Publications & Expertise

36. Cynthia Al Hageh, Ryan Rahy, Georges Khazen, Francois Brial, Rony S. Khnayzer*, Dominique Gauguier, Pierre Zalloua. "Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels" PlosOne. 2020, 15 (11), e0242019.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242019


35. Christelle Fayad, Hassib Audi, Rony S. Khnayzer*, Costantine Daher. "The Anti-Cancer Effect of Series of Strained Photoactivatable Ru(II) Polypyridyl Complexes on Non-Small-Cell Lung Cancer and Triple Negative Breast Cancer Cells" Journal of Biological Inorganic Chemistry. 2020 https://doi.org/10.1007/s00775-020-01835-7

https://link.springer.com/article/10.1007/s00775-020-01835-7


34. Mansour, Najwa; Bodman-Smith, Kikki; Khnayzer, Rony. S.; Daher, Costantine. "A photoactivatable Ru (II) complex bearing 2,9-diphenyl-1,10-phenanthroline: A potent chemotherapeutic drug inducing caspase-3 independent apoptosis in Triple Negative Human Breast Adenocarcinoma cells" Chemico-Biological Interactions. 2020 https://doi.org/10.1016/j.cbi.2020.109317

https://www.sciencedirect.com/science/article/abs/pii/S0009279720313004


33. Mehanna, S.; Bodman-Smith, K.; Daher, C. F. and Khnayzer, R. S.* "Rapid quantification of ruthenium(II) polypyridyl anti-cancer drugs using selective ligand dissociation LC-MS/MS method" Analytical Methods, 2020, 12, 4517-4525.

https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay01250e#!divAbstract

This paper will be highlighted on the front cover of Analytical Methods.

32. Christian Khalil, Joe Braham Chahine, Tony Haykal, Cynthia Al Hageh, Sandra Rizk and Rony S. Khnayzer "E-cigarette aerosol induced cytotoxicity, DNA damages and late apoptosis in dynamically exposed A549 cells" Chemosphere, 2020, https://doi.org/10.1016/j.chemosphere.2020.127874

https://www.sciencedirect.com/science/article/abs/pii/S0045653520320695


31. Linda Bechnak, Christian Khalil, Riham El Kurdi, Rony S. Khnayzer*, Digambara Patra “Enhancement of anti-cancer and photodynamic activities of curcumin by encapsulation in amphiphilic block co-polymer”, Photochem. Photobiol. Sci., 2020, DOI: 10.1039/D0PP00032A

https://pubs.rsc.org/en/content/articlelanding/2020/pp/d0pp00032a#!divAbstract


30. Khalifeh, M.; Hobeika, R.; El Hayek, L; Nasrallah, P.; Jabre, V.; Stephan, J. S.; Khnayzer, R. S.; Khalil, C.; Sleiman, S. F. “Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco smoking by activating hippocampal BDNF signaling”. Behavioural Brain Research, 2020, 382, 112499.

https://www.sciencedirect.com/science/article/pii/S0166432819318212?via%3Dihub

29. Khalil, C.; Chahine, J. B.; Chahla, B.; Hobeika, T.; Khnayzer, R. S. “Characterization and cytotoxicity assessment of nargile smoke using dynamic exposure”. Inhalation Toxicology, 2019, 31, 343-356.

https://www.tandfonline.com/doi/abs/10.1080/08958378.2019.1683104?journalCode=iiht20

28. Mehanna, S.; Mansour, N.; Audi, H.; Bodman-Smith, K.; Mroueh, M. A.; Taleb, R. I.; Daher, C. F. and Khnayzer, R. S.* “Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex” RSC Advances, 2019, 9, 17254 – 17265.

https://pubs.rsc.org/en/content/articlelanding/2019/ra/c9ra02615k#!divAbstract

27. Khalil, C.; Al Hageh, C.; Korfali, S.; Khnayzer, R. S. "Municipal leachates health risks: chemical and cytotoxicity assessment from regulated and unregulated municipal dumpsites in Lebanon." Chemosphere, 2018, 208, 1-18.

https://www.sciencedirect.com/science/article/pii/S0045653518310026

26. Mansour, N.; Mehanna, S.; Taleb, R. I.; Mroueh, M.; Bodman‐Smith, K.; El-Sibai, M.; Daher, C. F.; Khnayzer, R. S.* "Photoactivatable Ru(II) complex bearing 2,9-diphenyl-1,10-phenanthroline: unusual photochemistry and significant potency on cisplatin-resistant cell lines." Eur. J. Inorg. Chem., 2018, 22, 2524-2532.

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.201800194

25. Al Hageh, C.; Al Assaad, M.; El Masri, Z.; Samaan, N.; El-Sibai, M.; Khalil, C.; and Khnayzer, R. S.* "Long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer." Dalton Trans. 2018, 47, 4959 - 4967.

https://pubs.rsc.org/en/content/articlelanding/2018/dt/c8dt00140e#!divAbstract

24. Audi, H.; Azar, A.; Mahjoub, H. Farhat, S.; El-Masri, Z.; El-Sibai, M.; Abi-Habib, R.; and Khnayzer, R. S.* “Cytotoxicity Modulation of Ruthenium (II) tris-bathophenanthroline Complexes With Systematically Varied Charge.” J. Photochem. Photobiol. A, 2018, 351, 59–68.

https://www.sciencedirect.com/science/article/abs/pii/S1010603017306172

Azar, D. F.; Audi, H.; Farhat, S.; El-Sibai, M.; Abi-Habib, R. J.; Khnayzer, R. S.* Cover Picture, 2017, 46.

23. Azar, D. F.; Audi, H.; Farhat, S.; El-Sibai, M.; Abi-Habib, R. J.; Khnayzer, R. S.* Phototoxicity of strained Ru(II) complexes: is it the metal complex or the dissociating ligand? Dalton Trans., 2017, 46, 11529 – 11532.

http://pubs.rsc.org/en/content/articlelanding/2017/dt/c7dt02255g#!divAbstract

22. Khnayzer, R. S.*; Olaiya, B. S.; El Roz, K. A.; Castellano, F. N. Cover Picture and Cover Profile. ChemPlusChem 2016, 81, 1016.

http://onlinelibrary.wiley.com/doi/10.1002/cplu.201600424/full

21. Khnayzer, R. S.*; Olaiya, B. S.; El Roz, K. A.; Castellano, F. N. Homogeneous Photocatalytic H2 Production using a Ru(II) Bathophenanthroline MLCT Photosensitizer. ChemPlusChem 2016, 81, 1090-1097.

http://onlinelibrary.wiley.com/doi/10.1002/cplu.201600227/abstract

20. McGoorty, M. M.; Khnayzer, R. S.; Castellano, F. N., Enhanced Photophysics from Self-Assembled Cyclometalated Ir(III) Complexes in Water. Chem. Commun. 2016, 52, 7846-7849.

http://pubs.rsc.org/en/content/articlehtml/2016/cc/c6cc03932d

19. El-Assaad, T.H.; Auer, M.; Castañeda, R.; Hallal, K. H.; Jradi, F. M.; Mosca, L.; Khnayzer, R. S.; Patra, D.; Timofeeva, T. V.; Brédas, J-L.; List-Kratochvil, E. J. W.; Wex, B.; Kaafarani, B. R. “Tetraaryl Pyrenes: Photophysical Properties, Computational Studies, Crystal Structures, and Application in OLEDs”, J. Mater. Chem. C. 2016, 4, 3041-3058.

http://pubs.rsc.org/en/content/articlelanding/2016/tc/c5tc02849c#!divAbstract

18. Jurss, J. W.; Khnayzer, R. S.; Panetier, J. A.; El Roz, K. A.; Nichols, E. M.; Head-Gordon, M.; Long, J. L.; Castellano, F. N.; Chang, C. J. "Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water" Chem. Sci., 2015, 6, 4954.

http://pubs.rsc.org/en/content/articlelanding/2015/sc/c5sc01414j#!divAbstract

17. Khnayzer, R. S.*; Martin, D. R.; Codding, C. L.; Castellano, F. N. “Parallelization of Photocatalytic Gas-Producing Reactions”, 2015, Rev. Sci. Instrum. 2015, 86, 034101.

http://scitation.aip.org/content/aip/journal/rsi/86/3/10.1063/1.4915349

16. Mosca, L.; Khnayzer, R. S.; Lazorski, M. S.; Danilov, E. O.; Castellano, F. N.; and Anzenbacher P. “Sensing of 2,4,6-Trinitrotoluene (TNT) and 2,4-Dinitrotoluene (2,4-DNT) in the Solid State with Photoluminescent Ru(II) and Ir(III) Complexes.” Chem. Eur. J., 2015, 21, 4056-4064.

http://onlinelibrary.wiley.com/doi/10.1002/chem.201405717/full

15. Khnayzer, R. S.; Thoi, V. S.; Nippe, M.; King, A. E.; Jurss, J. W.; El Roz, K. A.; Long, J. R.; Chang, C. J.; and Castellano, F. N. “Towards a Comprehensive Understanding of Visible-Light Photogeneration of Hydrogen from Water Using Cobalt(II) Polypyridyl Catalysts” Energy Environ. Sci., 2014, 7, 1477-1488.

http://pubs.rsc.org/en/content/articlelanding/2014/ee/c3ee43982h#!divAbstract

14. Khnayzer, R. S.; McCusker, C. E.; Olayai, B. S.; Castellano, F. N. "Robust Cuprous Phenanthroline Sensitizer for Solar Hydrogen Photocatalysis". J. Am. Chem. Soc. 2013, 135, 14608-14070.

http://pubs.acs.org/doi/abs/10.1021/ja407816f

13. El-Ballouli, A. O.; Khnayzer, R. S.; Khalife, J. C.; Fonari , A.; Hallal, K. M.; Timofeeva, T. V.; Patra, D.; Castellano, F. N.; Wex, B.; Kaafarani, B. R. “Diarylpyrenes vs. Diaryltetrahydropyrenes: Synthesis, Crystal Structures, Fluorescence, and Upconversion Photochemistry ”. J. Photochem. Photobiol. A 2013, 272, 49-57.

http://www.sciencedirect.com/science/article/pii/S1010603013003560


12. Nippe M.; Khnayzer, R. S.; Panetier, J. A.; Zee, D. Z.; Olaiya, B. S.; Gordon, M. H.; Chang, C. J.; Castellano, F. N.; Long, J. R. “Catalytic Proton Reduction with Transition Metal Complexes of the Redox-Active Ligand bpy2PYMe”. Chem. Sci. 2013, 4, 3934-3945.

http://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc51660a#!divAbstract

This paper has been listed among most read papers on the RSC website.

11. Khnayzer, R. S. Photocatalytic Water Splitting: Materials Design and High-Throughput Screening of Molecular Compositions. Ph. D. Dissertation, Bowling Green State University, Bowling Green, OH, 2013.

https://etd.ohiolink.edu/ap:10:0::NO:10:P10_ETD_SUBID:5036

10. Xin Yang, X.; Walpita, J.; Zhou, D.; Luk, H. L.; Vyas, S.; Khnayzer, R. S.; Tiwari, S. C.; Diri, K.; Hadad, C. M.; Castellano, F. N.; Krylov, A. I.; Glusac, K. D. Towards Organic Photohydrides: Excited-state Behavior of 10-Methyl-9-phenyl-9, 10-dihydroacridine. J. Phys Chem B. 2013, In Press.

http://pubs.acs.org/doi/abs/10.1021/jp401770e

9. Khon, E.; Lambright, K.; Khnayzer, R. S.; Moroz, P.; Dimuthu, P.; Butaeva, E.; Lambright, S.; Castellano, F. N.; Zamkov, M. Improving the Catalytic Activity of Semiconductor Nanocrystals through Selective Domain Etching. Nano Lett. 2013, 13, 2016-2023.

http://pubs.acs.org/doi/abs/10.1021/nl400715n

8. Kaafarani, B. R.; El-Ballouli, A. O.; Trattnig, R.; Fonari, A.; Sax, S.; Wex, B.; Risko, C.; Khnayzer, R. S.; Barlow, S.; Patra, D.; Timofeeva, T. V.; List, E. J. W.; Brédas, J.-L.; Marder, S. R. Bis(Carbazolyl) Derivatives of Pyrene and Tetrahydropyrene: Synthesis, Structures, Optical Properties, Electrochemistry, and Electroluminescence. J. Mater. Chem. C 2013, 1, 1638-1650.

http://pubs.rsc.org/en/content/articlelanding/2013/tc/c2tc00474g

7. Perera, D.; Lorek, R.; Khnayzer, R. S.; Moroz, P.; O'Connor, T.; Khon, D.; Diederich, G.; Kinder, E.; Lambright, S.; Castellano, F. N.; Zamkov, M., Photocatalytic Activity of Core/Shell Semiconductor Nanocrystals Featuring Spatial Seperation of Charges. J. Phys. Chem. C 2012, 116, 22786-22793.

http://pubs.acs.org/doi/abs/10.1021/jp308921s

6. Khnayzer, R. S.; Mara, M. W.; Huang, J.; Shelby, M. L.; Chen, L. X.; Castellano, F. N., Structure and Activity of Photochemically Deposited "CoPi" Oxygen Evolving Catalyst on Titania. ACS Catal. 2012, 2, 2150-2160.

http://pubs.acs.org/doi/abs/10.1021/cs3005192

This paper has been listed among most read papers on the ACS website.

5. Haefele, A.; Blumhoff, J.; Khnayzer, R. S.; Castellano, F. N., Getting to the (Square) Root of the Problem: How to Make Noncoherent Pumped Upconversion Linear. J. Phys. Chem. Lett. 2012, 3, 299-303.

http://pubs.acs.org/doi/abs/10.1021/jz300012u|

This work has been highlighted in a slide-share.

http://www.slideshare.net/jpcoffice/jpcl-jz300012u-castellano-presentation

4. Khnayzer, R. S.; Thompson, L. B.; Zamkov, M.; Ardo, S.; Meyer, G. J.; Murphy, C. J.; Castellano, F. N., Photocatalytic Hydrogen Production at Titania-Supported Pt Nanoclusters That Are Derived from Surface-Anchored Molecular Precursors. J. Phys. Chem. C 2012, 116, 1429-1438.

http://pubs.acs.org/doi/abs/10.1021/jp206943s

3. Khnayzer, R. S.; Blumhoff, J.; Harrington, J. A.; Haefele, A.; Deng, F.; Castellano, F. N., Upconversion-powered photoelectrochemistry. Chem. Commun. 2012, 48, 209-211. http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c1cc16015j

This paper has been listed among most read papers on the RSC website.

2. Acharya, K. P.; Khnayzer, R. S.; O’Connor, T.; Diederich, G.; Kirsanova, M.; Klinkova, A.; Roth, D.; Kinder, E.; Imboden, M.; Zamkov, M., The Role of Hole Localization in Sacrificial Hydrogen Production by Semiconductor–Metal Heterostructured Nanocrystals. Nano Lett. 2011, 11, 2919-2926. http://pubs.acs.org/doi/abs/10.1021/nl201388c

This work has been featured in Science Newsline magazine.

http://www.sciencenewsline.com/articles/2012082318200034.html

1. Acharya, K. P.; Khon, E.; O’Conner, T.; Nemitz, I.; Klinkova, A.; Khnayzer, R. S.; Anzenbacher, P.; Zamkov, M., Heteroepitaxial Growth of Colloidal Nanocrystals onto Substrate Films via Hot-Injection Routes. ACS Nano 2011, 5, 4953-4964.

http://pubs.acs.org/doi/abs/10.1021/nn201064n

Expertise:

1. Organic and inorganic syntheses: including Schlenk line and glovebox operation, along with product isolation and characterization (Liquid chromatography, ESI-MS, MALDI, NMR, etc.).

2. Gas analysis: quantitative detection of volatile products, including gas chromatography and residual gas analyzer operation and assembly.

3. Spectroscopy: time-resolved and steady-state measurements, infra-red and Raman spectroscopy.

4. Equipment engineering: design and assembly of high-throughput photochemical reactors for quantitative hydrogen production analysis.

5. Expertise in electrochemistry, photochemistry and photoelectrochemistry: employment of transition metal complexes and semiconductors for usage in solar energy conversion and storage.

6. Materials and device assembly: Semiconductors thin-film formation along with operational photoelectrochemical cell assembly.

Publications:

33. Mehanna, S.; Bodman-Smith, K.; Daher, C. F. and Khnayzer, R. S.* "Rapid quantification of ruthenium(II) polypyridyl anti-cancer drugs using selective ligand dissociation LC-MS/MS method" Analytical Methods, 2020, 12, 4517-4525.