Publications

1. Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun-Hee Youm, and Vishwa Deep Dixit. Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity. Journal of Clinical Investigation, 2023; 133(19):e169173. PMID: 37781916

2. Yizhou Zhu, Seungjin Ryu , Archana Tare , Nir Barzilai , Gil Atzmon, Yousin Suh. Targeted sequencing of the 9p21.3 region reveals association with reduced disease risks in Ashkenazi Jewish centenarians. Aging Cell, 2023; online ahead of print, e13962. PMID: 37605876

3. Brenda Gonzalez*, Archana Tare*, Seungjin Ryu*, Simon C. Johnson, Gil Atzmon, Nir Barzilai, Matt Kaeberlein, and Yousin Suh. High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity (*Co-first author) GeroScience, 2023; 45(1):311-330. PMID: 35948858

4. Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim N. Artyomov, Akiko Iwasaki, Andrew Wang, and Vishwa Deep Dixit. The Matricellular Protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity, 2022; 55(9):1609-1626. PMID: 35963236

- Selected for Preview, Immunity, 2022; 55(9):1583-1585

- Selected for Highlight, Science Immunology, 2022; 7(75):eade5698

5. Matthew Simon, Jiping Yang, Jonathan Gigas, Tory M Schaff, Lei Zhang, Maria Zagorulya, Gregory Tombline, Michael Gilbert, Samantha Yu, Alexis Pope, Michael Van Meter, Stephan Emmrich, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam Hudgins, Gil Atzmon, Nir Barzilai, Aaron Wolfe, Kelsey Moody, Benjamin Garcia, David Thomas, Paul Robbins, Vijg Jan, Andrei Seluanov, and Yousin Suh, Vera Gorbunova. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin. EMBO Journal, 2022; 41(21):e110393. PMID: 36215696

6. Olga Spadaro, Yun-Hee Youm, Irina Shchukina, Seungjin Ryu, Sviatoslav Sidorov, Anthony Ravussin, Kim Nguyen, Ekatirina Aladyeva, Alexander N. Predeus, Steven R. Smith, Eric Ravussin, Craig Galban, Maxim N.Artyomov, and Vishwa Deep Dixit. Caloric restriction in humans reveals immunometabolic regulators of healthspan. Science, 2022; 375(6581):671-677. PMID: 35143297

7. Emily L Goldberg, Irina Shchukina, Yun-Hee Youm, Seungjin Ryu, Takeshi Tsusaka, Kyrlia C Young, Christina D. Camell, Tamara Dlugos, Maxim N. Artyomov, and Vishwa Deep Dixit. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metabolism, 2021; 33(11):2277-2287. PMID: 34473956

8. Seungjin Ryu*, Jeehae Han, Trina Norden-Krichmar, Quanwei Zhang, Seunggeun Lee, Zhengdong Zhang, Gil Atzmon, Laura J. Niedernhofer, Paul D. Robbins, Nir Barzilai, Nicholas J. Schork, and Yousin Suh*. Genetic signature of human longevity in PKC and NF-κB signaling. Aging Cell. 2021; 20(7):e13362. PMID: 34197020 (*Co-corresponding author)

9. Seungjin Ryu, Irina Shchukina, Yun-Hee Youm, Hua Qing, Brandon K. Hilliard, Tamara Dlugos, Xinbo Zhang, Yuki Yasumoto, Carmen J. Booth, Carlos Fernández-Hernando, Yajaira Suárez, Kamal M. Khanna, Tamas L. Horvath, Marcelo O. Dietrich, Maxim N. Artyomov, Andrew Wang, and Vishwa Deep Dixit. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. eLife. 2021;10:e66522. PMID: 34151773

10. Seungjin Ryu, Inkyung Baek, and Hyunjeong Liew. Sumoylated α-synuclein translocates into the nucleus by karyopherin α6. Molecular & Cellular Toxicology. 2019; 15(1):103-109

11. Anthony Ravussin, Yun-Hee Youm, Jil Sander, Seungjin Ryu, Kim Nguyen, Luis Varela, Gerald I. Shulman, Sviatoslav Sidorov, Tamas L. Horvath, Joachim L. Schultze, and Vishwa Deep Dixit. Loss of Nucleobindin-2 causes insulin-resistance in obesity without impacting satiety or adiposity. Cell Reports. 2018. 24(5):1085-1092. PMID: 30067966

12. Seungjin Ryu*, Jeehae Han*, Trina Norden-Krichmar, Nicholas J. Schork, and Yousin Suh. Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing. Mutation Research. 2018. 809: 24-31. PMID: 29677560

13. Catherine Manix Feintuch, Archana Tare, Lucas R. Cusumano, Jacqueline Benayoun, Seungjin Ryu, Alick Sixpence, Karl Seydel, Miriam Laufer, Terrie Taylor, Yousin Suh, and Johanna P. Daily. Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi. American Journal of Tropical Medicine and Hygiene. 2018. 98(6): 1692–1698. PMID: 29677560

14. Seungjin Ryu, Gil Atzmon, Nir Barzilai, Nalini Raghavachari, and Yousin Suh. Genetic landscape of APOE in human longevity revealed by high-throughput sequencing. Mechanisms of Ageing and Development. 2016. 155: 7-9. PMID: 26930295

15. Seungjin Ryu, Francesca Teles, Tommaso Russo, Michael G. Rosenfeld, and Yousin Suh. An epigenomic role of Fe65 in the cellular response to DNA damage. Mutation Research. 2015. 776: 40-47. PMID: 26255939

16. Jeehae Han*, Seungjin Ryu*, David M. Moskowitz, Devorah Rothenberg, Daniel J. Leahy, Gil Atzmon, Nir Barzilai, and Yousin Suh. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next generation sequencing. Mechanisms of Ageing and Development. 2013. 134(10): 478-85. PMID: 23376243 (*Co-first author)