Embedded Files
Publications:
51. Petra Krtenova, Stephanie Mehanna, Hassib Audi, Costantine F. Daher, and Rony S. Khnayzer* “A dicationic Ru(II) polypyridyl complex bearing bathophenanthroline ligand induces photocytotoxicity through serum albumin-mediated cellular uptake”, Journal of Photochemistry and Photobiology B: Biology, 2024, Minor revisions submitted.
50. Saab, Y.; Rahme,R.; Nakad, Z.; and Khnayzer, R.S. “Detection of impurities in acetaminophen intravenous and oral formulations: Health-risk assessment”, Microchemical Journal 2024, in press, https://doi.org/10.1016/j.microc.2024.112019
49. Elias, M.G.; Mehanna, S.; Nasser, S.; Daher, C.F.; Khnayzer, R.S.* A Ru(II) Polypyridyl Complex Bearing Bathocuproine Ligand is a Potent Chemotherapeutic Agent Against Chemically Induced Skin Cancer Model. Advanced Therapeutics 2024, 2400313, in press, doi:https://doi.org/10.1002/adtp.202400313.
48. Abboud, M.; Gemayel, J.; Khnayzer, R.S.* Replacing Tobacco with Hemp in the Beqaa Is Financially Rewarding for Farmers and Government in Lebanon. Agriculture 2024, 14, 1349.
47. Alousi, S.; Saad, J.; Panossian, B.; Makhlouf, R.; Khoury, C.A.; Rahy, K.; Thoumi, S.; Araj, G.F.; Khnayzer, R. S.*; Tokajian, S. Genetic and structural basis of colistin resistance in Klebsiella pneumoniae: Unravelling the molecular mechanisms. Journal of Global Antimicrobial Resistance 2024, 38, 256-264.
46. Saab, Y.; Zgheib, R.; Nakad, Z.; Khnayzer, R.S. Determination of volatile impurities and ethanol content in ethanol-based hand sanitizers: Compliance and toxicity. Toxicology Reports 2024, 13, 101709.
45. Omeiri, M.; Khnayzer, R. S.; Yusef, H.; Tokajian, S.; Salloum, T. Biodegradation of chlorpyrifos by bacterial strains isolated from Lebanese soil and its association with plant growth improvement. Biorem. J. 2024, 28, 14-33.
44. Mansour, N.; Mehanna, S.; Bodman-Smith, K.; Daher, C. F.; Khnayzer, R. S.*, A Ru(II)-Strained Complex with 2,9-Diphenyl-1,10-phenanthroline Ligand Induces Selective Photoactivatable Chemotherapeutic Activity on Human Alveolar Carcinoma Cells via Apoptosis. Pharmaceuticals 2024, 17 (1), 50.
43. Yolande Saab, Emilia Oueis, Stephanie Mehanna, Zahi Nakad, Rita Stephan, Rony S Khnayzer*. “Risk Assessment of Phthalates and Their Metabolites in Hospitalized Patients: A Focus on Di-and Mono-(2-ethylhexyl) Phthalates Exposure from Intravenous Plastic Bags”, Toxics, 2022, 10, 357.
42. Katia Sayyed; Wared Nour-ElDine; Anthony Rufka; Stephanie Mehanna; Rony S Khnayzer; Aniella Abi-Gerges; Christian Khalil. “Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line”, Toxicology in Vitro, 2022, 83, 105409
doi.org/10.1016/j.tiv.2022.105409
www.sciencedirect.com/science/article/pii/S0887233322001060
41. Mohamad Omeiri; Rony Khnayzer; Hoda Yusef “Monitoring of Pesticide Residues in Lebanese Vegetables and Agricultural Soils and Their Impact on Soil Microbiological Properties”, Asian Journal of Water, Environment and Pollution, 19, 2022, 27-35.
40. Mohamad Omeiri; Rony Khnayzer; Hoda Yusef; Sima Tokajian; Tamara Salloum; Samia Mokh “Bacillus spp. isolated from soil in Lebanon can simultaneously degrade methomyl in contaminated soils and enhance plant growth”, Biocatalysis and Agricultural Biotechnology, 39, 2022, 102280.
39. Wared Nour-Eldine, Katia Sayyed, Zeina Harhous, Carole Dagher-Hamalian, Stephanie Mehanna, Donna Achkouti, Hanan ElKazzaz, Rony S. Khnayzer, Firas Kobeissy, Christian Khalil, Aniella Abi-Gerges, “Gasoline fume inhalation induces apoptosis, inflammation, and favors Th2 polarization in C57BL/6 mice” Journal of Applied Toxicology, 2022, 42, 1178-1191.
analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/jat.4286
38. Mehanna, S.; Mansour, N.; Daher, C. F.; Elias, M. G.; Daher, C. F.; Khnayzer R. S.* “Drug-free phototherapy of superficial tumors: White light at the end of the tunnel” Journal of Photochemistry and Photobiology B: Biology, 2021, 224, 112324.38. 38
37. Elias, M. G.; Mehanna, S.; Elias, E.; Khnayzer R. S.; Daher, C. F. “A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway” Chemico-Biological Interactions, 2021, 348, 109644.
36. Cynthia Al Hageh, Ryan Rahy, Georges Khazen, Francois Brial, Rony S. Khnayzer*, Dominique Gauguier, Pierre Zalloua. "Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels" PlosOne. 2020, 15 (11), e0242019.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242019
35. Christelle Fayad, Hassib Audi, Rony S. Khnayzer*, Costantine Daher. "The Anti-Cancer Effect of Series of Strained Photoactivatable Ru(II) Polypyridyl Complexes on Non-Small-Cell Lung Cancer and Triple Negative Breast Cancer Cells" Journal of Biological Inorganic Chemistry. 2021, 336, 109317.
https://doi.org/10.1007/s00775-020-01835-7
https://link.springer.com/article/10.1007/s00775-020-01835-7
34. Mansour, Najwa; Bodman-Smith, Kikki; Khnayzer, Rony. S.; Daher, Costantine. "A photoactivatable Ru (II) complex bearing 2,9-diphenyl-1,10-phenanthroline: A potent chemotherapeutic drug inducing caspase-3 independent apoptosis in Triple Negative Human Breast Adenocarcinoma cells" Chemico-Biological Interactions. 2021, 336, 109317 https://doi.org/10.1016/j.cbi.2020.109317
https://www.sciencedirect.com/science/article/abs/pii/S0009279720313004
33. Mehanna, S.; Bodman-Smith, K.; Daher, C. F. and Khnayzer, R. S.* "Rapid quantification of ruthenium(II) polypyridyl anti-cancer drugs using selective ligand dissociation LC-MS/MS method" Analytical Methods, 2020, 12, 4517-4525.
https://pubs.rsc.org/en/content/articlelanding/2020/ay/d0ay01250e#!divAbstract
This paper will be highlighted on the front cover of Analytical Methods.
32. Christian Khalil, Joe Braham Chahine, Tony Haykal, Cynthia Al Hageh, Sandra Rizk and Rony S. Khnayzer "E-cigarette aerosol induced cytotoxicity, DNA damages and late apoptosis in dynamically exposed A549 cells" Chemosphere, 2020, https://doi.org/10.1016/j.chemosphere.2020.127874
https://www.sciencedirect.com/science/article/abs/pii/S0045653520320695
31. Linda Bechnak, Christian Khalil, Riham El Kurdi, Rony S. Khnayzer*, Digambara Patra “Enhancement of anti-cancer and photodynamic activities of curcumin by encapsulation in amphiphilic block co-polymer”, Photochem. Photobiol. Sci., 2020, DOI: 10.1039/D0PP00032A
https://pubs.rsc.org/en/content/articlelanding/2020/pp/d0pp00032a#!divAbstract
30. Khalifeh, M.; Hobeika, R.; El Hayek, L; Nasrallah, P.; Jabre, V.; Stephan, J. S.; Khnayzer, R. S.; Khalil, C.; Sleiman, S. F. “Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco smoking by activating hippocampal BDNF signaling”. Behavioural Brain Research, 2020, 382, 112499.
https://www.sciencedirect.com/science/article/pii/S0166432819318212?via%3Dihub
29. Khalil, C.; Chahine, J. B.; Chahla, B.; Hobeika, T.; Khnayzer, R. S. “Characterization and cytotoxicity assessment of nargile smoke using dynamic exposure”. Inhalation Toxicology, 2019, 31, 343-356.
https://www.tandfonline.com/doi/abs/10.1080/08958378.2019.1683104?journalCode=iiht20
28. Mehanna, S.; Mansour, N.; Audi, H.; Bodman-Smith, K.; Mroueh, M. A.; Taleb, R. I.; Daher, C. F. and Khnayzer, R. S.* “Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex” RSC Advances, 2019, 9, 17254 – 17265.
https://pubs.rsc.org/en/content/articlelanding/2019/ra/c9ra02615k#!divAbstract
27. Khalil, C.; Al Hageh, C.; Korfali, S.; Khnayzer, R. S. "Municipal leachates health risks: chemical and cytotoxicity assessment from regulated and unregulated municipal dumpsites in Lebanon." Chemosphere, 2018, 208, 1-18.
https://www.sciencedirect.com/science/article/pii/S0045653518310026
26. Mansour, N.; Mehanna, S.; Taleb, R. I.; Mroueh, M.; Bodman‐Smith, K.; El-Sibai, M.; Daher, C. F.; Khnayzer, R. S.* "Photoactivatable Ru(II) complex bearing 2,9-diphenyl-1,10-phenanthroline: unusual photochemistry and significant potency on cisplatin-resistant cell lines." Eur. J. Inorg. Chem., 2018, 22, 2524-2532.
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejic.201800194
25. Al Hageh, C.; Al Assaad, M.; El Masri, Z.; Samaan, N.; El-Sibai, M.; Khalil, C.; and Khnayzer, R. S.* "Long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer." Dalton Trans. 2018, 47, 4959 - 4967.
https://pubs.rsc.org/en/content/articlelanding/2018/dt/c8dt00140e#!divAbstract
24. Audi, H.; Azar, A.; Mahjoub, H. Farhat, S.; El-Masri, Z.; El-Sibai, M.; Abi-Habib, R.; and Khnayzer, R. S.* “Cytotoxicity Modulation of Ruthenium (II) tris-bathophenanthroline Complexes With Systematically Varied Charge.” J. Photochem. Photobiol. A, 2018, 351, 59–68.
https://www.sciencedirect.com/science/article/abs/pii/S1010603017306172
Azar, D. F.; Audi, H.; Farhat, S.; El-Sibai, M.; Abi-Habib, R. J.; Khnayzer, R. S.* Cover Picture, 2017, 46.
23. Azar, D. F.; Audi, H.; Farhat, S.; El-Sibai, M.; Abi-Habib, R. J.; Khnayzer, R. S.* Phototoxicity of strained Ru(II) complexes: is it the metal complex or the dissociating ligand? Dalton Trans., 2017, 46, 11529 – 11532.
http://pubs.rsc.org/en/content/articlelanding/2017/dt/c7dt02255g#!divAbstract
22. Khnayzer, R. S.*; Olaiya, B. S.; El Roz, K. A.; Castellano, F. N. Cover Picture and Cover Profile. ChemPlusChem 2016, 81, 1016.
http://onlinelibrary.wiley.com/doi/10.1002/cplu.201600424/full
21. Khnayzer, R. S.*; Olaiya, B. S.; El Roz, K. A.; Castellano, F. N. Homogeneous Photocatalytic H2 Production using a Ru(II) Bathophenanthroline MLCT Photosensitizer. ChemPlusChem 2016, 81, 1090-1097.
http://onlinelibrary.wiley.com/doi/10.1002/cplu.201600227/abstract
20. McGoorty, M. M.; Khnayzer, R. S.; Castellano, F. N., Enhanced Photophysics from Self-Assembled Cyclometalated Ir(III) Complexes in Water. Chem. Commun. 2016, 52, 7846-7849.
http://pubs.rsc.org/en/content/articlehtml/2016/cc/c6cc03932d
19. El-Assaad, T.H.; Auer, M.; Castañeda, R.; Hallal, K. H.; Jradi, F. M.; Mosca, L.; Khnayzer, R. S.; Patra, D.; Timofeeva, T. V.; Brédas, J-L.; List-Kratochvil, E. J. W.; Wex, B.; Kaafarani, B. R. “Tetraaryl Pyrenes: Photophysical Properties, Computational Studies, Crystal Structures, and Application in OLEDs”, J. Mater. Chem. C. 2016, 4, 3041-3058.
http://pubs.rsc.org/en/content/articlelanding/2016/tc/c5tc02849c#!divAbstract
18. Jurss, J. W.; Khnayzer, R. S.; Panetier, J. A.; El Roz, K. A.; Nichols, E. M.; Head-Gordon, M.; Long, J. L.; Castellano, F. N.; Chang, C. J. "Bioinspired design of redox-active ligands for multielectron catalysis: effects of positioning pyrazine reservoirs on cobalt for electro- and photocatalytic generation of hydrogen from water" Chem. Sci., 2015, 6, 4954.
http://pubs.rsc.org/en/content/articlelanding/2015/sc/c5sc01414j#!divAbstract
17. Khnayzer, R. S.*; Martin, D. R.; Codding, C. L.; Castellano, F. N. “Parallelization of Photocatalytic Gas-Producing Reactions”, 2015, Rev. Sci. Instrum. 2015, 86, 034101.
http://scitation.aip.org/content/aip/journal/rsi/86/3/10.1063/1.4915349
16. Mosca, L.; Khnayzer, R. S.; Lazorski, M. S.; Danilov, E. O.; Castellano, F. N.; and Anzenbacher P. “Sensing of 2,4,6-Trinitrotoluene (TNT) and 2,4-Dinitrotoluene (2,4-DNT) in the Solid State with Photoluminescent Ru(II) and Ir(III) Complexes.” Chem. Eur. J., 2015, 21, 4056-4064.
http://onlinelibrary.wiley.com/doi/10.1002/chem.201405717/full
15. Khnayzer, R. S.; Thoi, V. S.; Nippe, M.; King, A. E.; Jurss, J. W.; El Roz, K. A.; Long, J. R.; Chang, C. J.; and Castellano, F. N. “Towards a Comprehensive Understanding of Visible-Light Photogeneration of Hydrogen from Water Using Cobalt(II) Polypyridyl Catalysts” Energy Environ. Sci., 2014, 7, 1477-1488.
http://pubs.rsc.org/en/content/articlelanding/2014/ee/c3ee43982h#!divAbstract
14. Khnayzer, R. S.; McCusker, C. E.; Olayai, B. S.; Castellano, F. N. "Robust Cuprous Phenanthroline Sensitizer for Solar Hydrogen Photocatalysis". J. Am. Chem. Soc. 2013, 135, 14608-14070.
13. El-Ballouli, A. O.; Khnayzer, R. S.; Khalife, J. C.; Fonari , A.; Hallal, K. M.; Timofeeva, T. V.; Patra, D.; Castellano, F. N.; Wex, B.; Kaafarani, B. R. “Diarylpyrenes vs. Diaryltetrahydropyrenes: Synthesis, Crystal Structures, Fluorescence, and Upconversion Photochemistry ”. J. Photochem. Photobiol. A 2013, 272, 49-57.
http://www.sciencedirect.com/science/article/pii/S1010603013003560
12. Nippe M.; Khnayzer, R. S.; Panetier, J. A.; Zee, D. Z.; Olaiya, B. S.; Gordon, M. H.; Chang, C. J.; Castellano, F. N.; Long, J. R. “Catalytic Proton Reduction with Transition Metal Complexes of the Redox-Active Ligand bpy2PYMe”. Chem. Sci. 2013, 4, 3934-3945.
http://pubs.rsc.org/en/content/articlelanding/2013/sc/c3sc51660a#!divAbstract
This paper has been listed among most read papers on the RSC website.
11. Khnayzer, R. S. Photocatalytic Water Splitting: Materials Design and High-Throughput Screening of Molecular Compositions. Ph. D. Dissertation, Bowling Green State University, Bowling Green, OH, 2013.
https://etd.ohiolink.edu/ap:10:0::NO:10:P10_ETD_SUBID:5036
10. Xin Yang, X.; Walpita, J.; Zhou, D.; Luk, H. L.; Vyas, S.; Khnayzer, R. S.; Tiwari, S. C.; Diri, K.; Hadad, C. M.; Castellano, F. N.; Krylov, A. I.; Glusac, K. D. Towards Organic Photohydrides: Excited-state Behavior of 10-Methyl-9-phenyl-9, 10-dihydroacridine. J. Phys Chem B. 2013, In Press.
9. Khon, E.; Lambright, K.; Khnayzer, R. S.; Moroz, P.; Dimuthu, P.; Butaeva, E.; Lambright, S.; Castellano, F. N.; Zamkov, M. Improving the Catalytic Activity of Semiconductor Nanocrystals through Selective Domain Etching. Nano Lett. 2013, 13, 2016-2023.
8. Kaafarani, B. R.; El-Ballouli, A. O.; Trattnig, R.; Fonari, A.; Sax, S.; Wex, B.; Risko, C.; Khnayzer, R. S.; Barlow, S.; Patra, D.; Timofeeva, T. V.; List, E. J. W.; Brédas, J.-L.; Marder, S. R. Bis(Carbazolyl) Derivatives of Pyrene and Tetrahydropyrene: Synthesis, Structures, Optical Properties, Electrochemistry, and Electroluminescence. J. Mater. Chem. C 2013, 1, 1638-1650.
http://pubs.rsc.org/en/content/articlelanding/2013/tc/c2tc00474g
7. Perera, D.; Lorek, R.; Khnayzer, R. S.; Moroz, P.; O'Connor, T.; Khon, D.; Diederich, G.; Kinder, E.; Lambright, S.; Castellano, F. N.; Zamkov, M., Photocatalytic Activity of Core/Shell Semiconductor Nanocrystals Featuring Spatial Seperation of Charges. J. Phys. Chem. C 2012, 116, 22786-22793.
6. Khnayzer, R. S.; Mara, M. W.; Huang, J.; Shelby, M. L.; Chen, L. X.; Castellano, F. N., Structure and Activity of Photochemically Deposited "CoPi" Oxygen Evolving Catalyst on Titania. ACS Catal. 2012, 2, 2150-2160.
http://pubs.acs.org/doi/abs/10.1021/cs3005192
This paper has been listed among most read papers on the ACS website.
5. Haefele, A.; Blumhoff, J.; Khnayzer, R. S.; Castellano, F. N., Getting to the (Square) Root of the Problem: How to Make Noncoherent Pumped Upconversion Linear. J. Phys. Chem. Lett. 2012, 3, 299-303.
http://pubs.acs.org/doi/abs/10.1021/jz300012u|
This work has been highlighted in a slide-share.
http://www.slideshare.net/jpcoffice/jpcl-jz300012u-castellano-presentation
4. Khnayzer, R. S.; Thompson, L. B.; Zamkov, M.; Ardo, S.; Meyer, G. J.; Murphy, C. J.; Castellano, F. N., Photocatalytic Hydrogen Production at Titania-Supported Pt Nanoclusters That Are Derived from Surface-Anchored Molecular Precursors. J. Phys. Chem. C 2012, 116, 1429-1438.
3. Khnayzer, R. S.; Blumhoff, J.; Harrington, J. A.; Haefele, A.; Deng, F.; Castellano, F. N., Upconversion-powered photoelectrochemistry. Chem. Commun. 2012, 48, 209-211. http://pubs.rsc.org/en/Content/ArticleLanding/2012/CC/c1cc16015j
This paper has been listed among most read papers on the RSC website.
2. Acharya, K. P.; Khnayzer, R. S.; O’Connor, T.; Diederich, G.; Kirsanova, M.; Klinkova, A.; Roth, D.; Kinder, E.; Imboden, M.; Zamkov, M., The Role of Hole Localization in Sacrificial Hydrogen Production by Semiconductor–Metal Heterostructured Nanocrystals. Nano Lett. 2011, 11, 2919-2926. http://pubs.acs.org/doi/abs/10.1021/nl201388c
This work has been featured in Science Newsline magazine.
http://www.sciencenewsline.com/articles/2012082318200034.html
1. Acharya, K. P.; Khon, E.; O’Conner, T.; Nemitz, I.; Klinkova, A.; Khnayzer, R. S.; Anzenbacher, P.; Zamkov, M., Heteroepitaxial Growth of Colloidal Nanocrystals onto Substrate Films via Hot-Injection Routes. ACS Nano 2011, 5, 4953-4964.
Expertise:
1. Organic and inorganic syntheses: including Schlenk line and glovebox operation, along with product isolation and characterization (Liquid chromatography, ESI-MS, MALDI, NMR, etc.).
2. Gas analysis: quantitative detection of volatile products, including gas chromatography and residual gas analyzer operation and assembly.
3. Spectroscopy: time-resolved and steady-state measurements, infra-red and Raman spectroscopy.
4. Equipment engineering: design and assembly of high-throughput photochemical reactors for quantitative hydrogen production analysis.
5. Expertise in electrochemistry, photochemistry and photoelectrochemistry: employment of transition metal complexes and semiconductors for usage in solar energy conversion and storage.
6. Materials and device assembly: Semiconductors thin-film formation along with operational photoelectrochemical cell assembly.
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