Publications


2018

Flores VL, Parmet T, Mukherjee N, Nelson SB, Katz DB, and Levitan, D (2018) The role of the gustatory cortex in experience-evoked enhancement of learning. bioRxiv 369520 [Preprint]. doi: https://doi.org/10.1101/369520. Now published. Learning and Memory. 25(11):587-600. doi: 10.1101/lm.048181.118.

Phillips JW, Schulmann A, Hara E, Liu C, Shields B, Korff W, Lemire A, Dudman J, Nelson SB, and Hantman A. A topographic axis of transcriptional identity in thalamus. bioRxiv 241315 [Preprint]. doi: https://doi.org/10.1101/241315.

Sugino K, Clark E, Schulmann A, Shima Y, Wang L, Hunt DL, Hooks BM, Trankner D, Chandrashekar, J, Picard S, Lemire A, Spruston N, Hantman A, and Nelson SB. The transcriptional logic of mammalian neuronal diversity. bioRxiv 208355 [Preprint]. doi: https://doi.org/10.1101/208355. In Revision. ELife.

2016

Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, and Ginty DD (2016) The Cellular and synaptic architecture of the mechanosensory dorsal horn. Cell. pii: S0092-8674(16)31684-1. doi: 10.1016/j.cell.2016.12.010

Crittenden JR, Tillberg PW, Riad MH, Shima Y, Gerfen CR, Curry J, Housman DE, Nelson SB, Boyden ES, and Graybiel AM (2016) Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons. Proc. Natl. Acad. Sci. USA 113(40):11318-11323.

O'Toole SM, Ferrer MM, Mekonnen J, Zhang H, Shima Y, Ladle DR, and Nelson SB (2016) Dicer maintains the identity and function of proprioceptive sensory neurons. J Neurophysiol. jn.00763.2016. doi: 10.1152/jn.00763.2016

Shima Y, Hempel CM. Bullis J, Taneja P, Mehta S, Sugino K, Lois C, and Nelson SB (2016) A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types. Elife 5. pii: e13503. doi: 10.7554/eLife.13503.

Steinmetz CC, Tatavarty V, Sugino K, Shima Y, Joseph A, Line H, Rutlin M, Lambo M, Hempel CM, Okaty BW, Paradis S, *Nelson SB, and *Turrigiano GG (2016) Upregulation of µ3A drives homeostatic plasticity by rerouting AMPAR into the recycling endosomal pathway. Cell Reports. 16(10):2711-22. *co-corresponding authors

2015

Nelson SB and Valakh V (2015) Excitatory/Inhibitory balance and circuit homeostasis in Autism Spectrum Disorders. Neuron. 87:684-98.

Choy JM, Suzuki N, Shima Y, Budisantoso T, Nelson SB, and Bekkers JM (2015) Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex. Cereb Cortex. pii: bhv258.

Clark EA, Nelson SB (2015) Synapse and genome: An elusive tête-à-tête. Sci Signal. 2015 Sep 29;8(396):pe2

Guo Z, Tzvetkova B, Bassik JM, Bodziak T, Wojnar BM, Qiao W, Obaida MA, Nelson SB, Hu BH, and Yu P (2015) RNASeqMetaDB: a database and web server for navigating metadata of publicly available mouse RNA-Seq datasets. Bioinformatics. 31(24):4038-40. doi: 10.1093/bioinformatics/btv503. Epub Aug 30.

2014

Grange P, Bohland JW, Okaty BW, Sugino K, Bokil H, Nelson SB, Ng L, Hawrylycz M, and Mitra PP (2014) Cell-type based model explaining co-expression patterns of genes in the brain. Proc Natl Acad Sci U S A. 111(14):5397-402.

Sugino K, Hempel CM, Okaty BW, Arnson HA, Kato S, Dani VS and Nelson SB (2014) Cell-type-specific repression by Mecp2 is biased toward long genes. J. Neurosci. 34:12877-83.

2012

Blackman M.P., Djukic B., Nelson S.B., and Turrigiano G.G. (2012) A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up. J. Neurosci. 32:13529-13536.

Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA (2012) Preclinical research in Rett syndrome: Setting the foundation for translational success. Dis. Mod. & Mech. 5: 733-745.

Nelson S and Ashe KH (2012) Neurobiology of Disease. Curr. Op. Neurobiol. 21:823-6.

2011

Boggio KJ, Obasuyi E, Sugino K, Nelson SB, Agar NY and Agar JN (2011) Recent Advances in Single-Cell MALDI Mass Spectrometry Imaging and Potential Clinical Impact. Expert Rev. Proteomics 8:591-604.

Okaty BW, Sugino K, Hempel CM, and Nelson SB (2011) A quantitative comparison of cell-type-specific microarray gene expression profiling methods in the mouse brain. PLOS One. 6:e16493.

Okaty BW, Sugino K, and Nelson SB (2011) Transcriptomics in the brain. J. Neurosci. 31:6939-43.

Okaty BW and Nelson SB (2011) The maturation of firing properties of forebrain GABAergic interneurons. In Comprehensive Encyclopedia of Developmental Neuroscience, J Rubenstein and P Rakic (eds), Elsevier.

Rutlin M and Nelson SB (2011) MeCP2: phosphorylated locally, acting globally. Neuron. 72(1):3-5.

Taniguchi H, He M, Wu P, Kim S, Paik R, Sugino K, Kvitsani D, Fu Y, Lin Y, Lu J, Nelson SB, and Huang ZJ (2011) A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 71(6):995-1013

2010

Miller MN, Okaty BW, Kato S, and Nelson SB (2010) Activity dependent-changes in the firing properties of neocortical fast-spiking interneurons in the absence of large changes in gene expression. Dev. Neurobiol. 71: 62–70.

Turrigiano GG and Nelson SB (2010) Homeostatic plasticity develops! In Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nature Rev. Neurosci. 11: 718-726.

2009

Dani VS and Nelson SB (2009) Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett Syndrome. J. Neurosci. 29:11263-70.

Kadener S, Menet J, Sugino K, Horwich MD, Nawathean P, Vagin VV, Zamore PD, Nelson SB and Rosbash M (2009) A role for microRNAs in the Drosophila circadian clocK Genes Dev. 23:2179-91.

Kadener S, Rodriguez J, Abruzzi KC, Khodor YL, Sugino K, Marr MT 2nd, Nelson S, and Rosbash M (2009) Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. RNA. 15:537-45.

Okaty BW , Miller MN, Sugino K, Hempel CM and Nelson SB (2009). Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons. J. Neurosci. 29:7040-52.

Nagoshi E, Sugino K, Kula E, Okazaki E, Tachibana T, Nelson S, and Rosbash M (2009) Gene expression dissection of the circadian neuronal circuit of drosophila. Nature Neurosci. 13:60-8.

Taneja, P, Ojier, M, Brooks-Harris G, Katz, DM, and Nelson SB (2009) Pathophysiology of locus coeruleus neurons in a mouse model of Rett Syndrome. J. Neurosci. 29:12187-95.

2008

Chen B, Wang S, Hattox AM, Rayburn H, Nelson SB, and McConnell SK (2008) The Fezf2-Ctip2 genetic pathway regulates the fate choice of layer 5 subcortical projection neurons. Proc. Natl. Acad. Sci. USA 105:11382-7.

Miller MN, Okaty BW and Nelson SB (2008) Region-specific spike-frequency acceleration in Layer 5 pyramidal neurons mediated by Kv1 subunits. J. Neurosci. 28:13716-26.

Nelson SB and Turrigiano GG (2008) Strength through diversity Neuron 60:477-82.

2007

Hattox AM and Nelson SB (2007) Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties. J. Neurophysiol. 98:3330-40.

Hempel CM, Sugino K and Nelson SB (2007) A manual method for the purification of fluorescently labeled neurons from the mammalian brain. Nature Protocols. 2:2924-9.

Sjöström PJ, Turrigiano GG and Nelson SB (2007) Multiple forms of long-term plasticity at unitary neocortical layer 5 Synapses. Neuropharmacology. 52:176-84.

2006

Chang Q., Khare G, Dani VS, Nelson S and Jaenisch R, (2006) The Disease Progression of Mecp2 Mutant Mice is Affected by the Level of BDNF Expression. Neuron. 49:341-348 (see preview p. 321-3).

Maffei A, Nataraj K, Nelson SB, and Turrigiano GG (2006) Potentiation of cortical inhibition by visual deprivation. Nature. 443:81-4.

Nelson SB, Hempel CM and Sugino K, (2006) Probing the transcriptome of neuronal cell types. Curr. Op. Neurobiol. 16:571-6.

Nelson SB, Sugino K, and Hempel CM (2006) The problem of cortical cell types: a physiological genomics approach. Trends Neurosci. 29:339-45.

Sugino K, Hempel CM, Miller M, Hattox AM, Shapiro P, Wu C, Huang ZH and Nelson SB (2006) Molecular taxonomy of major neuronal classes in the adult mouse forebrain. Nat. Neurosci. 9:99-107. (see also News&Views p. 10-12 ; see also Genomics Proving a Powerful Tool for Mapping the Landscape of the Brain, Kuehn JAMA.2006; 295: 145-148.)

Van Hooser SD and Nelson SB (2006) The squirrel as a rodent model of the human visual system. Vis. Neurosci. 23(5):765-78.

Van Hooser SD, Heimel JA, Chung S, and Nelson SB (2006) Lack of patchy horizontal connectivity in V1 of a mammal without orientation maps. J. Neurosci. 26:7680-92.

2005

Dani VS, Chang Q., Maffei A, Turrigiano GG, Jaenisch R, and Nelson SB (2005) Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome. Proc. Natl. Acad. Sci. 102:12560-5. PMC1194957

Heimel JA, Van Hooser SD, and Nelson SB (2005) Laminar organization of receptive field properties in primary visual cortex of the gray squirrel (Sciurus carolinensis). J. Neurophysiol. 94(5):3538-54.

Song S, Sjöström, PJ, Reigl M, Nelson SB, and Chklovskii DB (2005) Highly non-random features of synaptic connectivity in local cortical circuits. PLOS Biology. 3:507-519.

Van Hooser SD, Heimel JA, Chung S, Nelson SB, and Toth LJ (2005) Orientation selectivity without orientation maps in visual cortex of a highly visual mammal. J. Neurosci. 25:19-28.

Van Hooser SD and Nelson SB (2005) The Visual System. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester http://wwWels.net/

Van Hooser SD, Heimel JA, and Nelson SB (2005) Functional cell classes and functional architecture in the early visual system of a highly visual rodent. Prog. Brain Res. 149:127-45.

2004

Maffei,A, Nelson SB, and Turrigiano GG (2004) Selective reconfiguration of layer 4 intracortical circuitry by visual deprivation. Nature Neurosci. 7:1353-59.

Nelson SB (2004) Hebb and anti-Hebb meet in the brainstem. Nature Neuroscience 7:687-8.

Sjöström PJ, Turrigiano GG and Nelson SB (2004) Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spikinG J. Neurophysiol. 92:3338-43.

Turrigiano GG and Nelson SB (2004) Homeostatic synaptic plasticity in the developing nervous system. Nature Rev. Neurosci. 5: 97-107.

Watt AJ, Sjöström P.J, Haüsser M, Nelson SB, and Turrigiano GG (2004) A proportional but slower NMDA potentiation follows AMPA potentiation in LTP. Nature NeurosC 7:518-524.

2003

Myme C, Sugino K and Nelson SB (2003) The NMDA to AMPA ratio at synapses onto layer 2/3 pyramidal neurons is conserved across prefrontal and visual cortices. J. Neurophysiol. 90:771-779.

Pratt KG, Watt AJ, Griffith LC, Nelson SB, and Turrigiano GG (2003) Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII. Neuron 39:269-281.

Sjöström PJ, Turrigiano GG and Nelson SB (2003) Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. Neuron 39:641-654 (see also Preview 579-581).

Van Hooser SD, Heimel JA, and Nelson SB (2003) Receptive field properties and laminar organization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis). J. Neurophysiol. 90:3398-418.

2002

Abbott LF and Nelson SB (2002) Temporal dynamics of biological synapses. Arbib, M, ed. The Handbook of Brain Theory and Neural Networks - Second Edition, Bradford MIT Press, Cambridge pp 1156-1158.

Chung S, Li X, and Nelson SB (2002) Short-term Depression at Thalamocortical Synapses Contributes to Rapid Adaptation of Cortical Sensory Responses In Vivo. Neuron 34:437-446 (see also Preview 331-332).

Desai NS, Cudmore RH, Nelson SB, and Turrigiano, GG (2002) Critical periods for experience-dependent synaptic scaling in visual cortex. Nature Neurosci. 5:783-789 (see also News&Views p. 712-714).

Hempel CM, Sugino K and Nelson SB (2002) Multi-unit spike-triggered averaging: a method for probing the physiology of central synapses. J. Neurosci. Meth. 120: 121-129.

Nelson SB (2002) Cortical circuits: diverse or canonical? Neuron 36: 19-27.

Nelson SB and Sjöström PJ (2002) Spike timing, calcium signals and synaptic plasticity. Curr. Op. Neurobiol. 12(3) 305-314.

Nelson SB and Sjöström PJ (2002) Rate and timing in cortical synaptic plasticity. Phil. Trans. R. SoC B. 357:1851-1857.

van Rossum M, Turrigiano GG, and Nelson SB (2002) Fast propagation of firing rates through layered networks of noisy neurons. J. Neurosci. 22: 1956-66.

2001

Leslie KR, Nelson SB, and Turrigiano GG (2001) Postsynaptic depolarization scales quantal amplitude in cortical pyramidal neurons. J. Neurosci. 21: RC170.

Sjöström PJ, Turrigiano GG and Nelson SB (2001) Rate, timing, and cooperativity jointly determine cortical synaptic plasticity. Neuron 32:1149–1164 (see also Preview p. 966-968).

2000

Abbott LF and Nelson SB (2000) Synaptic plasticity: taming the beast. Nature Neuroscience 3:1178-1183.

Hempel CM, Hartman K, Wang XJ, Turrigiano GG, and Nelson SB (2000) Multiple forms of short-term plasticity in rat prefrontal cortex. J. Neurophysiol. 83:3031-41.

Nelson SB (2000) Timing isn’t everythinG Neuron 26: 545–546.

Turrigiano G and Nelson SB (2000) Hebb and homeostasis in neuronal plasticity. Curr. Op. Neurobiol. 10:358

Watt A, van Rossum M, MacLeod K, Nelson SB, and Turrigiano GG (2000) Activity co-regulates the quantal amplitude of AMPA and NMDA-mediated excitatory synaptic transmission. Neuron 26: 659–670.

1999

Chance FS, Nelson SB, and Abbott LF (1999) Complex cells as cortically amplified simple cellS Nature Neurosci. 2:277-282.

Chance F, Nelson SB, and Abbott LF (1999) Recurrent cortical amplification produces complex cell responses. In Kearns, MS, SA Solla, and DA Cohn, Eds. Advances in Neural Information Processing Systems 11 (MIT Press, Cambridge MA).

Desai NS, Nelson SB, and Turrigiano GG (1999) Activity-dependent regulation of excitability in rat visual cortical neurons. Neurocomputing 26-27:101-106.

Goldman MS, Nelson SB, and Abbott LF (1999) Decorrelation of spike trains by synaptic depression. Neurocomputing 26-27:147-153.

Moore CI,. Nelson SB, and Sur M (1999) Dynamics of neuronal integration in rat somatosensory cortex. Trends in Neuroscience 22:513-520.

Varela JA, Song S, Turrigiano GG, and Nelson SB (1999) Differential depression at excitatory and inhibitory synapses in visual cortex. J. Neurosci. 19: 4293-4304.

1998

Chance FS, Nelson SB, and Abbott LF (1998) Synaptic depression and the temporal response characteristics of V1 Cells. J. Neurosci. 18:4785-4799.

Chance F, Nelson SB, and Abbott LF (1998) Modeling cortical direction selectivity using synaptic depression. Computational Neuroscience: Trends in Research 1997. JM Bower (ed) Plenum Press. New YorK

Desai N, Leslie KR, Nelson SB, and Turrigiano GG (1998) A biological mechanism for synaptic stability in developing neocortical circuits. Computational Neuroscience: Trends in Research 1997. JM Bower (ed) Plenum Press. NY.

Moore CI and Nelson SB (1998) Spatio-temporal subthreshold receptive fields in the vibrissa representation of rat primary somatosensory cortex. J. Neurophysiol. 80:2882-2892.

Nelson SB and Turrigiano GG (1998): Synaptic depression: a key role in the cortical balancing act. Nature Neuroscience 1:539-541.

Rutherford LC, Nelson SB, and Turrigiano GG (1998) Opposite effects of BDNF on the quantal amplitude of pyramidal and interneuron excitatory synapses. Neuron 21:521-530.

Turrigiano GG, Leslie KR, Desai NS, Rutherford LC, and Nelson SB (1998) Activity-dependent scaling of quantal amplitude in neocortical pyramidal neurons. Nature 391: 892-895.

Turrigiano GG and Nelson SB (1998) Thinking globally, acting locally: AMPA receptor turnover and synaptic strength. Neuron 21:933-935.

1997

Abbott LF, Sen K, Varela JA, and Nelson SB (1997) Synaptic depression and cortical gain control. Science 275: 220.

Nelson SB, Varela JA, Sen K, and Abbott LF (1997) Functional significance of synaptic depression between cortical neurons. In Computational Neuroscience: Trends in Research 1996. JM Bower (ed) Plenum Press. NY. pp 429-434.

Todorov EV, Siapas A, Somers D, and Nelson SB (1997) Modeling Visual Cortical Contrast Adaptation Effects. In Computational Neuroscience: Trends in Research 1996. JM Bower (ed) Plenum Press. NY.

Varela JA, Sen K, Gibson J, Fost J, Abbott LF, and Nelson SB (1997) A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat visual cortex. J. Neurosci. 17:7926-7940.

Earlier

Somers D, Nelson SB, and Sur M (1995) An emergent model of orientation selectivity in cat visual cortical simple cells. J. Neurosci. (cover) 15:5448-5465.

Nelson SB, Toth LJ, Sheth B and Sur M (1994) Orientation selectivity of cortical neurons during intracellular blockade of inhibition. Science 265:774-777.

Kwon YH, Nelson SB, Toth LJ, and Sur M (1992) Effect of stimulus contrast and size on NMDA receptor activity in cat lateral geniculate nucleus. J. Neurophysiol. 68:182-196.

Nelson SB and Sur M (1992) NMDA receptors in sensory information processing. Curr. Op. Neurobiol. 2:484-488.

Nelson SB (1991a) Temporal interactions in the cat visual system. I. Orientation-selective suppression in the visual cortex. J. Neurosci. 11:344-356.

Nelson SB (1991b) Temporal interactions in the cat visual system. II. Suppressive and facilitatory effects in the lateral geniculate nucleus. J. Neurosci. 11:357-368.

Nelson SB (1991c) Temporal interactions in the cat visual system. III. Pharmacological studies of cortical suppression suGGest a presynaptic mechanism. J. Neurosci. 11:369-380.

LeVay S and Nelson SB (1991) The columnar organization of visual cortex. In: Vision and Visual Dysfunction Vol. 4: The Neural Basis of Visual Function, A Leventhal, (Ed.), Macmillan Press, Boca Raton, Fla pp. 266-316.

Nelson SB, Schwartz MA, and Daniels JD (1985) Clonidine and cortical plasticity: possible evidence for noradrenergic involvement. Dev. Brain Res. 23:39-50.

Nelson SB and LeVay S (1985) Topographic organization of the optic radiation of the cat. J. Comp. Neurol. 240:322-330.

Daniels JD, Pressman E, Schwartz M, Nelson SB, and Kraus DJ (1984) Effects of luminance and flicker on ocular dominance shift in kitten visual cortex. Exp. Brain Res. 54:186-190.

Bear MF, Paradiso MA, Schwartz M, Nelson SB, Carnes KM, and Daniels JD (1983) Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity. Nature 302:245-47.