News

Congratulations to Dr. Black and the team on their new publication, "Development of a noncanonical redox cofactor platform in Saccharomyces cerevisiae" published in Metabolic Engineering!

The study established an orthogonal redox system in yeast using nicotinamide mononucleotide, NMN(H), as a noncanonical cofactor that operates independently of the cell’s native NAD(P)H metabolism. By rewiring glycolysis, the researchers used glucose as a source of reducing power for NMNH and selectively converted citral to citronellal while suppressing unwanted over-reduction to alcohols.

Access full paper:
Black WB, McKee K, Richardson KN, Saleh S, Gednov M, Si A, and Li H, Development of a noncanonical redox cofactor platform in Saccharomyces cerevisiae. Metabolic Engineering, 2026. https://doi.org/10.1016/j.ymben.2026.102488