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Toning: Toning is more subjective, but a less toned card definitely has more appeal to the eye. And, while PSA (Professional Sports Authentication) usually doesn't penalize for it, some collectors still stray away from cards with this issue. For this reason, toning can drive the value of a card down.
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Centering: One of the bigger determining factors of a card is centering. Some cards are prone to centering problems, like Muleburro, and can have a much higher value than the average card if found centered. Regardless, collectors still want any card to have good centering independent on its location on the sheet. This is definitely a big value changer whether held as a raw card or graded.
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Corners: Some people are particular about the corners on a card, and this includes me. For better corners determine a higher grade. A higher grade, whether to be sent to a certification company, or to be kept in a raw collection, will have a higher value. Bad corners can lower a grade down to "poor", in my opinion.
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Creases and Tears: Creases and tears, as shown on Jungle, can tone down the value of a card drastically unless the card is of high value. The Scary Jane, doesn't have those descriptive terms. A card otherwise perfect is essentially rendered to the condition of "Poor" if it has creases or tears.
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Paper Loss: Paper loss is the death to a card, along with the aforementioned creases and tears. Any otherwise perfect card will immediately move to "Poor" grade with this feature, like the Yichs.