publications
Selected Publications
(‡equal contribution, *corresponding author)
2023
Hyejin Kim‡, Jihyeon Park‡, Hyunwoo Kim‡, Naho Ko‡, Jumi Park, Eunhong Jang, So Young Yoon, Joyce Anne R. Diaz, Changwook Lee*, and Youngsoo Jun*. Proc Natl Acad Sci USA 2023; 120(18): e2211501120.
2022
Hyunwoo Kim, Seowhang Lee, Youngsoo Jun, and Changwook Lee*. Nature Communications 2022; 13: 3702.
2021
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site.
Nam Gu Yoon‡, Hakbong Lee‡, So-Yeon Kim, Sung Hu, Darong Kim, Sujae Yang, Ki Bum Hong, Ji Hoon Lee, Soosung Kang, Byung-Gyu Kim, Kyungjae Myung, Changwook Lee*, and Byoung Heon Kang*. J. Am. Chem. Soc. 2021; 143, 47: 19684-19696.
2020
Quaternary structure of Vac8 differentially regulate the Cvt and PMN pathways.
Jumi Park‡, Hye-In Kim‡, Hanbin Jeong, Miriam Lee, Se Hwan Jang, So Young Yoon, Hyejin Kim, Zee-Yong Park, Youngsoo Jun*, and Changwook Lee*. Autophagy 2020; 16(6): 991-1006.
2019
Jumi Park‡, Song-Yi Lee‡, Hanbin Jeong, Myeong-Gyun Kang, Lindsey Van Haute, Michal Minczuk, Jeong Kon Seo, Youngsoo Jun, Kyungjae Myung, Hyun-Woo Rhee*, and Changwook Lee*. Nucleic Acids Research 2019; 47(13): 7078-7093.
2017
Hanbin Jeong, Jumi Park, Youngsoo Jun, and Changwook Lee*. Proc Natl Acad Sci USA 2017; 114(45): E9502-E9511.
Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure.
Hanbin Jeong‡, Jumi Park‡, Hye-In Kim‡, Miriam Lee, Young-Joon Ko, Sanghwa Lee, Youngsoo Jun*, and Changwook Lee*. Proc Natl Acad Sci USA 2017; 114(23): E4539–4548.
2016
Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex.
Hanbin Jeong‡, Jumi Park‡, and Changwook Lee*. EMBO Reports 2016; 17(12): 1857–1871.
Song-Yi Lee‡, Hakbong Lee‡, Hye-Kyeong Lee, Seung-Won Lee, Sung Chul Ha, Taejoon Kwon, Jeong Kon Seo*, Changwook Lee*, and Hyun-Woo Rhee*. ACS Central Science 2016; 2: 506–516.
2015
Changwook Lee‡*, Hye-Kyung Park‡, Hanbin Jeong, Jaehwa Lim, An-Jung Lee, Keun Young Cheon, Chul-Su Kim, Ajesh P. Thomas, Boram Bae, Nam Doo Kim, Seong Heon Kim, Pann-Ghill Suh, Ja-Hyoung Ryu* and Byung Heon Kang*. J. Am. Chem. Soc. 2015; 137:4358–4367.
Full Publications
(‡equal contribution, *corresponding author)
41. Pratyush Kumar Mishra*, Nirmali Sharma, Hyunwoo Kim, Changwook Lee, and Hyun-Woo Rhee*. GEN-Click: Genetically Encodable Click Reactions for Spatially Restricted Metabolite Labeling. ACS Central Science 2023; acscentsci.3c00511.
40. Jung-Min Oh, Yujin Kang, Jumi Park, Yubin Sung, Dayoung Kim, Yuri Seo, Eun A Lee, Jae Sun Ra, Enkhzul Amarsanaa, Young-Un Park, Seon Young Lee, Jung Me Hwang, Hongtae Kim, Orlando Schärer, Seung Woo Cho, Changwook Lee, Kei-ichi Takata, Ja Yil Lee, Kyungjae Myung. MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1. Nucleic Acids Research 2023; 51(11): 5584-5602.
39. Hyejin Kim‡, Jihyeon Park‡, Hyunwoo Kim‡, Naho Ko‡, Jumi Park, Eunhong Jang, So Young Yoon, Joyce Anne R. Diaz, Changwook Lee*, and Youngsoo Jun*. Structures of Vac8-containing protein complexes reveal the underlying mechanism by which Vac8 regulates multiple cellular processes. Proc Natl Acad Sci USA 2023; 120(18): e2211501120.
38. Eunhong Jang, Yeojin Moon, So Young Yoon, Joyce Anne R Diaz, Miriam Lee, Naho Ko, Jongseo Park, Soo Hyun Eom, Changwook Lee, Youngsoo Jun. Human atlastins are sufficient to drive the fusion of liposomes with a physiological lipid composition. J. Cell Biol. 2023; 222 (4): e202109090.
37. Seok Beom Lee, Jaeni Yu, Hyunwoo Kim, Kun Woo Kim, Jong Woo Jeong, Yun Lan Kim, Sung Jean Park, Tae-Sung Koo, Changwook Lee, Ki Bum Hong, and Sungwook Choi. Novel Strategy To Inhibit Transthyretin Amyloidosis via the Synergetic Effect of Chemoselective Acylation and Noncovalent Inhibitor Release. J. Med. Chem. 2023; 66, 4, 2893–2903.
36. Hyunwoo Kim, Seowhang Lee, Youngsoo Jun, and Changwook Lee*. Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites. Nature Communications 2022; 13: 3702.
35. Pratyush Kumar Mishra‡, Myeong-Gyun Kang‡, Hakbong Lee, Seungjoon Kim, Subin Choi, Nirmali Sharma, Cheol-Min Park, Jaewon Ko, Changwook Lee*, Jeong Kon Seo* and Hyun-Woo Rhee*. A Chemical Tool for Blue Light-Inducible Proximity Photocrosslinking in Live Cells. Chem. Sci. 2022; 13, 955.
34. Nam Gu Yoon‡, Hakbong Lee‡, So-Yeon Kim, Sung Hu, Darong Kim, Sujae Yang, Ki Bum Hong, Ji Hoon Lee, Soosung Kang, Byung-Gyu Kim, Kyungjae Myung, Changwook Lee*, and Byoung Heon Kang*. Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site. J. Am. Chem. Soc. 2021; 143, 47: 19684-19696.
33. Sujae Yang‡, Nam Gu Yoon‡, Dongyoung Kim‡, Eunsun Park, So-Yeon Kim, Ji Hoon Lee, Changwook Lee, Byoung Heon Kang, and Soosung Kang*. Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity. ACS Med. Chem. Lett. 2021; 12, 7: 1173–1180.
32. Darong Kim‡, So-Yeon Kim‡, Dongyoung Kim‡, Nam Gu Yoon, Jisu Yun, Ki Bum Hong, Changwook Lee*, Ji Hoon Lee*, Byoung Heon Kang*, Soosung Kang*. Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models. Bioorg Chem. 2020; 101: 103901.
31. Seowhang Lee‡, Seung-Han Lee‡, Hwan Heo, Eun Hye Oh, Jin-Hong Shin, Hyang-Sook Kim, Jae-Ho Jung, Seo Young Choi, Kwang-Dong Choi, Hakbong Lee, Changwook Lee*, Jae-Hwan Choi*. Impaired DNA-binding affinity of novel PAX6 mutations. Scientific Reports 2020; 10(1), 3062.
30. Eun Hye Oh, Jin-Hong Shin, Hyang-Sook Kim, Jae Wook Cho, Seo Young Choi, Kwang-Dong Choi, Je-Keun Rhee, Seowhang Lee, Changwook Lee, Jae-Hwan Choi. Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population. Front Neurol. 2020; 10: 1424.
29. Sejin Jung, Nam Gu Yoon, Sujae Yang, Darong Kim, Won Seok Lee, Ki Bum Hong, Changwook Lee, Byoung Heon Kang, Ji Hoon Lee, Soosung Kang. Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as Potent Hsp90 Inhibitors With Selectivity Over TRAP1. Bioorg Med Chem Lett. 2020; 30(2): 126809.
28. Jiwoong Kwon, Jong-Seok Park, Minsu Kang, Soobin Choi, Jumi Park, Gyeong Tae Kim, Changwook Lee, Sangwon Cha, Hyun-Woo Rhee and Sang-Hee Shim. Bright ligand-activatable fluorescent protein for high-quality multicolor live-cell super-resolution microscopy. Nature Communications 2020; 11(273)
27. Jumi Park‡, Hye-In Kim‡, Hanbin Jeong, Miriam Lee, Se Hwan Jang, So Young Yoon, Hyejin Kim, Zee-Yong Park, Youngsoo Jun*, and Changwook Lee*. Quaternary structure of Vac8 differentially regulate the Cvt and PMN pathways. Autophagy 2020; 16(6): 991-1006.
26. Jumi Park‡, Song-Yi Lee‡, Hanbin Jeong, Myeong-Gyun Kang, Lindsey Van Haute, Michal Minczuk, Jeong Kon Seo, Youngsoo Jun, Kyungjae Myung, Hyun-Woo Rhee*, and Changwook Lee*. The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination. Nucleic Acids Research 2019; 47(13): 7078-7093.
25. Miriam Lee, Yeojin Moon, Sanghwa Lee, Changwook Lee, and Youngsoo Jun. Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae. FASEB J. 2018; 33(3): 3590-3600.
24. Jae-Ho Jung, Eun Hye Oh, Jin-Hong Shin, Hyang-Sook Kim, Seo Young Choi, Kwang-Dong Choi, Changwook Lee, Jae-Hwan Choi Choi. Identification of a novel GPR143 mutation in X-linked ocular albinism with marked intrafamilial phenotypic variability. Journal of Genetics 2018; 97(5): 1479-1484.
23. Jae-Hwan Choi, Jae-Ho Jung, Eun Hye Oh, Jin-Hong Shin, Hyang-Sook Kim, Je Hyun Seo, Seo Young Choi, Min-Ji Kim, Hee Young Choi, Changwook Lee, Kwang-Dong Choi. Genotype and Phenotype Spectrum of FRMD7-Associated Infantile Nystagmus Syndrome. Invest Ophthalmol Vis Sci. 2018; 59(7): 3181-3188.
22. Hanbin Jeong, Jumi Park, Youngsoo Jun, and Changwook Lee*. Crystal Structures of Mmm1 and Mdm12-Mmm1 Reveal Mechanistic Insight into Phospholipid Trafficking at ER-Mitochondria Contact Sites. Proc Natl Acad Sci USA 2017; 114(45): E9502-E9511.
21. Jumi Park, Kyonghwa Song, Sohyeon Oh, Taewon Son, Jun Lee, Ayoung Park, Hyun Ji Kim, Youngsoo Jun, and Changwook Lee*. Purification, crystallization, and X-ray crystallographic analysis of Vac8p complexed with Atg13p from Saccharomyces cerevisiae. Biodesign 2017; 5 (3), 114–117.
20. Minjong Kim, Donghoon Jang, Eunseok Yoo, Yangkyun Oh, Jun Young Sonn, Jongbin Lee, Yoonhee Ki, Hyo Jin Son, Onyou Hwang, Changwook Lee, Chunghun Lim & Joonho Choe. Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila. Scientific Reports 2017; 7, 11368.
19. Kyung Tae Kim, Yeojin Moon, Yunsu Jang, Kang Taek Lee, Changwook Lee, Youngsoo Jun, and Sangwha Lee. The Molecular mechanisms of atlastin-mediated ER membrane fusion revealed by a FRET-based single-vesicle fusion assay. Scientific Reports 2017; 7, 8700.
18. Hye-Kyung Park‡, Hanbin Jeong‡, Eunhwa Ko, Geumwoo Lee, Ji-Eun Lee, Sang Kwang Lee, An-Jung Lee, Jin Young Im, Sung Hu, Seong Heon Kim, Ji Hoon Lee, Changwook Lee*, Soosung Kang*, and Byung Heon Kang*. Paralog specificity determines subcellular distribution, action mechanism, and anticancer activity of TRAP1 inhibitors of a Mitochondria-Targeted Hsp90 Inhibitor. J. Med. Chem. 2017; 60 (17), 7569–7578.
17. Myeong-Gyun Kang‡, Hakbong Lee‡, Beom Ho Kim, Yerkin Dunbayev, Jeong Kon Seo, Changwook Lee*, and Hyun-Woo Rhee*. Structure-Guided Synthesis of a Protein-Based Fluorescent Sensor for Alkyl Halides. Chem. Commun (Camb). 2017; 53(66), 9226–9229.
16. Hakbong Lee, Hanbin Jeong, Joonho Choe, Youngsoo Jun, Chunghun Lim, and Changwook Lee*. The crystal structure of human Rogdi provides insight into the causes of Kohlschutter-Tönz Syndrome. Scientific Reports 2017; 7, 3972.
15. Hanbin Jeong‡, Jumi Park‡, Hye-In Kim‡, Miriam Lee, Young-Joon Ko, Sanghwa Lee, Youngsoo Jun*, and Changwook Lee*. Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure. Proc Natl Acad Sci USA 2017; 114(23): E4539–4548.
14. Myeong-Gyun Kang, Jumi Park, Gianfranco Balboni, Mi Hee Lim, Changwook Lee, and Hyun-Woo Rhee*. Genetically Encodable Bacterial Flavin Transferase for Fluorogenic Protein Modification in Mammalian Cells. ACS Synth. Biol. 2017; 6(4): 667–677.
13. Hanbin Jeong‡, Jumi Park‡, and Changwook Lee*. Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex. EMBO Reports 2016; 17(12): 1857–1871.
12. Song-Yi Lee‡, Hakbong Lee‡, Hye-Kyeong Lee, Seung-Won Lee, Sung Chul Ha, Taejoon Kwon, Jeong Kon Seo*, Changwook Lee*, and Hyun-Woo Rhee*. Proximity-Directed Labeling Reveals a New Rapamycin-Induced Heterodimer of FKBP25 and FRB in Live Cells. ACS Central Science 2016; 2: 506–516.
11. Hwan Hee Lee, Satoru Sanada, Seung Min An, Byeong Jin Ye, Jun Ho Lee, Young-Kyo Seo, Changwook Lee, Whaseon Lee-Kwon, Christoph Kuper, Wolfgang Neuhofer, Soo Youn Choi, and Hyug Moo Kwon. LPS-induced NFkB enhanceosome requires TonEBP/NFAT5 without DNA binding. Scientific Reports 2016; 6, 24921
10. Hanbin Jeong, Hyo Jung Sim, Eun Kyung Song, Hakbong Lee, Sung Chul Ha, Youngsoo Jun,Tae Joo Park*, Changwook Lee*. Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway. Scientific Reports 2016; 6, 20261
9. Changwook Lee‡*, Hye-Kyung Park‡, Hanbin Jeong, Jaehwa Lim, An-Jung Lee, Keun Young Cheon, Chul-Su Kim, Ajesh P. Thomas, Boram Bae, Nam Doo Kim, Seong Heon Kim, Pann-Ghill Suh, Ja-Hyoung Ryu* and Byung Heon Kang*. Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the crystal structures of human Trap1. J. Am. Chem. Soc. 2015; 137:4358–4367.
8. Hanbin Jeong, Byung Heon Kang, Changwook Lee*. Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors. Acta Crystallogr F Struct Biol Commun. 2014; 70:1683-1687.
7. Hanbin Jeong, Hakbong Lee, Changwook Lee*. Crystallization and preliminary X-ray diffraction analysis of the Sel1-like repeats of SEL1L. Acta Crystallogr F Struct Biol Commun. 2014; 70:1624–1627.
[Before UNIST]
6. Changwook Lee and Jonathan Goldberg. Structure of Coatomer Cage Proteins and the Relationship among COPI, COPII and Clathrin Vesicle Coats. Cell 2010; 142: 123–132.
5. Jung-Hoon Lee, Jung Min Choi, Changwook Lee, Ki Joung Yi and Yunje Cho. Structure of a peptide: N-glycanase Rad23 complex : Insight into the deglycosylation for denatured glycoproteins. Proc Natl Acad Sci USA 2005; 102: 9144–9149.
4. Changwook Lee, Bumsoo Hong, Jung Min Choi, Yugene Kim, Saori Watanabe, Yukio Ishimi, Takemi Enomoto, Shusuke Tada, Youngchang Kim, and Yunje Cho. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. Nature 2004; 430: 913–917.
3. Taewoo Kwon, Jeong Ho Chang, Eunyee Kwak, Changwook Lee, Andrzej Joachimiak, Young Chang Kim, Jae Woon Lee and Yunje Cho. Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-Adomet. EMBO J. 2003; 22(2): 292–303.
2. Changwook Lee, Jeong Ho Chang, Hyun Sook Lee and Yunje Cho. Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor. Genes & Dev. 2002; 16: 3199–3212.
1. Changwook Lee and Yunje Cho. Interactions of SV40 large T antigen and other virol proteins with retinoblastoma tumor suppressor. Rev. Med. Virol. 2002; 12: 81–92.