Infectious disease prevention and control, and prediction face challenges such as diverse data sources, incomplete data, and complex systems. To effectively respond to the epidemic, it is necessary to integrate multi-source data and adopt a variety of modeling and analysis methods to achieve prevention, prediction, and intervention of the epidemic. This research framework aims to enhance the understanding and control of epidemic spread through the integration of databases, statistical and machine learning modeling, dynamic system prediction, and the evaluation of intervention effects. This framework is not only suitable for analyzing high-uncertainty time series data but can also be extended to other complex systems that require real-time modeling.