77. Lingchao Kong, Rahi M. Reja, Yuhan Lyu, and Jianmin Gao*, “Tuning the Residence Time of Lysine-Targeting Reversible Covalent Warheads,” in preparation for submission in July 2023. 

76. Yuhan Lyu, Fan Yang, Bharathi Sundaresh, Federico Rosconi, Tim van Opijnen, and Jianmin Gao*, “Covalent Inhibition of a Host-Pathogen Protein-Protein Interaction Curbs the Virulence of Streptococcus pneumoniae,” in preparation for submission in June 2023. 

75. Mengmeng Zheng and Jianmin Gao*, “Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins,” under review. 

74. Rahi M. Reja, Brittney Chau and Jianmin Gao*, “Diazaborine Mediated Bicyclization of Native Peptides with Inducible Reversibility,” Org. Lett., 2023, https://pubs.acs.org/doi/full/10.1021/acs.orglett.3c01496.

73. Brittney Chau, Kristi Liivak, and Jianmin Gao*, “Construction of Nonnatural Cysteine-Crosslinked Phage Libraries,” Methods in Molecular Biology – Bacteriophages, 2023, edited by Professor Ebenzer Tumban, in press. 

72. Fa-Jie Chen,# Nicole Pinnette,# Fan Yang, and Jianmin Gao*, “A Cysteine-Directed Proximity-Driven Crosslinking Method for Native Peptide Bicyclization,” Angew. Chem. Int. Ed., 2023, 10.1002/anie.202306813. #co-first authors


68. Dmitry Leshchiner, Emily Rudmann, Bharathi Sundaresh, Luisa Nieto, Andy Nishimoto, Federico Rosconi, Bimal Jana, Noemi Garcia, Kaiching Li, Jianmin Gao, Jason Rosch and Tim van Opijnen, “A Genome-Wide Atlas of Antibiotic Susceptibility: Targets and Pathways to Tolerance,” Nat Commun, 2022 doi/10.1038/s41467-022-30967-4

67. Fa-Jie Chen#, Mengmeng Zheng#, Vincent Nobile, Jianmin Gao*, “Fast and Cysteine-Specific Modification of Peptides, Proteins and Bacteriophage Using Chlorooximes,” Chem. Eur. J., 2022, 28, e202200058

66. Rahi M. Reja, Wenjian Wang, Yuhan Lyu, Fredrik Haeffner, and Jianmin Gao*, “Lysine-Targeting Reversible Covalent Inhibitors with Long Residence Time,” J. Am. Chem. Soc., 2022, 144, 1152-7. https://doi.org/10.1021/jacs.1c12702.

65.  Jianmin Gao* and Vincent Nobile, “Chemistry Perspectives of Reversible Covalent Drugs,” Ann. Rep. Med. Chem., 2021, 56, 75-94. https://doi.org/10.1016/bs.armc.2020.10.004

64. Michael Kelly,ǂ Samantha Cambray,ǂ Kelly A. McCarthy, Wenjian Wang, Juan Ortiz-Marquez, Tim van Opijnen, and Jianmin Gao*, “Peptide Probes of Colistin Resistance Discovered via Chemically Enhanced Phage Display,” ACS Infect. Dis., 2020, 6, 2410-18 ǂdenotes equal contribution authors.

63. Kaicheng Li,ǂ  Wenjian Wang,ǂ  and Jianmin Gao*, “Fast and Stable N-Terminal Cysteine Modification via Thiazolidino Boronate Mediated Acyl Transfer,” Angew. Chem. Int. Ed. 2020, 59, 14246-50. doi.org/10.1002/anie.202000837.  ǂdenotes equal contribution authors.

62. Narendra Kumar†, Wenjian Wang†, Juan C. Ortiz-Marquez †, Matthew Catalano, Mason Gray, Nadia Biglari, Kitadai Hikari, Xi Ling, Jianmin Gao*, Tim van Opijnen*, Kenneth S Burch*, “Dielectrophoresis assisted rapid, selective and single cell detection of antibiotic resistant bacteria with G-FETs,” Biosens. Bioelecton. 2020, 156:112123. doi:10.1016/j.bios.2020.112123. A preprint of this paper can be found in bioRxiv, https://www.biorxiv.org/content/10.1101/842187v1.

61. Wenjian Wang and Jianmin Gao*, “N, S-Double Labeling of N-Terminal Cysteines via an Alternative Conjugation Pathway with 2-Cyanobenzothiazole,” J. Org. Chem., 2020, 85, 1756-63.

60. Tolulope A. Aweda, F. Zumrut B. Muftuler, Adriana V. F. Massicano,  Dhruval Gadhia,  Stacy Queern,  Kelly A. McCarthy,  Anupam Bandyopadhyay,  Jianmin Gao, and Suzanne E. Lapi*, “Radiolabeled Cationic Peptides for Targeted Imaging of Infection,” Contrast Media & Molecular Imaging, 2019, in press. 

59. Kaicheng Li,ǂ  Michael A. Kelly,ǂ  and Jianmin Gao*, “Biocompatible conjugation of Tris base to 2-acetyl and 2-formyl phenylboronic acid,” Org. Biomol. Chem., 2019, 17, 5908-12. ǂdenotes equal contribution authors.

58. Sam Cambray and Jianmin Gao*, “Versatile Conjugation Chemistries of ortho-Boronyl Aryl Ketones and Aldehydes,” Acc. Chem. Res., 2018, 51, 2198-206.

57. Kelly A. McCarthy, Michael A. Kelly, Kaicheng Li, Samantha Cambray, Azade Hosseini,  Tim van Opijnen, and Jianmin Gao*, “Phage display of dynamic covalent binding motifs enables facile development of targeted antibiotics,” J. Am. Chem. Soc., 2018, 140, 6137-45.

56. Yang Liu, Ling Yuan, Changwei Pan, Jianmin Gao, Wenxiu Zhou, Qingyu Gao*, “Photo-Induced Oscillations and Pulse Waves in the Hydrogen Peroxide-Sulfite-Ferrocyanide Reaction," J. Phys. Chem. Part A, 2018, 122, 1175-84.

55. Kaicheng Li,ǂ Chelsea Weidman,ǂ and Jianmin Gao*, “Dynamic formation of imidazolidino boronate enables design of cysteine-responsive peptides,” Org. Lett., 2018, 20, 20-3. ǂdenotes equal contribution authors. 

54. Samantha Cambray, Anupam Bandyopadhyay, and Jianmin Gao*, “Fluorogenic Diazaborine Formation of Semicarbazide with Designed Coumarin Derivatives,” Chem. Comm., 2017, 53, 12532-5. 

53. Jianmin Gao*, “Cation-pi lights up 'Halo',” Biochemistry, 2017, 56, 5221-2. 

52. Azade S. Hosseini*, Christopher J. Pace, Adam A. Esposito and Jianmin Gao*, “Non-additive stabilization by halogenated amino acids reveals protein plasticity on a sub-angstrom scale,” Protein Science, 2017, 26, 2051-8.

51. Kaicheng Li and Jianmin Gao*, “Iminoboronate-mediated peptide cyclization with lysine homologues,” SynLett, 2017, 28, 1913-6. 

50. Azade Hosseini, Wenjian Wang, Fredrik Haeffner,* and Jianmin Gao*, “Metal-assisted Folding of Prolinomycin Allows Facile Design of Functional Peptides,” ChemBioChem, 2017, DOI: 10.1002/cbic.201600667.

49. Anupam Bandyopadhyay,# Samantha Cambray,# and Jianmin Gao*, “Fast diazaborine formation of semicarbazide enables facile labeling of bacterial pathogens,” J. Am. Chem. Soc., 2017, DOI: 10.1021/jacs.6b11115. (# denotes co-first authors.)

48. John W. Patrick, Breanna Zerfas, Jianmin Gao and David H. Russell*, “Rapid capillary mixing experiments for the analysis of hydrophobic membrane complexes directly from aqueous lipid bilayer solutions,” Analyst, 2017, DOI: 10.1039/C6AN02290A.

47. Yan-Jiun Lee, M. J. Schmidt, Jeffery M. Tharp, Annemarie Weber, Amber L. Koenig, Hong Zheng, Jianmin Gao, Marcey L. Waters, Daniel Summerer* and Wenshe R. Liu*, “Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader,” Chem Commun., 2016, 52, 12606-9.

46. Jianmin Gao* and Azade S. Hosseini, “Current understanding of π–π interactions and the applications in protein design,” Chapter 21 – “Non-covalent Interactions in the Synthesis and Design of New Compounds” by the Wiley Publishing Group, 2016, ISBN: 978-1-119-10989-1.

45. Anupam Bandyopadhyay and Jianmin Gao*, “Targeting Biomolecules with Reversible Covalent Chemistry,” Curr. Opion. Chem. Biol., 2016, 34, 110-6.

44. Anupam Bandyopadhyay, Samantha Cambray, and Jianmin Gao*, “Fast and Selective Labeling of N-terminal Cysteines via Boronic Aid-Accelerated Conjugation,” Chem. Sci., 2016, 7, 4589-93. 

43. Breanna Zerfas, Yechaan Joo, and Jianmin Gao*, “Gramicidin A mutants with antibiotic activity against both gram-positive and gram-negative bacteria,” ChemMedChem, 2016, 11, 629-36.

42. Anupam Bandyopadhyay and Jianmin Gao*, “Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators,” J. Am. Chem. Soc. 2016, 138, 2098-101.

41. Anupam Bandyopadhyay and Jianmin Gao*, “Iminoboronate Formation Leads to Fast and Reversible Conjugation Chemistry of a-Nucleophiles at Neutral pH,” Chem. Eur. J., 2015, 21, 14748-52.

40. Breanna Zerfas and Jianmin Gao*, “Recent Advances in Peptide Immunomodulators,” Curr. Top. Med. Chem., 2015, 16, 187-205.

39. Tao He, Anne Gershenson, Stephen J. Eyles, Yan-Jiun Lee, Wenshe R. Liu, Jiangyun Wang, Jianmin Gao, and Mary F. Roberts*, “Fluorinated aromatic amino acids distinguish cation-π interactions from membrane insertion,”  J. Biol. Chem., 2015, 290, 19334-42.

38. Anupam Bandyopadhyay, Kelly A. McCarthy, Michael A. Kelly and Jianmin Gao*, “Targeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids,” Nat. Commun., 2015, DOI: 10.1038/ncomms7561.

37. Anupam Bandyopadhyay and Jianmin Gao*, “Cancer-Targeting Peptides,” eBook Chapter (Page 71-84) – “Advances in the discovery and development of peptide therapeutics” by the Future Science Group, 2015, ISBN: 978-1-910419-01-4.

36. Ya-Juan Wang*, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting-Wei Mu, Xiaofeng Zhu* "The Association of the Vanin-1 N131S Variant with Blood Pressure is Mediated by Endoplasmic-Reticulum-Associated Degradation and Loss of Function, " PLOS Genetics 2014, doi:10.1371/journal.pgen.1004641.

35. Azade Hosseini, Hong Zheng and Jianmin Gao*, "Understanding Lipid Recognition by Protein-Mimicking Cyclic Peptides, " Tetrahedron 2014, 70, 7632-8.

34. Fang Wang, Luoheng Qin, Patrick Wong and Jianmin Gao*, “Effects of Lysine Methylation on Gramicidin A Folding in Lipid Membranes,” Biopolymers: Peptide Science 2013, 100, 656-61.

33. Lauren K. Regula, Richard Harris, Fang Wang, Jayne F. Koellhoffer, Chelsea D. Higgins, Kartik Chandran, Jianmin Gao, Mark E. Girvin, and Jonathan R. Lai*, “Conformation and Lipid-Binding Properties of Peptides Corresponding to the Ebolavirus GP2 Membrane-Proximal External Region,” Biochemistry, 2013, 52, 3393-404.

32. Jianmin Gao* and Hong Zheng , “Illuminating the lipidome to advance biomedical research: peptide-based probes of membrane lipids,”  Future Med. Chem. 2013, 5, 947-59.

31. Christopher Pace and Jianmin Gao*, “Exploring and Exploiting Polar-p Interactions with Fluorinated Aromatic Amino Acids,” Acc. Chem. Res. 2013, 46, 907-15.  

30. Christopher Pace, Diane Kim and Jianmin Gao*, “Experimental Evaluation of CH—π Interactions in a Protein Core,” Chem. Euro. J. 2012, 18, 5832-6.

29. Yue Zhao and Jianmin Gao*, “Split Ligand for Lanthanide Binding: Facile Evaluation of Dimerizing Proteins,” Chem. Comm. 2012, 48, 2997-9.

28. Luoheng Qin, Christopher Sheridan and Jianmin Gao*, “Synthesis of Tetrafluorinated Aromatic Amino Acids with Distinct Signatures in 19F-NMR,” Org. Lett. 2012, 14, 528-31. 

27. Fang Wang, Luoheng Qin, Christopher J. Pace, Patrick Wong, Ryan Malonis and Jianmin Gao*, “Solubilized Gramicidin A as Potential Systemic Antibiotics,” ChemBioChem 2012, 13, 51-5.

26. Christopher Pace, Hong Zheng, Ruben Mylvaganam, Diane Kim and Jianmin Gao*, “Stacked Fluoroaromatics as Supramolecular Synthons for Programming Protein Dimerization Specificity,” Angew. Chem., Int. Ed. 2012, 51, 103-7.

25. Hong Zheng, Fang Wang, Qin Wang and Jianmin Gao*, “Cofactor-Free Detection of Phosphatidylserine with Cyclic Peptides Mimicking Lactadherin,” J. Am. Chem. Soc. 2011, 133, 15280-3.

24. Christopher Pace, Qiongying Huang, Fang Wang, Kanwal S. Palla, Amelia A. Fuller and Jianmin Gao*, “A FlAsH-tetracysteine Assay for Quantifying the Association and Orientation of Transmembrane a-Helices,” ChemBioChem 2011, 12, 1018-22.

23. Fang Wang, Luoheng Qin, Patrick Wong and Jianmin Gao*, “Facile Synthesis of Tetrafluorotyrosine and Its Application in pH Triggered Membrane Lysis,” Org. Lett. 2011, 13, 236-9. This paper is highlighted in the recent ACS virtual issue on Peptide Chemistry.

22. Hong Zheng and Jianmin Gao*, “Highly Specific Heterodimerization Mediated by Quadrupole Interactions,” Angew. Chem., Int. Ed. 2010, 49, 8635-9. This article was rated as a Very Important Paper. See highlight by Kros et al. “Introducing Quadrupole Interactions into the Peptide Design Toolkit,” Angew. Chem., Int. Ed. 2010, 49, 8570-2.

21. Luoheng Qin, Julian Vastl and Jianmin Gao*, “Highly Sensitive Amyloid Detection Enabled by Thioflavin T Dimers,” Mol. Biosyst. 2010, 6, 1791-5. 

20. Hong Zheng, Kristofer Comeforo and Jianmin Gao*, “Expanding the Fluorous Arsenal: Tetrafluorinated Phenylalanines for Protein Design,” J. Am. Chem. Soc. 2009, 131, 18-9.

Publications from Scripps

19. Jianmin Gao, Daryl A. Bosco, Evan T. Powers, and Jeffery W. Kelly*, “Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Significantly Stabilizes Proteins,” Nat. Struct. Mol. Biol. 2009, 16, 684-90.

18. Michelle R. Bunagan, Jianmin Gao, Jeffery W. Kelly*, and Feng Gai* “Probing the Folding Transition State Structure of the Villin Headpiece Subdomain via Sidechain and Backbone Mutagenesis,” J. Am. Chem. Soc.   2009, 131, 7470-6.

17. Marcus Jager, Songpon Deechongkit, Edward K. Koepf, Houbi Nguyen, Jianmin Gao, Evan T. Powers, Martin Gruebele, and Jeffery W. Kelly*, “Understanding the Mechanism of b-sheet Folding from a Chemical and Biological Perspective,” Biopolymers 2008, 90, 751-8.

16. Jianmin Gao and Jeffery W. Kelly*, “Towards Quantification of Protein Backbone-Backbone Hydrogen Bonding Energies: An Energetic Analysis of an Amide-to-Ester Mutation in an a-Helix within a Protein,” Protein Sci. 2008, 1096-101.

15. Yanwen Fu, Jianmin Gao, Jan Bieschke, Maria, A. Dendle, and Jeffery W. Kelly*, “Amide-to-E-Olefin versus Amide-to-Ester Backbone H-Bond Perturbations: Evaluating the Repulsive Lone Pair-Lone Pair interaction for Extracting H-Bond Energies,” J. Am. Chem. Soc.   2006, 128, 15948-9.

14. Yan Zhang, Youngjun Kim, Nicolas Genoud, Jianmin Gao, Jeffery W. Kelly, Samuel L. Pfaff, Gordon N. Gill, Jack E. Dixon, and Joseph P. Noel* “Determinants for Dephosphorylation of the RNA Polymerase II C-terminal Domain by Scp1,” Mol. Cell. 2006, 24, 759-70.  

Publications from Stanford

13. Sarah K. Jarchow-Choy, Andrew T. Krueger, Haibo Liu, Jianmin Gao and Eric T. Kool*, “Fluorescent xDNA Nucleotides as Efficient Substrates for a Template-independent Polymerase,” Nucleic Acids Res.2011, 39, 1586-94.

12. Haige Lu, Andrew T. Kruger, Jianmin Gao, Haibo Liu and Eric T. Kool*, “Toward a Designed Genetic System with Biochemical Function: Polymerase Synthesis of Single and Multiple Size-Expanded DNA Base Pairs,” Org. Biomol. Chem. 2010, 8, 2704-10.

11. James C. Delaney, Jianmin Gao, Haibo Liu, Nidhi Shrivastav, John M. Essigmann* and Eric T. Kool*, “Efficient Replication Bypass of Size-expanded DNA Base Pairs in Bacterial Cells,” Angew. Chem., Int. Ed. 2009, 48, 4254-7.

10. James N. Wilson, Jianmin Gao, and Eric T. Kool*, “Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission,” Tetrahedron 2007, 63, 3427-33.

9. Stephen R. Lynch, Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Toward a Designed, Functioning Genetic System With Expanded-size Base Pairs: Solution Structure of the 8-Base xDNA Double Helix,” J. Am. Chem. Soc. 2006, 128, 14704-11 (This work is featured in a Research Highlight in Nature, 2006, 444, 5 and highlighted in the News and Views  in Nature, 2006, 444, 554-5) .

8. Jianmin Gao†, Haibo Liu†, and Eric T. Kool*, “Assembly of the Complete Eight-Base Artificial Genetic Helix, xDNA, and Its Interaction with the Natural Genetic System,”Angew. Chem., Int. Ed. 2005, 44, 3118-22. (†co first author. This paper is featured in Chemical and Engineering News, 2005, 83, 23.)

7. Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Helix-forming Properties of Size-expanded DNA (xDNA), an Alternative Four-base Genetic Form,” J. Am. Chem. Soc. 2005, 127, 1396-402.

6. Haibo Liu, Jianmin Gao, and Eric T. Kool*, “Size-expanded Analogues of dG and dC.  Synthesis and Pairing Properties in DNA,” J. Org. Chem. 2005, 70, 639-47.

5. Jianmin Gao, Soichiro Watanabe, and Eric T. Kool*, “Modified DNA Analogues That Sense Light Exposure with Color Changes,” J. Am. Chem. Soc. 2004, 126, 12748-9. (This work is featured in a Research Highlight in Nature Methods 2004, 1, 100-1.)

4. Jianmin Gao, Haibo Liu, and Eric T. Kool*, “Expanded-Size Bases in Naturally Sized DNA: Evaluation of Steric Effects in Watson-Crick Pairing,” J. Am. Chem. Soc. 2004, 126, 12748-9.

3. Haibo Liu, Jianmin Gao, Y.David Saito, Lystranne Maynard, Eric T. Kool*, “Toward a New Genetic System with Expanded Dimensions: Size-expanded Analogues of Deoxyadenosine and Thymidine,” J. Am. Chem. Soc. 2004, 126, 1102-9.

2. Haibo Liu, Jianmin Gao, Stephen Lynch, Y.David Saito, Lystranne Maynard, Eric T. Kool*, “A Four-base-pair Genetic Helix with Expanded Size,” Science 2003, 302, 868-71. (This paper is reported in Chemical and Engineering News 2003, 81, 3, highlighted in Angew. Chem., Int. Ed. 2004, 43, 1625-6, and featured in ChemBioChem 2004, 5, 765-7.)

1. Jianmin Gao, Christoph Strassler, Deborah Tahmassebi, and Eric T. Kool*, “Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides,” J. Am. Chem. Soc., 2002, 124, 11590-1.