Bibliography

Peer Reviewed

1. Lawrence, T.S., Canman, C.E., Maybaum, J., and Davis, M.A. Dependence of etoposide-induced cytotoxicity and topoisomerase II-mediated DNA strand breakage on the intracellular environment. Cancer Res. 49: 4775-4779, 1989.

2. Dusenbury, C.E., Davis, M.A., Lawrence, T.S., and Maybaum, J. Induction of megabase DNA fragments by 5-Fluorodeoxyuridine in human colorectal tumor (HT29) cells. Mol Pharmacol. 39: 285-289, 1991.

3. Maybaum, J., Burton, E.C., Shelton, D.A., Jing, H., Dusenbury, C.E., Ensminger, W.D., and Stetson, P.L. Divergent patterns of incorporation of bromodeoxyuridine and iododeoxyuridine in human colorectal tumor cell lines. Biochem Pharmacol. 42: 131-137, 1991.

4. Canman, C.E., Tang, H., Normolle, D.P., Lawrence, T.S., and Maybaum, J. Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine - Implications for mechanisms of resistance and cytotoxicity. Proc Natl Acad Sci USA 89: 10474-10478, 1992.

5. Canman, C.E., Lawrence, T.S., Shewach, D.S., Tang, H., and Maybaum, J. Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with and elevation of dUTPase activity and failure to accumulate dUTP. Cancer Res. 53: 5219-5224, 1993.

6. El-Deiry, W.S., Harper, J.W., O’Conner, P.M., Velculescu, V., Canman, C.E., Jackman, J., Pietenpol, J., Burrell, M., Jill, D.E., Wiman, K.G., Mercer, W.E., Kastan, M.B., Kohn, K.W., Elledge, S.J., Kinzler, K.W., and Vogelstein, B. WAF1/CIP1 is induced in p53-mediated G₁ arrest and apoptosis. Cancer Res. 54: 1169-1174, 1994.

7. Canman, C.E., Radany, E.H., Parcels, L.A., Davis, M.A., Lawrence, T.S., and Maybaum, J. Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase. Cancer Res. 54: 2296-2298, 1994.

8. Canman, C.E., Wolff, A.C., Chen, C-Y., Fornace, A.J., Jr., and Kastan, M.B. The p53-dependent G1 cell cycle checkpoint and Ataxia-Telangiectasia. Cancer Res. 54: 5054-5058, 1994.

9. Canman, C.E., Gilmer, T.M., Coutts, S.B., and Kastan, M.B. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev. 9: 600-611, 1995.

10. Lawrence, T.S., Davis, M.A., Chang, E.Y., Canman, C.E., Maybaum, J., Radany, E.H. Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity. Radiation Res. 143: 281-285, 1995.

11. Inaba, T., Inukai, T., Yoshihara, T., Seyschab, H., Ashmun, R.A., Canman, C.E., Laken, S.J., Kastan, M.B., and Look, A.T. Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature 382: 541-544, 1996.

12. Baskaran, R., Wood, L.D., Whitaker, L.L., Canman, C.E., Morgan, S.E., Xu, Y., Barlow, C., Baltimore, D., Wynshaw-Boris, A., Kastan, M.B., and Wang, J.Y.J. Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature 387: 516-519, 1997.

13. Metcalfe, S.M., Canman, C.E., Milner, J., Morris, R.E., Goldman, S., and Kastan, M.B. Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells. Oncogene 15: 1635-1642, 1997.

14. Siliciano, J.D., Canman, C.E., Taya,Y., Sakaguchi, K., Appella, E., and Kastan, M.B. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11: 3471-3481, 1997.

15. Canman, C.E. and Kastan, M.B. Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis. Oncogene 16: 957-956, 1998.

16. Lim, D-L., Kirsch, D.G., Canman, C.E., Ahn, J-H., Ziv, Y., Newman, L.S., Darnell, R.B., Shiloh, Y., and Kastan, M.B. ATM binds to b-Adaptin in cytoplasmic vesicles. Proc Natl Acad Sci USA 95: 10146-10151, 1998.

17. Canman, C.E., Lim, D-L., Cimprich, K.A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M.B., and Siliciano, J.D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 282: 1677-1679, 1998.

18. Westpal, C.H., Hoyes, K.P., Canman, C.E., Huang, X., Kastan, M.B., Hendry, J.H., and Leder, P. Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res. 58: 5637-5639, 1998.

19. Kim, S-T., Lim, D-L, Canman, C.E., and Kastan, M.B. Substrate specificities and identification of putative substrates of ATM kinase family members. J Bio. Chem. 274: 37538-37543, 1999.

20. Ahn, J-Y., Schwarz, J.K., Piwnica-Worms, H., and Canman, C.E. Threonine 68 phosphorylation by ATM is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res. 60: 5934-5936, 2000.

21. Ahn, J-Y., Li, X., Davis, H.L., and Canman, C.E. Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. J Biol Chem. 277: 19389-19395. 2002.

22. Lee, J.H., Xu, B., Lee, C.H., Ahn, J-Y., Song, M.S., Lee, H., Canman, C.E., Lee, J.S., Kastan, M.B., Lim, D.S. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res. 1: 674-81, 2003.

23. Garg, R., Callens, S., Lim, D-S., Canman, C.E., Kastan, M.B., Xu, B. Chromatin Association of Rad17 is required for an Ataxia Telangiectasia and Rad-related Kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation. Mol Cancer Res. 2: 362-369, 2004.

24. Nyati MK, Feng FY, Maheshwari D, Varambally S, Zielske SP, Ahsan A, Chun PY, Arora VA, Davis MA, Jung M, Ljungman M, Canman CE, Chinnaiyan AM, Lawrence TS. Ataxia telangiectasia mutated down-regulates phospho-extracellular signal-regulated kinase 1/2 via activation of MKP-1 in response to radiation. Cancer Res. 66: 11554-11559, 2006.

25. Derheimer, F.A., Hicks, J.K., Paulsen, M.T., Canman, C.E., Ljungman, M. Psoralen-induced interstrand DNA cross-links block transcription and induce p53 in an ATR-dependent manner. Mol Pharmacol. 75: 599-607, 2009.

26. Parsels, L.A., Morgan, M.A., Tanska, D.M., Parsels, J.D., Palmer, B.D., Booth, R.J., Denny, W.A. Canman, C.E., Kraker, A.J., Lawrence, T.S., Maybaum, J. Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells. Mol Cancer Ther. 8: 45-54, 2009.

27. Hicks J.K., Chute C.L., Paulsen M.T., Ragland R.L., Howlett N.G., Guéranger Q., Glover T.W., Canman C.E. Differential roles for the DNA Polymerases Eta, Zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol. 30: 1217-30, 2010.

28. Morgan, M.A., Parsels, L.A., Zhao, L., Parsels, J.D., Davis, M.A., Hassan, M.C., Arumugarajah, S., Hylander-Gans, L., Morosini, D., Simeone, D.M., Canman, C.E., Normolle, D.P., Zabludoff, S.D., Maybaum, J., and Lawrence, T.S. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res 70: 4972-4981, 2010.

29. Sharma, S., Hicks, J.K., Chute, C.L., Brennan, J.R., Ahn, J-Y., Glover, T.W., Canman, C.E. REV1 and Polymerase ζ Facilitate Homologous Recombination. Nucleic Acids Res 40: 682-691, 2012.

30. Sharma, S., Shah, N.A., Joiner, A., Roberts, K.H., and Canman, C.E. DNA polymerase zeta is a major determinant of resistance to platinum-based chemotherapeutic agents. Mol Pharmacol 81: 778-87, 2012.

31. Tian, F, Sharma, S, Zou, J, Lin, S-Y, Wang, B, Rezvani, K, Wang, H, Parvin, JD, Ludwig, T, Canman, CE, and Zhang, D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade, Proc Natl Acad Sci USA 110: 13558-13563, 2013.

32. Helchowski, CM, Skow, LF, Roberts, KH, Chute, CL, and Canman, CE. A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci, Cell Cycle 12: 1-10, 2013.

33. Ladd, B, Ackroyd, JJ, Hicks, JK, Canman, CE, Flanagan, SA, and Shewach, DS. Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity. DNA repair 12: 1114-21, 2013.

34. Wang L, Yang H, Palmbos P, Ney G, Detzler TA, Coleman D, Leflein J, Davis M, Zhang M, Tang W, Hicks JK, Helchowski CM, Prasad J, Lawrence TS, Xu L, Yu X, Canman CE, Ljungman M, Simeone DM. ATDC/TRIM29 phosphorylation by ATM/ MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. Cancer Res 74: 1778-88, 2014.

35. Prensner JR, Chen W, Iyer MK, Cao Q, Ma T, Han S, Sahu A, Malik R, Wilder-Romans K, Navone N, Logothetis CJ, Araujo JC, Pisters LL, Tewari AK, Canman CE, Knudsen KE, Kitabayashi N, Rubin MA, Demichelis F, Lawrence TS, Chinnaiyan AM, Feng FY. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res 74:1651-60, 2014.

36. A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits Repair of Interstrand DNA Crosslink, enhances DNA Double-strand Break, and sensitizes Cancer Cells to Cisplatin. Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. J Biol Chem 289: 7109-20, 2014.

37. Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin. Omer Ziv, Amit Zeisel, Nataly Mirlas, Umakanta Swain, Reinat Nevo, Nir Ben-Chetrit,Maria Paola Martelli, Roberta Rossi, Stefan Schiesser, Christine E. Canman, Thomas Carell, Nicholas Geacintov, Brunangelo Falini, Eytan Domany and Zvi Livneh. Nat Commun, 5: 5437 doi: 10.1038/ncomms6437, 2014.

Book Chapters and Reviews

1. Canman, C.E., Chen, C-Y., Lee, M-H., and Kastan, M.B. DNA Damage Responses: p53 Induction, Cell Cycle Perturbations and Apoptosis. Cold Spring Harbor Symp. Quant. Biol. 59: 277-286, 1994.

2. Canman, C.E. and Kastan, M.B. Induction of apoptosis by tumor suppressor genes and oncogenes. Seminars in Cancer Biology 6: 17-25, 1995.

3. Kastan, M.B., Canman, C.E., and Leonard, C.L. P53, Cell Cycle Control and Apoptosis: Implications for Cancer. Cancer and Metastasis Reviews 14: 3-15, 1995.

4. Leonard, C.J., Canman, C.E., and Kastan, M.B. p53, cell cycle control, and apoptosis. Important Advances in Oncology, J.B. Lippincott Company, 1995.

5. Canman, C.E., and Kastan, M.B. Signal transduction: Three paths to stress relief. Nature 384: 213-214, 1996.

6. Canman, C.E. and Kastan, M.B. Role of p53 in Apoptosis. Advances in Pharmacology, Academic Press, 41: 429-60, 1997.

7. Canman, C.E. and Lim, D-S. The role of ATM in DNA damage responses and cancer. Oncogene, 17: 3301-8, 1998.

8. Ziv, Y., Banin, S., Lim D-S., Canman, C.E, Kastan, M.B, and Shiloh Y. Expression and assay of recombinant ATM. Methods Mol. Biol. 99: 99-108, 2000.

9. Kastan, M.B., Lim, D-S., Kim, S-T., Xu, B., Canman, C., Multiple signaling pathways involving ATM. Cold Spring Harb. Symp. Quant. Biol. 65:521-526, 2000.

10. Canman, C.E. Replication checkpoint: preventing mitotic catastrophe. Curr. Biol. 11: R121-R124, 2001.

11. Canman, C.E. Checkpoint Mediators: relaying signals from DNA strand breaks. Curr. Biol. 12:R488-490, 2003.

12. Sharma, S. and Canman, C.E., REV1 and DNA polymerase zeta in DNA interstrand crosslink repair. Environ Molecular Mutagen 53:725-740, 2012.

13. Sharma S, Helchowski CM, Canman CE., The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability. Mutat Res, 743-744:97-110, 2013.