最近亮點成果

主持人介紹

研究方向

化膿性鏈球菌 (Streptococcus pyogenes, Strep A) 致病機轉

化膿性鏈球菌為革蘭氏陽性的人類致病菌，可引起多種疾病。若傷口感染處理不當，可能進展為嚴重的蜂窩性組織炎或壞死性筋膜炎，後者因導致嚴重的肌肉組織壞死，使該菌又被稱為「噬肉菌」。本實驗室致力於解析其感染與致病的分子機制。

核心研究主題：CovR/CovS 二元調控系統 (Two-component regulatory system)

細菌的轉錄調控系統是其適應環境變化的關鍵。本實驗室深入研究化膿性鏈球菌的 CovR/CovS 二元調控系統，闡明其如何感應環境訊號並控制下游基因表達的分子機制。由於此系統與化膿性鏈球菌引發侵襲性感染的能力密切相關，釐清其運作方式將有助於我們更深入理解該菌的致病機制。

無害梭狀桿菌與細菌抗藥性研究

實驗室亦參與腸道菌群相關研究計畫。其中一個重要方向是針對無害梭狀芽孢桿菌 (Clostridium innocuum) 進行分子分型，並深入探討其萬古黴素抗藥性的相關分子機制。這類研究對於理解抗生素抗藥性如何在複雜的微生物群落中傳播具有重要意義。

近年研究計畫

團隊成員

畢業成員 | Alumni

碩、博士班生及其研究主題

大學部專題研究生 (查看更多)

研究成果

近三年期刊論文 | Journal articles

2025

• Chiang-Ni C*, Lee CC, Chi CY, Lin MC, Hsu YC, Pan MH, Hsu CY, Chiu CH. 2025. Horizontal transfer of ΦHKU.vir and its role in the evolution of acapsular emm89 group A Streptococcus in Taiwan. Infection. https://doi.org/10.1007/s15010-025-02646-1

• Lu CH, Ma J, Lin MC, Wu CJ, Kuo CY, Chiang-Ni C, Kuo ML*. 2025. Streptococcal pyrogenic exotoxin A induces regulatory T cells via TNF-α-TNFR2 signaling. Med Microbiol Immunol. 214:25. https://doi.org/10.1007/s00430-025-00835-1

• Chen YM*, Chien KY, Shieh HR, Luo CJ, Chang YX, Chiang-Ni C, Lai CH, Chiu CH. 2025. Impact of vancomycin and Clostridioides difficile on the secretome and pathogenicity of Clostridium innocuum. Med Microbiol Immunol. 214:21. https://doi.org/10.1007/s00430-025-00831-5

2024

• Chiang-Ni C*, Huang JY, Hsu CH, Lo YC, Chen YYM, Lai CH, Chiu CH. 2024. Genetic diversity, biofilm formation, and vancomycin resistance of clinical Clostridium innocuum isolates. BMC Microbiol. 24:353. https://doi.org/10.1186/s12866-024-03503-1

• Shi YA, Lu SL, Noda T, Chiu CH, Chiang-Ni C*. 2024. Capsule-deficient group A Streptococcus evades autophagy-mediated killing in macrophages. mBio. 15:e0077124. https://doi.org/10.1128/mbio.00771-24

• Lai CY, Xie JX, Lai MC, Wu ZY, Lin JS, Huang YT, Chi CY, Chiang-Ni C, Walker MJ, Chang YC*. 2024. Conserved molecular chaperone PrsA stimulates protective immunity against group A Streptococcus. NPJ Vaccines. 9:46. https://doi.org/10.1038/s41541-024-00839-7

• Chiang-Ni C*, Hsu CY, Yeh YH, Chi CY, Wang S, Tsai PJ, Chiu CH. 2024. Detection of toxigenic M1UK lineage group A Streptococcus clones in Taiwan. J Microbial Immun Infect. 57:269-277. https://doi.org/10.1016/j.jmii.2024.01.004

2023

• Wu HY, Kuo CJ, Chou CH, Ho MW, Chen CL, Hsu TS, Chen YC, Chiang-Ni C, Chen YM, Chiu CH, Lai CH*. 2023. Clostridium innocuum, an emerging pathogen that induces lipid raft-mediated cytotoxicity. Virulence. 14:2265048. https://doi.org/10.1080/21505594.2023.2265048

• Chiang-Ni C*, Chiang CY, Chen YW, Shi YA, Chao YT, Wang S, Tsai PJ, Chiu CH. 2023. RopB-regulated SpeB cysteine protease degrades extracellular vesicles-associated streptolysin O and bacterial proteins from group A Streptococcus. Virulence. 14:2249784. https://doi.org/10.1080/21505594.2023.2249784

• Chiang-Ni C*, Chen YW, Chen KL, Jiang JX, Shi YA, Hsu CY, Chen YYM, Lai CH, Chiu CH. 2023. RopB represses the transcription of speB in the absence of SIP in group A Streptococcus. Life Sci Alliance. 6:e202201809. https://doi.org/10.26508/lsa.202201809

書籍章節 | Book chapters

江倪全 (2020). 不只是壞人 隱藏在生活中的細菌好朋友. 科學月刊. 51(4):75-77.

江倪全 (2019). 生生不息：細菌，是敵人還是朋友？ 科學月刊. 50(3):24-27.

江倪全、吳俊忠 (2009). 醫學分子檢驗: 細菌分子檢驗分型法. 五南出版社. 18:381-406.

研究室動態

研究合作

加入我們