Publications
2024
81. Park, S. G., Lee, H. B., and Kang, S.* Development of plug-and-deliverable intracellular protein delivery platforms based on botulinum neurotoxin. Int. J. Biol. Macromol., 2024, 261, 129622.
80. Park, S. G., Kim, H. J., Lee, H. B., Eom, S., Jun, H., Jang, Y., Park, S. H.* and Kang, S.* Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites and suppress tumor growth. Nano Today, 2024, 54, 102075.
2023
79. Park, J., Bae, Y., Eom, S., Choi, Y., Lee, G., and Kang, S.* Development of Recombinant Secondary Antibody Mimics (rSAMs) for Immunoassays through Genetic Fusion of Monomeric Alkaline Phosphatase with Antibody Binders. Int. J. Biol. Macromol., 2023, 251, 126299.
78. Kim, S., Bae, Y., Park, S., Chen, N., Eom, S., Kang, S.*, and Park, J.* Compact and Modular Bioprobe: Integrating SpyCatcher/SpyTag Recombinant Proteins with Zwitterionic Polymer-Coated Quantum Dots. J. Colloid Interface Sci., 2023, 652, 184-194.
77. Kang, Y., Yeo, M., Choi, H., Jun, H., Eom, S., Park, S. G., Yoon, H., Kim, E.,* and Kang, S.* Lactate Oxidase/vSIRPa Conjugates Efficiently Consume Tumor-produced Lactate and Locally Produce Tumor-necrotic H2O2 to Suppress Tumor Growth. Int. J. Biol. Macromol., 2023, 231, 123577.
76. Choi, H., Yeo, M., Kang, Y., Kim, H. J., Park, S. G., Jang, E., Park, S. H.,* Kim, E.,* and Kang, S.* Lactate Oxidase/Catalase-displaying Nanoparticles Efficiently Consume Lactate in the Tumor Microenvironment to Effectively Suppress Tumor Growth. J. Nanobiotechnology, 2023, 21, 5.
2022
75. Lee, K., Noh, Y., Bae, Y., Kang, S.* and Cha, C.* Tunable Physicomechanical and Drug Release Properties of In Situ Forming Thermoresponsive Elastin-like Polypeptide Hydrogels. Biomacromolecules, 2022, 23, 5193-5201.
74. Park, S. G., Kim, H., Jun, H., Choi, S. Y., Kim, E.,* and Kang, S.* Directing Ricin-based Immunotoxins with Targeting Affibodies and KDEL Signal Peptide to Cancer Cells Effectively Induces Apoptosis and Tumor Suppression. J. Nanobiotechnology, 2022, 20, 387.
73. Jun, H., Jang, E., Kim, H., Yeo, M., Park, S. G., Lee, J., Shin, K. J., Chae, Y. C. Kang, S.,* and Kim, E.* TRAIL & EGFR Affibody Dual-display on a Protein Cage Nanoparticle Synergistically Suppresses Tumor Growth. J. Control. Release, 2022, 349, 367-378.
72. Kim, S., Ahn, Y., Bae, Y., Woo, S., Park, J., Han, I. K., Kim, H., Eom, S., Kang, S., Jung, W.,* and Park, J.* Highly Sensitive Pregnancy Test Kit Via Oriented Antibody Conjugation on Brush-type Ligand-coated Quantum Beads. Biosens. Bioelectron., 2022, 213, 114441.
71. Kim, B. R., Yoon, J. W., Choi, H., Kang, S.,* and Kim, J. H.,* Application of Periostin Peptide-decorated Self-assembled Protein Cage Nanoparticles for Therapeutic Angiogenesis. BMB Rep., 2022, 55, 175-180.
70. Moon, K., Jeon, J., Choi, H., Park, J., Park, S., Lee, H., Park, J. M., Cho, H. S., Moon, J. S., Oh, H., Kang, S., Mason, H. S., Kwon, S., and Kim, H.,* Construction of SARS-CoV-2 Virus-like Particles in Plant. Scientific Rep., 2022, 12, 1005.
2021
69. Choi, H., Eom, S., Kim, H., Bae, Y., Jung, H. S., and Kang, S.,* Load & Display: Engineering Encapsulin as a Modular Nanoplatform for Protein-cargo Encapsulation and Protein-ligand Decoration Using Split Intein and SpyTag/SpyCatcher. Biomacromolecules, 2021, 22, 3028-3039.
68. Kim, H., Jin, S., Choi, H., Kang, M., Park, S. G., Jun, H., Cho, H., and Kang, S.,* Target-Switchable Gd(III)-DOTA/Protein Cage Nanoparticle Conjugates with Multiple Targeting Affibody Molecules as Target Selective T1 Contrast Agents for High-field MRI. J. Control. Release, 2021, 335, 269-280.
67. Lee, C. and Kang, S., Development of HER2 Targeting Ligand-modified Albumin Nanoparticles based on SpyTag/SpyCatcher System for Photothermal Therapy. Biomacromolecules, 2021, 22, 2649-2658.
66. Bae, Y., Lee. S. K., Chae, Y. C., Park, C. Y., and Kang, S.,* Accessibility-dependent Topology Studies of Membrane Proteins Using a SpyTag/SpyCatcher Protein-ligation System. Int. J. Biol. Macromol., 2021, 175, 171-178.
2020
65. Bae, Y., Jang, D. G., Eom, S., Park, T. J., and Kang, S.,* HRP-conjugated Plug-and-playable IgG-binding Nanobodies as Secondary Antibody Mimics in Immunoassays. Sens. Actuators B Chem., 2020, 320, 128312.
64. Park, S. G., Choi, B., Bae, Y., Lee, Y. G., Park, S. A., Chae, Y. C., and Kang, S.,* Selective and Effective Cancer Treatments using Target-Switchable Intracellular Bacterial Toxin Delivery Systems. Adv. Therap., 2020, 3, 202000043.
63. Eom, S., Bae, Y., Kim, S., Choi, H., Park, J. and Kang, S.,* Development of recombinant IgG-binding Luciferase-based Signal Amplifiers (rILSAs) in Immunoassays. Anal. Chem., 2020, 92, 5473-5481.
2019
62. Kim, H.,Choi, H., Bae, Y., and Kang, S.,* Development of Target-Tunable P22 VLP-Based Delivery Nanoplatforms Using Bacterial Superglue. Biotechnol. Bioeng., 2019, 116, 2843-2851. *Editor's Choice Article
2018
61. Oh, J. Y,# Kim, H.,# Palanikumar, L.,# Go, E. M., Jana, B., Park, S. A., Kim, H. Y., Kim, K., Seo, J. K., Kwak, S. K., Kim, C.,* Kang, S.,* and Ryu, J-H.* Cloaking Nanoparticles with Protein Corona Shield for Targeted Drug Delivery. Nat. Comm., 2018, 9, 4548.
# Equal contribution to this work
60. Choi, B., Kim, H., Choi, H., and Kang, S.* Protein Cage Nanoparticles as Delivery Nanoplatforms. Adv. Exp. Med. Biol. 2018, 1064, 27-43.
59. Choi, H., Choi, B., Kim, H., Kim, G. J., Kim, H., Jung, H. S., and Kang, S.* Fabrication of Nano-reaction Clusters with Dual-functionalized Protein Cage Nano-building Blocks. Small, 2018, 14, 1801488.
58. Bae, Y., Kim, G.J., Kim, H., Park, S.G., Jung, H.S., and Kang, S.* Engineering Tunable Dual Functional Protein Cage Nanoparticles using Bacterial Superglue. Biomacromolecules, 2018, 19, 2896-2904.
2017
57. Kim, W.G., Kang, M.E., Lee, J.B., Jeon, M.H., Lee, S., Lee, J., Choi, B., Cal, P.M.S.D., Kang, S., Kee, J.M., Bernardes, G.J.L., Rohde, J., Choe, W., and Hong, S.Y. Nickel-Catalyzed Azide−Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water. J. Am. Chem. Soc. 2017, 139, 12121-12124.
2016
56. Moon, H., Bae, Y., Kim, H. and Kang, S.* Plug-and-Playable Fluorescent Cell Imaging Modular Toolkits Using the Bacterial Superglue, SpyTag/SpyCatcher. Chem. Comm. 2016, 52, 14051-14054.
55. Kim, E. G.,# Choi, B.,# Yang, H. J., Han, J. A., Jung, H., Cho, H. J., Kang, S.* and Hong, S. Y.* Covalent Conjugation of Small-Molecule Adjuvants to Nanoparticles Induces Robust Cytotoxic T Cell Responses via DC Activation. Bioconjugate Chem. 2016, 27, 2007-2013.
54. Choi, B.,# Moon, H.,# Hong, S. J., Shin, C. S., Do, Y., Ryu, S.* and Kang, S.* Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cytotoxic T cell Activation and Tumor Rejection. ACS Nano, 2016, 10, 7339-7350.
53. Min, J., Song, E. K., Kim, H., Kim, K. T., Park, T. J.* and Kang, S.* A Recombinant Secondary Antibody Mimic as a Target-specific Signal Amplifier and an Antibody Immobilizer in Immunoassays. Sci. Rep. 2016, 6, 24159.
52. Kim, H., Kang, Y. J., Min, J., Choi, H. and Kang, S. Development of an Antibody-binding Modular Nanoplatform for Antibody-guided Targeted Cell Imaging and Delivery. RSC Adv. 2016, 6, 19208-19213.
2015
51. Song, Y. K., Kang, Y. J., Jung, H., Kim, H., Kang, S.* and Cho, H. J.* Lumazine Synthase Protein Nanoparticle-Gd(III)-DOTA Conjugate as a T1 contrast agent for high-field MRI. Sci. Rep. 2015, 5, 15656.
50. Lee, J., Song, E., Bae, Y., Min, J., Rhee, H.-W., Park, T. J., Kim, M.,* and Kang, S.* An Enhanced Ascorbate Peroxidase 2/Antibody-Binding Domain Fusion Protein (APEX2-ABD) as a Recombinant Target-Specific Signal Amplifier. Chem. Comm. 2015, 51,10945-10948.
49. Nguyen, H. H., Park, J., Kang, S.*, and Kim, M.* Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications. Sensors, 2015, 15, 10481-10510.
48. Park, C., La, Y., An, T. H., Jeong, Y., Kang, S., Joo, S. H., Ahn, H., Shin, T. J., and Kim, K. T. Mesoporous Monoliths of Inverse Bicontinuous Cubic Phases of Block Copolymer Bilayers. Nat. Comm. 2015, 6, 6392.
2014
47. Min, J., Kim, S., Lee, J. and Kang, S. Lumazine Synthase Protein Cage Nanoparticles as Modular Delivery Platforms for Targeted Drug Delivery. RSC Adv. 2014, 4, 48596-48600.
46. Moon, H., Lee, J., Kim, H., Heo, S., Min, J. and Kang, S. Genetically Engineering Encapsulin Protein Cage Nanoparticle as a SCC-7 Cell Targeting Optical Nanoprobe. Biomater. Res., 2014, 18,21.
45. Moon, H., Lee, J., Min, J., and Kang, S. Developing Genetically Engineered Encapsulin Protein Cage Nanoparticles as a Targeted Delivery Nanoplatform. Biomacromolecules, 2014, 15, 3794-3801.
44. Moon, K., Lee, J., Kang, S., Kim, M., Mason, H. S., Jeon, J., and Kim, H. Overexpression and Self-assembly of Virus-like Particles in Nicotiana benthamiana by a Single-vector DNA Replicon System. Appl. Microbiol. Biotechnol. 2014, 98, 8281-8290.
43. Ra, J. S., Shin, H., Kang, S., and Do, Y. Lumazine Synthase Protein Cage Nanoparticles as Antigen Delivery Nanoplatforms for DC-based Vaccine Development. Clin. Exp. Vaccine Res. 2014, 3, 227-234.
42. La, Y., Park, C., Shin, T. J., Joo, S. H., Kang, S. and Kim, K. T. Colloidal Inverse Bicontinuous Cubic Membranes of Block Copolymers with Tunable Surface Functional Groups. Nat. Chem. 2014, 6, 534-541.
41. Raghunathan, G., Munussami, G., Moon, H., Paik, H., An, S. S., Kim Y., Kang, S. and Lee, S. A Variant of Green Fluorescent Protein Exclusively Deposited to Active Intracellular Inclusion Bodies. Microbial Cell Factories, 2014, 13, 68.
40. Kang, Y. J., Yang, H. J., Jeon S., Kang, Y., Do, Y., Hong, S. Y.*, and Kang, S.* Polyvalent Display of Monosaccharides on Ferritin Protein Cage Nanoparticles for the Recognition and Binding of Cell-surface Lectins. Macromol. Biosci. 2014, 14, 619-625.
39. Han, J., Kang, Y. J., Shin, C., Ra J., Shin, H., Hong, S. Y., Do, Y.*, and Kang, S.* Ferritin Protein Cage Nanoparticles as Versatile Antigen Delivery Nanoplatforms for Dendritic (DC)-based Vaccine Development. Nanomed-Nanotechnol. 2014, 10, 561-569.
38. Min, J., Moon, H., Yang, H. J., Shin H. Hong, S. Y., and Kang, S. Development of P22 Viral Capsid Nanocomposites as Anti-cancer Drug, Bortezomib (BTZ), Delivery Nanoplatforms. Macromol. Biosci. 2014, 14, 557-564.
2013
37. Kim, K., Bae, B., Kang, Y. J., Nam, J., Kang, S., and Ryu, J., Natural Polypeptide-Based Supramolecular Nanogels for Stable Noncovalent Encapsulation. Biomacromolecules, 2013, 14, 3515-3522.
36. Min, J., Jung, H., Shin, H., Cho, G., Cho, H.*, and Kang, S.* Implementation of P22 Viral Capsids as Intravascular MR T1 Contrast Conjugates via Site-selective Attachment of Gd (III)-chelating agents. Biomacromolecules, 2013, 14, 2332-2339.
35. Moon, H., Kim, W. G., Lim S., Kang, Y. J., Shin, H., Ko, H., Hong, S. Y., and Kang, S., Fabrication of Uniform Layer-by-layer Assemblies with Complementary Protein Cage Nanobuilding Blocks via Simple His-tag/metal Recognition. J. Mater. Chem. B, 2013, 1, 4504-4510.
2012
34. Kang, Y. J., Park, D. C., Shin, H., Park, J., and Kang, S. Incorporation of Thrombin Cleavage Peptide into a Protein Cage for Constructing a Protease-responsive Multifunctional Delivery Nanoplatform. Biomacromolecules, 2012, 13, 4057-4064
33. Kwon, C., Kang, Y.J., Jeon, S., Jung, S., Hong, S.Y., and Kang, S. Development of Protein Cage-based Delivery Nanoplatforms by Polyvalently Displaying beta-CDs on the Surface of Ferritins through Copper(I)-catalyzed Azide-alkyne Cycloaddition. Macromol. Biosci. 2012, 12, 1452-1458
32. Kim, H., Kang, Y. J., Jeong, E. S., Kang, S., and Kim, K. T. Glucose-Responsive Disassembly of Polymersomes of Sequence-Specific Boroxole-Containing Block Copolymers under Physiologically Relevant Conditions. ACS Macro Lett. 2012, 1, 1194-1198
31. Kang, H.J., Kang, Y.J., Lee, Y.M., Shin, H., Chung, S.J.*, and Kang, S.* Developing an Antibody-binding Protein Cage as a Molecular Recognition Drug Modular Nanoplatform. Biomaterials, 2012, 33, 5423-5430
30. Kim, H., Kang, Y.J., Kang, S., and Kim, K.T. Monosaccharide-Responsive Release of Insulin from Polymersomes of Polyboroxole Brock Copolymers at Neutral pH. J. Am. Chem. Soc. 2012, 134, 4030-4033
29. Uchida, M., Morris, D.S., Kang, S., Jolley, C.C., Lucon, J., Liepold, L.O., Lafrance, B., Prevelige, P.E., Douglas, T. Site-directed Coordination Chemistry with P22 Virus-like Particles. Langmuir, 2012, 28, 1998-2006
2011
28. Kang, Y.J., Uchida, M., Shin, H.,Douglas, T.* and Kang, S.* Biomimetic FePt nanoparticle synthesis within Pyrococcus furiosus ferritins and their layer-by-layer formation. Soft Matter, 2011, 7, 11078-11081
27. Cortines, J. R., Monroe, E. B., Kang, S., and Prevelige, P. E. A Retroviral Chimeric Capsid Protein Reveals the Role of the N-Terminal β-Hairpin in Mature Core Assembly. J. Mol. Biol. 2011, 410, 641-652
26. Xia, G., Boerma, L. J., Cox, B. D., Qiu, C., Kang, S., Smith, C. D., Renfrow, M. B., and Muccio, D. D. Structure, Energetics and Dynamics of Binding Coactivator Peptide to Human Retinoid X Receptor Alpha Ligand Binding Domain Complex with 9-cis-Retinoic Acid. Biochemistry, 2011, 50, 93-105
2010
25. Kang, S. and Douglas, T. Some Enzymes Just Need a Room of Their Own. Science 2010, 327, 42-43.
24. Kang, S., Uchida, M., O'Neil, A., Li, R., Prevelige, P. E., Douglas, T. Implementation of P22 Viral Capsids as Nanoplatforms. Biomacromolecules, 2010, 11, 2804-2809.
23. *Monroe, E. B.,* Kang, S., Kyere, S. K., Li R., and Prevelige, P. E. Hydrogen/Deuterium Exchange Analysis of HIV-1 Capsid Assembly and Maturation. Structure, 2010, 18, 1483-1491. * Equal contribution
April 2011 technical highlight at Nature Structural Biology Knowledgebase
22. Okuda, M., Suzumoto, Y., Iwahori, K., Kang, S., Uchida, M., Douglas, T., and
Yamashita, I. Bio-templated Q1 CdSe nanoparticle synthesis in a cage shaped protein, Listeria-Dps, and their two dimensional ordered array self-assembly. Chem. Comm. 2010, 46, 8797-8799.
21. Jolley, C., Uchida, M., Reichhardt, C., Harrington, R., Kang, S., Klem, M., Parise, J., and Douglas, T. Size and crystallinity in protein-templated inorganic nanoparticles. Chem. Mater. 2010, 22, 4612-4618.
20. Suci, P.A., Kang, S., Gmur, R., Douglas, T., and Young, M. Targeted delivery of a photosensitizer to Aggregatibacter actinomycetemcomitans biofilm. Antimicrob. Agents Chemother. 2010, 54, 2489-2496.
19. Fu, C., Uetrecht, C., Kang, S., Morais, M. C., Heck, A. J. R., Walter, M. R., and Prevelige, P. E. ADocking Model Based on Mass Spectrometric and Biochemical Data Describes Phage Packing Motor Incorporation. Mol. Cell. Proteomics, 2010, 9, 1764-1773.
18. Uchida, M., Kang, S., Reichhardt, C., Harlen, K., and Douglas, T. The Ferritin Superfamily: Supramolecular Templates for Materials Synthesis. Biochim. Biophys. Acta, 2010, 1800, 834-845.
~ 2009
17. Suci, P.A., Kang, S., Young, M., and Douglas T. A Streptiavidin-Protein Cage Janus Particle for Polarlized Targeting and Modular Functionalization. J. Am. Chem. Soc. 2009, 131, 9164-9165.
16. Kang, S., Suci, P.A., Broomell, C.C., Iwahori, K., Kobayashi, M., Yamashita, I., Young, M., and Douglas T. Janus-like Protein Cages; Spatially Controlled Dual-functional Surface Modification of Protein Cages. Nano Lett. 2009, 9, 2360-2366.
15. Kang, S., Jolley, C.C., Liepold, L., Young, M., and Douglas T. From Metal Binding to Nanoparticle Formation; Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry. Angew. Chem. Int. Ed. 2009, 48, 4772-4776.
14. Kang, S., Mou, L., Lanman, J., Velu, S., Brouillette, W.J., and Prevelige, P.E. Synthesis of Biotin Tagged Chemical Cross-linkers and Their Applications for Mass Spectrometry. Rapid Comm. Mass Spectrom. 2009, 23, 1719-1726.
13. Flenniken, M.L., Uchida, M., Liepold, L.O., Kang, S., Young, M.J., and Douglas, T. A Library of Protein Cage Architectures as Nanomaterials. Curr. Top. Microbiol. Immunol. 2009, 327, 71-94.
12. Kang, S., Oltrogge, L.M., Broomell, C.C., Liepold, L., Prevelige, P.E., Young, M., and Douglas T. Controlled Assembly of a Bifunctional Chimeric Protein Cage and Composition Analysis using Non-covalent Mass Spectrometry.J. Am. Chem. Soc. 2008,130, 16527-16529.
11. Kang, S., Lucon, J., Varpness, Z. B., Liepold, L., Uchida, M., Willits, D., Young, M., and Douglas, T. Monitoring Biomimetic Platinum Nanocluster Formation using Mass Spectrometry and Cluster Dependent H2 production. Angew. Chem. Int. Ed. 2008, 47, 7845-7848.
10. Kang, S., Poliakov, A., Sexton, J., Renfrow, M. B., and Prevelige, P. E. Probing Conserved Helical Modules of Portal Complexes by Mass Spectrometry based Hydrogen/deuterium Exchange. J. Mol. Biol. 2008, 381,772-784.
9. Kang, S. and Prevelige, P.E. Hydrogen/Deuterium Exchange Studies of Viruses. Chapter 6 in Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics, Wiley, New Jersey, 2008.
8. Kang, S., Lander, G.C., Johnson, J.E., and Prevelige, P.E. Development of Bacteriophage P22 as a Platform for Molecular Display: Genetic and Chemical Modifications of the Procapsid Exterior Surface. ChemBiochem, 2008, 9, 514-518.
7. Nemecek, D., Gilcrease, E. B., Kang, S., Prevelige, P. E., Casjen, S. R., and Thomas, G. J. Subunit Conformations and Assembly States of a DNA Translocating Motor: The Terminase of Bacteriophage P22. J. Mol. Biol. 2007, 374:817-836.
6. Kang, S., Hawkrigde, A. M., Johnson, K. L., Muddiman, D. C., and Prevelige, P. E. Identification of Subunit-Subunit Interactions in Bacteriophage P22 Procapsids by Chemical Crosslinking and Mass Spectrometry. J. Proteome Res. 2006, 5:370-377.
5. Kang, S., and Prevelige, P. E. Domain Study of Bacteriophage P22 Coat Protein and Characterization of the Capsid Lattice Transformation by Hydrogen/Deuterium Exchange. J. Mol.Biol. 2005, 347: 935-948.
4. Lee, S., Kang, S., Kim, J. N. and Jung, S. Structural Analyses of the Novel Phosphoglycolipids Containing the Unusual very Long Bifunctional Acyl Chain, a,w-13,16-Dimethyloctacosanedioate in Thermoanaerobacter ethanolicus. Bull. Korean Chem. Soc. 2002, 23: 1778-1784.
3. Kim, H., Kang, S. and Jung, S. A thermotropic behavior of egg PC liposome containing the very long chain fatty acyl component, a,w-13,16-dimethyloctacosanedioate dimethyl ester (DME C30) isolated from the thermophilic anaerobic bacteria, Thermoanaaerobater ethanolicus. Bull. Korean Chem. Soc. 2001, 22: 979-983.
2. Lee, J., Kang, S., Kim, H., Jung, S., Choo, J. and Sohn, D. Behaviors of Long-Chain Bifunctional Molecule, a,w-13,16-dimethyloctacosanedioate dimethylester (C30DME), at the Air-Water Interface. Mol. Cryst. and Liq. Cryst. 2001, 371: 25-28.
1. Choi, Y., Kang, S., Yang, C., Kim, H. and Jung, S. On the Unusual Homeoviscous Adaptation of the Membrane Fatty Acyl Components against the Thermal Stress in Rhizobium meliloti. Bull. Korean Chem. Soc. 1999, 20: 753-756.