Until now there has been no short history of England covering all significant events, themes and individuals: this bestselling book, published in association with the National Trust, will be the standard work for years to come.

Coronavirus disease 2019 (COVID- 19) has now been declared a global pandemic. The literature on the histopathological changes associated with COVID-19 infection is currently limited. Early data consistently describe diffuse alveolar damage on lung histology from patients with COVID-19 pneumonia. We present the case of a 65-year-old female who died whilst self-isolating in the community following a short history of symptoms consistent with COVID-19. An invasive autopsy and subsequent lung histology demonstrated diffuse alveolar damage, in keeping with the previously reported cases of COVID-19 pneumonia. We hope to contribute to the growing body of literature available on the pathological findings in such cases. The challenges of ascertaining post mortem virological confirmation of infection are discussed.

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A 65-year-old Caucasian female cleaner with a background of chronic kidney disease and morbid obesity contacted her GP regarding a short history of dry cough and a sore throat. Her GP prescribed antibiotics and advised the patient to self-isolate in line with the NHS COVID-19 guidance. The following day she was discovered deceased at her home address.

Despite the good pharmacological effects of plants, several limitations were observed in clinical trials in terms of the heterogeneity of the study population, clinical protocols, and design and outcome evaluation parameters. Regarding the small sample size, an important consideration was that the number of patients initiating treatment was higher than those completing treatment which may be attributable to compliance and financial issues. The recruitment of healthy people for a clinical trial always remains a difficult task for researchers. Furthermore, the short study duration was a common limitation in all clinical trials (Zarrintan et al., 2016; Ranasinghe et al., 2017a; Asadi et al., 2019; Soltanian and Janghorbani, 2019; Gaytn Martnez et al., 2021). However, population size and duration of treatment must be considered because a larger study population with a longer treatment duration will depict more reliable safety and efficacy results. Another important limitation was the burden of polypharmacy and compliance of patients that were affected due to large size dosage form, i.e., capsule or tablet, with frequent dosing each day (Talaei et al., 2017; Tavakoly et al., 2018; Jovanovski et al., 2021). Moreover, clinical trials did not portray the dose-response relationship in patients, instead, even phase 1 clinical trials were based on single-dose utilization that cannot depict a complete safety profile (Sengsuk et al., 2016; Asadi et al., 2019; Jovanovski et al., 2021). The inclusion criteria were a crucial reason why some clinical trials failed to produce effective glycemic control. The inclusion criteria must specify that patients with diabetes with a history of a number of years with increased HbA1c levels can enter the study and/or set the exclusion criteria for patients with diabetes with high HbA1c levels or having diabetes for a long period of time (Zarrintan et al., 2016; Zarvandi et al., 2017). A lack of control groups was observed in some clinical trials which must not be ignored before drawing conclusions (Banerji and Banerjee, 2016; Ranasinghe et al., 2017b). Also, none of the clinical trials addressed if there was a difference between male and female patients with diabetes. Most of the population in the studies were women which may be due to a low willingness of men to participate in the study. 589ccfa754

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