Chen Lab at ICOB

Zebrafish model in regeneration research

About the Chen Lab

Some vertebrate animals, such as salamanders and zebrafish, are capable of regenerating complex tissues after major injuries. We are excited about the phenomenon- the how and why, and focus our efforts on key knowledge gaps ideally suited for investigation using the zebrafish model. Through the integration of large-scale cell imaging, genetics, and systems-level analyses, we aim to dissect the cellular and molecular mechanisms governing the intricate process of regeneration.

實驗室的目標

某些脊椎動物像是蠑螈和斑馬魚有很強的再生能力。這些動物可以再生複雜組織，像是身體肢體，主要器官或是脊柱神經。了解再生過程是如何發生? 為什麼這些動物有很強的再生能力? 回答這兩個問題是我們實驗室所有研究計畫的核心。我們利用斑馬魚作為模式生物的優勢，開發新型的細胞標誌工具和影像平台。結合大尺度、多維度的細胞行為分析和遺傳學方法，從個體的角度, 系統性地解構再生反應的細胞和分子機制。實驗室的長期目標是發展、應用我們的研究成果, 增強人類組織和器官的再生能力。

Latest news

2023/11/30: Congratulations to Lyra on being awarded a fellowship as an Academia Sinica Postdoctoral Scholar.

2023/11/25: Congratulations to Yuh, Lyra, and Megan for receiving poster awards in the 2023 Taiwan zebrafish symposium.

2023/11/04: Congratulations to Fio and Lyra for receiving presentation and poster awards in the 2023 International Conference of Developmental Biology, Stem Cells and Regenerative Medicine.

2023/11/02: Congratulations to Uday and Yuh for for receiving poster awards in the 2023 ICOB poster competition.

2023/10/17: Congratulations to Hsuan and Yu-Hsiu for receiving “Image of Distinction” in the 2023 Nikon’s Small World Competition.

2023/10/17: Congratulations to Lyra, Marco, Yu-Hsiu, and Uday for receiving an award in the 2023 Taiwan Olympus Microscope Image Contest.

2023/09/13: Congratulations to Marco for his study being featured as a cover story.

2023/06/08: Congratulations to Marco for an imaging study accepted in Nature Physics.

2023/01/18: Congratulations to Marco for for receiving the best poster award in the 2023 Annual Meeting of the Physical Society of Taiwan.

2022/12/03: Congratulations to Yuh, Fio, and Hsuan for receiving presentation awards in the 2022 Taiwan zebrafish symposium.

2022/11/07: Congratulations to Fio and Hsuan for for receiving poster awards in the 2022 ICOB poster competition.

2022/11/05: Congratulations to Uday for receiving an award in the 2022 Taiwan Olympus Microscope Image Contest.

2022/10/12: Congratulations to Keat Ying for receiving “Image of Distinction” in the 2022 Nikon’s Small World Competition.

2022/08/20: Congratulations to Keat Ying and Uday for receiving best poster awards in the 2022 International Conference of Taiwanese Society of Developmental Biology.

2022/03/10: Congratulations to Keat Ying for an imaging study accepted in Nature.

2022/01/28: Congratulations to Marco for receiving the oral presentation award in the 2022 Taiwan Physics Society conference.

2021/11/27: Congratulations to Uday for receiving the Gold Medal Award in the 2021 Taiwan Olympus Microscope Image Contest.

2021/11/27: Congratulations to Yuh, Keat Ying, and Uday for receiving presentation awards in the 2021 Taiwan zebrafish symposium.

2021/10/21: Congratulations to Keat Ying and Uday for receiving presentation awards in 2021 International Conference of Developmental Biology, Stem Cells and Regenerative Medicine.

2021/08/20: Congratulations to Yuh for an imaging study accepted in Development.

2021/07/05: Congratulations to Alan for a mutant study accepted in Development.

2020/12/10: Congratulations to Marco, Keat Ying, and Uday for receiving presentation awards in the TIGP-MBAS retreat.

2020/11/28: Congratulations to Uday, Alan, and Fio for receiving presentation awards in the 2020 Taiwan zebrafish symposium.

2020/06/08: We welcome Michael Wen, Longan Su, and Jade Hsu joining the lab as summer interns.

2019/11/22: Congratulations to Marco for receiving the best performance award in 2019 TIGP-MBAS retreat.

2019/11/16: Congratulations to Keat Ying, Yuh, and Alan for receiving best flash talk awards in 2019 Taiwan zebrafish meeting.

2019/11/07: Congratulations to Keat Ying, Marco, and Lisa for receiving poster awards in 2019 ICOB poster competition.

2019/10/30: Congratulations to Lisa and Alan for a mutant study accepted in Current Biology.

2019/08/24: Congratulations to Keat Ying for receiving a poster award in 2019 Joint Conference of Taiwanese Society of Developmental Biology and Taiwan Society for Stem Cell Research.

2019/07/01: We welcome Lu Wu and 顏薇珉 joining the lab as summer interns.

2018/12/10: Congratulations to Marco for receiving the award for the best oral presentation and Keat-Ying for receiving awards for the best flash talk and the best poster presentation in 2018 Taiwan zebrafish symposium.

2018/07/06: We welcome Claudia Lacombe, Yew Hong Wen, and 唐晏鍾 joining the lab as summer interns.

2018/04/09: We welcome Uday Kumar from TIPG-MBAS program joining the lab.

2018/03/05: We welcome Chung-Han Wang joining the lab.

2018/02/22: We welcome Keat Ying Chan from TIPG-MBAS program joining the lab for rotation.

20231206-TIGP ceremony

20240131-lab year-end lunch

Nature Physics. Volume 19 Issue 9, September 2023

Mechanical first aid for zebrafish

"It is known that mechanical waves play a role in collective motion of cells, including during the healing of wounds. Marco De Leon and collaborators now show that these waves can help an amputated zebrafish know where its fin was cut off, and that this can aid regeneration" @NaturePhysics.