Jonathan Fisher, Associate Professor
joined SLU faculty in 2001
Skeletal muscle plays predominant roles in clearance of glucose from the blood and whole body energy metabolism. The lab investigates aspects of muscle metabolism including regulation of glucose transport into muscle, alteration of growth-related and metabolic signaling within muscle cells, and control of mitochondrial function. In particular, we are interested in regulation of glucose transport under basal conditions, under the influence of hormones such as insulin (which stimulates glucose transport into muscle), and under conditions of metabolic stress.
The signaling pathways and players that are central in our work include:
Susan Spencer, a neuroscientist in the department, took the photo shown above and the one to the right
showing myoblasts (mono-nucleated cultured muscle cells) expressing GLUT1-GFP with a nuclear stain (red). The GLUT1-GFP expression plasmid was generously provided by Jeffrey Rathmell (Duke University).
Here's our 2013 PhunWeek visit to Park Elementary School in the Ferguson-Florissant School District. Left to right: Jon, Stan (doctoral student), Gaytri (senior), Rikki (first year medical student), Liz (masters student), Emma (junior), and Obi (senior).
Stan Andrisse (shown handing out certificates and cash prizes with an assist from me) mentored Andrea Webber, Gatryi Patel, and Joe Chen in a project to determine factors that regulate GLUT1 localization and activity. Andrea, Gaytri, and Joe received the second place award for undergraduate research from the Department of Biology in May, 2012.
The lab's work on regulation of glucose transport is relevant to diabetes mellitus, the hallmark of which is high blood glucose levels.
Below: The GLUT1 Crew!
Larry at EB2012: