Learning and psychiatric disorders from the synapse level

Humans accumulate vast amounts of information in their brains to adapt to today's complex society. Synaptic plasticity may play a major role for the information storage for adaptation especially since adolescent period when the physical development of the brain reaches to adult level. Instead, dysfunction of the adaptation process may cause several psychiatric disorders, whose onsets are frequent in this periods and which often involves synaptic function and brain regions relevant to the adaptive learning. Importantly, the brain are required not only to  passively internalize environmental structure but also to actively infer and explore for genuine adaptation. Thus, we utilize the cutting-edge techniques to clarify mechanisms of adaptive learning from synapse to behavior in mice, and aim to understand psychiatric disorders from a new perspective, where predisposition in brain dysfunction and environmental information interact at synapses to cause psychiatric disorders.


Department of Structural Physiology,

Center for Disease Biology and Integrative Medicine,

Graduate School of Medicine

Faculty of Medicine Education and Research Bldg N202, 

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 JAPAN


〒113-0033 東京都文京区本郷7-3-1 医学部教育研究棟N202

TEL   +81-(0)3-5841-1441

FAX  +81-(0)3-5841-1442 

Last update: Jan, 2024