PUBLICATION

Yong Cheol Shin*, Nam Than*, Soyoun Min, Woojung Shin+, and Hyun Jung Kim+. Modelling host-microbiome interactions in organ-on-a-chip platforms. Nat. Rev. Bioeng., 2023. (*Equally contributed, +Co-correspondence)

Soyoun Min*, Nam Than*, Yong Cheol Shin, Grace Hu, Woojung Shin, Yoko M. Ambrosini, and Hyun Jung Kim. Live probiotic bacteria administered in a pathomimetic Leaky Gut Chip ameliorate impaired epithelial barrier and mucosal inflammation. Sci. Rep., 2022, 12, 22641. 

Woojung Shin*, Zhe Su*, S. Stephen Yi+, and Hyun Jung Kim+. Single-cell transcriptomic mapping of intestinal epithelium that undergoes mechanodynamic stimulation and 3D morphogenesis in a gut-on-a-chip. iScience, 2022, 25 (12), 105521. (*Equally contributed, +Co-correspondence)

Woojung Shin* and Hyun Jung Kim. Editorial: Advances in tissue repair and regeneration. Front. Med. Technol., 2022. (*Correspondence) 

Woojung Shin+ and Hyun Jung Kim+. Draft Genome Sequences of a Bifidobacterium strain and a Bacteroides strain isolated from a human stool sample. Microbiol. Resour. Announc., 2022, 11 (4), e00011-22. (+Co-correspondence)

Woojung Shin and Hyun Jung Kim. 3D In Vitro Morphogenesis of Human Intestinal Epithelium in a Gut-on-a-chip or a Hybrid Chip with a Cell Culture Insert. Nat. Protoc., 2022, 17 (3), 910-939.

• • Featured in Cockrell School of Engineering News.

Jaeseung Youn*, Hyeonjun Hong*, Woojung Shin, Dohui Kim, Hyun Jung Kim+, and Dong Sung Kim+. An Ultra-thin, Mechanically Robust, and Transparent Extracellular Matrix Hydrogel Membrane Reinforced by Electrospun Nanofibers for Developing In Vitro Tissue Barrier Models. Biofabrication, 2022, 14 (2), 025010. (*Equally contributed, +Co-correspondence) 

Hyein Lee, Woojung Shin, Hyun Jung Kim+, and Joohoon Kim+. Turn-on Fluorescent Sensing of Oxygen with Dendrimer-Encapsulated Platinum Nanoparticles as a Tunable Oxidase Mimicry for Spatially Resolved Measurement of Oxygen Gradient in a Human Gut-on-a-Chip. Anal. Chem., 2021, 93 (48), 16123-16132. (+Co-correspondence) 

Hohyeon Han, Yejin Park, Yoo-mi Choi, Uijung Yong, Byeongmin Kang, Woojung Shin, Soyoun Min, Hyun Jung Kim, and Jinah Jang. A Bioprinted Tubular Intestine Model using a Colon-Specific Extracellular Matrix Bioink. Adv. Healthc. Mater., 2021, 11 (2), 2101768. 

Hyeon Beom Chong, Jaeseung Youn, Woojung Shin, Hyun Jung Kim, and Dong Sung Kim. Multiplex Recreation of Human Intestinal Morphogenesis on a Multi-well Insert Platform by Basolateral Convective Flow. Lab Chip 2021, 21 (17), 3316-3327.

Woojung Shin, Alexander Wu, Soyoun Min, Yong Cheol Shin, R.Y. Declan Fleming, S. Gail Eckhardt, and Hyun Jung Kim. Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids. iScience, 2020, 21, 101372.

 Woojung Shin*, Yoko M. Ambrosini*, Yong Cheol Shin*, Alexander Wu, Soyoun Min, Domin Koh, Sowon Park, Seung Kim, Hong Koh, and Hyun Jung Kim. Robust Formation of an Epithelial Layer of Human Intestinal Organoids in a Polydimethylsiloxane-based Gut-on-a-chip Microdevice. Front. Med. Technol, 2020, 2, 2 (*Equally contributed).

Yong Cheol Shin*, Woojung Shin*, Yoko M. Ambrosini, Domin Koh, Alexander Wu, Soyoun Min, S. Gail Eckhardt, R.Y. Declan Fleming, Seung Kim, Sowon Park, Hong Koh, Tae Kyung Yoo, and Hyun Jung Kim. Three-dimensional Regeneration of Patient-derived Intestinal Organoid Epithelium in a Physiodynamic Mucosal Interface-on-a-chip. Micromachines, 2020, 11, 663 (*Equally contributed).

Yoko M. Ambrosini, Yejin Park, Albert E. Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C. Borcherding, Jinah Jang, Karin Allenspach, Jonathan P. Mochel, and Hyun Jung Kim. Recapitulation of the Accessible Interface of Biopsy-Derived Canine Intestinal Organoids to Study Epithelial-Luminal Interactions. PLoS ONE, 2020, 15 (4), e0231423.

Yoko M. Ambrosini*, Woojung Shin*, Soyoun Min, and Hyun Jung Kim. Microphysiological Engineering of Immune Responses in Inetstinal Inflammation. Immune Netw., 2020, 20, e18 (*Equally contributed).

Chris P. Miller*, Woojung Shin*, Eun Hyun Ahn, Hyun Jung Kim, and Deok-Ho Kim. Engineering Microphysiological Immune System Responses on Chips. Trens Biotechnol, 2020, 38, 857-872 (*Equally contributed).

• • Featured in a special collection of Trends Collection on Inflammation and Immunity, Cell Press, May, 2020

 Woojung Shin, Landon A. Hackley, and Hyun Jung Kim. “Good Fences Make Good Neighbors”: How does the Human Gut Microchip Unravel Mechanism of Intestinal Inflammation?. Gut Microbes, 2020, 11, 581-586.

 Woojung Shin, Christopher D. Hinojosa, Donald E. Ingber, Hyun Jung Kim. Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-dependent Physical Cues in a Microengineered Gut-on-a-chip. iScience, 2019, 15, 391-406.

Woojung Shin*, Alexander Wu*, Miles Massidda*, Charlie Foster, Newin Thomas, Dong-Woo Lee, Hong Koh, Youngwon Ju, Joohoon Kim, and Hyun Jung Kim, A Robust Longitudinal Co-culture of Obligate Anaerobic Gut Microbiome with Human Intestinal Epithelium in an Anoxic-Oxic Interface-on-a-Chip. Front. Bioeng. Biotechnol. 2019, 7, 13. (*Equally contributed)

Woojung Shin and Hyun Jung Kim. Intestinal Barrier Dysfunction Orchestrates the Onset of Inflammatory Host-Microbiome Crosstalk in a Human Gut Inflammation-on-a-chip. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E10539-E10547.

• • • Highlighted in EurekAlert, Natl Acad of Sciences, Gut Microbiota Health, UT News, Texas BME, Medical Xpress, ScienceDaily, GEN, R&D, News Medical, Technology Network, Bric, News1, BioSpectator, Donga Science, Donga.com, Alliance of Advanced BioMedical Engineering, Laboratory News, Statesman.

    • Featured in Editor’s Choice, “Model for maintaining integrity”, Science, 2018, 362, 907.

    • Highlighted in National Anti-Vivisection Society (NAVS).

    • Interviewed at KUT Austin NPR statin, “How Probiotics Could Be Problematic For Those With Damaged Guts”. 

Woojung Shin and Hyun Jung Kim, Pathomimetic Modeling of Human Intestinal Diseases and Underlying Host-gut Microbiome Interactions in a Gut-on-a-chip. Methods in Cell. Biol., Microfluidics in Cell Biology, Part C – Microfluidics in multicellular models. 2018, 146, 135-148.

Amir Bein*, Woojung Shin*, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim+, and Donald E. Ingber+. Microfluidic Organ-on-a-Chip Models of Human Intestine. Cell. Mol. Gastro. Hep. 2018, 5, 659-668. (*Equally contributed; +Co-correspondence)

Gun-Seok Park, Min Hee Park, Woojung Shin, Connie Zhao, Sameer Sheikh, So Jung Oh, and Hyun Jung Kim. Emulating Host-microbiome Ecosystem of Human Gastrointestinal Tract In Vitro. Stem Cell Rev. Rep. 2017, 13, 312-334.

• • Published in the Special Issue of “Organs-on-chips and 3D Bioprinting for Personalized Medicine”.

Sun-Hee Cho, Ahreum Kim, Woojung Shin, Min Beom Heo, Hyun Jong Noh, Kwan Soo Hong, Jee-Hyun Cho, and Yong Taik Lim. Photothermal-modulated Drug Delivery and Magnetic Relaxation Based on Collagen/poly(γ-glutamic acid) Hydrogel. Int. J. Nanomedicine. 2017, 12, 2607-2620.

Woojung Shin, Seung Won Shin, Ji Soo Yuk, Lunjakorn Amornkitbamrung, Min Su Jang, In Hyun Song, Soon Won Choi, Insung Kang, Jin Young Lee, Hojae Bae, Kyung-Sun Kang, and Soong Ho Um. Cell Surface Nano-modulation for Non-invasive in vivo Near-IR Stem Cell Monitoring. ChemMedChem 2017, 12, 28-32.

• • Selected for a Hot Topic Special Collection in Nanomedicine, 2020.

 Woojung Shin, Hyun Jong Noh, Young-Woock Noh, Sohyun Kim, Soong Ho Um, and Yong Taik Lim. Hyaluronic Acid-supported Combination of Water Insoluble Immunostimulatory Compounds for Anti-cancer Immunotherapy. Carbohydr. Polym. 2017, 155, 1-10.

Jin-Ha Choi, Jaewon Lee, Woojung Shin, Jeong-Woo Choi, and Hyun Jung Kim. Priming Nanoparticle-Guided Diagnostics and Therapeutics towards Human Organs-on-Chips Microphysiological System. Nano Convergence 2016, 3, 24.

Seung Won Shin, Kyung Soo Park, In Hyun Song, Woojung Shin, Byung Woo Kim, Dong-Ik Kim, and Soong Ho Um. Multiplexed Labeling System for High-throughput Cell Sorting. Anal. Biochem. 2016, 508, 124-128.

Seung Won Shin, Kyung Soo Park, Woojung Shin, and Soong Ho Um. mRNA-producing Pseudo-Nucleus System. Small. 2015, 11 (41), 5515-5519.

Kyung Soo Park, Seung Won Shin, Min Su Jang, Woojung Shin, Kisuk Yang, Junhong Min, Seung-Woo Cho, Byung-Keun Oh, Jong Wook Bae, Sunghwan Jung, Jeong-Woo Choi, and Soong Ho Um. A Fluorescent Tile DNA Diagnocode System for In Situ Rapid and Selective Diagnosis of Cytosolic RNA Cancer Markers. Sci. Rep., 5, 2015.