Publications
11. So H.C., Kwan J.S., Cherny S.S. and Sham P.C. (2011) Risk prediction of complex diseases from family history and known susceptibility loci, with applications to cancer screening. Am J Hum Genet. 88(5):548-65. link to publisher
12. So H.C., Li MX and Sham P.C. (2011) Uncovering the total heritability explained by all true susceptibility variants in a genome-wide association study. Genetic Epidemiology. Epub ahead of print. pdf link to publisher
13. Wong EHM*, So HC*, Li MX, Wang Q, Butler AW, Paul B, Wu HM, Hui TCK, Choi SC, Ling VHM, SO MT, GARCIA-BARCELO MM, McAlonan GM, Chen EYH, Cheung EFC, Chan RCK, Cherny SS, Chen RL, LI T, Sham PC (2013) Genome-wide association study of schizophrenia in Han Chinese identifies a susceptibility locus on Xq28. Schizophrenia Bulletin. (*equal first authors)
14. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature 511 (7510), 421-427
15. Mario Falchi, Julia Sarah El-Sayed Moustafa, Petros Takousis, Francesco Pesce, Amélie Bonnefond, Johanna C Andersson-Assarsson, Peter H Sudmant, Rajkumar Dorajoo, Mashael Nedham Al-Shafai, Leonardo Bottolo, Erdal Ozdemir, Hon-Cheong So, Robert W Davies, Alexandre Patrice, Robert Dent, Massimo Mangino, Pirro G Hysi, Aurélie Dechaume, Marlène Huyvaert, Jane Skinner, Marie Pigeyre, Robert Caiazzo, Violeta Raverdy, Emmanuel Vaillant, Sarah Field (2014). Low copy number of the salivary amylase gene predisposes to obesity. Nature genetics, 46(5), 492-497.
16. Chan SK, So HC, Hui CL, Chang WC, Lee EH, Chung DW, Tso S, Hung SF, Yip KC, Dunn E, Chen EY. 10-year outcome study of an early intervention program for psychosis compared with standard care service. Psychol Med. 2014 Sep 19:1-13.
17. Gusev A, Lee SH, Trynka G, Finucane H, Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-Sullivan B, Stahl E; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M, Pasaniuc B, Sullivan PF, Neale BM, Wray NR, Raychaudhuri S, Price AL; Schizophrenia Working Group of the Psychiatric Genomics Consortium; SWE-SCZ Consortium. Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases. Am J Hum Genet. 2014 Nov 6;95(5):535-52.
(Book chapter)
18. Hon-Cheong So and Pak C. Sham: Multiple Testing and Power Calculations in Genetic Association Studies. In
Genetics of Complex Human Diseases: A Laboratory Manual. Cold Spring Harbour Laboratory Press. Link
(PhD thesis)
19. Hon-Cheong So. Genetic architecture and risk prediction of complex diseases (2010) pdf (awarded the Dr KP Steven Chang Gold Medal for the best PhD thesis in the Faculty of Medicine)
20. So, H. C., & Sham, P. C. (2016). Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits. Bioinformatics, 33(6), 886-892. pdf
21. So, H. C., & Sham, P. C. (2017). Improving polygenic risk prediction from summary statistics by an empirical Bayes approach. Scientific Reports, 7, 41262.
3 So HC, Chen EY, Sham PC: Genetics of schizophrenia spectrum disorders: Looking back and peering ahead. Ann Acad Med Singapore 2009;38:436-434. pdf
4 So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC: Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a southern Chinese population. Am J Med Genet B Neuropsychiatr Genet 2010;153B:103-113. pdf Link
5. So HC, Sham PC (2010) Effect Size Measures in Genetic Association Studies and Age-Conditional Risk Prediction. Hum Hered 70: 205-218. pdf supp info link to publisher
6. So HC, Sham PC (2010) A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained. PLoS Genet 6, e1001230. pdf supp methods link to publisher
7. So H.C., Yip B.H., Sham P.C. (2010) Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies. PLoS One 5, e13898. pdf link to publisher
8. Garcia-Barcelo, M.M., Miao, X., Tang, C.S.,So, H.C., Tang, W., Leon, T.Y.Y., Chen, R.Y.L., Cheung, E.F.C., Chen, E.Y.H., Li, T., Tam, P.K., Cherny, S.S. & Sham, P.C. (2010) Absence of NRG1 V266L mutation in schizophrenia in Chinese. Psychiatr Genet.
9. So H.C. and Sham P.C. (2011) Robust association tests under different genetic models, allowing for binary or quantitative traits and covariates. Behavior Genetics. pdf
10. So H.C., Gui H.S., Cherny S.S. and Sham P.C. (2011) Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genetic Epidemiology. 35(5):310-7. pdf supp info
1. So HC, Chen RY, Chen EY, Cheung EF, Li T, Sham PC: An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population. Am J Med Genet B Neuropsychiatr Genet 2008;147B:77-85. pdf Link
2. Zhang F, Sham PC, Fan H, Xu Y, Huang X, So H, Song Y, Liu P: An association study of ADSS gene polymorphisms with schizophrenia. Behav Brain Funct 2008;4:39.