Publications

1. Singh P*, Gollapalli K*……....Nair T……….. Kennedy BK, Andersen JK, Lithgow GJ, Ali AM,  Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK^ (2023) Taurine deficiency as a driver of aging. Science 280 (6649):1-11. DOI: 10.1126/science.abn9257

2. Kar A*, Jain D*, Kumar S, Rajput K, Pal S, Rana K, Kar K, Jha SK, Medatwal N, Yavvari PS, Pandey N, Mehta D, Sharma H, Bhattacharya D, Pradhan MK, Datta Sharma R, Srivastava A, Agarwal U, Mukhopadhyay A, Sengupta S, Patil VS, Bajaj A^, Dasgupta U^ (2023) A Localized Hydrogel-mediated Chemotherapy Causes Immunogenic Cell Death via Activation of Ceramide-mediated Unfolded Protein Response. Science Advances DOI:10.1126/sciadv.adf2746

3. Nair T and Mukhopadhyay A^ (2023) Diet-gene interactions ensure optimal life span and health. J Biosci (in press)

4. Garg A, Alam M, Bai S, Dandawate M, Kumari N, Gupta S, Agrawal U, Nagarajan P, Reddy DS, Kulkarni MJ, and Mukhopadhyay A^ (2023) Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes. ACS Pharmacology and Translational Science [http://doi.org/10.1021/acsptsci.2c00082] 

5. Sarkar GC, Rautela U*, Goyala G*, Datta S, Anand N, Singh A, Singh P, Chamoli M, Mukhopadhyay A^ (2022) A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage, 21 January 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1119544/v1]

6. Rajput K*, Ansari MN *, Jha SK, Medatwal N, Sharma P, Datta,S Kar A, Pani T, Cholke K,  Rana K, Khan A,  Mukherjee G,  Deo SVS,  Prabhu JS, Mukhopadhyay A, Bajaj A^, Dasgupta U^ (2022) mTORC2 Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression bioRxiv 2022.01.10.475595 (doi: https://doi.org/10.1101/2022.01.10.475595)

7. Tripti Nair, Rahul Chakraborty, Praveen Singh, Sabnam Sahin Rahman, Akash Kumar Bhaskar, Shantanu Sengupta and Arnab Mukhopadhyay^ (2021) Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span. Aging Cell (https://doi.org/10.1111/acel.13518)

8. Swati Priya, Kaur E, Kulshrestha S, Pandit A, Gross I, Kumar N, Agarwal H, Khan A, Shyam S, Bhagat P, Prabhu JS, Nagarajan P, Deo SVS, Bajaj A, Freund J-N, Mukhopadhyay A, Sengupta S^ (2021) CDX2 inducible microRNAs sustain colon cancer by targeting multiple DNA damage response pathway factors. Journal of Cell Science (https://doi.org/10.1242/jcs.258601)

9. Pani T*, Rajput K*, Kar A*, Sharma H, Basak R, Medatwal N, Saha S, Dev G, Kumar S, Gupta S, Mukhopadhyay A, Malakar D, Maiti T, Arimbasseri AG, Deo SVS, Datta Sharma R, Bajaj A, and Dasgupta U^ (2021) Alternative Splicing of Ceramide Synthase 2 Alters Levels of Specific Ceramides and Modulates Cancer Cell Proliferation and Migration in Luminal B Breast Cancer Subtype. Cell Death and Disease 10;12(2):171.

10. Sreekanth V*, Kar A*, Kumar S, Pal S, Yadav P, Sharma Y, Komalla V, Sharma H, Shyam R, Sharma RD, Mukhopadhyay A, Sengupta S, Dasgupta U^, and Bajaj A^ (2020) Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes. Angewandte Chemie International Edition (doi.org/10.1002/anie.202015173)

11. Goyala A, Baruah A and Mukhopadhyay A^ (2020) The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations, PLoS One 15(11):e0241478. DOI:10.1371/journal.pone.0241478

12. Chamoli M*, Goyala A*, Tabrez SS*, Siddiqui AA, Singh A, Antebi A, Lithgow GJ, Watts JL and Mukhopadhyay A^ (2020) Polyunsaturated fatty acids and p38 MAPK pathway link metabolic reprogramming to cytoprotective gene expression during Dietary Restriction. Nature Communications 11 (1), 1-13.

13. Matai L*, Sarkar GC*, Chamoli M, Malik Y, Kumar SS, Rautela U, Jana NR, Chakraborty K#, Mukhopadhyay A#^ (2019) Dietary restriction improves proteostasis and increases life span through Endoplasmic Reticulum hormesis. Proceedings National Academy of Sciences USA 116 (35) 17383-17392.

14. Verma S, Jagtap U, Goyala A and Mukhopadhyay A^ (2018) A novel gene-diet pair modulates C. elegans aging. PLOS Genetics 14(8): e1007608. (doi.org/10.1371/journal.pgen.1007608)

15. Tabrez SS, Datta Sharma R, Jain V, Siddiqui AA and Mukhopadhyay A (2017) Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity. Nature Communications 8:306. DOI: 10.1038/s41467-017-00370-5.

16. Shariq M, Dhamgaye S, Nair R, Goyal N, Jain V, Mukhopadhyay A, Mondal AK, Mukhopadhyay G and Prasad R (2017) The global regulator Ncb2 escapes from the core promoter and impacts transcription in response to drug stress in Candida albicans cells. Scientific Reports 7:46084 | DOI: 10.1038/srep46084.

17. Maity S*, Rajkumar A*, Matai L*, Bhat A, Ghosh A, Agam G, Kaur S, Bhatt NR, Mukhopadhyay A#, Sengupta S#, Chakraborty K#^ (2016) Oxidative homeostasis regulates response to reductive Endoplasmic Reticulum stress through translation control. Cell Reports 16, 851–865.

18. Singh A, Kumar N, Matai L, Jain V, Garg A and Mukhopadhyay A^ (2016) A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity. Aging Cell 15, pp694–705.

19. Kumar N^, Jain V, Singh A, Jagtap U, Verma S and Mukhopadhyay A^ (2015) Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans. Oncotarget 6(39):41418-33.

20. Golegaonkar S*, Tabrez SS*, Pandit A, Shalini S, JagadeeshaPrasad MG, Bansode S, Sampathkumar SG, Kulkarni MJ^ and Mukhopadhyay A^ (2015) Rifampicin reduces Advanced Glycation End products and activates DAF-16 to increase life span in Caenorhabditis elegans. Aging Cell 14(3):463-73.

21. Pandit A, Jain V, Kumar N, Mukhopadhyay A^ (2014) PHA-4/FOXA-regulated microRNA feed forward loops during Caenorhabditis elegans dietary restriction. Aging (Albany NY) 6(10): 835-55.

22. Chamoli M, Singh A, Malik Y, Mukhopadhyay A^ (2014) A novel kinase regulates Dietary Restriction-mediated longevity in C. elegans. Aging Cell 13(4):641-55.

23. Ritter AD, Shen Y, Fuxman Bass J, Jeyaraj S, Deplancke B, Mukhopadhyay A, Xu J, Driscoll M, Tissenbaum HA, Walhout AJ. (2013) Complex expression dynamics and robustness in C. elegans insulin networks. Genome Res. 23(6):954-65.

24. Khurana R, Kathuria H, Mukhopadhyay A, Kapoor S, Tyagi AK (2013) A 286 bp upstream regulatory region of a rice anther-specific gene, OSIPP3, confers pollen-specific expression in Arabidopsis. Biotechnol Lett. 35(3):455-62.

25. Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. (2012) Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J Neurosci. 32(36):12630-40.

26. Narasimhan S, Mukhopadhyay A, Tissenbaum HA (2009) InAKTivation of insulin/IGF-1 signaling by dephophorylation. Cell Cycle 8(23): 3878-3884.

27. Padmanabhan S*, Mukhopadhyay A*, Narasimhan S*, Tesz G, Czech MP, Tissenbaum HA (2009) A PP2A regulatory subunit, PPTR-1, regulates C. elegans insulin signaling by modulating AKT-1 phosphorylation. Cell 136:939-951.

28. Mukhopadhyay A*, Deplancke B*, Walhout AJM, Tissenbaum HA (2008) Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nature Protocols 3(4):698-709.

29. Mukhopadhyay A, Pan X, Lambright D, Tissenbaum HA (2007) An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Reports 8(10):931-938.

30. Mukhopadhyay A and Tissenbaum HA (2007) Reproduction and longevity: secrets revealed by C. elegans. Trends in Cell Biology 17(2): 65-70.

31. Mukhopadhyay A, Oh SW, Tissenbaum HA (2006) Worming pathways to and from DAF-16/FOXO. Experimental Gerontology 41:928-934.

32. Deplancke B, Mukhopadhyay A, Ao W, Elewa AM, Grove CA, Martinez NJ, Sequerra R, Doucette-Stamm L, Tissenbaum HA, Mango SE, Walhout AJM (2006) A gene-centered C. elegans protein-DNA interaction network. Cell 125(6):1193-205.

33. Oh SW*, Mukhopadhyay A*, Dixit BL, Raha T, Green MR, Tissenbaum HA (2006) Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nature Genetics 38(2):251-257.

34. Mukhopadhyay A, Deplancke B, Walhout AJM, Tissenbaum HA (2005) C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metabolism 2:35-41.

35. Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA (2005) JNK regulates life span in C. elegans by modulating nuclear translocation of FOXO/DAF-16. Proceedings National Academy of Sciences USA 102(12):4494-4499.

36. Mukhopadhyay A, Vij S, Tyagi AK (2004) Overexpression of a zinc-finger protein gene from rice confers tolerance to cold, dehydration, and salt stress in transgenic tobacco. Proceedings National Academy of Sciences USA 101(16):6309-6314.

37. Mukhopadhyay A, Sharma S, Tyagi AK (2001)  Isolation and characterization of a novel S-adenosyl-L-methionine synthase cDNA from rice (Orzya sativa L. var. Pusa Basmati 1). Journal Plant Biochemistry and Biotechnology 10:25-29.

38. Mukhopadhyay A, Minhas D, Grover A (1997) Callusing from rice root explants: adventitious root formation precedes callus initiation response. Current Science 73(5): 465-9.

*Co-first author ^corresponding authors #Equally contributing senior authors

CHAPTERS CONTRIBUTED TO BOOKS

1.   Kumar N and Mukhopadhyay A (2019) Using ChIP-based approaches to characterize FOXO recruitment to its target promoters. Methods in Molecular Biology 1890:115-130. DOI: 10.1007/978-1-4939-8900-3_10.

2.   Tyagi AK, Khurana JP, Sharma AK, Mohanty A, Dhingra A, Raghuvanshi S, Mukhopadhyay A, Gupta V, Anand S, Kathuria H, Bhushan S, Thakur J and Kumar D (2008). Organ-specific gene expression and genetic transformation for improving rice. Advance in Rice Genetics (Part 2), Gurdev S Khush, Darshan S Brar and Bill Hardy (Eds.), pp 552-554. (doi.org/10.1142/9789812814319_0211)