Publications
MAIN AUTHOR PAPERS:
1. Lee YS, Lee HH, Park J, Yoo EJ, Glackin CA, Choi YI, Jeon SH, Seong RH, Park SD, and Kim JB. Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Research 31:7165-7174. 2003. 12.
(Research Article)
2. Lee YS, Koh HY, Park SD and Kim JB. Identification of Ku70/Ku80 as ADD1/SREBP1c interacting proteins. Korean Journal of Biological Sciences 8:49-55. 2004
(Research Article)
3. Lee YS#, Kim WS# (#, co-first authors), Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye J-M, Lee CH, Oh WK, Kim CT, Beherns CH, Gosby A, Kraegen EW, James DE*, and Kim JB* (*, co-corresponding authors). Berberine, a natural plant product, activates AMPK with beneficial metabolic effects in diabetic and insulin resistant states. Diabetes 55:2256-2264 2006. 8. (*, co-1st authors)
(Research Article)
4. Lee YS, Sohn DH, Han D, Lee HW, Seong RH, and Kim JB. Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression. Molecular and Cellular Biology.27(2):438-52. 2007. 1.
(Research Article)
5. Lee YS, Kim AY, Choi JW, Kim M, Yasue S, Son HJ, Masuzaki H, Park KS, Kim JB. Dysregulation of adipose GPx3 in obesity contributes to local and systemic oxidative stress. Molecular Endocrinology 22(9):2176-89. 2008. 9.
(Research Article)
6. Kim WS#, Lee YS#, Cha SH# (#, co-first authors), Jeong HW, Choe SS, Lee MR, Oh GT, Park HS, Lee KU, Lane MD, Kim JB. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. American Journal of Physiology Endocrinology and Metabolism 296(4):E812-9. 2009. 4.
(Research Article)
7. Lee YS, Choi JW, Hwang I, Lee JW, Lee JH, Kim AY, Huh JY, Koh YJ, Koh GY, Son HJ, Masuzaki H, Hotta K, Alfadda AA, Kim JB. Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation. Journal of Biological Chemistry 285(29):22174-85. 2010. 7.
(Research Article)
8. Lee YS#, Li P#, Huh JY# (#, co-first authors), Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GT, Schwendener R, Olefsky M, and Kim JB. Inflammation Is Necessary for Long-Term but not Short-Term HFD-Induced Insulin Resistance. Diabetes 60(10):2272-83. 2011. 10.
(Research Article)
9. Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshiwani M, Perkins G, Dong H, Kayali AG, Sweet I, Olefsky JM. The Fractalkine and CX3CR1 System Regulates Beta Cell Function and Insulin Secretion. Cell 153(2):413-425. 2013. 4. (PMID: 23582329)
(Research Article)
10. Lee YS#, Kim J-W# (#, co-first authors), Osborne O, Oh DA, Sasik D, Schenk S, Chen A, Chung H, Murphy A, Watkins SM, Quehenberger O, Johnson RS*, Olefsky JM* (*, co-corresponding authors). Increased Adipocyte O2Consumption Triggers HIF-1alpha Causing Inflammation and Insulin Resistance in Obesity. Cell 157(6):1339-1352. 2014. 6. (PMID: 24906151)
(Research Article)
11. Lee YS, Wollam J, Olefsky JM. An Integrated View of Immunometabolism. Cell 172:22-40. (2018. 01)(PMID: 29328913)
(Review Article) (Featured Article of The Issue)
12. Riopel M#, Seo JB# (#, co-first authors), Bandyopadhyay GK, Li P, Wollam J, Chung H, Jung S-R, Murphy A, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Koh D-S, Larson CJ, Olefsky JM* and Lee YS* (*, co-corresponding authors). Chronic Fractalkine Administration Improves Glucose Tolerance and Pancreatic Endocrine Function. Journal of Clinical Investigation 128:1458-1470. (2018. 04) (PMID: 29504946)
(Research Article)
13. Seo JB, Riopel M, Cabrales P, Huh JY, Andreyev AY, Murphy A, Beeman SC, Smith GI, Klein S, Lee YS* and Olefsky JM* (*, co-corresponding authors). Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity. Nature Metabolism. (2018. 11) (Doi: 10.1038/s42255-018-0003-x; PMID: 31528845) (highlighted in Nature, Doi: 10.1038/d41586-018-07248-6, and also in Nature Reviews Endocrinology, Doi: 10.1038/s41574-018-0140-z)
(Research Article)
14. Riopel M, Vassallo M, Ehinge E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum J, Olefsky JM*, Lee YS* (*, co-corresponding authors). Fractalkine-Fc Treatment Prevents Atherosclerosis in Ldlr KO mice. Molecular Metabolism 20:89-101 (2019. 02). (Doi: 10.1016/j.molmet.2018.11.011). (PMID: 30553772)
(Research Article)
15. Ying W#, Lee YS# (#, co-first authors), Dong Y, Seo JB, Yang M, Seidman JS, Yang B-H, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM* and Fu W* (*, co-corresponding authors). Macrophages Lead to Islet Inflammation by Local Proliferation and Impact Beta Cell Proliferation and Function in Obese Mice. Cell Metabolism 29:1-18 (2019. 02). (Doi: 10.1016/j.cmet.2018.12.003) (PMID: 30595478)
(Research Article)
16. Lee YS* (*, Single Senior/Corresponding Author), Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α Ablation Improves Obesity-Induced Glucose Intolerance by Reducing First Pass GLP-1 Degradation. Science Advances 5(7):eaaw4176 (2019. 07). (DOI: 10.1126/sciadv.aaw4176) (PMID: 31281892)
(Research Article)
17. Ying W#, Fu W#, Lee YS# (#, co-first authors), Olefsky JM. The role of macrophages in obesity-associated islet inflammation and beta cell abnormalities. Nature Reviews Endocrinology 16(2):81-90 (2020.02) (PMID: 31836875)
(Review Article)
18. Riopel M#, Moon J-S# (#, co-first authors), Bandyopadhyay GK, Gustafson TA, Whaley J, Hedrick J, Patch R, Camacho R, You S, Lam K, Lui X, Kisseleva T, Brenner D, and Lee YS. Inhibition of Prolyl Hydroxylases Improves Glucose Tolerance by A HIF-2a-Dependent Mechanism to Increase Hepatic Insulin And Decrease Glucagon Sensitivity. Molecular Metabolism 41:101039 (2020.11) (PMID: 32534258)
(Research Article)
19. Lee YS and Olefsky J. Chronic Tissue Inflammation and Metabolic Disease. Genes and Development 35:307-328 (2021.03) (PMID: 33649162).
(Review Article)
20. Moon J-S, Cunha F, Huh JY, Andreyev AY, Lee J, Mahata SK, Reis FCG, Nasamran CA, and Lee YS. ANT2 drives proinflammatory macrophage activation in obesity. JCI Insight 6:e147033 (2021.10) (PMID: 34676827)
(Research Article)
21. Moon J-S, Riopel M, Seo JB, Herrero-Aguayo V, Isaac R, Lee YS. HIF-2α Preserves Mitochondrial Activity And Glucose Sensing in Compensating Beta Cells in Obesity. Diabetes 71(7):1508-1524 (2022.07) (PMID: 35472707; PMCID: PMC9233300) (DOI: 10.2337/db21-0736)
(Research Article)
22. Lee YS. The Mechanism for Adipose Endotrophin Production. Diabetes 71(8):1617-1619 (2022.08). (PMID: 35881834)
(Commentary)
23. Lee YS and Olefsky J. Eating macrophages for a healthy fatty meal. Immunity 56(1):3-5 (2023. 01) (Doi: 10.1016/j.immuni.2022.12.011)
(Commentary)
COLLABORATORY PAPERS:
24. Seo JB, Lee YS, Moon H, and Kim JB. A Novel Mechanism of Adipocyte Differentiation and Lipid Metabolsim. Kor. Diabetes 27:31-36. (2003.)
(Research Article)
25. Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MK, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, and Kim JB. Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of PPARgamma Expression. Molecular and Cellular Biology 24:3430-3444. (2004. 04.)
(Research Article)
26. Seo JB, Moon HM, Noh MJ, Lee YS, Jeong HW, Yoo EJ, Kim WS, Park J, Youn BS, Kim JW, Park SD, and Kim JB. Adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element-binding protein 1c regulates mouse adiponectin expression. Journal of Biological Chemistry 279:22108-22117. (2004. 05.)
(Research Article)
27. Cho HJ, Park J, Lee HW, Lee YS, and Kim JB. Regulation of Adipocyte Differentiation and Insulin Action with Rapamycin. Biochemical and Biophysical Research Communications 321:942-948. (2004. 09.)
(Research Article)
28. Park JY, Rho HK, Kim KH, Choe SS, Lee YS, and Kim JB. Overexpression of Glucose-6-Phosphate Dehydrogenase is Associated with Lipid Dysregulation and Insulin Resistance in Obesity. Molecular and Cellular Biology 25:5146-5157. (2005.06)
(Research Article)
29. Kim MK, Lee JH, Kim H, Park SJ, Kim SH, Kang GB, Lee YS, Kim JB, Kim KK, Suh SW, and Eom SH. Crystal Structure of Visfatin/Pre-B Cell Colony-enhancing Factor 1/Nicotinamide Phosphoribosyltransferase, Free and in Complex with the Anti-cancer Agent FK-866. Journal of Molecular Biology 8;362(1):66-77. (2006. 09.)
(Research Article)
30. Lee HW, Suh JH, Kim AY, Lee YS, Park SY and Kim JB. HDAC1-Mediated Histone Modification Regulates Osteoblast Differentiation. Molecular Endocrinology 20(10):2432-43. (2006.10.)
(Research Article)
31. Chung SS, Kim M, Youn BS, Lee NS, Park JW, Lee IK, Lee YS, Kim JB, Cho YM, Lee HK, Park KS. Glutathione peroxidase 3 mediates the antioxidant effect of PPAR{gamma} in human skeletal muscle cells. Molecular and Cellular Biology 29(1):20-30. (2009.01.)
(Research Article)
32. Kim SY, Kim AY, Lee HW, Son YH, Lee GY, Lee JW, Lee YS, Kim JB. miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochemical and Biophysical Research Communications 392(3):323-8. (2010.02.)
(Research Article)
33. Okada S, Kozuka C, Masuzaki H, Yasue S, Ishii-Yonemoto T, Tanaka T, Yamamoto Y, Noguchi M, Kusakabe T, Tomita T, Fujikura J, Ebihara K, Hosoda K, Sakaue H, Kobori H, Ham M, Lee YS, Kim JB, Saito Y, Nakao K. Adipose tissue–specific dysregulation of angiotensinogen by oxidative stress in obesity. Metabolism 59(9):1241-51. (2010.09.) (Research Article)
34. Kim AY, Lee YS, Kim KH, Lee JH, Lee HK, Jang SH, Kim SE, Lee GY, Lee JW, Jung SA, Chung HY, Jeong S, Kim JB. Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation. Molecular Endocrinology 24(7):1441-52. (2010.07.)
(Research Article)
35. Alfadda AA, Fatma S, Chishti MA, Al-Naami MY, Elawad R, Mendoza CD, Jo H, Lee YS. Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans. Mol. Cells 33(1):35-41. (2012.01.)
(Research Article)
36. Kim J-W, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, and Johnson RS. Loss of fibroblast HIF-1α accelerates tumorigenesis. Cancer Research 72:3187-3195. (2012.06.)
(Research Article)
37. Huh JY, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, Lee DS, Park SH, Seong RH, Choi CS, Kim JB. A novel function of adipocytes in lipid antigen presentation to iNKT cells. Mol. Cell Biol. 33(2):328-339. (2013.01.)
(Research Article)
38. Guo Y, Darshi M, Ma Y, Perkins GA, Shen G, Chen A, Lee YS, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. Quantitative Proteomic Analysis of Liver Mitochondria from High Fat Diet Diabetic Mice. Molecular and Cellular Proteomics 12(12):3744-3758. (2013.12.) (PMID:24030101)
(Research Article)
39. Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky JM, Sams A, Klip A. Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans. Obesity 22(3):747-757. (2014.03.) (PMID: 24030890)
(Research Article)
40. Chung H, Lee YS, Siu JT, Oh DY, Mayoral R, Webster NJ, Sears DD, Olefsky JM, Ellies LG. Omega-3 fatty acids reduce obesity-induced tumor progression independently of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene, 34(27):3504-3513. (2015.07.) (PMID: 25220417).
(Research Article)
41. Kim JI, Huh JY, Sohn JH, Choe SS, Lee YS, Lim CY, Jo A, Park SB, Han W, Kim JB. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Molecular and Cellular Biology 35(10):1686-1699. (2015.05.) (PMID:25733684)
(Research Article)
42. McNelis J, Lee YS, Mayoral R, Kant Rik van der, Johnson A, Wollam J, Olefsky JM. GPR43 potentiates beta cell function in obesity. Diabetes 64(9):3203-3217. (2015. 09.) (PMID: 26023106)
(Research Article)
43. Borgeson E, Johnsson A, Lee YS, Hussain Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Charlie N. Serhan CN, Sharma K, Godson C. Lipoxin A4 attenuates obesity-induced adipose inflammation and associated liver and kidney disease. Cell Metabolism 22(1):125-137. (2015.07) (PMID: 26052006)
(Research Article)
44. Ying W, Wollam J, Ofrecio J, Bandyopadhyay G, Ouarrat DE, Lee YS, Oh DY, Li P, Osborn O, Olefsky JM. Adipose tissue B2 cells promote insulin resistance through an LTB4/Ltb4r1 mechanism. Journal of Clinical Investigation 127(3):1019-1030. (2017.03.) (PMID:28192375)
(Research Article)
45. Wollam J, Xu Y-J, Johnson AMF, Ofrecio JM, Ying W, Riopel M, Ouarrat D, Chan LS, Han AW, Mahmood NA, Ryan CN, Lee YS, Watrous JD, Chordia MD, Pan D, Jain M, Olefsky JM. The microbiota-produced N-formyl peptide fMLF promotes obesity-induced glucose intolerance. Diabetes 68(7):1415-1426. (2019.07.) (Doi: 10.2337/db18-1307) (PMID: 31010956)
(Research Article)
46. Lackey D, Isaac R, Ouarrat DE, Lee YS, Reis FCG, Bandyopadhyay G, Ofrecio J, Oh DY, Osborn O. Adipocyte PU.1 knockout promotes insulin sensitivity in chronic HFD-fed obese mice. Scientific Reports 9(1):14779. (2019.10.) (PMID: 31611602)
(Research Article)
47. Ouarrat DE*, Isaac R* (*, co-first authors), Wollam J, Lackey D, Riopel M, Lee YS, Bandyopadhyay G, Sampath-Kumar R, Olefsky JM. Adipocyte Taz is a negative regulator of PPARg activity, insulin sensitivity and glucose tolerance. Cell Metabolism 31(1):162-173.e5. (2020.01.) (PMID: 31708444)
(Research Article)
48. Si R, Cabrera JT, Tsuji-Hosokawa A, Gao L, Guo R, Watanabe M, Lee YS, Moon J-S, Scott B, Wang J, Ashton A, Rao J, Yuan J, Wang J-Y, Makino A. HuR-mediated posttranscriptional modification of Cx40 and coronary microvascular dysfunction in type 2 diabetes. JCI Insights, 6(21):e147982. (2021.11.) (PMID: 34747371)
(Research Article)