Publications
Publications (last 5 years)
C. Pulido and T. A. Ryan. Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals. Science Advances (2021) in press
The Schizophrenia Working Group of the Psychiatric Genomics Consortium. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia . Nature (2021) in press
R. J. Farrell and T. A. Ryan. Local sourcing of secretory protein in far away places. TINS (2020) in press
G. Ashrafi, J. de Juan-Sanz, R. Farrell and T. A. Ryan. Molecular tuning the axonal mitochondrial Ca2+ uniporter ensures metabolic flexability of neurotransmission. Neuron (2020). doi.org/10.1016/j.neuron.2019.11.020
C. L. Torturo, Z. Zhou, T. A. Ryan, and H. Hemmings . Isoflurane inhibits dopaminergic synaptic vesicle exocytosis coupled to CaV2.1 and CaV2.2 in rat midbrain neurons. eNeuro (2019) in press
J. S. Dittman and T. A. Ryan. Control of release probability at nerve terminals. Nature Neuroscience Reviews (2019) in press
T. A. Ryan and B. P. Sleckman. A path(way) to keeping your synapses on an even keel. Neuron (2018) 100 (5) 1013-1014. doi:10.1016
L. M. Weatherly, A. J. Nelson, J. Shim, A. M. Riitano, E.D. Gerson, A. J. Hart, J. de Juan-Sanz, T. A. Ryan, R. Sher, S. T. Hess, J. A. Gosse. Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation .Toxicol Appl Pharmacol. (2018) Jun 15;349:39-54. doi: 10.1016
T. A. Ryan. Munc13 marks the spot. Nature Neurosci (2018) 21(1):5-6. doi: 10.1038 .
R.i Chakrabarti, W-K Ji, R. Stan, J. de Juan-Sanz, T. A. Ryan, and H. Higgs . Actin enhances ER-Mitochondrial calcium transfer and IMM constriction during mitochondrial division. J.Cell Bio (2018) 217(1):251-268. doi: 10.1083
P-Y. Pan, X. Li, J. Wang, J. Powell, Q. Wang, Y. Zhang, Z. Chen, B. Wicinski, P. Hof, T. A. Ryan, and Z. Yue. Parkinson's disease associated LRRK2 hyperactive kinase mutant disrupts synaptic vesicle trafficking in ventral midbrain neurons. J. Neurosci (2017) 37(47):11366-11376. doi: 10.1523
Y. Wang, M. Subramanian, A. Yurdagul, V.C. Barbosa-Lorenzi, B. Cai, J. de Juan Sanz, T. A. Ryan, M. Nomura, F. R. Maxfield & I. Tabas. Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages. Cell (2017) 171(2):331-345.e22. doi: 10.1016
G. Ashrafi & T. A. Ryan. Glucose Metabolism in Nerve Terminals. Curr. Opinion in Neurobiology (2017) 45:156-161. doi: 10.1016
J. W. Kyung, I.H. Cho, S. Lee, W. K. Song, T. A. Ryan, M. B. Hoppa & S. H. Kim. Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons. Sci. Reports (2017) 7:41620. doi: 10.1038.
J. de Juan Sanz, G. T. Holt, F. de Juan, D. S. Kim & T. A. Ryan. Axonal endoplasmic reticulum Ca2+ content controls release probability in CNS nerve terminals. Neuron (2017) 93(4):867-881.e6. doi: 10.1016.
N. Lipstein, N. M. Verhoeven-Duif, F. E. Michelassi, N. Calloway, P. M. van Hasselt, K. Pienkowska, G. van Haaften, M. M. van Haelst, R. van Empelen, I. Cuppen, H. C. van Teeseling, A. M. V. Evelein, J. A, Vorstman, K. Duran, G. R. Monroe, O. Jahn, T. A. Ryan, H. Taschenberger, J. S. Dittman, J-S. Rhee, G. Visser, J. J. Jans and N. Brose. An UNC13AP814L-variant causes increased synaptic transmission and dyskinetic movement disorder. J.C.I (2017) in press
M. Cao, Y. Wu, G. Ashrafi, A. J. McCartney, H. Wheeler, E. A. Bushong, D. Boassa, M.H. Ellisman, T. A. Ryan and P. De Camilli. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron (2017) 93(4):882-896.e5. doi: 10.1016 .
G. Ashrafi, Z. Wu, R.J. Farrell & T. A. Ryan. Glut4 mobilization supports energetic demands of active synapses. Neuron (2017) in press
R. Nishi, E. Castañeda, G.W. Davis G, A. A. Fenton, H. A. Hofmann, J. King, T. A. Ryan, K. A. Trujillo. The Global Challenge in Neuroscience Education and Training: The MBL Perspective. Neuron (2016) 92:632-636.
R. Cottrell, B. Li, J. W. Kyung, C. J. Ashford, J. J. Mann, T. L. Horvath, T. A. Ryan, S. H. Kim, D. J. Gerber. Calcineurin Agamma is a functional phophatase that modulates synaptic vesicle endocytosis. J. Biol. Chem. (2016) 291(4):1948-56.