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Dolinoy Lab - Environmental Epigenetics and Nutrition
It is increasingly recognized that environmental exposure to chemical, nutritional, and behavioral factors alters gene expression and affects health and disease by not only mutating promoter and coding regions of genes, but also by modifying the epigenome — modifications to DNA that confer an additional layer of heritable gene regulation that lead to disease when deregulated. The Dolinoy Lab investigates environmental epigenetics and gene-environment interactions using animal models, human clinical samples, and human population studies. Specifically, research focuses on nutrition and environmental chemicals and how many common compounds, such as bisphenol A (BPA), phthalates (e.g. DEHP, DINP, DBP), mercury (Hg), and lead (Pb), may have deleterious physiological consequences through abnormal epigenetic and genetic regulation.
Dana Dolinoy, Ph.D.NSF International Chair & Professor, Environmental Health SciencesProfessor, Nutritional SciencesUniversity of Michigan School of Public HealthDirector, Epigenomics Core
Michigan Medicine
ddolinoy@umich.edu
Twitter:@ddolinoy
Other Affiliations:
Director, Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) Center
Faculty Member, Michigan Momentum Center for Childhood Obesity
Research Professor, Michigan Center for Human Growth and Development
Consortia Participation:
TaRGET II: Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription
CHEAR: Children's Health Exposure Analysis Resource
ECHO: Environmental Health Influences on Child Health Outcomes
More Information:
Pursuit article by EHS Doctoral Student, Rachel Morgan: The Organism-Environment Interface: How Epigenetics Can Help Us Understand the Impacts of Climate Change
Podcast: You Make Me Sick: The Mysteries of the Epigenome (Hosted by the Environmental Defense Fund)
NIH Directors Blog: Creative Minds: Building the RNA Toolbox