Guzmán, L. E.*; Wijetunge, A. N.*; Riske, B. F.; Massani, B. M.; Riehle, M. A.; Jewett, J. C. "Chemical Probes to Interrogate the Extreme Environment of Mosquito Larval Guts," J. Am. Chem. Soc. 2024, 146, 8480-8485.

Cornejo, N. R.; Amofah, B.; Lipinski, A.; Langlais, P. R.; Ghosh, I.; Jewett, J. C. "Direct Intracellular Delivery of Benzene Diazonium Ions As Observed by Increased Tyrosine Phosphorylation," Biochemistry 2022, 61, 656-664.

Bedard, N.; Foley, C.; Davis, G. J.; Jewett, J. C.; Hulme, C. "Sequential Knoevenagel [4+1] Cycloaddition–Condensation–Aza-Friedel–Crafts Intramolecular Cyclization: A 4-Center-3-Component Reaction Toward Tunable Fluorescent Indolizine Tetracycles," J. Org. Chem. 2021, 86, 17550-17559. [Link]

Davis, G. J.; Townsend, J. A.; Morrow, M. G.; Hamie, M.; Shepard, A. J. Hsieh, C.-C.; Marty, M. T.; Jewett, J. C. "Protein Modification via Mild Photochemical Isomerization of Triazenes to Release Aryl Diazonium Ions," Bioconjugate Chem. 2021, 32, 2432-2438.

Shepard, A. J.; Townsend, J. A.; Foley, C.; Hulme, C.; Marty, M. T.; Jewett, J. C. “Suzuki Coupling of Protected Aryl Diazonium Ions: Expanding the Knowledge of Triazabutadiene Compatible Reactions,” Org. Lett. 2021, 23, 1851-1855.

Wijetunge, A. N.*; Davis, G. J.*; Shadmehr, M.; Townsend, J. A.; Guzmán, L. E.; Marty, M. T.; Jewett, J. C. "Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization," Bioconjugate Chem. 2021, 32, 254-258.

Moinpour, M.; Barker, N. K.; Guzmán, L. E.; Jewett, J. C.; Langlais, P. R.; Schwartz, J. C. "Discriminating changes in protein structure using PTAD conjugation to tyrosine," Protein Science 2020, 29, 1784-1793. [Link]

Davis, G. J.*; Sofka, H. A.*; Jewett, J. C. "Highly Stable Meldrum's Acid Derivatives for Irreversible Aqueous Covalent Modification of Amines," Org. Lett. 2020, 22, 2626-2629.

Shadmehr, M.*; Davis, G. J.*; Mehari, B. T.; Jensen, S. M.; Jewett, J. C. "Coumarin triazabutadienes for fluorescent labeling of proteins," ChemBioChem 2018, 19, 2550-2552.

Martinez-Ariza, G.; Mehari, B. T.; Pinho, L. A.; Foley, C.; Day, K.; Jewett, J. C.; Hulme, C. "Synthesis of fluorescent heterocycles via a Knoevenagel/[4+1]-cycloaddition cascade using acetyl cyanide," Org. Biomol. Chem. 2017, 15, 6076-6079. [link]

Knyazeva, D. C.; Kimani, F. W.; Blanche, J.-L.; Jewett, J. C. "Hexyl triazabutadiene as a potent alkylating agent," Tetrahedron Lett. 2017, 58, 2700-2702.

He, J.; Kimani, F. W.; Jewett, J. C. "Rapid in Situ Generation of Benzene Diazonium Ions under Basic Aqueous Conditions from Bench-Stable Triazabutadienes," Synlett 2017, 28, 1767-1770.

Guzmán, L. E.; Kimani, F. W.; Jewett, J. C. "Protecting triazabutadienes to afford acid resistance," ChemBioChem 2016, 17, 2220-2222

Jensen, S. M.; Kimani, F. W.; Jewett, J. C. "Light-Activated Triazabutadienes for the Modification of a Viral Surface," ChemBioChem 2016, 17, 2216-2219.

Cornali, B. M.; Kimani, F. W.; Jewett, J. C. "Cu-Click Compatible Triazabutadienes To Expand the Scope of Aryl Diazonium Ion Chemistry," Org. Lett. 2016, 18, 4948–4950. [[Highlighted in Synfacts]]

Jensen, S. M.; Nguyen, C. T.; Jewett, J. C. "A Gradient-Free Method for the Purification of Infective Dengue Virus for Protein-Level Investigations," J. Virol. Met. 2016, 235, 125-130.

He, J.; Kimani, F. W.; Jewett, J. C. "A Photobasic Functional Group," J. Am. Chem. Soc. 2015, 137, 9764-9767.

Highlighted in Science. See: Szuromi, P. "An E-Z route to photobases," Science 2015, 349, 940-941.

Kimani, F. W.; Jewett, J. C. "Water-soluble triazabutadienes that release diazonium species upon protonation under physiologically relevant conditions," Angew. Chem. Int. Ed.2015, 54, 4051-4054.

Ahad, A. M.; Jensen, S. M.; Jewett, J. C. "A traceless Staudinger reagent to deliver diazirines," Org. Lett. 2013, 15, 5060-5063.

Work done prior to University of Arizona:

Siegrist, M. S.; Whiteside, S.; Jewett, J. C.; Aditham, A.; Cava, F.; Bertozzi, C. R. "D-Amino Acid Chemical Reporters Reveal Peptidoglycan Dynamics of an Intracellular Pathogen," ACS Chem. Biol. 2013, 8, 500-505.

Swarts, B. M.; Holsclaw, C. M.; Jewett, J. C.; Alber, M.; Fox, D. M.; Siegrist, M. S.; Leary, J. A.; Kalscheuer, R.; Bertozzi, C. R. "Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry," J. Am. Chem. Soc. 2012, 134, 16123-16126.

Gordon, C. G.; Mackey, J. L.; Jewett, J. C.; Sletten, E. M.; Houk, K. N.; Bertozzi, C. R. "Reactivity of biarylazacyclooctynones in copper-free click chemistry," J. Am. Chem. Soc. 2012, 134, 9199-9208.

Jewett, J. C.; Bertozzi, C. R. "Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry," Org. Lett. 2011, 13, 5937-5939.

Dang, Y.; Schneider-Poetsch, T.; Eyler, D. E.; Jewett, J. C.; Bhat, S.; Rawal, V. H.; Green, R.; Liu, J. O. “Inhibition of eukaryotic translation elongation by the antitumor natural product mycalamide B,” RNA 2011, 17, 1578-1588.

Jewett, J. C.; Rawal, V. H. “Temporary restraints to overcome steric obstacles: efficient strategy for the synthesis of mycalamide B,” Angew. Chem. Int. Ed. 2010, 49, 8682-8685.

Sletten, E. M.; Nakamura, H.; Jewett, J. C.; Bertozzi, C. R. “Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by β-cyclodextrin,” J. Am. Chem. Soc. 2010, 132, 11799-11805.

Jewett, J. C.; Bertozzi, C. R. “Cu-free click cycloaddition reactions in chemical biology,” Chem. Soc. Rev. 2010, 39, 1272-1279.

Jewett, J. C.; Sletten, E. M.; Bertozzi, C. R. “Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones,” J. Am. Chem. Soc. 2010, 132, 3688-3690.

Gálvez, E.; Romea, P.; Urpi F. (checkers: Jewett, J. C.; Rawal, V. H.) “Preparation of (S)-4-isopropyl-N-propanoyl-1,3-thiazolidine-2-thione,” Org. Synth. 2009, 86, 70-80.

Jewett, J. C.; Rawal, V. H. “Total synthesis of pederin,” Angew. Chem. Int. Ed. 2007, 46, 6502-6504.

Moncarz, J. R.; Brunker, T. J.; Jewett, J. C.; Orchowski, M.; Glueck, D. S.; Sommer, R. D.; Lam, K.-C.; Incarvito, C. D.; Concolino, T. E.; Ceccarelli, C.; Zakharov, L. N.; Rheingold, A. L. “Palladium-catalyzed asymmetric phosphination. Enantioselective synthesis of PAMP-BH3, ligand effects on catalysis, and direct observation of the stereochemistry of transmetalation and reductive elimination,” Organometallics, 2003, 22, 3205-3221.