Research interests

Food toxicology: some food contaminants, like Bipshenol A, may have impact on Human Health. Our aim is to study potential metabolic effects according to different doses and during critical Human development phases (e.g. pregnancy).

Bioinformatics: developing methods to study genome-scale metabolic networks. These approaches are mainly based on graph models and constraint based models (e.g. FBA). The aim is to use experimental data like metabolomics ones in order to retrieve parts of the organism metabolism affected by genetic or environmental perturbations.

Keywords: metabolic networks, metabolomics, information visualization, food toxicology

Affiliations

1 Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France

2 MetaboHUB-Metatoul, National Infrastructure of Metabolomics and Fluxomics, Toulouse, France 

Seleced publications

• Cooke J, Delmas M, Wieder C, Rodríguez Mier P, Frainay C, Vinson F, Ebbels T, Poupin N, Jourdan F (2024). Genome scale metabolic network modelling for metabolic profile predictions. PLoS Comput Biol. 2024 Feb 22;20(2):e1011381. doi: 10.1371/journal.pcbi.1011381. PMID: 38386685; PMCID: PMC10914266.

• Fresnais L, Perin O, Riu A, Grall R, Ott A, Fromenty B, Gallardo JC, Stingl M, Frainay C, Jourdan F, Poupin N. (2024). A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration techniques. BMC Bioinformatics. 2024 Jul 11;25(1):234. doi: 10.1186/s12859-024-05845-z.

• Pablo Rodríguez-Mier, Nathalie Poupin, Carlo de Blasio, Laurent Le Cam, Fabien Jourdan (2021). DEXOM: Diversity-based enumeration of optimal context-specific metabolic networks. PLoS Computational Biology 17(2):e1008730. doi: 10.1371/journal.pcbi.1008730, https://hal.archives-ouvertes.fr/hal-03154775v1. [IF: 4.475, MATHEMATICAL & COMPUTATIONAL BIOLOGY, Q1, 7/66]

• Clément Frainay, Sandrine Aros, Maxime Chazalviel, Thomas Garcia, Florence Vinson, Nicolas Weiss, Benoit Colsch, Frédéric Sedel, Dominique Thabut, Christophe Junot and Fabien Jourdan (2019). MetaboRank: network-based recommendation system to interpret and enrich metabolomics results. Bioinformatics, 35 (2), 274-283, https://dx.doi.org/10.1093/bioinformatics/bty577, https://hal.inrae.fr/hal-02627792 [IF: 6.937, MATHEMATICAL & COMPUTATIONAL BIOLOGY, Q1, 3/58]

• Ludovic Cottret, Clément Frainay, Maxime Chazalviel, Floréal Cabanettes, Yoann Gloaguen, Etienne Camenen, Benjamin Merlet, Stephanie Heux, Jean-Charles Portais, Nathalie Poupin, Florence Vinson and Fabien Jourdan (2018). MetExplore: collaborative edition and exploration of metabolic networks. Nucleic Acids Research, 46 (W1), 8 p., https://dx.doi.org/10.1093/nar/gky301, https://hal.inrae.fr/hal-01886470 [IF: 16.971, BIOCHEMISTRY & MOLECULAR BIOLOGY, Q1, 4/300]

Ongoing international projects

• Horizon Europe (Doctoral Network) HUMAN (Partner) : 2023-2027. Title: Harmonising and Unifying Blood Metabolomic Analysis Networks. Total funding: 2,697 k€

• ANR-DFG MetCalssNet (Coordinator)   : 2020-2023. Title : New approaches to bridge the gap between genome-scale metabolic networks and untargeted metabolomics. Total funding : 928 k€

• H2020 SAFFI (Partner)  : 2020-2024 Title : Safe Food for Infants in China and the EU. Coordinatorr : Erwan Engel (INRAE, France). Total funding : 6,752 k€

• H2020 GOLIATH (Partner, WP leader)  : 2019-2023. Title : GOLIATH Generation Of NoveL, Integrated and Internationally Harmonised Approaches for Testing Metabolism Disrupting Compounds. Coordinator : Pr. Juliette Legler (University of Utrecht, NL). Total funding : 6,761 k€. 

Ongoing projects national projects

• ANR, MicroMetabo (Partner) : 2022-2026. Title: Influence of intestinal microbiota metabolic cross-talk on host metabolic allocation during animal juvenile growth. Coodrinator. Floriant Bellvert (CNRS, TBI). Total funding: 645 k€

• FRM, EndoxOmics (Partner) : 2021-2024. Title: Persistent organic pollutants and endometriosis: a metabolome wide association study. Coodrinator. German Cano Sancho (INRAE, Laberca). Total funding: 537 k€

• ANR-MRSEI, EU-Met (Coordinator) : 2021-2023. Title: New methods and tools for translational metabolomics. Consortium: MetaboHUB total funding: 30k€.

• PIA equipex+, ANR MetEx+ (Coordinator)  : 2021-2025. Title: Next generation metabolomics and fluxomics, from population to single cell. Consortium : MetaboHUB. Total funding: 5,675 k€. 

• PIA 3, ANR MetaboHUB 2.0 (Coordinator)  : 2020-2024 Title: National metabolomics and fluxomics infrastructure. Consortium : MetaboHUB. Total funding : 2,900 k€. 

• ADEM Metalisabet (Partner, WP leader)  : 2021-2024 Titre: Évaluation de l’impact métabolique de l’exposition environnementale, résidentielle et professionnelle aux polluants : une approche métabolomique. Coordinator : Luc Dauchet (Institut Pasteur, Lille). Total funding : 170 k€. 

• ANSES ToxMining (Coordinator)  : 2019-2022. Title: Predictive toxicology approach for prioritizing the assessment of chemical agents. Total funding : 197 k€. 

• ANR Sentinel (Partner)  : 2020-2023 Title: High-throughput screening tools for a reinforced chemical safety surveillance of food.  Coordinator: Erwan Engel (INRAE, France). Total funding : 596 k€. 

• INCA MDM2 (Partenaire, WP leader)  : 2019-2023. Title: MDM2 and serine metabolism: New therapeutic targets for liposarcomas. Coordinator: Dr Laetitia Linares (INSERM, Montpellier). Total funding : 592 k€. 

Other stuffs

• Cycling

• Scuba diving

• Golfing

• Windsurfing (not kitesurfing yet!)

• Visiting the world ... if we can