PUBLICATION

1.     Hye-Yeon Hwang, Dongmin Gim, Hwalin Yi, Hyewon Jung, Jaecheol Lee*, Daesik Kim*. Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor. Nucleic Acids Res. 2024 Apr 25. (* Co-corresponding author)

2.     Hoyeon Lee, Boyoung Kim, Jiyue Yun, Jinseung Bae, Sungsu Park, Junseok Jeon, Hye Ryoun Jang, Jaecheol Lee, Soah Lee. PIV-MyoMonitor: an accessible particle image velocimetry-based software tool for advanced contractility assessment of cardiac organoids. Front Bioeng Biotechnol. 2024 Mar 12:12:1367141.

3.     Do Hyun Bae, Hayeon Bae, Hyung-Seok Yu, Banzragch Dorjsembe, Young Hyun No, Taejung Kim, Nam Hyeong Kim, Jin-Woo Kim, Jiyool Kim, Bok-Soo Lee, Ye Ji Kim, Seongchan Park, Zinah Hilal Khaleel, Deok Hyang Sa, Eui-Chul Lee, Jaecheol Lee, Jungyeob Ham, Jin-Chul Kim, Yong Ho Kim. Peptide-Drug Conjugate with Statistically Designed Transcellular Peptide for Psoriasis-Like Inflammation. Adv Healthc Mater. 2024 Feb 29:e2303480.

4.     Un Na Koh, Ji Hyun Lee, Hyoung Jin Kang, Kyeung Min Joo, Jae Cheol Lee, Si-Keun Lim. Application of RapidHIT™ ID for cell authentication by fast and convenient STR profiling. Genes Genomics 2023 Oct;45(10):1263-1271.  

5.     Nam Hyeong Kim, Sudong Chae, Sang Ah Yi, Deok Hyang Sa, Seungbae Oh, Eun Sung Kang, Suhyeon Kim, Kyung Hwan Choi, Jaecheol Lee*, Jae-Young Choi*, Yong Ho Kim*. Peptide-Assembled Single-Chain Atomic Crystal Enhances Pluripotent Stem Cell Differentiation to Neurons. Nano Lett. 2023 Jul 20. (* Co-corresponding author)

6.     Donghoon Ahn, Davide Provasi, Nguyen Minh Duc, Jun Xu, Leslie Salas-Estrada, Aleksandar Spasic, Min Woo Yun, Juyeong Kang, Dongmin Gim, Jaecheol Lee, Yang Du, Marta Filizola, Ka Young Chung. Gαs slow conformational transition upon GTP binding and a novel Gαs regulator. iScience. 2023 Apr 8;26(5):106603.

7.     Sang Ah Yi, Ye Ji Jeon, Min Gyu Lee, Ki Hong Nam, Sora Ann, Jaecheol Lee*, Jeung-Whan Han*. S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2. Exp Mol Med. 2022 Mar;54(3):324-333. (* Co-corresponding author)

8.     Young Hyun No, Nam Hyeong Kim, Muhammad Shahzad Zafar, Seon Hwa Park, Jaecheol Lee, Heeyeop Chae, Wan Soo Yun, Young Dok Kim, Yong Ho Kim. Effect of Secondary Structures on the Adsorption of Peptides onto Hydrophobic Solid Surfaces Revealed by SALDI-TOF and MD Simulations. ACS Omega. 2022 Nov 18

9.     Ye Ji Jeon, Sang Ah Yi, Jaecheol Lee*, Jeung-Whan Han*. Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway. Biochem Biophys Res Commun. 2022 Feb 26;594:101-108. doi: 10.1016/j.bbrc.2022.01.015. (* Co-corresponding author)

10.    Sang Ah Yi, Ki Hong Nam, Min Gyu Lee, Hwamok Oh, Jae Sung Noh, Jae Kyun Jeong, Sangwoo Kwak, Ye Ji Jeon, So Hee Kwon, Jaecheol Lee, Jeung-Whan Han. Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator. Molecules. 2021 Sep 18;26(18):5665. doi: 10.3390/molecules26185665.

11.    So-Mi Kang, Min-Ho Yoon, Su-Jin Lee, Jinsook Ahn, Sang Ah Yi, Ki Hong Nam, Soyoung Park, Tae-Gyun Woo, Jung-Hyun Cho, Jaecheol Lee, Nam-Chul Ha, Bum-Joon Park. Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A. Sci Rep. 2021 Apr 27;11(1):9122. doi: 10.1038/s41598-021-88325-1.

12.    Mary Dwyer, Paul J. Bushway Alexandre R. Colas, Joseph J. Lancman, Dennis Schade, Isaac Perea-Gil, Arne A.N. Bruyneel, Jaecheol Lee, Nirmal Vadgama, Justine Quach, Wesley L. McKeithan, Travis L. Biechele, Joseph C. Wu, Randall T. Moon, P. Duc Si Dong, Ioannis Karakikes, John R. Cashman, Mark Mercola. Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell Chem Biol. 2021 Jan 20;S2451-9456(21)00001-5.

13.    Su Cheol Baek, Sang Ah Yi, Bum Soo Lee, Jae Sik Yu, Jin-Chul Kim, Changhyun Pang, Tae Su Jang, Jaecheol Lee*, Ki Hyun Kim*. Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius). Biomedicines. 2021 Jan 19;9(1). (* Co-corresponding author)

14.    Lim SH, Nam KH, Kim K, Yi SA, Lee J, Han JW. Rosmarinic Acid Methyl Ester Regulates Ovarian Cancer Cell Migration and Reverses Cisplatin Resistance by Inhibiting the Expression of Forkhead Box M1. Pharmaceuticals (Basel). 2020 Oct 12;13(10):E302.

15.    Yi SA, Nam KH, Yun J, Gim D, Joe D, Kim YH, Kim HJ, Han JW, Lee J. Infection of brain organoids and 2D cortical neurons with SARS-CoV-2 pseudovirus. Viruses. 2020 Sep 8;12(9):1004.

16.    Nam KH, Yi SA, Jang HJ, Han JW, Lee J. In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid. Archives of Pharmacal Research. 2020 

17.    Baek SC, Lee BS, Yi SA, Yu JS, Lee J, Ko YJ, Pang C, Kim KH. Discovery of Dihydrophaseic Acid Glucosides from the Florets of Carthamus tinctorius. Plants (Basel). 2020 Jul 7;9(7):E858.

18.    Yi SA, Lee DH, Kim GW, Ryu HW, Park JW, Lee J, Han J, Park JH, Oh H, Lee J, Choi J, Kim HS, Kang HG, Kim DH, Chun KH, You JS, Han JW, Kwon SH. HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53. Cell Death Differ. 2020 Mar 23. 

19.    Kim K, Nam KH, Yi SA, Park JW, Han JW, Lee J. Ginsenoside Rg3 Induces Browning of 3T3-L1 Adipocytes by Activating AMPK Signaling. Nutrients. 2020 Feb 7;12(2):427. 

20.    Lee SR, Yi SA, Nam KH, Park JG, Hwang JS, Lee J, Kim KH. (±)-Kituramides A and B, pairs of enantiomeric dopamine dimers from the two-spotted cricket Gryllus bimaculatus. Bioorg Chem. 2019 Dec 24;95:103554.

21.    Yi SA, Nam KH, Kim S, So HM, Ryoo R, Han JW, Kim KH, Lee J. Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis. Genes (Basel). 2019 Dec 23;11(1).

22.    Baek SC, Nam KH, Yi SA, Jo MS, Lee KH, Lee YH, Lee J*, Kim KH*. Anti-adipogenic Effect of β-Carboline Alkaloids from Garlic (Allium sativum). Foods. 2019 Dec 12;8(12) (* Co-corresponding author)

23.    Lee SR, Yi SA, Nam KH, Ryoo R, Lee J, Kim KH. Pantheric Acids A-C from a Poisonous Mushroom, Amanita pantherina, Promote Lipid Accumulation in Adipocytes. J Nat Prod. 2019 Dec 27;82(12):3489-3493

24.    Nam KH, Yi SA, Nam G, Noh JS, Park JW, Lee MG, Park JH, Oh H1, Lee J, Lee KR, Park HJ, Lee J, Han JW. Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer. BMC Cancer. 2019 Aug 6;19(1):773.

25.    Lee J*, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I*, Wu JC*. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019 Jul 17 (* Co-corresponding author)

26.    Wu H, Yang H, Rhee JW, Zhang JZ, Lam CK, Sallam K, Chang ACY, Ma N, Lee J, Zhang H, Blau HM, Bers DM, Wu JC. Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients. Eur Heart J. 2019 Jun 20.

27.    Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC. Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer. Circulation. 2019 May 21;139(21):2451-2465.

28.    Churko JM, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, Wessells QN, Chen SY, Chen WY5, Chetal K, Mantalas G, Neff N, Jabart E, Sharma A, Nolan GP, Salomonis N, Wu JC. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis Nat Commun. 2018 Nov 21;9(1):4906

29.    Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC. Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. Circulation Research. 2018 Jul 9.

30.    Lee J, Shao NY, Paik DT, Wu H, Guo H, Termglinchan V, Churko JM, Kim Y, Kitani T, Zhao MT, Zhang Y, Wilson KD, Karakikes I, Snyder MP, Wu JC. SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation. Cell Stem Cell. 2018 Mar 1;22(3):428-444

31.    Zhao M, Shao NY, Hu S, Srinivasan R, Jahaniani F, Lee J, Snyder M, Wu, J. Cell type-specific chromatin signatures underline regulatory DNA elements in human induced pluripotent stem cells and somatic cells. Circulation Research. 2017; 121(11):1237-1250.

32.    Churko J, Lee J, Ameen M, Gu M, Diecke S, Sallam K, Im H, Wang G, Gold JD, Salomonis N, Snyder MP, Wu J. Transcriptomic and Epigenomic Differences in Human Induced Pluripotent Stem Cells Generated from Six Reprogramming Methods. Nature Biomedical Engineering. 2017 October 3; 1(10):826-837.

33.    Go GY, Lee SJ, Jo A, Seo DW, Kang JS, Kim YK, Kim SK, Kim SN, Lee J, Bea GU. Ginsenoside Rg1 from Panax ginseng Enhances Myoblast Differentiation and Myotube Growth. Journal of Ginseng Research. 2017; 41(4):608-614.

34.    Lee S, Serpooshan V, Tong X, Venkatraman S, Lee M, Lee J, Chirikian O, Wu JC, Wu SM, Yang F. Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness. Biomaterials. 2017 Jul;131:111-120.

35.    Gu M, Shao NY, Sa S, Li D, Termglinchan V, Ameen M, Karakikes I, Sosa G, Grubert F, Lee J, Cao A, Taylor S, Ma Y, Zhao Z, Chappell J, Hamid R, Austin ED, Gold JD, Wu J, Snyder MP, Rabinovitch M. Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers. Cell Stem Cell. 2017 Apr 6

36.    Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo NA, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC. A Comprehensive TALEN-Based Knockout Library for Generating Human Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Circulation Research. 2017 Feb 28 pii:116.309948.

37.    Yi SA, Um SH, Lee J, Yoo JH, Bang SY, Park EK, Lee MG, Nam KH, Jeon YJ, Park JW, You JS, Lee SJ, Bae GU, Rhie JW, Kozma SC, Thomas G, Han JW. S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis. Molecular Cell. 2016 May 5;62(3):443-52.

38.    Lee JC, Jung S, Ebert A, Wu H, Diecke S, Kim Y, Yi H, Park SH, Ju JH. Generation of functional cardiomyocytes from the synoviocytes of patients with rheumatoid arthritis via induced pluripotent stem cells. Scientific Report. 2016 Sep 9;6:32669.

39.    Park EK*, Lee JC*, Park JW, Bang SY, Yi SA, Kim BK, Park JH, Kwon SH, You JS, Nam SW, Cho EJ, Han JW. Transcriptional Regulation of Cancer Stem Cell Marker CD133 by Tumor Suppresser p53. Cell Death and Disease. 2015 Nov 5;6:e1964. (*These authors contributed equally to this work)

40.    Wu H, Lee JC, Vincent L, Wang Q, Gu M, Lan F, Churko J, Sallam K, Matsa E, Sharma A, Gold J, Engler AJ, Xiang Y, Bers D, Wu J. Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. Cell Stem Cell. 2015 Jul 2;17(1):89-100

41.    Diecke S, Lu J, Lee JC, Termglinchan V, Kooreman NG, Burridge PW, Ebert AD, Churko JM, Sharma A, Kay MA, Wu JC. Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Scientific Report. 2015 Jan 28;5:8081.

42.    Gu M, Mordwinkin N, Kooremen N, Lee JC, Wu H, Hu S, Churko J, Diecke S, Burridge P, He C, Barron F, Ong S, Gold J, Wu J. Pravastatin Reverses Dysfunction of Pre-Diabetic Induced Pluripotent Stem Cell Derived Endothelial Cells via a Nitric Oxide-Dependent Mechanism. European Heart Journal. 2014 Nov 2; Epub

43.    Bang SY, Kwon SH, Yi SH, Yi SA, Park EK, Lee JC, Jang CG, You JS, Lee SH, Han JW. Epigenetic Activation of the Foxa2 Gene Is Required for Maintaining the Potential of Neural Precursor Cells to Differentiate into Dopaminergic Neurons after Expansion. Stem Cells and Development. 2014 Nov 3; Epub

44.    Ebert AD, Kodo K, Liang P, Wu H, Huber BC, Riegler J, Churko J, Lee J, Almeida P, Lan F, Diecke S, Burridge P, Gold J, Mochly-Rosen D, Wu J. Molecular mechanism underlying increased ischemic damage in the ALDH2*2 genetic polymorphism using a human iPSC model system. Science Translational Medicine 2014 Sep 24;6;255

45.    Diecke S, Jung SM, Lee J, Ju JH. Recent technological updates and clinical applications of induced pluripotent stem cells. Korean J Intern Med. 2014 Sep 29(5):547-57

46.    Lee JC, Kim Y, Yi H, Diecke S, Kim J, Jung H, Rim YA, Jung SM, Kim M, Kim YG, Park SH, Kim HY, Ju JH. Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis. Arthritis Research & Therapy. 2014 16(1), R41. [F1000 Prime Recommended: F1000Prime.com/718264480]

47.    Lee JC, Kang SU, Jeon YJ, Park JW, You JS, Ha SW, Bea NH, Lubec G, Kwon SH, Lee JS, Cho EJ, Han JW. Regulation of p53 Activity by Protein L-isoaspartyl Methyltransferase. Nature Commun. 2012 Jun 26;3:927

48.    Park JW*, Lee JC*, Ha SW, Bang SY, Park EK, Yi SA, Lee MG, Kim DS, Nam KH, Yoo JH, Kwon SH, Han JW. Requirement of Protein L-Isoaspartyl Methyltransferase for Transcriptional Activation of Trefoil Factor 1 (TFF1) Gene by Estrogen Receptor Alpha. Biochem Biophys Res Commun. 2012 Apr 6;420(2):223-229 (*These authors contributed equally to this work)

49.    Park JW, Jeon YJ, Lee JC, Ahn SR, Ha SW, Bang SY, Park EK, Yi SA, Lee MG, Han JW. Destabilization of TNF-α mRNA by Rapamycin. Biomolecules & Therapeutics. 2012 Jan;20(1):43-49

50.    Park JW*, Lee JC*, Ahn SR, Seo DW, Choi WS, Yoo YH, Park SK, Choi JY, Um SH, Ahn SH, Han JW. A Fermented Ginseng Extract, BST204, Inhibits Proliferation and Motility of Human Colon Cancer Cells. Biomolecules & Therapeutics. 2011 Apr;19(2):211-217 (*These authors contributed equally to this work)

51.    You JS, Kang Jk, Seo DW, Lee JC, Jeon YJ, Park JW, Park JH, Cho EJ, and Han JW. Depletion of Embryonic Stem Cell-Like Signature by HDACI in NCCIT Cells: Involvement of Nanog Down-Regulation. Cancer Res. 2009 Jul 15;69(14):5716-5725.

52.    Jin HK, Ahn SH, Yoon JW, Park JW, Lee EK, Yoo JS, Lee JC, Choi WS, Han JW. Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation. Biol Pharm Bull. 2009 Jun;32(6):988-992.

53.    Lee EK, Bae GU, You JS, Lee JC, Jeon YJ, Park JW, Park JH, Ahn SH, Kim YK, Choi WS, Kang JS, Han G and Han JW. Reversine Increases the Plasticity of Lineage-Committed Cells Toward Neuroectodermal Lineage. J Biol Chem. 2009 Jan 30;284(5):2891-2901.

54.    You JS, Kang JK, Lee EK, Lee JC, Lee SH, Jeon YJ, Koh DH, Ahn SH, Seo DW, Lee HY, Cho EJ, Han JW. Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells. Oncogene. 2008 Feb 28;27(10):1376- 1386.

55.    Eun DW, Ahn SH, You JS, Park JW, Lee EK, Lee HN, Kang GM, Lee JC, Choi WS, Seo DW, Han JW. PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. Biochem Biophys Res Commun. 2007 Mar 16;354(3):769.

56.    Chun JK, Seo DW, Ahn SH, Park JH, You JS, Lee CH, Lee JC, Kim YK, Han JW. Suppression of the NF-κB Signaling Pathway by Ergolide, Sesquiterpene Lactone, in HeLa cells. J Pharm Pharmacol. 2007 Apr;59(4):561-566.

57.    Kim S, Kang JK, Kim YK, Seo DW, Ahn SH, Lee JC, Lee CH, You JS, Cho EJ, Lee HW, Han JW. Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1168-1173.