ORCID: https://orcid.org/0000-0002-0753-035X
Profiles in CGU: https://pure.lib.cgu.edu.tw/zh/persons/chuan-chiang-ni-2
*: Corresponding author; #: Equal contribution
2025
Lu CH, Ma J, Lin MC, Wu CJ, Kuo CY, Chiang-Ni C, Kuo ML*. 2025. Streptococcal pyrogenic exotoxin A induces regulatory T cells via TNF-α-TNFR2 signaling. Med Microbiol Immunol. 214:25. https://doi.org/10.1007/s00430-025-00835-1.
Chen YM*, Chien KY, Shieh HR, Luo CJ, Chang YX, Chiang-Ni C, Lai CH, Chiu CH. 2025. Impact of vancomycin and Clostridioides difficile on the secretome and pathogenicity of Clostridium innocuum. Med Microbiol Immunol. 214:21. https://doi.org/10.1007/s00430-025-00831-5.
2024
Chiang-Ni C*, Huang JY, Hsu CH, Lo YC, Chen YYM, Lai CH, Chiu CH. 2024. Genetic diversity, biofilm formation, and vancomycin resistance of clinical Clostridium innocuum isolates. BMC Microbiol. 24:353. https://doi.org/10.1186/s12866-024-03503-1
Shi YA, Lu SL, Noda T, Chiu CH, Chiang-Ni C*. 2024. Capsule-deficient group A Streptococcus evades autophagy-mediated killing in macrophages. mBio. 15:e0077124. https://doi.org/10.1128/mbio.00771-24
Lai CY, Xie JX, Lai MC, Wu ZY, Lin JS, Huang YT, Chi CY, Chiang-Ni C, Walker MJ, Chang YC*. 2024. Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus. NPJ Vaccines. 9:46. https://doi.org/10.1038/s41541-024-00839-7.
Chiang-Ni C*, Hsu CY, Yeh YH, Chi CY, Wang S, Tsai PJ, Chiu CH. 2024. Detection of toxigenic M1UK lineage group A Streptococcus clones in Taiwan. J Microbial Immun Infect. 57:269-277. https://doi.org/10.1016/j.jmii.2024.01.004
2023
Wu HY, Kuo CJ, Chou CH, Ho MW, Chen CL, Hsu TS, Chen YC, Chiang-Ni C, Chen YM, Chiu CH, Lai CH*. 2023. Clostridium innocuum, an emerging pathogen that induces lipid raft-mediated cytotoxicity. Virulence. 14:2265048. https://doi.org/10.1080/21505594.2023.2265048.
Chiang-Ni C*, Chiang CY, Chen YW, Shi YA, Chao YT, Wang S, Tsai PJ, Chiu CH. 2023. RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus. Virulence. 14:2249784. https://doi.org/10.1080/21505594.2023.2249784
Chiang-Ni C*, Chen YW, Chen KL, Jiang JX, Shi YA, Hsu CY, Chen YYM, Lai CH, Chiu CH. 2023. RopB represses the transcription of speB in the absence of SIP in group A Streptococcus. Life Sci Alliance. 6:e202201809. https://doi.org/10.26508/lsa.202201809
2022
Shi YA, Chen TC, Chen YW, Liu YS, Chen YYM, Lai CH, Chiu CH, Chiang-Ni C*. 2022. The bacterial markers of identification of invasive CovR/CovS-inactivated group A Streptococcus. Microbiol Spectr. 02033-22. https://doi.org/10.1128/spectrum.02033-22
Chang CH, Lee SH, Lin YC, Hsu CY, Cheng CC, Teng SH, Chen MF, Hsieh PH, Chang Y, Chiang-Ni C*. 2022. Characterization of the phenotypes of methicillin- and vancomycin-susceptible Staphylococcus argenteus after vancomycin passages. J Glob Antimicrob Resist. 31:63-71. https://doi.org/10.1016/j.jgar.2022.08.006
2021
Chiang-Ni C*, Liu YS, Lin CY, Hsu CH, Shi YA, Chen YYM, Lai CH, Chiu CH. 2021. Incidence and effects of acquisition of the phage-encoded ssa superantigen gene in invasive group A Streptococcus. Front Microbiol. 12:685343. https://doi.org/10.3389/fmicb.2021.685343
2020
Chen YW, Huang MZ, Chen CL, Kuo CY, Yang CY, Chiang-Ni C, Chen YM, Hsieh CM, Wu HY, Kuo ML, Chiu CH, Lai CH*. 2020. PM2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis. Part Fibre Toxicol 17:37. https://doi.org/10.1186/s12989-020-00362-2
Chiang-Ni C*, Chiou HJ, Tseng HC, Hsu CY, Chiu CH. 2020. RocA regulates phosphatase activity of virulence sensor CovS of group A Streptococcus in growth phase- and pH-dependent manners. mSphere. 5:e00361-20. https://doi.org/10.1128/mSphere.00361-20
Hsieh CL, Hsieh SY, Huang HM, Lu SL, Omori H, Zheng PX, Ho YN, Cheng YL, Lin YS, Chiang-Ni C, Tsai PJ, Wang SY, Liu CC, Noda T, Wu JJ*. 2020. Nicotinamide increases intracellular NAD+ content to enhance autophagy-mediated group A streptococcal clearance in endothelial cells. Front Microbiol. 11:117. https://doi.org/10.3389/fmicb.2020.00117
2019
Chiang-Ni C*, Tseng HC, Shi YA, Chiu CH. 2019. Effect of the phosphatase activity of the control of virulence sensor (CovS) on clindamycin-mediated streptolysin O production in group A Streptococcus. Infect Immun. 87:e00583-19. https://doi.org/10.1128/IAI.00583-19
Chen MF, Chang CH, Chiang-Ni C, Hsieh PH, Shih HN, Ueng SWN, Chang Y*. 2019. Rapid analysis of bacterial composition in periprosthetic joint infection by 16S rRNA metagenomic sequencing. Bone Joint Res. 8:367-377. https://doi.org/10.1302/2046-3758.88.BJR-2019-0003.R2
Hou TY, Chiang-Ni C, Teng SH*. 2019. Current status of MALDI-TOF mass spectrometry in clinical microbiology. J Food Drug Anal. 27:404-414. https://doi.org/10.1016/j.jfda.2019.01.001
Chiang-Ni C*, Kao CY#, Hsu CY#, Chiu CH. 2019. Phosphorylation at the D53 but not T65 residue of CovR determines the repression of rgg and speB transcription in emm1- and emm49-type group A streptococci. J Bacteriol. 201:e00681-18. https://doi.org/10.1128/JB.00681-18
2018
Chiang-Ni C*, Shi YA, Lai CH, Chiu CH. 2018. Cytotoxicity and survival fitness of invasive covS mutant of group A Streptococcus in phagocytic cells. Front Microbiol. 9:2592. https://doi.org/10.3389/fmicb.2018.02592
Hsieh CL, Huang HM, Hsieh SY, Zheng PX, Lin YS, Chiang-Ni C, Tsai PJ, Wang SY, Liu CC, Wu JJ*. 2018. NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells. Front Microbiol 9:1733. https://doi.org/10.3389/fmicb.2018.01733
2017
Chiang-Ni C*, Tseng HC, Hung CH, Chiu CH. 2017. Acidic stress enhances CovR/S-dependent gene repression through activation of the covR/S promoter in emm1-type group A Streptococcus. Int J Med Microbiol 307:329-339. https://doi.org/10.1016/j.ijmm.2017.06.002
Zheng PX, Chan YC, Chiou CS, Hsieh CL, Chiang-Ni C, Wu JJ*. 2017. Highly prevalent emmSTG840.0 and emmSTC839.0 types of erythromycin non-susceptible group G Streptococcus isolated from bacteremia in southern Taiwan. J Microbiol Immunol Infect 50:831-838. https://doi.org/10.1016/j.jmii.2016.12.010
Hou JN, Chen TH, Chiang YH, Peng JY, Yang TH, Cheng CC, Sofiyatun E, Chiu CH, Chiang-Ni C*, Chen WJ*. 2017. PERK signal-modulated protein translation promotes the survivability of Dengue 2 virus-infected mosquito cells and extends viral replication. Viruses 9. https://doi.org/10.3390/v9090262
Lin HJ, Liu HH, Lin CD, Kao MC, Chen YA, Chiang-Ni C, Jiang ZP, Huang MZ, Lin CJ, Lo UG, Lin LC, Lai CK, Lin H, Hsieh JT, Chiu CH, Lai CH*. 2017. Cytolethal distending toxin enhances radiosensitivity in prostate cancer cells by regulating autophagy. Front Cell Infect Microbiol 7:223. https://doi.org/10.3389/fcimb.2017.00223
2016
Chiang-Ni C*, Chu TP, Wu JJ, Chiu CH. 2016. Repression of Rgg but not upregulation of LacD.1 in emm1-type covS mutant mediates the SpeB repression in group A Streptococcus. Front Microbiol 7:1935. https://doi.org/10.3389/fmicb.2016.01935
Chiang-Ni C, Zheng PX, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2016. Epidemiology analysis of Streptococcus pyogenes in a hospital in Southern Taiwan by use of the updated emm cluster typing system. J Clin Microbiol 54:157-162. https://doi.org/10.1128/JCM.02089-15
Chiang-Ni C*, Nian SY, Wu JJ, Chen CJ. 2016. Oxygen-dependent phenotypic variation in group A Streptococcus. J Microbiol Immunol Infect 49:837-842. https://doi.org/10.1016/j.jmii.2014.11.010
Lai CH*, Huang JC, Chiang-Ni C, Li JP, Wu LT, Wu HS, Sun YC, Lin ML, Lee JF, Lin HJ. 2016. Mixed infections of Helicobacter pylori isolated from patients with gastrointestinal diseases in Taiwan. Gastroenterol Res Pract 2016:7521913. https://doi.org/10.1155/2016/7521913
Lai CK, Chen YA, Lin CJ, Lin HJ, Kao MC, Huang MZ, Lin YH, Chiang-Ni C, Chen CJ, Lo UG, Lin LC, Lin H, Hsieh JT, Lai CH*. 2016. Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin. Front Cell Infect Microbiol 6:9. https://doi.org/10.3389/fcimb.2016.00009
2015
Zheng PX, Chan YC, Chiou CS, Chiang-Ni C, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2015. Clustered regularly interspaced short palindromic repeats are emm type-specific in highly prevalent group A streptococci. PLoS One 10:e0145223. https://doi.org/10.1371/journal.pone.0145223
Tsou YA, Lin CD, Chen HC, Hsu HY, Wu LT, Chiang-Ni C, Chen CJ, Wu TF, Kao MC, Chen YA, Peng MT, Tsai MH, Chen CM, Lai CH*. 2015. Interleukin-13 inhibits lipopolysaccharide-induced BPIFA1 expression in nasal epithelial cells. PLoS One 10:e0143484. https://doi.org/10.1371/journal.pone.0143484
2014
Chiang-Ni C, Zheng PX, Wang S, Tsai PJ, Kuo CF, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2014. Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments. Pathog Dis 70:194-201. https://doi.org/10.1111/2049-632X.12114
Zheng PX, Chiang-Ni C, Wang SY, Tsai PJ, Kuo CF, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2014. Arrangement and number of clustered regularly interspaced short palindromic repeat spacers are associated with erythromycin susceptibility in emm12, emm75 and emm92 of group A Streptococcus. Clin Microbiol Infect 20:516-523. https://doi.org/10.1111/1469-0691.12379
Wen YT, Wang JS, Tsai SH, Chiang-Ni C, Wu JJ, Liao PC*. 2014. Label-free proteomic analysis of environmental acidification-influenced Streptococcus pyogenes secretome reveals a novel acid-induced protein histidine triad protein A (HtpA) involved in necrotizing fasciitis. J Proteomics 109:90-103. https://doi.org/10.1016/j.jprot.2014.06.026
2013
Zheng PX, Chung KT, Chiang-Ni C, Wang SY, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2013. Complete genome sequence of emm1 Streptococcus pyogenes A20, a strain with an intact two-component system, CovRS, isolated from a patient with necrotizing fasciitis. Genome Announc 1. https://doi.org/10.1128/genomeA.00149-12
Wang CH#, Chiang-Ni C#, Kuo HT, Zheng PX, Tsou CC, Wang S, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ. 2013. Peroxide responsive regulator PerR of group A Streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress. PLoS One 8:e81882. https://doi.org/10.1371/journal.pone.0081882 (#: Equal contribution)
2012
Chiang-Ni C#, Zheng PX#, Tsai PJ, Chuang WJ, Lin YS, Liu CC, Wu JJ*. 2012. Environmental pH changes, but not the LuxS signalling pathway, regulate SpeB expression in M1 group A streptococci. J Med Microbiol 61:16-22. https://doi.org/10.1099/jmm.0.036012-0 (#: Equal contribution)
Hung CH, Tsao N, Zeng YF, Lu SL, Chiang-Ni C, Lin YS, Wu JJ, Kuo CF*. 2012. Synergistic effects of streptolysin S and streptococcal pyrogenic exotoxin B on the mouse model of group A streptococcal infection. Med Microbiol Immunol 201:357-369. https://doi.org/10.1007/s00430-012-0241-6
2011
Chiang-Ni C, Wu AB, Liu CC, Chen KT, Lin YS, Chuang WJ, Fang HY, Wu JJ*. 2011. Emergence of uncommon emm types of Streptococcus pyogenes among adult patients in southern Taiwan. J Microbiol Immunol Infect 44:424-429. https://doi.org/10.1016/j.jmii.2011.04.005
Su YF, Chuang WJ, Wang SM, Chen WY, Chiang-Ni C, Lin YS, Wu JJ, Liu CC*. 2011. The deficient cleavage of M protein-bound IgG by IdeS: insight into the escape of Streptococcus pyogenes from antibody-mediated immunity. Mol Immunol 49:134-142. https://doi.org/10.1016/j.molimm.2011.08.002
Wu AB, Wang MC, Tseng CC, Lin WH, Teng CH, Huang AH, Hung KH, Chiang-Ni C, Wu JJ*. 2011. Clinical and microbiological characteristics of community-acquired Staphylococcus lugdunensis infections in Southern Taiwan. J Clin Microbiol 49:3015-3018. https://doi.org/10.1128/JCM.01138-11
2010
Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ*. 2010. Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes. Int J Med Microbiol 300:259-264. https://doi.org/10.1016/j.ijmm.2009.09.002
2009
Chiang-Ni C, Zheng PX, Ho YR, Wu HM, Chuang WJ, Lin YS, Lin MT, Liu CC, Wu JJ*. 2009. emm1/sequence type 28 strains of group A streptococci that express covR at early stationary phase are associated with increased growth and earlier SpeB secretion. J Clin Microbiol 47:3161-3169. https://doi.org/10.1128/JCM.00202-09
2008
Chiang-Ni C, Tsou CC, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ*. 2008. The transcriptional terminator sequences downstream of the covR gene terminate covR/S operon transcription to generate covR monocistronic transcripts in Streptococcus pyogenes. Gene 427:99-103. https://doi.org/10.1016/j.gene.2008.08.025
Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, Wu JJ*. 2008. An iron-binding protein, Dpr, decreases hydrogen peroxide stress and protects Streptococcus pyogenes against multiple stresses. Infect Immun 76:4038-4045. https://doi.org/10.1128/IAI.00477-08
Chiang-Ni C, Wu JJ*. 2008. Effects of streptococcal pyrogenic exotoxin B on pathogenesis of Streptococcus pyogenes. J Formos Med Assoc 107:677-685. https://doi.org/10.1016/S0929-6646(08)60112-6
2006
Chiang-Ni C, Wang CH, Tsai PJ, Chuang WJ, Lin YS, Lin MT, Liu CC, Wu JJ*. 2006. Streptococcal pyrogenic exotoxin B causes mitochondria damage to polymorphonuclear cells preventing phagocytosis of group A Streptococcus. Med Microbiol Immunol 195:55-63. https://doi.org/10.1007/s00430-005-0001-y
2020
江倪全 2020. 不只是壞人 隱藏在生活中的細菌好朋友. 科學月刊. 51(4):75-77.
2019
江倪全 2019. 生生不息：細菌，是敵人還是朋友？ 科學月刊. 50(3):24-27.
2009
江倪全、吳俊忠 2009. 醫學分子檢驗: 細菌分子檢驗分型法. 五南出版社. 18:381-406.