Recent Publications

2023

Aggarwal M, Kuo M, Zhu Z, Gould S, Zhang K, Johnson P, Beheshtian S, Kuhlman L, Zhao Z, Fang H-B, Kallakury B, Creswell K, Mueller SC, Kroemer A, He AR, Chung F-L. (2023) Detection of ϒ-OHPdG in circulating tumor cells in the blood of patients with hepatocellular carcinoma. Submitted

2021

IARC Monographs Vol 128 group, Marques MM, Beland FA, Lachenmeier DW, Phillips DH, Chung FL, Dorman DC, Elmore SE, Hammond SK, Krstev S, Linhart I, Long AS, Mandrioli D, Ogawa K, Pappas JJ, Parra Morte JM, Talaska G, Tang M, Thakur N, van Tongeren M, Vineis P, Grosse Y, Benbrahim-Tallaa L, Suonio E, Turner MC, El Ghissassi F, Middleton D, Miranda-Filho A, Chung F, Liu Y, Vega S, Mattock H, Schubauer-Berigan MK, Guyton KZ. (2021) Carcinogenicity of Acrolein, Crotonaldehyde, and Arecoline. Lancet Oncology. Lancet Oncology. 22(1), 19–20.

Burmistrov V, Saxena R, Pitushkin D, Butov GM, Chung FL, Aggarwal M. (2021) Adamantyl Isothiocyanates as Mutant P53 Rescuing Agents and Their Structure-Activity Relationships. Journal of Medicinal Chemistry. 64(10), 6621–6633.

Coia H, Ma N, Hou Y, Permaul E, Berry DL, Cruz MI, Pannkuk E, Girgis M, Zhu Z, Lee Y, Rodriquez O, Cheema A, Chung FL. (2021) Theaphenon E Prevents Fatty Liver Disease and Increases CD4+ T Cell Survival in Mice Fed a High-Fat Diet. Clinical Nutrition. 40(1), 110–119.

2019

Aggarwal M, Saxena R, Asif N, Sinclair E, Tan J, Cruz I, Berry D, Kallakury B, Pham Q, Wang TTY, Chung FL. (2019) p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition. Clinical Cancer Research. Published online.

2018

Coia, H., Ma, N., Hou, Y., Dyba, M. D., Fu, Y., M. Idalia Cruz, M. I., Benitez, C., Graham, G. T., McCutcheon, J. N., Zheng, Y. L., Sun, B., Kallakury, B. V., Ma, J., Fang, H. B., Berry, D. L., Muralidaran, V., and Chung, F. L. (2018) Prevention of lipid peroxidation-derived cyclic DNA adduct and mutation in high fat dietinducedhepatocarcinogenesis by Theaphenon E. Cancer Prevention Research. Published online.

Dyba, M., da Silva, B., Coia, H., Hou, Y., Noguchi, S., Pan, J., Berry, D., Creswell, K., Krzeminski, J., Desai, D., Amin, S., Yang, D., and Chung, F. L. (2018) Monoclonal Antibodies for the Detection of a Specific Cyclic DNAAdduct Derived from ω‑6 Polyunsaturated Fatty Acids. Chemical Research in Toxicology. 31, 772-783.

Coia, H., Ma, N., He, A. R., Kallakury, B., Berry, D. L., Permaul, E., Makambi, K. H., Fu, Y., Chung, F. L. (2018) Detection of a lipid peroxidation-induced DNA adduct across liver disease stages. Hepatobiliary Surgery and Nutrition. 7(2), 85–97.

2017

Fu, Y., Silverstein, S., McCutcheon, J. N., Dyba, M., Nath, R. G., Aggarwal, M., Coia, H., Bai, A., Pan, J., Jiang, J., Kallakury, B., Wang, H., Zhang, Y.-W., Giaccone, G., He, A. R. and Chung, F.-L. (2017), An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice. Hepatology. 67(1), 159–170.

2016

Aggarwal, M., Saxena, R., Sinclair, E., Fu, Y., Jacobs, A., Dyba, M.,Chung, F.-L. (2016). Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell Death and Differentiation, 23(10), 1615–1627.

Fu Y, Mi L, Sanda M, Silverstein S, Aggarwal M, Wang D, Gupta P, Goldman R, Appella DH, Chung FL. A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate. RSC Adv., 4(8):3920-3923.

Pan, J., Sinclar, E., Xuan, Z., Fu, Y., Sen, S., Berry, D., Creswell, K., Hu, J., Roy, R., and Chung, F. L. Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein. Mutation Research 789, 33-38, 2016.

2014

Fu Y, Dyba M, Pan J, Schultz C, Yang P, Desai D, Amin S, Chung FL. Detection in vivo of a Novel Endogenous Etheno DNA Adduct Derived from Arachidonic Acid and the Effects of Antioxidants on its Formation. Free Radical Biology and Medicine. In Press, 2014.

Fu Y, Lixin M, Sanda M, Silverstein S, Aggarwal M, Wang D, Gupta P, Goldman R, Appella D, Chung FL. A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate. RSC Adv., 4: 3920-3, 2014.

2013

Choudry S, Dyba M, Pan J, Roy R, Chung FL. Repair kinetics of acrolein- and (E)-4-hydroxy-2-non-enal- derived DNA adducts in human colon cell extracts. Mutat Res. ,751-2:15-23,2013.

Wang HT, Weng MW, Chen WC, Yobin M, Pan J, Chung FL, Wu XR, Rom W, Tang MS. Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis. Carcinogenesis. 34(1):220-7, 2013.

2012

Pan J, Awoyemi B, Xuan Z, Vohra P, Wang HT, Dyba M, Greenspan E,Fu Y, Creswell K, Zhang L, Berry D, Tang MS, Chung FL. Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies. Chem Res Toxicol. 17;25(12):2788-95, 2012.

Greenspan EJ, Lee H, Dyba M, Pan J, Mekambi K, Johnson T, Blancato J, Mueller S, Berry DL, Chung FL. High-throughput, Quantitative Analysis of Acrolein-derived DNA Adducts in Human Oral Cells by Immunohistochemistry. J Histochem Cytochem, 60(11):844-53, 2012.

Chung FL, Wu MY, Basudan A, Dyba M, Nath RG. Regioselective formation of acrolein-derived cyclic 1,n(2)-propanodeoxyguanosine adducts mediated by amino acids, proteins, and cell lysates. Chem Res Toxicol, 17;25(9):1921-8, 2012.

Dash C, Chung FL, Rohan JA, Greenspan E, Christopher PD, Makambi K, Hara Y, Newkirk K, Davidson B, Adams-Campbell LL. A six-month crossover chemoprevention clinical trial of tea in smokers and non-smokers: methodological issues in a feasibility study. BMC Complement Altern Med, 16;12:96, 2012.

Xiao Z, Mi L, Chung FL, Veenstra TD. Proteomic analysis of covalent modifications of tubulins by isothiocyanates. J Nutr, 142(7):1377S-81S, 2012.

Wang HT, Hu Y, Tong D, Huang J, Gu L, Wu XR, Chung FL, Li GM, Tang MS. Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem, 287(15):12379-86, 2012.

2011

Mi L, Hood BL, Stewart NA, Xiao Z, Govind S, Wang X, Conrads TP, Veenstra TD, Chung FL. Identification of Potential Protein Targets of Isothiocyanates by Proteomics. Chem Res Texicol. 2011 Aug 26

Sun X, Mi L, Liu J, Song L, Chung FL, Gan N. Sulforaphane prevents microcystin-L-R-induced oxidative damage and apoptosis in BALB/c mice. Toxicol Appl Pharmacol., 255(1):9-17, 2011

Mi L, Di Pasqua AJ, Chung FL. Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis, 2011 July 16.

Kang HJ, Hong YB, Kim HJ, Rodriguez OC, Nath RG, Tilli EM, Albanese C, Chung FL, Kwon SH, Bae I. Detoxification: a novel function of BRCA1 in tumor suppression? Toxicol Sci. 122(1), 26-37, 2011.

Wang X., Govind S., Mi L., Sajankila S. P., Roy and Chung F.-L. Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. Mol. Nutr. Food Res., 55(7), 2011.

Wang, X., Di Pasqua, A.J., Govind, S., McCracken E., Hong C., Mi, L., Mao, Y., Wu, J., Tomita Y., Woodrick, J.C., Fine R., and Chung, F-L. Selective depletion of mutant p53 by cancer chemopreventative isothiocyanates and its structure-activity relationships. J. Medicinal Chem., 54(3), 809-816, 2011.

Mi L., Gan N., Chung F-L. Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. Carcinogenesis, 32(2), 216-23, 2011.

Fowke, J.H., Gao Y-T. Chow, W-H., Cai, Q., Shu, X-O., Li, H-I., Ji, B-T., Rothman, N., Yang, G., Chung, F-L., Zheng, W. Urinary isothiocyanate levels and lung cancer risk among non-smoking women: a prospective investigation, Lung Cancer, 73(1), 18-24, 2011.

2010

Gan N, Wu Y-C, Brunet M, Garrido C, Chung F-L, Dai C, and Mi L., Sulforaphane activates heat shock response and enhances proteasome activity through upregulation of HSP27. J. Biol. Chem., 285, 35528-36, 2010.

Dyba M, Wang A, Noone A-M, Goerlitz, D, Shields, Zheng, Y-L, Rivlin, R, and Chung F-L. Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juice. Clin. Nutr., 29(6), 813-8, 2010.

Di Pasqua A.J. Hong C. Wu M., McCracken E. Wang X. Chung F-L. Sensitization of non-small cell lung cancer cells to the platinum anticancer agent cisplatin by naturally occurring isothiocyanates. Chem. Res. Toxicol., 23(8), 1307-9, 2010.

Yang G, Gao YT, Shu XO, Cai Q, Li GL, Li HL, Ji BT, Rothman N, Dyba M, Xiang YB, Chung F.-L, Chow WH, Zheng W. Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk. Am. J. Clin. Nutr., 91(3),704-11, 2010.

Kotsopoulos J, Tworoger SS, Campos H, Chung F.L, Clevenger CV, Franke AA, Mantzoros CS, Ricchiuti V, Willet WC, Hankinson SE, Eliassen AH. Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses’ HealthStudies. Cancer Epidemiol. Biomarkers Prev.,19(4), 938-46, 2010.

Nath Rg, Wu My, Emami A, Chung F.-L. Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation.Nutr. Cancer. 62(5),622-9, 2010.

Gan N, Mi L, Sun X, Dai G, Chung F.-L, Song L. Sulforaphane Protects Microcystin-LR-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response. Toxicol Appl Pharmacol., 247(2), 129-37, 2010.

2009

Mi L., Gan N., Chung F.-L. Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery. Biochem. Biophys. Res. Commun., 16;388(2) , 456-62, 2009.

Moy, K.A., Yuan, J-M., Chung, F-L., Wang X-L., Van Den Berg, D., Wang, R., Gao, Y-T., Yu, M.C. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China. International J. of Cancer, 125(11), 2652-9, 2009.

Pan J., Keffer J., Emami A., Ma X., Lan R., Goldman R., Chung F-L. Formation of acrolein-derived DNA adduct in human colon cells: its role in apoptosis induction by docosahexaenoic acid. Chem. Res. Toxicol., 22, 798-806, 2009.

Mi L., Gan N., CheemaA, DakshanamurthyS, Yang D. C. H., Chung F-L. Cancer preventive isothiocyanates induce selective degradation of cellular α- and β-tubulins by proteasomes. J. Biol. Chem., 284, 17039-17051, 2009.

Epplein M., Wilkens L.R., Tiirikainen M., Dyba, M., Chung FL., Goodman M.T., Murphy S.P., Henderson B. E., Kolonel L.N., Le Marchand L. Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study. Cancer Epidemiol. Biomarkers Prev., 18(1), 314-20, 2009.

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