The song received mixed reviews from most music critics. For Entertainment Weekly, Kyle Anderson praised its "sweet" Mars' hook; with "'song of summer' written all over it", it "could have been a graduation anthem for stoners everywhere" if it was released in May.[14] MTV's Jenna Rubenstein gave the song a generally-positive review as more than a "reckless party jam"; the three singers are not bothered by the judgments of others, and "that's the positive, family-friendly message we're taking".[13] Billboard magazine gave it three-and-a-half out of five stars, calling it "a haze of nostalgia". The review praised Snoop Dogg's effortless flow, but called Whiz Khalifa's delivery "forceful" and "punchy"; it "gets on top of the beat and harshes the mellow laid-back production."[6] In a similar review, Lewis Corner of Digital Spy praised Dogg's verses and called the single "cool and addictive"; however, he found the song's "flavor" short-lived.[11] In a negative review, Shea Serrano of LA Weekly compared the track's atmosphere to the "inside of a cloud (smoke), a celebration or idea of what some teenagers who smoke pot would like". Serrano noted, ironically, that the song's performers were neither young, wild nor free.[22]
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Background: Tooth loss is closely associated with Alzheimer's disease (AD). Previously, we reported that tooth loss induced memory impairment in amyloid precursor protein knock-in mice by decreasing neuronal activity and synaptic protein levels and increasing glial activation, neuroinflammation, and pyramidal neuronal cell loss without altering amyloid- levels in the hippocampus. However, the effects of tooth loss in young wild-type mice have not been explored yet.
Objective: We investigated the effects of tooth loss on memory impairment, neuronal activity, synaptic protein levels, glial activation, and pyramidal neuronal cell loss in young wild-type mice.
Methods: Two-month-old wild-type mice were randomly divided into control and tooth loss groups. In the tooth loss group, maxillary molar teeth on both sides were extracted, whereas no teeth were extracted in the control group. Two months after tooth extraction, we performed a novel object recognition test to evaluate memory function. Glial activation, neuronal activity, synaptic protein levels, and the number of pyramidal neurons were evaluated using immunofluorescence staining, immunohistochemistry, and western blotting.
Conclusion: Tooth loss in the young wild-type mice will attenuate neuronal activity, decrease synaptic protein levels, and induce pyramidal neuronal loss, and eventually lead to memory impairment.
Finally, we present the kinematic properties of a few prototypical systems in Fig. 5. We selected two young (< 30 Myr) clusters, namely NGC 6193 and NGC 4103, and two older systems, LP 2219 and NGC 3114. Within each group, we picked one system showing significant evidence of expansion (NGC 6193 and LP 2219), whereas the other one is compatible with equilibrium (NGC 4103 and NGC 3114). Relevant cluster properties are reported in Table 1 for reference.
The reference age compilation adopted in this analysis is the one by Cantat-Gaudin et al. (2020). Here we test the robustness of our results against different compilations of clusters ages from literature. In particular, we used cluster ages obtained by Kharchenko et al. (2013), Bossini et al. (2019), and Dias et al. (2021) determined ages for several star clusters in our Galaxy through isochrone fitting. We note that Kharchenko et al. (2013) exploited pre-main-sequence stars as a further age indicator to obtain more reliable ages in the young end. Hunt & Reffert (2023), performed an all-sky search for open clusters and they provided ages for every cluster in their sample obtained by means of a convolutional neural network. We crossmatched the sample of 509 clusters adopted in this study with these catalogs.
In summary, the excellent agreement with previous, detailed studies that focused on a handful of systems suggests that our results are solid and that we are effectively probing the expansion of young stellar clusters.
Changing the conversation around mental health requires advocacy at every level. We partnered with Active Minds to share this important content about the role youth and young adults play in mental health legislation.
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