Publications

Xiao J, McGill JR, Nasir A, Lekan A, Johnson B, Wilkins DJ, Pearson GW, Tanner K, Goodarzi H, Glasgow E, Schlegel R, Agarwal S. Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231. Mol Biomed. 2022 May 26;3(1):16. doi: 10.1186/s43556-022-00080-5. PMID: 35614362; PMCID: PMC9133282. Xiao-2022-Identifying drivers of breast cancer metastasis

Issa NT, Wathieu H, Glasgow E, Peran I, Parasido E, Li T, Simbulan-Rosenthal CM, Rosenthal D, Medvedev AV, Makarov SS, Albanese C, Byers SW, Dakshanamurthy S. A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer. Ecotoxicol Environ Saf. 2022 Mar 15;233:113330. doi: 10.1016/j.ecoenv.2022.113330. Epub 2022 Feb 19. PMID: 35189517. Issa-2022-A novel chemo-phenotypic method

Roth SM, Berens EB, Sharif GM, Glasgow E, Wellstein A. Cancer Cell Invasion and Metastasis in Zebrafish Models (Danio rerio). Methods Mol Biol. 2021;2294:3-16. doi: 10.1007/978-1-0716-1350-4_1. PMID: 33742390. PMCID: PMC9012325. Roth-2021-Cancer Cell Invasion and Metastasis in Zebrafish Models

Xiao J, Glasgow E*, Agarwal S*. Zebrafish Xenografts for Drug Discovery and Personalized Medicine. Trends Cancer. 2020 Jul;6(7):569-579. doi: 10.1016/j.trecan.2020.03.012. Epub 2020 Apr 17. PMID: 32312681. PMCID: PMC9012325. Xia-2020-Cancer Drug Discovery

Shahi Thakuri P, Gupta M, Singh S, Joshi R, Glasgow E, Lekan A, Agarwal S, Luker GD, Tavana H. Phytochemicals inhibit migration of triple negative breast cancer cells by targeting kinase signaling. BMC Cancer. 2020 Jan 2;20(1):4. doi: 10.1186/s12885-019-6479-2. PubMed PMID: 31898540; PubMed Central PMCID: PMC6941316. Shahi Thakuri-2020-Phytochemicals inhibit

Tiek DM, Khatib SA, Trepicchio CJ, Heckler MM, Divekar SD, Sarkaria JN, Glasgow E, Riggins RB. Estrogen-related receptor β activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma. FASEB J. 2019 Dec;33(12):13476-13491. doi:10.1096/fj.201901075R. Epub 2019 Sep 28. PubMed PMID: 31570001. Tiek-2019-Estrogen-related receptor

Simbulan-Rosenthal CM, Dougherty R, Vakili S, Ferraro AM, Kuo LW, Alobaidi R, Aljehane L, Gaur A, Sykora P, Glasgow E, Agarwal S, Rosenthal DS. CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis. Cancers (Basel). 2019 Oct 3;11(10). pii: E1490. doi: 10.3390/cancers11101490. PubMed PMID: 31623313; PubMed Central PMCID: PMC6827046. Simbulan-Rosenthal-2019-CRISPR-Cas9 knockdown

Parasido E, Avetian GS, Naeem A, Graham G, Pishvaian M, Glasgow E, Mudambi S, Lee Y, Ihemelandu C, Choudhry M, Peran I, Banerjee PP, Avantaggiati ML, Bryant K, Baldelli E, Pierobon M, Liotta L, Petricoin E, Fricke ST, Sebastian A, Cozzitorto J, Loots GG, Kumar D, Byers S, Londin E, DiFeo A, Narla G, Winter J, Brody JR, Rodriguez O, Albanese C. The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells. Mol Cancer Res. 2019 Sep;17(9):1815-1827. doi: 10.1158/1541-7786.MCR-19-0191. Epub 2019 Jun 4. PubMed PMID: 31164413; PubMed Central PMCID: PMC6726538. Parasido-2019-The sustained induction

Maimouni S, Lee MH, Sung YM, Hall M, Roy A, Ouaari C, Hwang YS, Spivak J, Glasgow E, Swift M, Patel J, Cheema A, Kumar D, Byers S. Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Oncotarget. 2019 Feb 26;10(17):1606-1624. doi: 10.18632/oncotarget.26600. eCollection 2019 Feb 26. PubMed PMID: 30899431; PubMed Central PMCID: PMC6422194. Maimouni-2019-Tumor suppressor

Spikol ED, Glasgow E. Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression. Biology open. 2018;7(3). Epub 2018/03/14. doi: 10.1242/bio.031229. PubMed PMID: 29530929; PMCID: PMC5898263. Spikol-2018-Separate roles for Med12 and Wnts

Chen C, Choudhury S, Wangsa D, Lescott CJ, Wilkins DJ, Sripadhan P, Liu X, Wangsa D, Ried T, Moskaluk C, Wick MJ, Glasgow E, Schlegel R, Agarwal S. A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug. Sci Rep. 2017 Sep 12;7(1):11410. doi: 10.1038/s41598-017-11764-2. PubMed PMID: 28900283; PubMed Central PMCID: PMC5595986. Chen-2017-A multiplex preclinical model.pdf

Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium.; Deciphering Developmental Disorders Consortium., Glasgow E, McNeill A. MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. eCollection 2017 Aug. PubMed PMID: 28859103; PubMed Central PMCID: PMC5597252 Blanchet-2017-MYT1L mutations.pdf

Shin J, Mishra V, Glasgow E, Zaidi S, Ohshiro K, Chitti B, Kapadia AA, Rana N, Mishra L, Deng CX, Rao S, Mishra B. PRAJA is overexpressed in glioblastoma and contributes to neural precursor development. Genes Cancer. 2017 Jul;8(7-8):640-649. doi: 10.18632/genesandcancer.151. PubMed PMID: 28966725; PubMed Central PMCID: PMC5620009. Shin-2017-Praja is overexpressed in glioblastoma

Berens EB, Sharif GM, Schmidt MO, Yan G, Shuptrine CW, Weiner LM, Glasgow E, Riegel AT, Wellstein A. Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene. 2017 Feb 2;36(5):593-605. doi: 10.1038/onc.2016.234. Epub 2016 Jul 4. PubMed PMID: 27375028; PubMed Central PMCID: PMC5215748. Berens-2016-Keratin-associated.pdf

Berens EB, Sharif GM, Wellstein A, Glasgow E. Testing the Vascular Invasive Ability of Cancer Cells in Zebrafish (Danio Rerio). J Vis Exp. 2016 Nov 3;(117). doi: 10.3791/55007. PubMed PMID: 27842376; PubMed Central PMCID: PMC5226185. Berens-2016-JOVE video. Text at Berens-2017-Testing the Vasc.pdf

AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G. Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance. Cancer Res. 2016 Jun 1;76(11):3376-86. doi: 10.1158/0008-5472.CAN-15-2654. Epub 2016 Apr 11. PubMed PMID: 27197181; PubMed Central PMCID: PMC4910623. Hossiny-2016-Ly6E.pdf

Spikol ED, Laverriere CE, Robnett M, Carter G, Wolfe E, Glasgow E. Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics. Diseases. 2016 Mar;4(1). pii: 13. Epub 2016 Mar 8. PubMed PMID: 27857842; PubMed Central PMCID: PMC5110251. Spikol-2016-Zebrafish Models.pdf

Kasher PR, Schertz KE, Thomas M, Jackson A, Annunziata S, Ballesta-Martinez MJ, Campeau PM, Clayton PE, Eaton JL, Granata T, Guillén-Navarro E, Hernando C, Laverriere CE, Liedén A, Villa-Marcos O, McEntagart M, Nordgren A, Pantaleoni C, Pebrel-Richard C, Sarret C, Sciacca FL, Wright R, Kerr B, Glasgow E, Banka S. Small 6q16.1 Deletions Encompassing POU3F2 Cause Susceptibility to Obesity and Variable Developmental Delay with Intellectual Disability. Am J Hum Genet. 2016 Feb 4;98(2):363-72. doi: 10.1016/j.ajhg.2015.12.014. Epub 2016 Jan 28. PubMed PMID: 26833329; PubMed Central PMCID: PMC4746363. Kasher-2016-Small 6q16.1 Deletions.pdf

Sharif GM, Schmidt MO, Yi C, Hu Z, Haddad BR, Glasgow E, Riegel AT, Wellstein A. Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling. Oncogene. 2015 Nov 26;34(48):5879-89. doi: 10.1038/onc.2015.44. Epub 2015 Mar 16. PubMed PMID: 25772246; PubMed Central PMCID: PMC4573390. Sharif-2015-Cell growth density.pdf

Çelik H, Hong SH, Colón-López DD, Han J, Kont YS, Minas TZ, Swift M, Paige M, Glasgow E, Toretsky JA, Bosch J, Üren A. Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box. Mol Cancer Ther. 2015 Nov;14(11):2497-507. doi: 10.1158/1535-7163.MCT-15-0511. Epub 2015 Sep 10. PubMed PMID: 26358752; PubMed Central PMCID: PMC4636458. Çelik-2015-Identification of.pdf

Johnston, N. and Glasgow, E. (2015) Use of the Zebrafish Model to Understand Behavioral Disorders Associated with Altered Oxytocin System Development: Implications for Autism and Prader-Willi Syndrome, NEUROMETHODS series: Organism Models of Autism Spectrum Disorders, Pierre L. Roubertoux, ed., Springer, New York. DOI 10.1007/978-1-4939-2250-5 Johnston-2015-Use of the Zebrafish.pdf

Coffey CM, Solleveld PA, Fang J, Roberts AK, Hong SK, Dawid IB, Laverriere CE, Glasgow E. Novel oxytocin gene expression in the hindbrain is induced by alcohol exposure: transgenic zebrafish enable visualization of sensitive neurons. PLoS One. 2013;8(1):e53991. doi: 10.1371/journal.pone.0053991. Epub 2013 Jan 14. PubMed PMID: 23342055; PubMed Central PMCID: PMC3544674. Coffey-2013-Novel oxytocin gene.pdf

Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget. 2012 Oct;3(10):1220-35. PubMed PMID: 23100451; PubMed Central PMCID: PMC3717962. Catalina-Rodriguez-2012-The mitochondrial citrate.pdf

Adhikari S, Karmahapatra SK, Karve TM, Bandyopadhyay S, Woodrick J, Manthena PV, Glasgow E, Byers S, Saha T, Uren A. Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction. BMC Res Notes. 2012 Mar 9;5:134. doi: 10.1186/1756-0500-5-134. PubMed PMID: 22405347; PubMed Central PMCID: PMC3315744. Adhikari-2012-Characterization of magnesium require.pdf

Bulut G, Hong SH, Chen K, Beauchamp EM, Rahim S, Kosturko GW, Glasgow E, Dakshanamurthy S, Lee HS, Daar I, Toretsky JA, Khanna C, Uren A. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. doi: 10.1038/onc.2011.245. Epub 2011 Jun 27. PubMed PMID: 21706056; PubMed Central PMCID: PMC3513970. Bulut-2012-Small molecule inhibitors.pdf

Noche RR, Lu PN, Goldstein-Kral L, Glasgow E, Liang JO. Circadian rhythms in the pineal organ persist in zebrafish larvae that lack ventral brain. BMC Neurosci. 2011 Jan 13;12:7. doi: 10.1186/1471-2202-12-7. PubMed PMID: 21232144; PubMed Central PMCID: PMC3031267. Noche-2011-Circadian rhythms in the p.pdf

Egan RJ, Bergner CL, Hart PC, Cachat JM, Canavello PR, Elegante MF, Elkhayat SI, Bartels BK, Tien AK, Tien DH, Mohnot S, Beeson E, Glasgow E, Amri H, Zukowska Z, Kalueff AV. Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. Behav Brain Res. 2009 Dec 14;205(1):38-44. doi: 10.1016/j.bbr.2009.06.022. Epub 2009 Jun 18. PubMed PMID: 19540270; PubMed Central PMCID: PMC2922906. Egan-2009-Understanding behavioral and phys.pdf

Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, Zasloff M, Marshall JL, Shetty K, Johnson L, Mishra L, He AR. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene. 2009 Feb 19;28(7):961-72. doi: 10.1038/onc.2008.448. Epub 2009 Jan 12. PubMed PMID: 19137011; PubMed Central PMCID: PMC2703464. Lin-2009-The STAT3 inhibitor.pdf

Glasgow, E., Said, A.H. and Mishra, L. (2008). Transforming Growth Factor-Beta (TGF- b), Encyclopedia of Molecular Pharmacology, 2^nd edition, Offermanns, S., Rosenthal, W., eds., Springer Reference

Eaton JL, Holmqvist B, Glasgow E. Ontogeny of vasotocin-expressing cells in zebrafish: selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area. Dev Dyn. 2008 Apr;237(4):995-1005. doi: 10.1002/dvdy.21503. PubMed PMID: 18330923. Eaton-2008-Ontogeny of vasotocin-exp.pdf

Glasgow E, Mishra L. Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocr Relat Cancer. 2008 Mar;15(1):59-72. doi: 10.1677/ERC-07-0168. Review. PubMed PMID: 18310276; PubMed Central PMCID: PMC3821554. Glasgow-2008-Transforming growth factor.pdf

Eaton JL, Glasgow E. Zebrafish orthopedia (otp) is required for isotocin cell development. Dev Genes Evol. 2007 Feb;217(2):149-58. Epub 2006 Dec 19. PubMed PMID: 17180684. Eaton-2007-Zebrafish orthopedia.pdf

Eaton JL, Glasgow E. The zebrafish bHLH PAS transcriptional regulator, single-minded 1 (sim1), is required for isotocin cell development. Dev Dyn. 2006 Aug;235(8):2071-82. PubMed PMID: 16691572. Eaton-2006-The zebrafish bHLH PAS.pdf

Glasgow E, Ryu SL, Yamashita M, Zhang BJ, Mutsuga N, Gainer H. APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus. Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):143-51. Epub 2005 Apr 8. PubMed PMID: 15950772. Glasgow-2005-APeg3, a novel paternally.pdf

Unger JL, Glasgow E. Expression of isotocin-neurophysin mRNA in developing zebrafish. Gene Expr Patterns. 2003 Mar;3(1):105-8. PubMed PMID: 12609611. Unger-2003-Expression of isotocin.pdf

Yamashita, M., Glasgow, E., Zhang, B., Kusano, K. and Gainer, H. (2002) Identification of cell-specific mRNAs in oxytocinergic and vasopressinergic magnocellular neurons in rat supraoptic nucleus by single-cell differential hybridization. Endocrinology 143, 4464-4476. Yamashita-2002-Identification of cell-specific.pdf

Zhang B., Glasgow, E., Murase, T., Verbalis, J.G., and Gainer, H. (2001). Chronic hypoosmolality induces a selective decrease in magnocellular neuron soma and nuclear cell size in the rat hypothalamic supraoptic nucleus. J. Neuroendocrinology 13, 29-36. Zhang-2001-Chronic hypoosmolality.pdf

Glasgow, E., Murase, T., Zhang, B., Verbalis, J.G., and Gainer, H. (2000). Gene expression in the rat supraoptic nucleus induced by chronic hyperosmolality versus hypoosmolality. Am. J. Physiol., Regul. Integr. Comp. Physiol. 279, R1239-R1250. Glasgow-2000-Gene expression in the.pdf

Glasgow, E., Kusano, K., Chin, H., Mezey, E., Young, W.S.III, and Gainer, H. (1999). Single cell RT-PCR analysis of rat supraoptic magnocellular neurons: neuropeptide phenotypes and high voltage-gated calcium channel subtypes. Endocrinology 140, 5391-5401. Glasgow-1999-Single cell RT-PCR analysis.pdf

Glasgow, E. and Tomarev, S. I. (1998). Restricted expression of the homeobox gene prox 1 in developing zebrafish. Mech. Dev. 76, 175-178. Glasgow-1998- Restricted expression of the homeobox gene prox 1.pdf

Cangor, A. K., Passini, M. A., Asch, W. S., Leake, D., Zafonte, B.T., Glasgow, E., and Schechter, N. (1998). Restricted expression of the neuronal intermediate filament protein plasticin during zebrafish development. J. Comp. Neurol. 399, 561-572. Cangor-1998-Restricted expression of the neuronal intermediate filament.pdf

Glasgow, E., Karavanov, A. A., and Dawid, I. B. (1997). Neuronal and neuroendocrine expression of lim3, a LIM class homeobox gene, is altered in zebrafish mutants with axial signaling defects. Dev. Biol. 192, 405-419. Glasgow-1997-Neuronal and neuroendocrine expression of lim3.pdf

Levine, E. M., Passini, M., Hitchcock, P. F., Glasgow, E., and Schechter, N. (1997). Vsx-1 and Vsx-2: two Chx10-like homeobox genes expressed in overlapping domains in the adult goldfish retina. J. Comp. Neurol. 387, 439-448. Levine-1997-Vsx-1 and Vsx-2: two Chx10-like homeobox genes.pdf

Appel, B., Korzh, V., Glasgow, E., Thor, S., Edlund, T., Dawid, I. B., and Eisen, J. S. (1995). Motoneuron fate specification and patterned LIM homeobox gene expression in embryonic zebrafish. Development 121, 4117-4125. Appel-1995-Motoneuron fate specification.pdf

Giordano, S., Glasgow, E., Druger, R., and Schechter, N. (1995). Intermediate filaments: a molecular link to nerve development and regeneration in the goldfish visual pathway, in Neuron - Glia Interrelations During Phylogeny, A. Vernadakis, and B. Roots, eds., Humana Press, Inc.

Fuchs, C., Glasgow, E., Hitchcock, P. F., and Schechter, N. (1994). Plasticin, a newly identified neurofilament protein, is preferentially expressed in young retinal ganglion cells of adult goldfish. J. Comp. Neurol. 350, 452-462. Fuchs-1994-Plasticin, a newly identified neurofilament.pdf

Levine, E. M., Hitchcock, P. F., Glasgow, E., and Schechter, N. (1994). Restricted expression of a new paired-class homeobox gene in normal and regenerating adult goldfish retina. J. Comp. Neurol. 348, 596-606. Levine-1994-Restricted expression of a new paired-class homeobox gene.pdx

Glasgow, E., Druger, R. K., Fuchs, C., Levine, E. M., Giordano, S., and Schechter, N. (1994). Cloning of multiple forms of goldfish vimentin: differential expression in CNS. J. Neurochem. 63, 470-481. Glasgow-1994-Cloning of multiple forms of goldfish vimentin.pdf

Glasgow, E., Hall, C. M., and Schechter, N. (1994). Organization, sequence, and expression of a gene encoding goldfish neurofilament medium protein. J. Neurochem. 63, 52-61. Glasgow-1994-Organization, sequence, and expression.pdf

Fuchs, C., Druger, R. K., Glasgow, E., and Schechter, N. (1994). Differential expression of keratins in goldfish optic nerve during regeneration. J. Comp. Neurol. 343, 332-340. Fuchs-1994-Differential expression of keratins.pdf

Glasgow, E., Druger, R. K., Fuchs, C., Lane, W. S., and Schechter, N. (1994). Molecular cloning of gefiltin (ON1): serial expression of two new neurofilament mRNAs during optic nerve regeneration. EMBO J. 13, 297-305. Glasgow-1994-Molecular cloning of gefiltin.pdf

Druger, R. K., Glasgow, E., Fuchs, C., Levine, E. M., Matthews, J. P., Park, C. -Y., and Schechter, N. (1994). Complex expression of keratins in goldfish optic nerve. J. Comp. Neurol. 340, 269-280. Druger-1994-Complex Expression of Keratins

Druger, R. K., Levine, E. M., Glasgow, E., Jones, P. S., and Schechter, N. (1993). Cloning of a type I keratin from goldfish optic nerve: differential expression of keratins during regeneration. Differentiation 52, 33-43.

Glasgow, E., Druger, R. K., Levine, E. M., Fuchs, C., and Schechter, N. (1992). Plasticin, a novel type III neurofilament protein from goldfish retina: increased expression during optic nerve regeneration. Neuron 9, 373-381. Glasgow-1992-Plasticin, a novel type III neurofilament

Giordano, S., Hall, C., Quitschke, W., Glasgow, E., and Schechter, N. (1990). Keratin 8 of simple epithelia is expressed in glia of the goldfish nervous system. Differentiation 44, 163‑172.

Giordano, S., Glasgow, E., Tesser, P., and Schechter, N. (1989). A type II keratin is expressed in glial cells of the goldfish visual pathway. Neuron 2, 1507‑1516. Giordano-1989-A type II keratin is expressed