Publications

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2021

36- Plasmodium berghei-Released Factor, PbTIP, Modulates the Host Innate Immune Responses Inderjeet Kalia, Rajesh Anand, Afshana Quadiri, Shreya Bhattacharya, Bijayalaxmi Sahoo, Agam Prasad Singh*

Published: 07 December 2021 DOI: 10.3389/fimmu.2021.699887 Frontiers in Immunology IF=8.78 (2022)

35- Essential role of a Plasmodium berghei heat shock protein (PBANKA_0938300) in gametocyte development Mohammad Kashif, Afshana Quadiri, Agam Prasad Singh *      Published: 08 December 2021    DOI: https://doi.org/10.1038/s41598-021-03059-4 Scientific Reports 5 year IF=5.5 (2021) current 4.997 (2022)

34- Synthesis of new analogs of morpholine and their antiplasmodial evaluation against human malaria parasite Plasmodium falciparum

Upadhyay, Charu ; Sharma, Neha; Kumar, Sumit; Sharma, Prem; Fontinha, Diana; Chhikara, Bhupender; Mukherjee, Budhaditya; Kumar, Dhruv; Prudêncio, Miguel; Singh, Agam; Singh, Poonam* Accepted Nov 2021      https://doi.org/10.1039/D1NJ04198C RSC- New Journal of Chemistry   46:250-262         IF=3.6

P6-    Hydroxiethyamine based Piperazine compounds, and methods of producing and using the same for treating disease.   Brijesh Rathi, Snigdha Singh, Bryn Mounce, Poonam, Prakasha Kempaiah, Agam Prasad Singh and Ravi Durvasula. USA Patent Application No. 17/347,720 filed 15 June 2021 

P5- Bidirectional Constitutive promoter and uses, and transfection method for B. Microti  Kavitha Govindasamy, Agam P. Singh, Dabbu K. Jaijyan. 

USA Patent Application No. 16/813940  Filed 10 Mar 2020 Publication date 16 Sep 2021 Pub No. US 2021/ 0285004 A1           Not granted

33- STK35L1 regulates Plasmodium infection and expression of cell cycle genes during liver stage of malaria. Phulwanti Sharma, Inderjeet Kalia, Vibha Kaushik, Daniela Brünnert, Afshana Quadiri, Mohammad Kashif, Kirti Chahar, Akhil Agarwal, Agam Prasad Singh*, Pankaj Goyal*   DOI: https://doi.org/10.1016/j.yexcr.2021.112764 Exp. Cell research, (Elseviers)   IF=3.0 Aug 2021

32- P. falciparum Metacaspase-2 Capture its Natural Substrate in a Non-Canonical Way. Vandana Kumari, Rajan Pandey, E Srinivasan, Inderjeet Kalia, Agam P Singh, Ajay K Saxena, R Rajaekaran, Dinesh Gupta, and Kailash C Pandey*. The Journal of Biochemistry (Oxford academic)   https://doi.org/10.1093/jb/mvab086    

 14 September 2021 IF=2.6

 31- Novel antiplasmodial compounds leveraged with multistage potency against Parasite Plasmodium falciparum: In vitro, in vivo evaluations and pharmacokinetic studies  Sharma, Neha; Kashif, Mohammad ; Singh, Vigyasa; Fontinha, Diana; Mukherjee, Budhaditya; Kumar, Dhruv ; Singh, Shailja; Prudêncio, Miguel; Singh, Agam *; Rathi, Brijesh* Journal of Medicinal Chemistry   https://doi.org/10.1021/acs.jmedchem.1c00659        14 June 2021 IF=8.02 (2021)

30- Conserved Plasmodium protein (PF3D7_0406000) of unknown function, in-silico analysis and cellular localization.  

Isha Pandey, Afshana Quadiri, Ishan Wadi, C.R. Pillai, Agam P. Singh*, Ashis Das*. Infect. Genet. Evol. 92:104848. doi: 10.1016/j.meegid.2021.104848. 3 April 2021 IF=2.7

 29- Pathogenic Pore Forming Proteins of Plasmodium Triggers the Necrosis of Endothelial Cells Attributed to Malaria Severity Shivappagowdar, Abhishek; Garg, Swati; Srivastava, Akriti; Hada, Rahul S.; Kalia, Inderjeet; Singh, Agam P.; Garg, Lalit C.; Pati, Soumya; Singh, Shailja*. 2021. Toxins 13, no. 1: 62. 

https://doi.org/10.3390/toxins13010062 15 Jan 2021 IF 3.4

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2020

28- Potent in vivo antimalarial activity of water-soluble Artemisinin nano-preparations Praveesh Valissery, Roshni Thapa, Jyoti Singh, Deepak Gaur, Jaydeep Bhattacharya*, Agam Prasad Singh*, Suman Kumar Dhar* RSC Advances, VOL 10, ISSUE 59 Doi: 10.1039/d0ra05597b 1 Oct 2020 IF=3.0

27- Multistage Antiplasmodial Activity of Hydroxyethylamine Compounds, In vitro and In vivo Evaluations

Sharma N, Gupta Y, Bansal M,Singh J, Kashif M,-----------Singh AP, Rathi B RSC Advances, VOL 10 ISSUE 58 doi:10.1039/d0ra03997g 25 Sep 2020 IF=3.0

26- Establishment of a stable transfection method in Babesia microti and Identification of a novel bidirectional promoter of Babesia microti

Jaijyan DK, Govindasamy K*, Singh J, Bhattacharya S, Singh AP* Scientific Reports VOL 10 ART NO 15614 DOI: 10.1038/s41598-020-72489-3 24 Sep 2020 5 year IF=5.5 (2021) 

25- Nonpeptidyl Molecule Modulates Apoptosis-like Cell Death by specifically inhibiting P.falciparum Metacapase-2  

Vandana, Sudha Sankar , Mohammad Kashif, Inderjeet , Rajkishor Rai, Agam P Singh, Kailash C Pandey* Biochemical J.   2020 Apr 17;477(7):1323-1344. doi:10.1042/BCJ20200050. April 17, 2020 IF=4.0

24- Plasmodium Perforin-like Protein pores on the host cell membrane contribute in its multistage growth and erythrocyte senescence  Swati Garg, Abhishek Shivappagowdar, Rahul S Hada, Rajagopal Ayana, Chandramohan Bathula, Subhabrata Sen, Inderjeet Kalia, Soumya Pati, Agam P Singh, Shailja Singh* Frontiers in Cellular and Infection Microbiology, 

10:121. doi: 10.3389/fcimb.2020.0012. PMID: 32266171 24 Mar  2020 IF=4.3

P4-  New Antiparasitic Agents Based on Piperazine and Uses thereof Neha Sharma, Brijesh Rathi, Agam P Singh,    

 INDIAN Patent Application No. 202011043767 Filed  08/10/2020

P3-  Hydroxiethyamine based Piperazine compounds, methods of producing and using the same for treating disease Brijesh Rathi, Snigdha Singh, Bryn Mounce, Poonam, Prakash Kempaih, Agam Prasad Singh and Ravi Durvasula INDIAN Patent Application No. 202011056923 Filed   29/12/2020

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2019

 23- Identification and characterization of protective CD8+ T epitopes in a malaria vaccine candidate SLTRiP

Afshana Quadiri, Inderjeet Kalia, Mohammad Kashif, Agam Prasad Singh #  

Immunity, Inflammation and Disease [Wiley Publishers]  PMID:31967737 doi: 10.1002/iid3.283 25 Dec 2019 IF 2.493 (2022)

22- Metacaspase-3 of Plasmodium falciparum: An atypical trypsin-like serine protease

 Bhumika Kumar, Deepak Singla , Mohammad Kashif, Ruby Sharma, Rajnikant Dixit, Agam P. Singh, Ajay K. Saxena, Mohammad Abid, Kailash C. Pandey*

International Journal of Biological Macromolecules     138 (2019) 309–320 July 2019

21- Molecular characterization and expression profile of an alternate proliferating cell nuclear antigen homologue, PbPCNA2, in Plasmodium berghei .Sabyasachi Pradhan, Inderjeet Kalia, Sourav Singha Roy, Om P. Singh, Adak Tridibesh, Agam P. Singh* & Suman K. Dhar* IUBMB Life doi:10.1002/iub.2036 13 Mar 2019

20- Tryptophan-kyneurin pathway attenuates beta-catenin dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection .Tanmay Majumdar, Shagun Sharma, Manmohan Kumar, Md. Arafat Hussain, Inderjeet Kalia, Amit Kumar Sahu, Vipin Singh Rana, Ruchi Bharti, Arun Kumar Haldar, Agam P. Singh,Shibnath Mazumder

Cell death and disease  https://doi.org/10.1038/s41419-019-1420-9 Feb 2019

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2018

 19- Fast acting small molecules targeting malarial aspartyl-proteases, plasmepsins, inhibit malaria infection at multiple life stages

 Singh, Snigdha; Rajendran, Vinoth; He, Jiang; Singh, Amit; Achieng,  Angela; Pant, Akansha; Kumari, Vandana; Nasamu, Armiyaw; Pandit, Mansi; Singh, Jyoti; Quadri, Afshana ; Gupta, Nikesh; Ghosh, Prahlad; Singh, Brajendra; Narayanan, Latha; Kempaiah, Prakasha; Chandra, Ramesh; Dunn, Ben; Pandey, Kailash; Goldberg, Daniel; Singh, Agam*; Rathi, Brijesh*

ACS Infectious diseases  DOI: 10.1021/acsinfecdis.8b00197  

 P2-    A Chaperon family protein based malaria vaccine . Agam Prasad Singh, Himanshu Singh, Dabbu Kumar Jaijyan. Indian Patent No. 508461 Granted 8th Feb 2024

India Patent application number 201811008326 FILED 7 mar 2018   

18- Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2) Vandana, Agam P. Singh, Jitendra Singh, Ruby Sharma, Mymoona Akhter, Pradyumna K. Mishra, Ajay K. Saxena, Rajnikant Dixit, Brijesh Rathi, Anju Katyal, Kailash C. Pandey*

Molecular and Biochemical Parasitology    https://doi.org/10.1016/j.molbio

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2016- 2017

 17- Frequent inoculations with Radiation attenuated sporozoite is essential for inducing sterile protection that correlates with a threshold level of Plasmodia liver-stage specific CD8+ T cells.   Hardik Patel, Naveen Yadav, Rajesh Parmar, Satish Patel, Agam P. Singh, Neeta Shrivastava, Sarat K. Dalai* Cellular Immunology, https://doi.org/10.1016/j.cellimm.2017.05.001 

16- A novel FIKK kinase regulates the development of mosquito and liver stages of the malaria

Dabbu Kumar Jaijyan, Praveen Kumar Verma and Agam Prasad Singh* Scientific reports   www.nature.com/articles/srep39285  DOI: 10.1038/srep39285  

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2015

 15- Cytokines induce effector T-helper cells during invasive aspergillosis; what we have learned about T-helper cells ?

Raman Thakur, Rajesh Anand, Shraddha Tiwari, Agam P Singh, Bhupendra N Tiwary, Jata Shankar* Frontiers in Microbiology, 6, doi: 10.3389/fmicb.2015.00429

14- A Sporozoite and Liverstage Expressed Tryptophan Rich Protein Plays an Auxiliary Role in Plasmodium Liver Stage Development and is a Potential Vaccine Candidate Dabbu Kumar Jaijyan, Himanshu Singh, and Agam Prasad Singh* J. Biol. Chem. 290 (32):19496–19511

 13- Aspergillus flavus induces granulomatous cerebral aspergillosis in mice with display of distinct cytokine profile .

R. Anand*, J Shankar, BN Tiwary, AP Singh* Cytokine 72 (2), 166-17   

12- Liver-stage specific response among endemic populations:diet and immunity Sarat Kumar Dalai, Naveen  Yadav, Manoj Patidar, Hardik Patel  and Agam Prasad Singh

Frontiers in immunology. doi: 10.3389/fimmu.2015.00125

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2002-2014

 Older publications  ( 11) in the order of highest to lowest citation

 11- 2007   Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

AP Singh*, CA Buscaglia, Q Wang, A Levay, DR Nussenzweig, JR Walker, Cell 131 (3), 492-504 IF= 66.8 (2022)

10- 2005    Sulphated tyrosines mediate association of chemokines and Plasmodium vivax Duffy binding protein with the Duffy antigen/receptor for chemokines (DARC) H Choe, MJ Moore, CM Owens, PL Wright, N Vasilieva, W Li, AP Singh, ...                 Molecular microbiology 55 (5), 1413-1422

09- 2005 Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion AP Singh, H Ozwara, CHM Kocken, SK Puri, AW Thomas, CE Chitnis * Molecular microbiology 55 (6), 1925-1934

08- 2003  Definition of structural elements in Plasmodium vivax and P. knowlesi Duffy-binding domains necessary for erythrocyte invasion

S Singh, A Singh, S Pandey, S Yazdani, C Chitnis*, A Sharma* Biochem. J 374, 193-198

07- 2002  Antibodies raised against receptor-binding domain of Plasmodium knowlesi Duffy binding protein inhibit erythrocyte invasion.

AP Singh, SK Puri, CE Chitnis* Molecular and biochemical parasitology 121 (1), 21-31

06- 2010  Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth AP Singh*, Y Zhang, JH No, R Docampo, V Nussenzweig, E Oldfield*

Antimicrobial agents and chemotherapy 54 (7), 2987-2993

05- 2009  Triclosan inhibit the growth of the late liver‐stage of Plasmodium AP Singh*, N Surolia, A Surolia*  IUBMB life 61 (9), 923-928

04-2012  Apicoplast Triose Phosphate Transporter (TPT) gene Knockout Is lethal for Plasmodium.

  T Banerjee, DK Jaijyan, N Surolia, AP Singh*, A Surolia* Molecular and Biochemical Parasitology 186 (1), 44-50  

03- 2013  Cytokine milieu in renal cavities of immunocompetent mice in response to intravenous challenge of Aspergillus flavus leading to aspergillosis

R Anand, J Shankar, AP Singh, BN Tiwary* Cytokine 61 (1), 63-70

02- 2003  A Plasmodium yoelii yoelii erythrocyte binding protein that uses Duffy binding-like domain for invasion: a rodent model for studying erythrocyte invasion. CD Prasad, S Agam Prasad, CE   Chitnis, A Sharma* Molecular and biochemical parasitology 128 (1), 101

01- 2014   Evaluation of Aflatoxin B1 biosynthesis in A. flavus isolates from Central India and identification of atoxigenic isolates

Patel,T.K., Anand,R., Singh, A.P, Shankar, J., Tiwary,B.N. Biotechnology and Bioprocess Engineering 19:1105-13

P1- 2010  Plasmodium axenic liver stages as a noninfectious whole organism malaria vaccine (Granted)

SHI Kappe, V Nussenzweig, K Kaiser, N Camargo, AP Singh US Patent App. 12/684,464