Due to the fact that cancer is a complex disease and has been the major health issue in human disease, we would like to propose a variety of research goals from the aspects of genetics and biology of cancer, in order to unravel the cancer pathogenesis. Although KRAS, as the most frequently mutated oncogene in human cancers, has consequently been a major target of cancer drug discovery, there is still limited treatment efficacy for the tumors carrying KRAS mutations. Therefore, our research goals will start with achieving a comprehensive understanding of the molecular properties of KRAS-driven carcinogenesis, with an emphasis on the underlying genetics and molecular mechanisms. This information can be regarded as a potential target to predict cancer risk, understand cancer etiology, and design rational approaches for the drug discovery and therapeutic interventions. Our ultimate goal will be to translate basic research discoveries into applications that can be used in Precision Medicine strategies in the clinics for better management and treatment of cancer.