The primary focus of my lab is to understand the molecular mechanisms that determine the longevity of an organism. The main interests of the lab are:

• Diet-gene interactions that regulate longevity

• Regulation of the Insulin-IGF-1 signaling pathway

• Regulation of oogenesis and reproductive aging by nutrient-sensing pathways

• The biology of Dietary restriction

• Cancer metabolism

• Understanding the molecular link between aging and innate immune pathways

• Screening for novel compounds that extend longevity

We study signaling events that induce changes in gene expression during aging. Specifically, we examine the interactions of kinases, transcription factors, and co-regulators downstream of nutrient-sensing pathways that govern longevity, metabolism, stress response, and pathogen resistance. Additionally, we analyze the impact of micronutrients on life history traits and the evolution of regulatory mechanisms to counteract these effects. Our interests also extend to understanding how organisms detect cellular damage and regulate germline development and reproductive aging, collaborating with nutrient-sensing pathways. We are also exploring the conservation of metabolic rewiring defects during aging and cancer, using this knowledge to propose novel cancer therapies.  Furthermore, we explore phytochemicals in treating complications related to infection, metabolic disorders, and aging.