Dr. Xingcai Zhang

Selected Publication (H-index:75+, Citation: 16000+, Nature/Science family:27+ (including 15+ Corresponding)).

†: equal contribution; *: Corresponding.

27.    W Peng, Y Du, L Cui, Y Xiao, L Li, L Yan, Y Gu, L Zhang, B Li, Z Wang, H Wang, X Dai, Y Teng, T Wang, B Zheng, X Zhang*. Bioorthogonal optimized virus immuno-nanomedicine (BOVIN). Nature Communications, 2025, Nature Communications, 2025, 16, https://doi.org/10.1038/s41467-025-66089-w.

26.     F Dai, S Yao, M Wang, Y Zhu, X Qiu, Q Sun, J Yin, G Shen, J Sun, M Wang, Y Wang, Z Yang, J Sang, X Wang, F Sun*, WCai*, X Zhang*, H Lu*. Improving AI Models for Rare Thyroid Cancer Subtype by Text Guided Diffusion Models. Nature Communications, 2025, 16, 4449.

25.      S Koehler, Y Ling, S Yu, Y Zhang, J Luo, K Chen, J Luo, J Zeng, F Wang, W Li, D Li, X Yu, X Wu, S Zhao, H Lu, Z Deng, Z Yang, R Mai, Z Liu, X Huang, C Xing, W Zhang, H Chu, X Zhang, X Peng, Y Hu, G Yiming, Q Chen, H Yang, T Hermans, X Liao, X Qu, Z Niu, Y Qin. Fast, cost-effective and flexible DNA sequencing by roll-to-roll fluidics. Nature Methods, 2025, 22, 1662. (Featured cover paper)

24.       S Zhang, Q Zhang, X Liu, S Zhang, J Yue, M Lu, H Xu, J Yao, X Wei, J Cao, X Zhang, M Gao, J Shen, Y Hao, X Zhang, P Zhang, S Cui, Y Wang, S Wu, G Wang. Training Foundation Model Like an Expert Radiologist Towards Open-World Medical Segmentation. Nature Biomedical Engineering, 2025, 16, 7866.

23.       J Wang, J Feng, Y Kang, P Pan, J Ge, Y Wang, M Wang, Z Wu, X Zhang, J Yu, X Zhang, T Wang, L Wen, G Yan, Y Deng,H Shi, C-Y Hsieh, Z Jiang, T Hou. Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model. Science Advances, 2025, 11, ads8932. (ESI Top 1% highly cited paper)

22.       M Yu, W Li, Y Yu, Y Zhao, L Xiao, V M Lauschke, Y Cheng*, X Zhang*, Y Wang*. Deep learning large-scale drug discovery and repurposing. Nature Computational Science, 2024, 4, 600. (Nature research briefing paper) 

21.       X Zhang*, Y Wang. AI-Recognized Mitochondrial Phenotype Enables Identification of Drug Targets. Nature Computational Science, 2024, 4, 563. (Invited highlight)   

20.       B Zheng, Q Li, Y Liu, X Cai, B Li, Z Wu, Y Bai, B Shen, S Cheng*, X Zhang*. Microorganism Microneedle Microengine Depth Drug Delivery. Nature Communications, 2024, 15, 8947.  

19.      X Li, Y Hu, X Zhang*, X Shi, W J Parak*, A Pich*. Transvascular transport of nanocarriers for tumor delivery. Nature Communications, 2024, 15, 8172.  

18.      T Li, N Yang*, Y Xiao, Y Liu, X Pan, S Wang, F Jiang, Z Zhang, X Zhang*. Virus detection light diffraction fingerprints forbiological applications. Science Advances, 2024, adl3466. (Featured cover paper)

17.     H Lv, Y Yao, G Chen, Y Wang, L Rao, S Li, U I Kara, R L Dupont, C Zhang, B Chen, B Liu, X Zhou, R Wu, S Adera, R Che*, X Zhang*, X Wang*. Functional nanoporous graphene superlattice. Nature Communications, 2024, 15, 1295. (ESI Top 0.1% highly cited paper)

16.     Z He, W Chen, K Hu, Y Luo, X He, T Li, J Ouyang, L Xie, Y Zhang, Q Xu, S Yang, M Guo, W Zou, Y Li, L Huang, N Kong, X Zhang, Q Saiding, M Zhang, X Song*, W Tao*. Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment. Nature Nanotechnology, 2024, 19, 1386. (ESI Top 1% highly cited paper) 

15.     Y Wang, G Zheng*, N Jiang, G Ying, Y Li, X Cai, B Liu, J Meng, L Mai, M Guo, Y S Zhang, X Zhang*. Nature- inspired micropatterns. Nature Reviews Methods Primers, 2023, 3, 68. (Invited Featured paper, Hero Image Cover) (AI for materials/medicine)  

14.     Z Yang, D Gao, J Zhao, G Yang, M Guo, Y Wang, X Ren, J S Kim, L Jin, Z Tian, X Zhang*. Thermal Immuno- Nanomedicine in Cancer. Nature Reviews Clinical Oncology, 2023, 20, 116-134. (Featured cover paper, ESI Top 0.1% Highly Cited Paper) (AI for biomedicine)

13.     B Wang, Y Li, M Zhou, Y Han, M Zhang, Z Gao, Z Liu, P Chen, W Du, X Zhang*, X Feng*, B Liu*. Smartphone- based platforms implementing microfluidic detection with image-based artificial intelligence. Nature Communications, 2023, 14, 1341. (News Release Paper, AI for biomedicine, ESI Top 1% highly cited paper)

12.     X Huang†, N Kong†, X Zhang†, Y Cao*, R Langer*, W Tao*. The landscape of mRNA nanomedicine. Nature Medicine,2022, 28, 2237. (Featured article by Nature Medicine, collected in the Nature Portfolio Nobel Prize in Physiology or Medicine 2023 collection, Top 0.1% Hot Paper, Highly Cited Paper)

11.     D Zhang, D Zhong, J Ouyang, J He, Y Qi, W Chen, X Zhang*, W Tao*, M Zhou*. Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy. Nature Communications, 2022, 13, 1413.(ESI Top 1% highly cited paper) (Nature materials for medicine)

10.     Y Gu, C Wang, N Kim, J Zhang, T M Wang, J Stowe, R Nasiri, J Li, D Zhang, A Yang, L H H Hsu, X Dai, J Mu, Z Liu, M Lin, W Li, C Wang, H Gong, Y Chen, Y Lei, H Hu, Y Li, L Zhang, Z Huang, X Zhang, S Ahadian, P Banik, L Zhang, X Jiang, P J Burke, A Khademhosseini, A D McCulloch, S Xu* Three-dimensional transistor arrays for intra- and inter-cellular recording. Nature Nanotechnology, 2022,17, 232-300. (Featured cover paper, Highlighted paper)

9.       X Huang, E Kon, X Han, X Zhang, N Kong, M J Mitchell*, D Peer*, W Tao*. Nanotechnology-based strategies againstSARS-CoV-2 variants. Nature Nanotechnology, 2022,17,1027. (Featured by Nature Nanotechnology, Highlighted in the Nature Portfolio "Progress towards the Sustainable Development Goals" Collection)

8.        F Xu, C Qu, Q Lu, J Meng, X Zhang, X Xu, Y Qiu, B Ding, J Yang, F Cao, P Yang, G Jiang, S Kaskel, J Ma, L Li, X Zhang*, H Wang*. Atomic Sn–enabled high-utilization, large-capacity, and long-life Na anode. Science Advances, 2022, 8(19), eabm7489.

7.     D Zhong, D Zhang, W Chen, J He, C Ren, X Zhang, M Zhou. Orally deliverable strategy based on microalgal biomass for intestinal disease treatment.Science Advances, 2021, 7, eabi9265.(Featured cover paper)

6.      Y Yang, X Wei, N Zhang*, J Zheng, Q Wen, X Luo, C Lee, X Liu, X Zhang*, J Chen, C Tao, W Zhang*, X Fan*. Editor's highlighted top paper: A non-printed integrated-circuit textile for wireless theranostics. Nature Communications. 2021, 12, 4876. (Featured highlighted Paper, editor`s selection for top “Device” paper, Top 0.1% highly cited Hot Paper) 

5.      N Kong, H Zhang, C Feng, C Liu, Y Xiao, X Zhang, L Mei, JS Kim, W Tao, X Ji. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nature Communications, 2021, 12(1), 4777. (Top 0.1% highly cited Hot Paper)  

4.       X Ji, L Ge, C Liu, Z Tang, Y Xiao, Z Lei, W Gao, S Blake, D De, X Zeng*, N Kong*, X Zhang*, W Tao*. Capturing functionaltwo-dimensional nanosheets from sandwich-structure vermiculite: synthesis and application in cancer theranostics. Nature Communications, 2021,12,1124. (Highlighted in Nature Bioengineering Community, Top 0.1% highly cited Hot Paper) (2D/Nature materials, traditional medicine modernization)

3.      J Ouyang†, X Ji†, X Zhang†, C Feng, Z Tang, N Kong, A Xie, J Wang, X Sui, L Deng, Y Liu, J S Kim, Y Cao, W Tao*.In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment. PNAS, 2020, 117 (46), 28667-28677. (Web of Science Top 0.1% highly cited Hot Paper, Highlighted by: MRS)

2.     Z Tang†, N Kong†, X Zhang†, Y Liu, P Hu, S Mou, P Liljeström, J Shi, W Tan, J S Kim, Y Cao, R Langer, K W Leong, O C Farokhzad,* W Tao*. A materials-science perspective on tackling COVID-19. Nature Reviews Materials, 2020, 5, 847-860. (Featured Cover Paper, accessed>40,000 times, Top 1% highly cited paper)

1.     M S Chowdhury, W Zheng, S Kumari, J Heyman, X Zhang, P Dey, D Weitz, R Haag. Dendronized fluorosurfactant for highly stable water-in-fluorinated oil emulsions with minimal inter-droplet transfer of small molecules. Nature Communications, 2019, 10, 4546.