Abstracts

1

Agustin Ormazabal, Juliana Isabel Palma and Gustavo Pierdominici-Sottile

Study on the conformational diversity of the RsmE - RsmZ sRNA/protein complex by performing Molecular Dynamics Simulations

2

Marcelo Caparotta, Diego Bustos and Diego Masone

Intrinsic disorder in α-synuclein: Effects on bending lipid bilayers

3

Diego Zavallo, Juan Manuel Crescente, Magdalena Gantuz, Leone Melisa, Leonardo Vanzetti, Ricardo Masuelli and Sebastian Asurmendi

Genomic re-assessment of the transposable element landscape of the potato genome

4

Estefania Mancini, Malgorzata Rogalska and Juan Valcárcel Juárez

Reconstruction of splicing regulatory network

5

Marina Uhart, Luis G Moyano, Diego Masone and Diego M Bustos

Intrinsic structural disorder on proteins is involved in the interactome evolution

6

Dario Elias, Lucas Gimenez, Hugo Krupitzki, Fernando Poletta, Mariana Piola and Jorge Lopez Camelo

Topic modelling of preterm birth

7

Dario Elias, Hebe Campaña, Mónica Rittler, Viviana Cosentino, Fernando Poletta, Rita Santos, Mariela Pawluk, Lucas Gimenez, Julia Ratowiecki, Juan Gili and Jorge Lopez Camelo

Congenital anomaly associations: a graph theory approach

8

Matyas Pajkos and Zsuzsanna Dosztanyi

A novel motif centric protein alignment method

9

Dario Rocha, Aldana González Montoro, Laura B Prato and Elmer Fernandez

Breast cancer molecular subtypes with uncertainty assessment in a pan-cancer context

10

Salvador Nicosia, Sebastian Moschen, Paula Fernandez and Francisco Astigueta

Genómica funcional del proceso de senescencia foliar: Análisis bioinformatico del fenotipado masivo de líneas transgénicas que sobreexpresan genes de girasol promotores de la senescencia foliar

12

Nicolás Palopoli, Julia Marchetti, Cristian Emanuel Guisande Donadio, Alexander Monzon, Maria Silvina Fornasari, Silvio Tosatto and Gustavo Parisi

Ensemble-derived structural constraints shape evolutionary rate heterogeneity in disordered regions of proteins

13

Iván Gabriel Peros, Carolina Susana Cerrudo, Marcela Pilloff, Mariano Nicolás Belaich, Mario Lozano and Pablo Daniel Ghiringhelli

Comprehensive bioinformatic analysis of the 3 ’end of baculoviral genes

14

Jonathan Raad, Georgina Stegmayer and Diego Milone

Improving pre-miRNA prediction with complexity measures of the mature and deep learning

15

Bálint Mészáros, András Zeke, Borbála Hajdu-Soltész and Zsuzsanna Dosztanyi

Intrinsic protein disorder requires new targeting strategies in cancer

16

Sergio Gonzalez, Maximo Rivarola, Sergio Lew and Norma Paniego

Assessing bioinformatics strategies for de-novo transcriptome assembly

17

Ana Julia Velez Rueda, Leandro Matías Sommese, Sebastián M. Ardanaz, Guillermo Ignacio Benítez, Luis E Iglesias and Gustavo Parisi

To be or not to be: the promiscuity dilemma in serum albumins

18

Maximiliano Estravis Barcala, Tomás Moyano, Carolina Soliani, María Verónica Arana, Rodrigo A. Gutiérrez and Nicolás Bellora

Nothofagus pumilio (Lenga) genome sequencing as a resource for interdisciplinary and systemic studies in a context of Global Climate Change

19

Matias Miranda, Dario Rocha, M. Romina Girotti, Yamil D. Mahmoud, A. Fernandez Elmer, M. Alejandra Bosio, Gustavo Chiodi and Laura Prato

MIXTUREpy: A machine learning based method for immuno content characterization of tumor samples in python

20

Guillermo Ignacio Benítez, Ana Julia Velez Rueda, Juliana Glavina, Patricio Chinestrad, Felipe Tau, Martín Salas, Silvina Fornasari, Gustavo Parisi, Nicolás Palopoli and Leandro Matías Sommese

Bioinformatics goes to School: From the lab to the classroom, hand in hand with the teachers.

21

Patricio Chinestrad, Pablo Lorenzano Menna, Nazareno González, Georgina A. Cardama, Javier Robles-Valero, Sonia Rodríguez-Fdez, Luis Francisco Lorenzo-Martín, Xosé R. Bustelo and Daniel E. Gomez

Computational prediction of the conformational diversity impact on Rac1 and it’s novel inhibitor 1A-116 interaction

22

Sergio Sebastian Samoluk, David John Bertioli, Jose Guillermo Seijo and Brian Abernathy

Assembly of chloroplast genomes provides insights into the origin of cultivated peanut

23

Nahuel Escobedo, Alexander Monzon, Nicolas Palopoli and Gustavo Parisi

Characterization of conformational changes in homo-oligomeric proteins

24

Ariel Aptekmann

Metal-binding Predictor

25

Carolina L Gandini, Laura E Garcia, Cinthia C Abbona, Sergei Kushnir, Danny Geelen and Maria V Sanchez-Puerta

Inferring Recombination Events in Plant Mitochondria Using High-Throughput Sequencing Data

26

Juliana Glavina, Nicolás Sebastián González Foutel, Gregorio Fernández-Ballester, Wade Borcherds, Gary Daughdrill, Ignacio Enrique Sánchez and Lucía Beatriz Chemes

Conservation of high affinity binding between the viral adenovirus E1A and host Retinoblastoma proteins requires a flexible and disordered linker.

27

Juliana Glavina, Lucía Álvarez, Gregorio Fernández-Ballester, Peter Sehr, Joe Lewis, Toby James Gibson, Ignacio Enrique Sánchez and Lucía Beatriz Chemes

Comparative analysis of structure and sequence based methods for the prediction of linear motif binding energies.

28

Lucas Maldonado, Juan Arrabal, Gabriel Lichtenstein, Guilherme Oliveira and Laura Kamenetzky

Phylogenetic history of helminths through whole genome variants analysis: the case of the new Echinococcus oligarthrus genome

29

Gábor Erdős and Zsuzsanna Dosztányi

A novel structure centric method for binding partner discovery of linear motif binding proteins

30

Elizabeth Martínez Pérez and Cristina Marino Buslje

Models to predict Total Mutational Burden in Cancer

31

Matias Sebastian Carletti, Jorge Luis Porfido, Massimo Bellanda, Guillermo Benítez, Gustavo Salinas, Maria Silvina Fornasari and Gustavo Parisi

Analysis of the structure and function relationships and evolutionary origin of an atypical thioredoxin (IsTRP)

32

Salvador Nicosia, Sebastian Moschen and Paula Fernandez

Functional genomics of leaf senescence process: Bioinformatics analysis of massive phenotyping Arabidopsis thaliana transgenic lines overexpressing NAC transcription factors

33

Cristian Rohr

Machine learning methods for optimization of a control gut microbiome database in the Argentine population

34

Laura Chalup, Sergio Sebastián Samoluk, Federico Agostini, Germán Ariel Robledo Robladez and Guillermo Seijo

Comparative analysis of structure and variability of the ribosomal genes of the Peanut and their wild diploids parentals for evolutionary studies

35

Georgina Stegmayer, Leandro Bugnon, Cristian Yones, Jonathan Raad, Matias Gerard, Mariano Rubiolo, Gabriela Merino, Milton Pividori, Leandro DiPersia and Diego Milone

Deep learning for reading and interpreting biomedical papers

36

Georgina Stegmayer, Leandro Di Persia and Diego Milone

Annotation pipeline for inferring gene functions integrating GO annotations and expression data

37

Eliana G. Vallmitjana, Gabriela A. Merino and Victor H. Casco

Machine learning and bioinformatic analysis of transcriptomic data to identify colorectal cancer subtypes

38

Mauricio J. Lozano, José L. López, María Laura Fabre and Antonio Lagares

CUBES and CUBACR, script packages for the analysis of evolutionary traits of codon bias.

39

Bruno Alvarez and Morten Nielsen

NNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T cell epitope predictions

40

Ines Hugalde, Marcos Paolinelli, Cecilia Agüero, Summaira Riaz, Hernán Vila and Andy Walker

Molecular determinants of vegetative vigour in a Ramsey x Riparia GM population revealed by Gene Ontology analysis.

41

Heli Magalí García Álvarez, Mareike Wendorff, Hesham El Abd, Thomas Østerbye, Søren Buus, Andre Franke and Morten Nielsen

New predictors for peptide-MHC class II binding affinity trained on novel data from a peptide chip platform.

42

Maria I Freiberger, A. Brenda Guzovsky, Diego Ferreiro and Rodrigo Gonzalo Parra

On the role of local frustration on proteins’ catalytic sites

43

Cristian Yones, Leandro Bugnon, Jonathan Raad, Diego Milone and Georgina Stegmayer

MicroRNA prediction from genome-wide data with deep learning: a novel approach based on convolutional residual networks

44

Manuel Llanos, Felipe Gonzalez Casabianca, Layla Hirsh, Karla Pedraza, Robert Finn and Andrey V. Kajava

A protocol to construct structure-based Profile/Hidden Markov Models for tandem repeat identification and classification

45

Romina Armando, Diego Mengual Gomez, Ezequiel Juritz, Pablo Lorenzano Menna and Daniel Gomez

Novel strategy to inhibit telomerase for cancer treatment: Homology Modeling and Docking-Based Virtual Screening for Ligands of Human Dyskerin.

46

Patricio Chinestrad, Julian Maggio, Pablo Lorenzano Menna, Daniel Gomez and Diego Mengual Gomez

Rational design of PIN1 pharmacological inhibitors based on conformational analysis of a nonstructural point mutation

47

Bruno Kaufman, Maximiliano Sebastián Beckel, Andrés Rabinovich and Ariel Chernomoretz

Detecting pairwise correlations in 5' donors' RNA sequences

48

Estefanía Mancini, Andres Rabinovich, Javier Iserte, Marcelo Yanovsky and Ariel Chernomoretz

ASpli v2: detection and quantification of complex splicing patterns

49

Laura I. Giaccardi, Julieta M. Manrique, Misael A. Badenas, Andrea Y. Calvo and Leandro R. Jones

Taxa-area relationship among ubiquitous and profuse bacterial taxa (LUP) of the Argentine Sea

50

Lucio Aliperti Car, Ignacio Enrique Sánchez and Pablo Turjanski

Looking for archetypes for codon usage across genomes

51

Verónica Bornancini, Matías Irazoqui, Ariel Amadio and Paola Lopez Lambertini

Intra-host genetic diversity analysis of full-length begomovirus infecting pepper in Argentina

52

Jorge Emilio Kolomenski, Marisol Delea, Leandro Simonetti, Mónica Carolina Fabbro, Carlos David Bruque, Liliana Dain and Alejandro Daniel Nadra

Update of genetic variants in the NKX2.5 gene

53

Flavio E. Spetale, Javier Murillo, Pilar Bulacio and Elizabeth Tapia

Cross-Ontology Prediction of lncRNAs on Zebrafish

54

Fernando Villarreal, Agustin Amalfitano, Marcelo Atencio, Nicolás Stocchi and Arjen ten Have

Comprehensive characterization of the complex BAHD acyltransferase family from 25 plant species: phylogenetic analysis and identification of specificity determinant positions

55

Martin Eduardo Guerrero-Gimenez, Benjamin Lang, Juan Manuel Fernandez Muñoz, Daniel Ramon Ciocca, Stuart K. Calderwood and Felipe Carlos Martin Zoppino

A system biology approach finds miRNA-570 as a possible candidate for the disruption of the chaperome network in high-risk HER2 breast cancer tumors

56

Agustina Dinamarca, Diego M. Bustos and Luis G. Moyano

Learning complex protein interaction network representations

57

Agustín Amalfitano, Hugo Marcelo Atencio, Nicolas Stocchi, Arjen ten Have and Fernando Villarreal

SEQrutinator: Fast and objective sequence scrutiny for the analysis of highly complex protein superfamilies

58

Hugo Marcelo Atencio, Nicolás Stocchi, Agustín Amalfitano, Fernando Villarreal and Arjen ten Have

Phylogenetic relationships and characterization of UDP-glycosyltransferases (UGTs) in dicotyledonous plants

59

Nicolas Stocchi, Fernando Villarreal, Agustin Amalfitano, Marcelo Atencio and Arjen ten Have

Phylogenetic and Functional Classification of the Plant Cytochrome P450 superfamily by using SEQrutinator and HMMERCTTER inception

60

Romina Martinelli and Luis Esteban

IN SILICO ANALYSIS OF 1-α-HYDROXYLASE IN PROSTATE CANCER

61

Juan Manuel Fernandez Muñoz, Martin Eduardo Guerrero-Gimenez, Daniel Ramon Ciocca and Felipe Carlos Martin Zoppino

COPY NUMBER VARIATION OF THE HEAT SHOCK PROTEINS IN BREAST CANCER SUBTYPES AND THEIR RELATION WITH GENE EXPRESSION LEVELS.

62

Javier Murillo, Flavio Spetale, Ignacio Labari, Elizabeth Tapia and Pilar Bulacio

On the consistency of tools that predict the impact of SNPs in the BRCA1 gene

63

Maria Freiberger, Maximiliano Beckel, Ezequiel A. Galpern, Ariel Chernomoretz and Diego Ferreiro

Genomic structure of ankyrin repeat arrays

64

César Leonetti, Juliana Glavina, Lucia Chemes and Ignacio Sánchez

Relationship between the evolution of sequence, structure and function in the intrinsically disordered Mastadenovirus E1A oncoprotein

65

Diego M. Luna, Rodrigo Gonzalo Parra and Maria I. Freiberger

Patterns of frustration throughout the evolution in protein superfamilies.

66

German P. Barletta and Sebastian Fernandez Alberti

Apis Mellifera Odorant Binding Protein pH dependent ligand binding. A Constant pH Replica Exchange MD study.

67

Micaela Parra, Diego Libkind and Nicolás Bellora

Gene mining and characterization of intrinsically disordered regions of circadian clock components in Fungi

68

Fanny Rusman, Nicolás Tomasini, Noelia Floridia Yapur and Patricio Diosque

Deep description of mitochondrial guide RNA repertoires in the six main lineages of Trypanosoma cruzi