In the Duncan lab, we ask fundamental questions about how cells work. Our projects seek to understand the proteins important for membrane traffic, the process by which trans-membrane proteins and proteins inside organelle arrive at their correct location. Our work investigates the molecular mechanisms underlying the movement of proteins between organelles, we identify the proteins that function in this process, how they interact with one another, and broadly how the process of membrane traffic contributes to global cell functions including nutrient responses, signal transduction, and morphology at the cellular and tissue level. Follow the links to above or click here to find out more!
Our collaborative work with the Babst lab Plasma membrane tension regulates eisosome structure and function. was published in the Molecular Biology of the Cell.
The lab was awarded a grant from the National Institutes of General medicine to study how the Clathrin Adaptor Protein complex -1 is regulated in yeast, and how it contributes to morphology in human stem cells.
A team lead by Mara Duncan and Deb Gumucio was awarded a MICHR synergy grant to build a holistic model of membrane traffic in epithelia using pluripotent stem cells.
Chris published his paper entitled "Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast." in the Journal of Biological Chemsitry
Jorge published his paper entitled "Investigation of Ldb19/Art1 localization and function at the late Golgi." in PlosOne.
Mara presented on Chris's work elucidating a new AP-1 accessory factor at the Midwest Yeast Meeting.
Chao-wei published his paper entitled "A simple and inexpensive quantitative technique for determining chemical sensitivity in Saccharomyces cerevisiae. " in Scientific Reports
Jorge defended his dissertation entitled " Novel roles and molecular mechanisms of membrane traffic machinery in yeast"
Justin was awarded Congress-Bundestag Youth Exchange for Young Professionals (CBYX) to spend a year in Germany.