Heather grew up in Hugo, Minnesota and attended The College of St. Scholastica, where she double majored in Biochemistry and Biology with a minor in Spanish. As an undergraduate at CSS, Heather did research with Dr. Paul Stein on the effect of anti-oxidants on protein binding kinetics. She earned her M.S. and Ph.D. at the University of Minnesota - Twin Cities under Dr. Edgar A. Arriaga, where she developed novel methodologies for the multi-parametric analysis of autophagy flux at the whole cell and individual organelle levels via mass cytometry. Heather joined the faculty at St. Scholastica in 2018.

Education

University of Minnesota - Twin Cities • Minneapolis, MN • 2015 – 2018

Ph.D. in chemistry

University of Minnesota - Twin Cities • Minneapolis, MN • 2013 – 2015

M.S. in chemistry

The College of St. Scholastica • Duluth, MN • 2006 – 2010

B.S. in biochemistry and biology (minor in Spanish)

Training

NIH Biotechnology Trainee with Dr. Edgar Arriaga

University of Minnesota - Twin Cities • 2013 - 2017

Formulation Chemist

Coloplast • 2012 - 2013

Formulation Chemist

Ecolab • 2010 - 2012

Undergraduate Researcher with Dr. Paul Stein

The College of St. Scholastica • 2010

Selected Publications and Presentations

1. Brown, H.M.G.; Kuhns, M.M.; Maxwell, Z.; Arriaga, E.A., Nonspecific Binding Correction for Single-Cell Mass Cytometric Analysis of Autophagy and Myoblast Differentiation. Anal Chem., 2021, 93(3), 1401–1408.

2. Brown, H.M.G.; Kuhns, M.M.; Arriaga, E.A., High Resolution Interrogation of Biological Systems via Mass Cytometry. In Proteomics for Biological Discovery, 2nd Edition. Yates, J., Veenstra, T, Eds.; Wiley & Sons. In press, Expected April 2019.

3. Brown, H.M.G.; Arriaga, E.A., Quantifying Heterogeneity of Individual Organelles in Mixed Populations via Mass Cytometry. Anal Chem., 2018, 90 (22), 13315-21.

4. Shaklee, J.; Srivastava, K.; Brown, H.; Arriaga, E.; Pierre, V.C.; van Berlo, J.H., Development of a click-chemistry reagent for mass cytometry. Scientific Reports, 2018, 8, 6657.

5. Brown, H.M.G.; Arriaga, E.A., Quantitative multi-dimensional single-cell analysis of autophagy during myogenesis. American Chemical Society National Meeting, New Orleans, LA, UA. March 2018.

6. Bajaj, R.; Huang, Y.; Gebrechristos, S.; Mikolajczyk, B; Brown, H.; Prasad, R.; Varma, A.; Bushley, K., The root endophe Piriformopora indica alters lignin and phenylpropanoid metabolism of Glycine max. Scientific Reports, 2018, 8, 10227.

7. Arriaga, E.A.; Brown, H.M.G.; Muratore, K.A.; Wilson, T., Comparative Analysis of Subcellular Organelles Using Capillary Electrophoresis, Mass Cytometry, and Particle Tracking. Pittcon, Orlando, FL, USA. February 27, 2018.

8. Grundhofer, H. Antimicrobial Cleanser. Coloplast Corporation. US Patent 9,636,286, May 2, 2017.

9. Brown, H.M.G.; Arriaga, E.A., Detecting Age-Related Changes in Individual Organelle Populations via Multi-Dimensional ICP-MS Analysis. MUACC, Athens, OH, USA. October 20, 2017.

10. Arriaga, E.A.; Sachs, Z.; Grundhofer, H.M., Mass Cytometry: A new paradigm to interrogate mixed cell populations. Invited presentation, University of Calgary, Calgary, Alberta, CA. December 6, 2016.

11. Grundhofer, HM; Kuhns, M.M.; Arriaga, E.A.; Mass Cytometry for the Quantification of Autophagy in Individual Cells. SciX, Minneapolis, MN , USA. September 21, 2016.

12. Muratore, K.A.; Grundhofer, H.M.: Arriaga, E.A., Capillary Electrophoresis with Laser-Induced Fluorescent Detection of Immunolabeled Individual Autophagy Organelles Isolated from Liver Tissue. Anal Chem. 2016, 88 (23), 11691-8.

13. Grundhofer, H.M.; Arriaga, E.A., Mass Cytometry for the Quantification of Macroautophagy in Individual Cells. Graduate Student Research Symposium, University of Minnesota, Minneapolis, MN, USA. June 7, 2016.

14. Grundhofer, H.M.; Arriaga, E.A., A Quantitative Approach to Analyzing Autophagy: from single-cell proeomics to individual organelle analysis. Invited presentation. NAIST, Nara, JP. October 29, 2015.

15. Grundhofer, H.M.; Adventures in Analyzing Multiparametric Mass Cytometry Data: A Practical Guide. Invited Presentation. Minnesota Supercomputing Institute User Group, University of Minnesota, Minneapolis, MN, USA. May 27, 2015.

16. Arriaga, E.A.; Kuhns, M.M.; Grundhofer, H.M.; Satori, C.P., Teasing apart cellular self-eating: From individual organelle analysis to single cell proteomics. Invited Presentation, Dalhousie University, Halifax, Nova Scotia, CA. May 15, 2015.

17. Grundhofer, H.M.; Kuhns, M.M.; Arriaga, E.A., Using Mass Cytometry for the Proteomic Analysis of Single Skeletal Muscle Fibers. Pittcon, New Orleans, LA, USA. March 10, 2015