transporter in mesencephalic neurons. Neuroscience Letters, 480:40-43, 2010. PMCID 2907545

Perry M.L., Leinninger, G.M., Chen, R., Luderman, K.D., Yang, H., Gnegy, M.E., Myers, Jr., M.G., Kennedy, R.T.: Leptin promotes dopamine transporter and tyrosine hydroxylase activity to enhance amphetamine-evoked dopamine efflux in Sprague-Dawley rats. J. Neurochem., 114:666-674, 2010. PMCID: 2910163

Furman C.A., Lo C.B., Stokes S., Esteban J.A., and Gnegy M.E. Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells. Neurosci Lett: 29:78-81, 2009 PMCID: 2754726

Guptaroy, B., Zhang, M., Bowton, E., Binda, F., Shi, L., Weinstein, H., Galli, A., Javitch, J.A., Neubig, R.R., Gnegy, M.E.: A Juxtamembrane Mutation In The N-Terminus Of The Dopamine Transporter Induces Preference For An Inward-Facing Conformation. Molecular Pharmacology, 75(3):514-24 2009 PMCID: PMC2684905

Singer, B., Jutkiewicz, E., Fuller, C., Lichtenwalner, R., Zhang, H., Velander, A., Li, X., Gnegy, M., Burant, C., Parent, J. Conditional ablation and recovery of forebrain neurogenesis in the mouse. Journal of Comparative Neurology, 514:567-582 , 2009. PMCID: PMC2739050

Chen, R., Furman, C.A., Zhang, M., Kim, M.N., Gereau R.W. IV, Leitges, L. and Gnegy, M.E:.Protein kinase Cβ; is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J. Pharmacol. & Exp. Therap., 328: 912-20, 2009. PMCID: 2104492 .

Binda, F., Dipace, C., Bowton, E., Doughty, S.E., Lute, B.J., Fog, J.U., Zhang, M.A., Sen, N., Colbran, R.J., Gnegy, M.E., Gether, U., Javitch, J.A., Erreger, K., Galli, A.: Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol. Pharm., 74:1101-1108, 2008. PMCID: PMC2728020

Furman, C.A., Guptaroy, B., Zhang, M., Holz, R.W. and Gnegy, M.E.: Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live cell imaging using total internal reflection fluorescence microscopy. J. Neurosci., 29(10):3328-36, 2009. PMCID: PMC2684676