2020 - present Senior Software Engineer, Rshiny/Shadow IT, BT Openreach

2017 - 2019 Senior Data Analyst, Kent Surrey Sussex Academic Health Science Network

2012 - 2017 Research Fellow in bioinformatics and genomics.

School of Life Sciences, University of Sussex, UK

2006 - 2012 Research Technician

Neuropsychiatric Genetics group, Trinity College Dublin, Republic of Ireland

2003 – 2006 Research Technician

Neurogenetics group, The Institute for Neurology, University College London

Molecular genetics of Parkinson’s disease

Click on images for links to data and code

Consultancy

External: The Austrian Science Fund, Issues in Biological Sciences & Pharmaceutical Research, Evolutionary Applications, BMC Veterinary Research.

Departmental: (previous) personnel recruitment, project design, analysis methods, hardware purchasing, software use, graphical and analysis programming, Linux cluster usage.

Acknowledged in : Avinun, R & Knafo-Noam, A (in press). Behaviour genetics. The Cambridge Encyclopaedia of Child Development (2nd edition), for providing advice on genetics of common psychiatric diseases.

Bioinformatics experience

Bash, bcfTools, BedTools, BWA, FastQC, GATK, Genomestrip, Haploview, Integrated Genomics Viewer, Latex, Linux, Perl, Picard, Plink1.9, R, SamTools, shell scripting, SNPeff, Stampy, vcfTools.

Statistical experience

Uni-variate modelling (basic summaries, t-tests, linear and logisitic regression), enrichment-testing, multi-variate: (M)ANOVA, Principle components analysis, mult-variate/multiple regression, False discovery rate calculations, all in genomics, biological or healthcare setting, mostly using R.

Dashboards

R Shiny

Coronavirus forecasting, for job interview https://william-gilks.shinyapps.io/airfinity/

Children Looked After, (Adoption data) Office of National Statistics https://william-gilks.shinyapps.io/CLA_Outcomes/

London Underground Journey Times https://william-gilks.shinyapps.io/LondonUnderground/

Tableau

UK Regional Age Profiles https://public.tableau.com/profile/william.gilks#!/vizhome/CCGAgeProfiles/CCGAges

Stroke Care Provision in the the NHS https://public.tableau.com/profile/william.gilks#!/vizhome/StrokeDemo/LongTermTrends

Laboratory experience

Range of PCR and genotyping methods, including break-point sequencing, amplification of whole virus genomes, cell culture, microbiology, gene cloning, protein binding assays, gel electrophoresis, nucleic acid purification, Sanger sequencing, Taqman gene expression and genotyping. MALDI-TOF protein quantification of monoamine oxidase in human cerebellum, FACscan quantification of drug absorbtion by Leishmania parasites. Dissection, microscopy, field work.

Big data

Whole genome-resequencing data from individual Drosophila melanogaster https://www.ncbi.nlm.nih.gov/sra/?term=SRP058502

Whole genome-resequencing data from Wolbachia (residing within the aforementioned Drosophila) https://www.ncbi.nlm.nih.gov/sra/?term=SRP091004

Genomic vcf file for a Drosophilia melanogaster population sample https://zenodo.org/record/198880

Data & code

Genomic data from whole genome re-sequencing of Drosophila melanogaster hemiclones (Sussex LHM population)

Gene co-ordinates, gene expression levels; SNP identifiers and functions for https://zenodo.org/record/815472

Genotype data in vcf and Plink binary formats https://zenodo.org/record/804008

Preliminary population genetics analysis https://zenodo.org/record/806849

Genotype call reproducibility testing https://zenodo.org/record/160539

Detection and genotyping of structural variants https://zenodo.org/record/159472

Single-trait genome-wide association study, without correction for substructure, sex-specific evolutionary fitness https://zenodo.org/communities/sussex_drosophila_gwas/

Twitter feeds

Alerts for pre-submissions manuscripts on Genome-wide association studies https://twitter.com/gwas_lit

Genomic prediction studies https://twitter.com/genomic_pred

Mendelian Randomisation studies https://twitter.com/mendelian_lit

Me https://twitter.com/wpgilks

Google scholar https://scholar.google.co.uk/citations?user=ttaTo-EAAAAJ&hl=en

Orcid http://orcid.org/0000-0001-7814-3173.

ResearcherID http://www.researcherid.com/rid/P-9137-2015

Publications

13. Gilks WP, Pennell TM, Flis I, Webster MT, Morrow EH (2016) Whole-genome resequencing of a laboratory-adapted Drosophila melanogaster population sample. F1000Research 5:2644

12. Gilks WP (2016) Sex Differences in Disease Genetics. In: eLS. John Wiley & Sons, Ltd: Chichester

11. Gilks WP, Abbott JK, Morrow EH (2014) Sex differences in disease genetics: evidence, evolution, and detection. Trends in Genetics 30(10):453-63

10. Gilks WP, Hill M, Gill M, Donohoe G, Corvin AP, Morris DW (2011) Functional investigation of a schizophrenia GWAS signal at the CDC42 gene. World Journal of Biological Psychiatry 13(7):550-54

9. Kenny EM, Cormican P, Gilks WP, Gates AS, O’Dushlaine CT, Pinto C, Corvin AP, Gill M, Morris DW (2011) Multiplex target enrichment using DNA indexing for ultra-high throughput SNP detection. DNA Research 18(1):31-8

8. Gilks WP, Allott EH, Donohoe G, Cummings E, The International Schizophrenia Consortium, Gill M, Corvin AP, Morris DW (2010) Replicated genetic evidence supports a role for HOMER2 in schizophrenia. Neuroscience Letters 468(3):229-33

7. Muqit MM, Abou-Sleiman PM, Saurin AT, Harvey K, Gandhi S, Deas E, Eaton S, Payne Smith MD, Venner K, Matilla A, Healy DG, Gilks WP, Lees AJ, Holton J, Revesz T, Parker PJ, Harvey RJ, Wood NW, Latchman DS (2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. Journal of Neurochemistry 98(1):156-69

6. Khan NL, Jain S, Lynch JM, Pavese N, Abou-Sleiman P, Holton JL, Healy DG, Gilks WP, et al. (2005) Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson’s disease: clinical, pathological, olfactory and functional imaging and genetic data. Brain 128 (12):2786-96

5. Gandhi S, Abou-Sleiman PM, Healy DG, Weale M, Gilks W, Ahmadi K, Goldstein DB, Wood NW (2005) Population genetic approaches to neurological disease: Parkinson’s disease as an example. Philosophical Transactions of the Royal Society of London, Part B Biological Sciences 360(1460):1573-8

4. Gilks WP, Abou-Sleiman PM, Gandhi S, Jain S, Singleton A, Lees A, Bhatia K, Bonifati V, Quinn N, Lynch J, Healy D, Holton J, Revesz T & Wood N (2005) A common LRRK2 mutation in idiopathic Parkinson’s disease. The Lancet 365(9457):415-416

3. Paisán-Ruíz C, Jain S, Evans EW, Gilks WP, Simón J, van der Brug M, López de Munain A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de Silva R, Lees A, Martí-Massó JF, Pérez-Tur J, Wood NW, Singleton AB (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson’s disease. Neuron 44(4):595-600

2. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, González-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW (2004) Hereditary early-onset Parkinson’s disease caused by mutations in PINK1. Science 304(5674):1158-60

1. Healy DG, Abou-Sleiman PM, Valente EM, Gilks WP, Bhatia K, Quinn N, Lees AJ, Wood NW (2004) DJ-1 mutations in Parkinson’s disease . Journal of Neurology Neurosurgery and Psychiatry 75(1):144-5

(Full texts of all my publications are available at this link. ).