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We are experimentalists. We use fluorescence microscopy, lipid physical chemistry, and fluid mechanics to investigate the mechanical principles underlying the response of living cells to fluid flow.
We are experimentalists. We use fluorescence microscopy, lipid physical chemistry, and fluid mechanics to investigate the mechanical principles underlying the response of living cells to fluid flow.
NEWS
Great news! Sreeja will be joining the faculty of the School of Biosciences at Mahatma Ghandi University in Kottayam! A wonderful place for her to use her love for physics, biology and teaching to help students and to move science forward. We have been so lucky to have her at Lehigh. Congratulations to both Sreeja and the School of Biosciences!
Second-year students presented their 491 research posters to the Physics department! Suman is shown having a spirited discussion with Yashab
Kelly interests Prof. Vavylonis in polymer brushes
Yujin and Maryam contemplate membrane cholesterol
Azi convincing Adeeb that interleaflet friction is important
An IRES grant from the National Science Foundation and Lehigh's Iaccoca International Internship program jointly supported Lehigh students for eight-week internships in multiple CNRS labs in Bordeaux, learning hands-on biophysics.
Jing Yan creating semi-permable membranes
Matthew Marlowe culturing unicellular algae
There was also time for some bike polo!
Sreeja and Suman dressed up for international day
Aurelia and Sreeja went to the Biophysical Society meeting
Sreeja gave a BPS talk
And we met Amanda there!
You have to get the glass really clean!
Azi setting up microfluidics
Aurelia attended the 2024 meeting of the Molecular Biology Society of Japan in Fukuoka, with Prof. Sawako Yamashiro
Also visited beautiful Kyoto
And met Prof. Kimiko Yamamoto at the University of Tokyo
Sreeja's beautiful experiments are now published in Biophysical Journal! This paper is the culmination of several years of experiments, and a great collaboration with students in both the Thévenin lab and the Im lab! Sreeja measured the size and shape of lipid-anchored proteins by observing how they move under shear stress. Leah Knepper and Emily Ankrom made monomeric streptavidin constructs, and Lingyang Kong and Gabriel Cucé simulated a lipid-bound monomer . Congratulations and thanks to all authors!
Sreeja spent July at the Boulder school on Self-Organizing Matter!
At the Boulder school you listen to lectures, present posters...
and go hiking
Lots of hiking!
Queen prepares vesicles for extrusion
Quinn and Michael on their way to LOMA at University of Bordeaux
Exploring Bordeaux
Enjoying French public transit, with Prof. Ou-Yang
Institut d’Optique d’Aquitaine
The group in summer 2024!
Quinn and Reed in full gear to etch coverslips.
A strawberry tenure cake! Thanks to current and past lab members whose excellent science made this happen.
March 2024: We had a lab dinner to congratulate undergraduate researcher Gabriel on graduating and starting a lab tech position with Prof. Chen Zhao at the University of Florida. We look forward to seeing many cool cryo-EM images as a result!
We had a great time at the local (Philadelphia) 2024 Biophysical Society Meeting! We had dinner with the Thévenin lab.
Quinn and Sreeja presented posters!
Annual sightings of Markus Deserno and Sarah Keller
Why were there moustaches?
Fall 2023! Welcome to incoming graduate students Quinn and Queen!
Lehigh students and faculty enjoyed teaching and learning at the first summer school "Biological Physics: Soft Living Matter" held in Rethymno, Crete. The school was organized by faculty from Lehigh, University of Pennsylvania, and University of Crete.
Ethan, Minh, and Jamila's work was published in a paper on supported membrane expansion under shear flow. In addition to fluorescence measurements, this paper includes our first neutron reflectivity data.
Amanda's paper demonstrating a microfluidic and microscopy-based method to measure protein drift velocity in supported membranes was published in Biophysical Journal! We are very proud of this work, which many lab members contributed to over several years. Congratulations to all the authors!
Congratulations to rockstar undergraduate researcher Jamila Shah, who has been admitted to medical school! No one who has worked with Jamila will be surprised.
The Lehigh biophysics faculty at APS 2023
A mini Goldstein lab reunion in Las Vegas!
5:30 AM at the Allentown airport, ready to leave for the 2023 Biophysical Society meeting, in matching outfits, posters ready!
Sreeja at the BPS poster session
The best part of BPS: finding friends! We found Sarah Keller at the poster session.
We found Minh and had lunch
Gabriel presenting at the poster session
Sreeja and Aurelia went to Oak Ridge to do a little more neutron reflectometry before 2022 was over (again with remote help from Minh). We were looking for membrane structural changes under flow.
With sample in place, Sreeja opens the shutter so that we can start collecting neutrons
Sreeja at the spallation target
The flow cell, with a fresh supported lipid bilayer and bubble-free connections to the peristaltic pump
Autumn's beautiful work on inter-leaflet friction was published in Biophysical Journal! She did solid measurements of a challenging-to-measure membrane property, plus discovered a surprising phase transition. We were also lucky that Elizabeth Kelley and Fred Heberle wrote a really nice introduction to Autumn's research, in addition to thinking of a much funnier title.
The Honerkamp-Smith lab has been awarded a R01 grant from the NIH to continue our collaboration with the Thévenin lab studying flow transport and flow mechanosensing! The project is described and research re-enactment pictures appear in this story.
Summer 2022: the group after lunch, baklava and coffee at the Olive Branch.
Dr. Anthony and Dr. Ratajczak! They graduated on a beautiful and particularly warm day in Bethlehem.
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