As of December 2024, Singapore Airlines operates the largest fleet of Airbus A350s, with 65 aircraft in service. The airline uses these aircraft for long-haul and regional routes, taking advantage of the A350's fuel efficiency and passenger comfort.

Other major operators of the A350 include:

• Qatar Airways: 58 aircraft

• Cathay Pacific: 48 aircraft

• Delta Air Lines: 34 aircraft

• Lufthansa: 31 aircraft

These airlines rely on the A350 for a mix of ultra-long-haul and high-demand international routes.