Publications
F. Wechsler, R. Heintzmann. DeconvOptim.jl - Signal Deconvolution with Julia. JuliaCon Proceedings, 1(1), 99, https://doi.org/10.21105/jcon.00099 (2023, peer reviewed)
J. Becker, T. Deguchi, A. Jügler, R. Förster, U. Hübner, J. Ries, R Heintzmann. Better than a lens? Increasing the signal-to-noise ratio through pupil splitting, Optica 10, 308-315, (2023)
F. Ma, R. Kaufmann, J. Sedzicki, Z. Cseresnyés, C. Dehio, S. Hoeppener, M. T. Figge,R. Heintzmann. Guided-deconvolution for correlative light and electron microscopy, PLoS One18: e0282803 (2023)
K. Temma, R. Oketani, R. Lachmann, T. Kubo, NI. Smith, R. Heintzmann, K. Fujita. Saturated-excitation image scanning microscopy, Optics Express 30, 13825-13838, (2022)
Y. Gupta, C. Costa, E. Pinho, L. A. Bastião Silva, R. Heintzmann. IMAGE-IN: Interactive web-based multidimensional 3D visualizer for multi-modal microscopy images, Plos One 17, e0279825 (1-25), (2022)
K. Bermond, L. von der Emde, I.-S. Tarau, L. Bourauel, R. Heintzmann, F.G. Holz, C.A. Curcio, K. R. Sloan, T. Ach, Autofluorescent organelles within the retinal pigment epithelium in human donor eyes with and without age-related macular degeneration, Invest. Ophthalmol. Vis. Sci. 63, 23 (1-10), (2022)
D. McFadden, B. Amos, R. Heintzmann. Quality control of image sensors using gaseous tritium light sources, Philosophical Transactions of the Royal Society A 380, 20210130 (1-10), (2022)
H. Wang, R. Lachmann, B. Marsikova, R. Heintzmann, B. Diederich. UCsim2: two-dimensionally structured illumination microscopy using UC2, Philosophical Transactions of the Royal Society A 380, 20200148 (1-19), (2022)
D. Appelt, E. Ehler, S. Shukla Mukherjee, R. Heintzmann, K. Wicker. Polarized illumination coded structured illumination microscopy (picoSIM): experimental results, Philosophical Transactions of the Royal Society A 380, 20210193 (1-12), (2022)
K. Prakash, B. Diederich, R. Heintzmann, L. Schermelleh. Super-resolution microscopy: a brief history and new avenues, Philosophical Transactions of the Royal Society A 380, 20210110 (1-13), (2022)
F. Schock, G. Best, N. Celik, R. Heintzmann, S. Dithmar, C. Cremer. Structured illumination ophthalmoscope: super-resolution microscopy on the living human eye, Philosophical Transactions of the Royal Society A 380, 20210151 (1-11), (2022)
S.Y. Huang, J. Zhang, R. Förster, C. Karras, R. Heintzmann, J.S. Huang, Chiral structured illumination microscopy: fast imaging chiral domains at super-resolution, Unconventional Optical Imaging III 12136, 99-107, (2022)
W. Foo, A. Wiede, S. Bierwirth, R. Heintzmann, A.T. Press, W. Hauswald. Automated multicolor mesoscopic imaging for the 3-dimensional reconstruction of fluorescent biomarker distribution in large tissue specimens, Biomedical Optics Express 13, 3723-3742, (2022)
J. Tröger, E. Seemann, R. Heintzmann, M.M. Kessels, B. Qualmann. Spinal cord synaptic plasticity by GlyRβ release from receptor fields and syndapin I-dependent uptake, Journal of Neuroscience 42, 6706-6723, (2022)
M. Goswami, R. Lachmann, R. Kretschmer, R. Heintzmann. simpleISM—A straight forward guide to upgrade from confocal to ISM, Plos One 17, e0279378 (1-12), (2022)
L von der Emde, M Vaisband, J Hasenauer, L Bourauel, K Bermond, M. Sassmannshausen, R. Heintzmann, F.G. Holz, C.A. Curcio, K. R. Sloan, T. Ach. Histologic cell shape descriptors for the retinal pigment epithelium in age-related macular degeneration: a comparison to unaffected eyes, Translational Vision Science & Technology 11, 19 (1-13), (2022)
S. Lang, A. Kortgen, D. Thomas-Rüddel, A. Stallmach, A. Günther, M. Böhme, F. Kleiner, R. Heintzmann, H. Groesdonk, R. Laubinger, B. Velter,M. Bauer, P. Dickmann, Thüringen: COVID-Konzept senkt Mortalität, Dtsch. Arztebl. 119,A-17 / B-15 (2022)
V. Nasufović, P. Then, F. Dröge, M. Duong, C. Kaether, B. Dietzek, R. Heintzmann, H.-D. Arndt, Silicon-rhodamine isothiocyanate for fluorescent labelling, Organic & Biomolecular Chemistry 19, (2021)
A. Dasgupta, J. Deschamps, U. Matti, U. Hübner, J. Becker, S. Strauss, R. Jungmann; R. Heintzmann, J. Ries, Direct Supercritical Angle Localization Microscopy for Nanometer 3D Superresolution, Nat. Commun. 12, 1180-(1-9), https://doi.org/10.1038/s41467-021-21333-x (2021)
J. Scholz, W. Wetzker, A. Licht, R. Heintzmann, A. Scherag, S. Weis, M. W. Pletz, C. Betsch, M. Bauer, P. Dickmann, The role of risk communication in public health interventions. An analysis of risk communication for a community quarantine in Germany to curb the SARS-CoV-2 pandemic, PLoS One 16, e0256113-(1-15), (2021)
L. von der Emde, K. Bermond, I.-S. Tarau, L. Bourauel, R. Heintzmann, F. G. Holz, C. A. Curcio, K. R. Sloan, T. Ach, Organelle distribution of the human retinal pigment epithelium (RPE) in age-related macular degeneration (AMD), Invest. Ophthalmol. Vis. Sci. 62, 3279 (2021)
C. Cokca, F. J. Hack, D. Costabel, K. Herwig, J. Hülsmann, P. Then, R. Heintzmann, D. Fischer, K. Peneva, PEGylation of Guanidinium and Indole BearingPoly(methacrylamide)s – Biocompatible Terpolymers for pDNA Delivery, Macromol. Biosci. 21, 2100146-(1-7), (2021)
K. Bermond, A. Berlin, , I.-S. Tarau, C. Wobbe, R. Heintzmann, C. A. Curcio, K. R. Sloan, T. Ach, Characteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count, Ann. Eye Sci. 6, 3-(1-9), (2021)
R. Heintzmann, Answers to fundamental questions in superresolution microscopy, Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci. 379, 20210105 (1-11), https://doi.org/10.1098/rsta.2021.0105 (2021)
K. Prakash, B. Diederich, S. Reichelt, R. Heintzmann, L. Schermelleh, Super-resolution structured illumination microscopy: past, present and future, Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci. 379, 1-9 (2021)
S.-Y. Huang, J. Zhang, C. Karras, R. Förster, R. Heintzmann, and J.-S. Huang, Chiral Structured Illumination Microscopy, ACS Photonics 8, 130–134, DOI: 10.1021/acsphotonics.0c01360 (2021)
T. Tuckova, M. Siler, D. E. Boonzajer Flaes, P. Jákl S. Turtaev, S. Krátky, R. Heintzmann, H. Uhlirova, T. Čižmár, Computational image enhancement of multimode fibre based holographic endo-microscopy: harnessing the muddy modes, Opt. Express 29, 38206-38220, https://doi.org/10.1364/OE.434848, (2021)
H. Wang, R. Heintzmann, B. Diederich. The power in your pocket – uncover smartphones for use as cutting-edge microscopic instruments in science and research, Adv. Opt. Techn. 10, 89-108, DOI: 10.1515/aot-2021-0013, (2021)
M. T. Kuchenbrod, U. S. Schubert, R. Heintzmann, S. Hoeppener, Revisiting staining of biological samples for electron microscopy: perspectives for recent research, Materials Horizons 8, 685-699, DOI: 10.1039/D0MH01579B (2021)
K Bermond, C Wobbe, IS Tarau, R Heintzmann, J Hillenkamp, CA Curcio, K. R Sloan, T. Ach, Autofluorescent Granules of the Human Retinal Pigment Epithelium: Phenotypes, Intracellular Distribution, and Age-Related Topography Investigative Ophthalmology & Visual Science 61 (5), 35-35 (2020)
P. Rühl, D. Wang, F. Garwe, R. Müller, M. Haase, K. Krämer, W. Paa, R. Heintzmann, S.H. Heinemann, H. Stafast, Notes on thermometric artefacts by Er3+ luminescence band interference, Journal of Luminescence 232:117860, (2020)
B. Diederich, R. Lachmann, S. Carlstedt, B. Marsikova, H. Wang, X. Uwurukundo, A.S. Mosig, R. Heintzmann, A versatile and customizable low-cost 3D-printed open standard for microscopic imaging, Nature Communications, 11, 5979 DOI: 10.1038/s41467-020-19447-9 (2020)
B. Diederich, B, Masikova, B. Amos, R. Heintzmann One-shot phase-recovery using a cellphone RGB camera on a Jamin-Lebedeff microscope, PLoS One, DOI: 10.1371/journal.pone.0227096 (2019)
S-Y. Chen, R. Heintzmann and C. Cremer Sample drift estimation method based on speckle patterns formed by backscattered laser light, Biomed. Opt. Expr. 10, 6462-6475 (2019).
T. Chakraborty, M.K. Driscoll, E. Jeffery, E. et al. Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution. Nat Methods 16, 1109–1113 (2019) doi:10.1038/s41592-019-0615-4 (2019)
C. Karras, M. Chemnitz, R. Heintzmann, M.A. Schmidt, Impact of deuteration on the ultrafast nonlinear optical response of toluene and nitrobenzene, Opt. Expr. 27, 29491-29500. (2019)
A. Markwirth, M. Lachetta, V. Mönkemöller, R. Heintzmann, W. Hübner, T. Huser & M. Müller, Video-rate multi-color structured illumination microscopy with simultaneous real-time reconstruction, Nat. Commun. 10, 4315, DOI: 10.1038/s41467-019-12165-x (2019)
W Hauswald , R Förster, J Popp, R Heintzmann, Thermal illumination limits in 3D Raman microscopy: A comparison of different sample illumination strategies to obtain maximum imaging speed, PLoS One, DOI: 10.1371/journal.pone.0220824
M Reifarth, W Müller, B Shkodra‐Pula, H Görls, US Schubert, R. Heintzmann, S. Höppener, Electron Density of Polymeric Nanoparticles Determined by Image Processing of Transmission Electron Micrographs: Insights into Heavy Metal Staining Processes, 2019, Particle & Particle Systems Characterization, 1800324 (2019)
N Dey, S Li, K Bermond, R Heintzmann, CA Curcio, T Ach, G Gerig, Multi-modal image fusion for multispectral super-resolution in microscopy, Medical Imaging 2019: Image Processing 10949, 109490D, 2019
B Diederich, P Then, A Jügler, R Forster, R Heintzmann, cellSTORM — Super-Resolution on a Cellphone, PloS One, 2019, doi:10.1371/journal.pone.0209827.
E.A. Ingerman, R.A. London, R. Heintzmann, M.G.L Gustafsson, Signal, noise and resolution in linear and nonlinear structured‐illumination microscopy, Journal of Microscopy 273, 3-25, 2019, DOI: 10.1111/jmi.12753
C. Karras, M. Smedh, R. Foerster, H. Deschout, J. Fernandez-Rodriguez, R. Heintzmann, Successful optimization of reconstruction parameters in structured illumination microscopy - a practical guide, Opt. Commun. 436, 69-75, 2019, https://doi.org/10.1016/j.optcom.2018.12.005
M. Taariq, Y. Tong, J. Agee, N. Challa, R. Heintzmann, M. Hammer, C. A. Curcio, T. Ach, Z. Ablonczy and R. T. Smith, Ex Vivo Hyperspectral Autofluorescence Imaging and Localization of Fluorophores in Human Eyes with Age-Related Macular Degeneration, Vision 2, 38, 2018, DOI: 10.3390/vision2040038
S.-Y. Chen, F. Bestvater, W. Schaufler, R. Heintzmann, and C. Cremer, Patterned illumination single molecule localization microscopy (piSMLM): user defined blinking regions of interest, Opt. Expr. 26, 30009-30020
R. Förster, W. Müller, R. Richter, R. Heintzmann, Automated distinction of shearing and distortion artefacts in structured illumination microscopy, Opt. Expr. 26:20680, 2018, DOI: 10.1364/OE.26.020680
B. Diederich, R. Wartmann, H. Schadwinkel, R. Heintzmann, Using machine-learning to optimize phase contrast in a low-cost cellphone microscope, PLoS One doi: 10.1371/journal.pone.0192937, 2018
R. Heintzmann, T. Huser, Super-Resolution Structured Illumination Microscopy, Chem. Rev. 117, 13890–13908, 2017, doi:10.1021/acs.chemrev.7b00218
S. Abrahamsson, HJ. Blohm, A. Agostinho, D.C. Jans, A. Jost, M. Müller, L. Nilsson, K. Bernhem, T.J. Lambert, R. Heintzmann, H. Brismar, Multifocus structured illumination microscopy for fast volumetric super-resolution imaging, Biomed. Opt. Expr. 8, 4135-4140, 2017
M. Reifarth, E. Preußger, U. S. Schubert, R. Heintzmann, S. Hoeppener, Metal–Polymer Hybrid Nanoparticles for Correlative High-Resolution Light and Electron Microscopy, Part. Part. Syst. Charact., DOI: 10.1002/ppsc.201700180, 2017
O. Chernavskaia, T. Bocklitz, T. Meyer, N. Vogler, D. Akimov, S. Heuke, B. Dietzek, R. Heintzmann, J. Popp, Correction of mosaicking artifacts in multimodal Images caused by uneven illumination, J. Chemometrics 31, doi:10.1002/cem.2901
A. Trofimova, S. Nazarov, A. Tolstik, U. Mahilniy, E. Tolstik,R. Heintzmann, Multiplexed holograms in phenanthrenequinone–polymethylmethacrylate composite for microscopic applications, Opt. Mat. Expr. 7, 1446-1452, 2017
M. Walde, A. Jost, K. Wicker, R. Heintzmann, Engineering an achromatic Bessel beam using a phase-only spatial light modulator and an iterative Fourier transformation algorithm, Opt. Comm. 383, 64-68, 2017
A. Le Marois, S. Labouesse, K. Suhling, and R. Heintzmann, Noise-Corrected Principal Component Analysis of fluorescence lifetime imaging data, J. Biophot. DOI:10.1002/jbio.201600160, 2016
S. Roth, R. Heintzmann, Optical photon reassignment with increased axial resolution by structured illumination, Methods and Applications in Fluorescence 4, 045005, 2016
C. J. R. Sheppard, S. Roth, R. Heintzmann, M. Castello, G. Vicidomini, R. Chen, X. Chen, and A. Diaspro, Interpretation of the optical transfer function: Significance for image scanning microscopy, Optics Express 24 27280-27287
Y. Tong, T. Ben Ami, S. Hong, R. Heintzmann, G. Gerig,Z. Ablonczy, C. A. Curcio, T. Ach, R.T. Smith, Hyperspectral Autofluorescence Imaging of Drusen and Retinal Pigment Epithelium in Donor Eyes with Age-Related Macular Degeneration, Retina, 36, 127-136, doi: 10.1097/IAE.0000000000001325, 2016
H.-W. Lu-Walther, W. Hou, M. Kielhorn, Y. Arai, T. Nagai, M. M. Kessels, B. Qualmann, R. Heintzmann, Nonlinear structured illumination 1 using a fluorescent protein activating at the readout wavelength, PLoS One, DOI:10.1371/journal.pone.0165148, 2016
U. Mahilny, A. Trofimova, S. Nazarov, A. Tolstik, R. Heintzmann, E. Tolstik, Highly concentrated phenanthrenequinone – polymethylmethacrylate composite for thick reflection holograms recording at 532 nm, Optical Materials Express 6, 3427-3437, 2016
A. De la Cardena, D. Davydova, T. Tolstik, C. Reichardt, S. Shukla, D. Akimov, R. Heintzmann, J. Popp, B. Dietzek, Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru (bpy) 2dppz]2+, Scientific Reports 6, Article number: 33547, 2016
E. Tolstik, L. A. Osminkina, D. Akimov, M. B. Gongalsky, A. A. Kudryavtsev, V. Y. Timoshenko, R. Heintzmann, V. Sivakov, J. Popp, Linear and Non-Linear Optical Imaging of Cancer Cells with Silicon Nanoparticles, Int. J. Molec. Sci. 17, 1536, 2016.
R. Förster, K. Wicker, W. Müller, A. Jost, R. Heintzmann. Motion artefact detection in structured illumination microscopy for live cell imaging, Optics Express 24, 22121-22134, 2016
C. Roider, R. Heintzmann, R. Piestun, A. Jesacher. A multi-view deconvolution approach for high resolution 3D scanning microscopy with helical phase engineering. Optics Express 24, 15456-15467, 2016
A. Negash, S. Labouesse, N. Sandeau, M. Allain, H. Giovannini, J. Idier, R. Heintzmann, P. C. Chaumet, K. Belkebir, A. Sentenac, Improving the axial and lateral resolution of three-dimensional fluorescence microscopy using random speckle illuminations, JOSA A 33, 1089-1094, 2016.
W. Müller, M. Kielhorn, M. Schmitt, J. Popp, R. Heintzmann, Light sheet Raman micro-spectroscopy, Optica 3, 452-457, 2016.
E. Tolstik, L.A. Osminkina, C. Matthäus, M. Burkhardt, K.E. Tsurikov, U.A. Natashina, V.Yu. Timoshenko, R. Heintzmann, J. Popp, V. Sivakov, Studies of Silicon Nanoparticles Uptake and Biodegradation in Cancer Cells by Raman Spectroscopy, Nanomedicine: Nanotechnology, Biology and Medicine, DOI: 10.1016/j.nano.2016.04.004
L. Song, H.-W. Lu-Walter, R. Förster, R. Heintzmann, Fast structured illumination microscopy using rolling shutter cameras, Measurement Science and Technology 27(5):055401, 2016
S. Roth, C.J.R. Sheppard, R. Heintzmann, Superconcentration of light – Circumventing the classical limit to achievable irradiance, Opt. Lett. 41, 2109-2112, 2016
M. Reifarth, D. Pretzel, S. Schubert, C. Weber, R. Heintzmann, S. Hoeppener, U. S. Schubert, Cellular uptake of PLA nanoparticles studied by light and electron microscopy: Synthesis, characterization and biocompatibility studies using an iridium(III) complex as correlative label, Chemical Communications 52, 4361-4364, DOI:10.1039/C5CC09884J, 2016.
R. Horstmeyer, R. Heintzmann, G. Popescu, L. Waller and C. Yang, Standardizing the resolution claims for coherent microscopy, Nature Photonics 9, 68-71, 2016.
N. Chakrova, R. Heintzmann, B. Rieger, S. Stallinga, Studying different illumination patterns for resolution improvement in fluorescence microscopy, Optics Express 23, 31367-31383, 2015
E.Tolstik, S. Shukla, R. Heintzmann, High-resolution Far-field Microscopy, The Optics Encyclopedia, 1-31, DOI: 10.1002/9783527600441.oe1007, 2015
A Badgaa, R Büchler, N Wielsch, M Walde, R. Heintzmann, Y. Pauchet, A. Svatos, K. Ploss, W. Boland, The Green Gut: Chlorophyll Degradation in the Gut of Spodoptera littoralis, Journal of Chemical Ecology, doi: 10.1007/s10886-015-0636-0, 2015
S. W Hell, S. J. Sahl, M. Bates, X. Zhuang, R. Heintzmann, M. J. Booth, J. Bewersdorf, G. Shtengel, H. Hess, P. Tinnefeld, The 2015 super-resolution microscopy roadmap, J. Phys. D: Appl. Phys. 48 443001, 2015
S. Wolfram, N. Wielsch, Y. Hupfer, B. Mönch, H.-W. Lu-Walther, R. Heintzmann, O. Werz, A. Svatoš, G. Pohnert, A metabolic probe-enabled strategy reveals uptake and protein targets of polyunsaturated aldehydes in the diatom Phaeodactylum tricornutum, PLoS One, doi: 10.1371/journal.pone.0140927, 2015
A. Jost, E. Tolstik, P. Feldman, K. Wicker, A. Sentenac, R. Heintzmann, Optical Sectioning and High Resolution in Single-Slice Structured Illumination Microscopy by Thick Slice Blind-SIM Reconstruction, PLoS One 10, e0132174-1, 2015
S. Heuke, J. Zheng, D. Akimov, R. Heintzmann, M. Schmitt, J. Popp, Bessel beam CARS of axially structured samples, Scientific Reports 5, 10991, doi:10.1038/srep10991, 2015
S. E. Stanca, W. Fritzsche, V. Deckert, C. Matthäus, J. Dellith, C. Krafft, U. Neugebauer, R. Heintzmann, J. Popp, S. Nietzsched, K. Weber, Chemo-Spectroscopic Sensor for Carboxyl Terminus Overexpressed in Carcinoma Cell Membrane, Nanomedicine: Nanotechnology, Biology, and Medicine, doi:10.1016/j.nano.2015.04.004, 2015
S. Abrahamsson, M. McQuilken, S. B. Mehta, A. Verma, J. Larsch, R. Ilic, R. Heintzmann, C. I. Bargmann, A. S. Gladfelter, R. Oldenbourg, MultiFocus Polarization Microscope (MF-PolScope) for 3D polarization imaging of up to 25 focal planes simultaneously, Optics Express 23, 7734–7754 , 2015
T. Ach, E. Tolstik, J. D. Messinger, A. V. Zarubina , R. Heintzmann, C. A. Curcio, Lipofuscin re-distribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration, Investigative Ophthalmology & Visual Science, doi: 10.1167/iovs.14-16274, 2015
F. B. Legesse, O. Chernavskaia, S. Heuke, T. Bocklitz, T. Meyer, J. Popp, R. Heintzmann, Seamless Stitching of Tile Scan Microscope Images, Journal of Microscopy, 2015, 03/2015; DOI:10.1111/jmi.12236, 2015
H.W. Lu-Walther, M. Kielhorn, R. Förster, A. Jost, K. Wicker, R. Heintzmann, FastSIM: a practical implementation of fast structured illumination microscopy, Methods Appl. Fluoresc. 3 014001 doi:10.1088/2050-6120/3/1/014001, 2015
A. Silge, E. Abdou, K. Schneider, S. Meisel, T. Bocklitz, H.-W. Lu-Walther, R Heintzmann, P. Rösch, J. Popp, Shedding light on host niches: Label-free in situ detection of Mycobacterium gordonae via carotenoids in macrophages by Raman microspectroscopy, Cellular Microbiology 17, 832–842, DOI: 10.1111/cmi.12404, 2015
O. Mandula, I. Šumanovac Šestak, R. Heintzmann, C. K. I. Williams, Localisation microscopy with quantum dots using non-negative matrix factorisation, Optics Express 22, 24594–24605, 2014
R. Foerster, H.W. Lu-Walther, A. Jost, M. Kielhorn, K. Wicker, R. Heintzmann, Simple structured illumination microscope setup with high acquisition speed by using a spatial light modulator, Optics Express22, 20663-20677, 2014
K. Wicker, R. Heintzmann, Resolving a misconception about structured illumination, Nature Photonics 8, 342–344 doi:10.1038/nphoton.2014.88 , 2014
M. Walde, J. Monypenny, R. Heintzmann, G.E. Jones, S. Cox. Vinculin Binding Angle in Podosomes Revealed by High Resolution Microscopy. PLoS ONE 9: e88251. doi:10.1371/journal.pone.008825, 2014
A. Jost, R. Heintzmann, Superresolution Multidimensional Imaging with Structured Illumination Microscopy, Annual Review of Materials Research 07/2013; 43(1):261-282. doi:10.1146/annurev-matsci-071312-121648
S. Roth, C.J.R. Sheppard, K. Wicker, R. Heintzmann, Optical Photon Reassignment microscopy (OPRA), J. Opt. Nanosc., 2:5, doi:10.1186/2192-2853-2-5, 2013
R. Ayuk, H. Giovannini, A. Jost, E. Mudry, J. Girard, T. Mangeat, N. Sandeau, R. Heintzmann, K. Wicker, K. Belkebir, and A. Sentenac. Structured Illumination Fluorescence Microscopy with distorted excitations using Filtered blind-SIM algorithm, Optics Letters 38, 4723-4726, 2013
M. Brunstein, K. Wicker, K. Hérault, R.Heintzmann, M. Oheim, Full-field dual-color 100-nm super-resolution imaging reveals organization and dynamics of mitochondrial and ER networks, Opt. Expr. 21, 26162–26173, 2013. Republished in Virtual Journal for Biomedical Optics 9, 2013
S. Rossberger, G. Best, D. Baddeley, R. Heintzmann, U. Birk, S. Dithmar and C. Cremer Combination of Structured Illumination and Single Molecule Localization Microscopy in one Setup, J. Opt.15, 094003 doi:10.1088/2040-8978/15/9/094003, 2013
P. v. Olshausen, H. J. Defeu Soufo, K. Wicker, R. Heintzmann, P. L. Graumann, A. Rohrbach, Super-resolution imaging of dynamic MreB filaments in B. subtilis - a multiple motor driven transport?, Biophys. J. 105, 1171-1181, 2013
C. J. R. Sheppard, S. B. Mehta, and R. Heintzmann, Superresolution by image scanning microscopy using pixel reassignment, Opt. Lett. 38, 2889-2892, 2013
R. Heintzmann, Super-resolution imaging: Beyond the realm of fluorescence, Nature Photonics 7, 426-428, 2013
S. Rossberger, T. Ach, G. Best, C. Cremer, R. Heintzmann, S. Dithmar, High Resolution Imaging of Autofluorescent Particles within Drusen using Structured Illumination Microscopy, British Journal of Ophtalmology, doi:10.1136/bjophthalmol-2012-302350, 2013.
K. Wicker, O. Mandula, G. Best, R. Fiolka, R. Heintzmann, Phase optimisation for structured illumination microscopy, Optics Express 21, 2032–2049, 2013
J. Nedbal, P.S. Hobson, D. J. Fear, R. Heintzmann, H. J. Gould, Comprehensive FISH Probe Design Tool Applied to Imaging Human Immunoglobulin Class Switch Recombination, PLOS ONE 7, e51675, 2012
S. Cox, E. Rosten, J. Monypenny, T. Jovanovic-Talisman, D. T. Burnette, J. Lippincott-Schwartz, G. E. Jones und R.Heintzmann.Bayesian localization microscopy reveals nanoscale podosome dynamics. Nature Methods 9, 195-200, 2012
S. Munck, K. Miskiewicz, R. Sannerud, S. A. Menchon, L Jose, R. Heintzmann, P. Verstreken und W. Annaert, Sub-diffraction imaging on standard microscopes through photobleaching microscopy with nonlinear processing, J. Cell Science 125,2257-2266, 2012
O. Mandula, M. Kielhorn, K. Wicker, G. Krampert, I. Kleppe, and R. Heintzmann, Line scan - structured illumination microscopy super-resolution imaging in thick fluorescent samples, Optics Express 20, 24167-24174, 2012
T. Ach, G. Best, S. Rossberger, R. Heintzmann, C. Cremer, S. Dithmar, Autofluorescence imaging of human RPE cell granules using structured illumination microscopy Br J Ophthalmol 96:1141-1144, 2012
G. Best, R. Amberger, D. Baddeley, T. Ach, S. Dithmar, R. Heintzmann, C. Cremer, Structured illumination microscopy of autofluorescent aggregations in human tissue, Micron 42, 330-335, 2011
K. Wicker, R. Heintzmann, Single-shot optical sectioning using polarization-coded structured illumination, J. Opt. 12, 084010, 2010
R. Heintzmann, Correcting distorted optics: back to the basics, Nature Methods 7, 108-110, 2010
L. Schermelleh, R. Heintzmann, H. Leonhardt, A guide to super-resolution fluorescence microscopy, J. Cell Biol 190, 165-175, 2010
R. Heintzmann, M.G.L. Gustafsson, The requirements for sub-diffraction resolution in continuous samples, Nature Photonics 3, 362-364, 2009
G. Liaugaudas, A. T. Collins, K. Suhling, G. Davies, R. Heintzmann, Luminescence-lifetime mapping in Diamond, J. Phys.: Condens. Matter 21, 364210. 2009
K. Wicker, S. Sindbert, R. Heintzmann, Characterisation of resolution enhancing image inversion interferometers, Optics Express 17, 15491-15501, 2009
L. Hirvonen, K. Wicker., O. Mandula and R. Heintzmann, Structured illumination microscopy of a living cell, Europ. Biophys. J. 38, 807-812, 2009
A. H. Reshak, V. Sarafis, R. Heintzmann, Second harmonic imaging of chloroplasts using the Two-Photon Laser Scanning Microscope, Micron 40, 378-385, 2009
M.Beutler, K. Makrogianneli, R.J. Vermeij, M. Keppler, T. Ng T.M. Jovin, R. Heintzmann, satFRET: estimation of Förster resonance energy transfer by acceptor saturation, Eur. Biophys. J. 38, 69-82, 2008
A. Hoppe, S. L. Shorte, J. A. Swanson, R. Heintzmann, D-FRET Reconstruction Microscopy for Analysis of Dynamic Molecular Interactions in Live Cells, Biophys. J. 95, 400-418, 2008
M. Barszczewski, J. J. Chua, A. Stein, U. Winter, R. Heintzmann, F. E. Zilly, D. Fasshauer, T. Lang, and R. Jahn, A Novel Site of Action for a-SNAP in the SNARE Conformational Cycle Controlling Membrane Fusion, Mol. Biol. Cell 19, 776-784, 2008
K. Wicker and R. Heintzmann, Interferometric resolution improvement for confocal microscopes, Optics Express 15, 12206- 12216, 2007.
C. Ventalon, R. Heintzmann, and J. Mertz, Dynamic speckle illumination microscopy with wavelet pre-filtering, Opt. Letters 32, 1417-1419, 2007.
T. J. Siddiqui, O. Vites, A. Stein, R. Heintzmann, R. Jahn, and D. Fasshauer, Determinants of Synaptobrevin regulation in membranes, Mol. Biol. Cell 18, 2037-2046, 2007
R. Heintzmann. Estimating Missing Information by Maximum Likelihood Deconvolution, Micron 38, 136-144, 2007
R. Heintzmann and C.J.R. Sheppard. The Sampling Limit in Fluorescence Microscopy, Micron 38, 145-149, 2007
V. Sarafis, R. Heintzmann, A. Karnieli, Visualizing Cyanobacteria in Soil Crusts from a Semi-Arid Environment using Confocal Fluorescence Imaging, Phytomorphology 56, 1-4, 2006
R. Heintzmann and G. Ficz. Breaking the resolution limit in light microscopy, Briefings in Functional Genomics and Proteomics 5, 289-301, 2006
R. Heintzmann and P.A. Benedetti, High-Resolution Image Reconstruction in Fluorescence Microscopy with Patterned Excitation, Applied Optics 45, 5037-5045, 2006.
J. J. Sieber, K. I. Willig, R. Heintzmann, S. W. Hell, T. Lang, The SNARE-motif is essential for the formation of syntaxin clusters in the plasma membrane, Biophys. J. 90, 2843–2851, 2006.
R. F. Carvalho, M. Beutler, K. J.M. Marler, B. Knöll, E. Becker-Barroso, R. Heintzmann, T. Ng and U. Drescher, Silencing of EphA3 through a novel cis interaction with ephrinA5, Nature Neuroscience 9, 322-330, 2006
Q.S. Hanley, K.A. Lidke, R. Heintzmann, D.J. Arndt-Jovin, T.M. Jovin. Fluorescence lifetime imaging in an optically sectioning programmable array microscope (PAM), Cytometry Part A, 67A, 112-118, 2005.
G. Ficz, R. Heintzmann, D.J. Arndt-Jovin. Polycomb group protein complexes exchange rapidly in living Drosophila, Development 132, 3963-3976, 2005.
K.A. Lidke, B. Rieger, T.M. Jovin, R. Heintzmann. Superresolution by localization of quantum dots using blinking statistics. Opics Express 13, 7052-7062, 2005.
S.T. Berezhnaa, S. Schaefer, R. Heintzmann, M. Jahnz, G. Boese, A. Deniz, P. Schwille. New effects in polynucleotide release from cationic lipid carriers revealed by confocal imaging, fluorescence cross-correlation spectroscopy and single particle tracking. Biochimica et Biophysica Acta, 1669, 193-207, 2005.
M. A. Andrei, D. Ingelfinger, R. Heintzmann, T. Achsel, R. Rivera-Pomar, R. Lührmann, A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies, RNA 11, 717-727, 2005
E.A. Jares-Erijman, C. Spagnuolo, L. Giordano, M. Etchehon, J. Kawior, M.V. Mañalich-Arana, M. Bossi, D.S. Lidke, J.N. Post, R.J. Vermeij, R. Heintzmann, K.A. Lidke, D.J. Arndt-Jovin and T.M. Jovin: Novel (bio)chemical and (photo)physical probes for imaging live cells. In: Supramolecular Structure and Function, Vol. 8, G. Pifat-Mrzljak (ed.) Kluwer-Plenum Publishers, Amsterdam, pp. 99-118, 2004.
H.E. Grecco, K.A. Lidke, R. Heintzmann, D.S. Lidke, C. Spagnuolo, O.E. Martinez, E.A. Jares-Erijman and T.M. Jovin. Ensemble and single particle photophysical properties (two-photon excitation, anisotropy, FRET, lifetime, spectral conversion) of commercial quantum dots in solution and in live cells. Micr. Res. Tech. 65, 169-179, 2004.
N. Schaffert, M. Hoßbach, R. Heintzmann, T. Achsel and R. Lührmann. RNAi knockdown of hPrp31 leads to an accumulation of U4/U6 di-snRNPs in Cajal bodies. The EMBO J. 23, 3000-3009, 2004.
R. Heintzmann, K.A. Lidke, T.M. Jovin. Double-pass Fourier transform imaging spectroscopy. Optics Express, 12, 753-763, 2004.
D.S. Lidke, P. Nagy, R. Heintzmann, D.J. Arndt-Jovin, J.N. Post, H. Grecco, E.A. Jares-Erijman and T.M. Jovin. Quantum dot ligands provide new insights in receptor-mediated signal transduction. Nature Biotechnology, 22, 198-203, 2004
R. Heintzmann. Saturated patterned excitation microscopy with two-dimensional excitation patterns. Micron. 34, 283-291, 2003.
R. Heintzmann, V. Sarafis, P. Munroe, J. Nailon, Q.S. Hanley and T.M. Jovin. Resolution enhancement by subtraction of confocal signals taken at different pinhole sizes. Micron, 34, 293-300, 2003.
A. Cavallo, I. Solovei, L. Schermeleh, R. Heintzmann, T. Cremer, C. Cremer. A Hybrid Approach to the 3D High Precision Position Measurement and Particle Tracking in Human Cell Nuclei. Real-Time Imaging, 8, 467-473, 2002.
M. Heilemann, D.P. Herten, R. Heintzmann, C. Cremer, C. Müller, P. Tinnefeld, K.D. Weston, J. Wolfrum and M. Sauer. High-resolution colocalization of single dye molecules by fluorescence lifetime imaging microscopy. Anal. Chem., 74, 3511-3517, 2002.
R. Heintzmann, T.M. Jovin, and C. Cremer. Saturated patterned excitation microscopy (SPEM) - a novel concept for optical resolution improvement. J. Opt. Soc. Am. A, 19, 1599-1609, 2002.
R. Heintzmann and C. Cremer. Axial tomographic confocal fluorescence microscopy, J. Microsc., 206, 7-23, 2002.
R. Heintzmann, Q.S Hanley, D. Arndt-Jovin, and T.M. Jovin. A dual path programmable array microscope - simultaneous acquisition of conjugate and non-conjugate images. J. Microsc., 204, 119-137, 2001.
R. Heintzmann and V. Sarafis. Two point resolution in incoherent imaging. Optik, 112, 114-118, 2001.
B. Albrecht, A.V. Failla, R. Heintzmann, and C. Cremer. Spatially modulated illumination microscopy: online visualization of intensity distribution and prediction of nanometer precision of axial distance measurements by computer simulations. J. Biomed. Opt., 6, 292-299, 2001.
T. Cremer, G. Kreth, H. Koester, RHA. Fink, R. Heintzmann, M. Cremer, I. Solovei, D. Zink, and C. Cremer. Chromosome territories, interchromatin domain compartment, and nuclear matrix. An integrated view of the functional nuclear architecture. Critical Reviews in Eukaryotic Gene Expression, 10, 179-212, 2000.
R. Heintzmann, G. Kreth, and C. Cremer. Reconstruction of axial tomographic high resolution data from confocal fluorescence microscopy - a method for improving 3D FISH images. Analytical Cellular Pathology , 20, 7-15, 2000.
O. Diat, P. Boesecke, C. Ferrero, A.K. Freund, J. Lambard, and R. Heintzmann. Ultra-small-angle x-ray scattering with a bonse-hart camera on the high brilliance beamline at the esrf. Nuclear Instruments and Methods A, 356, 566-572, 1995.