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Purpose To compare overall survival between patients who received neoadjuvant therapy (NAT) followed by resection and those who received upfront resection (UR)-as well as a subgroup of UR patients who also received adjuvant therapy-for early-stage resectable pancreatic adenocarcinoma. Patients and Methods Adult patients with resected, clinical stage I or II adenocarcinoma of the head of the pancreas were identified in the National Cancer Database from 2006 to 2012. Patients who underwent NAT followed by curative-intent resection were matched by propensity score with patients whose tumors were resected upfront. Overall survival was compared by using a Cox proportional hazards regression model. Early postoperative and oncologic outcomes were evaluated. Results We identified 15,237 patients with clinical stage I or II resected pancreatic head adenocarcinoma. From the NAT group, 2,005 patients (95%) were matched with 6,015 patients who underwent UR. The NAT group was associated with improved survival compared with UR (median survival, 26 months v 21 months, respectively; stratified log-rank P < .01; hazard ratio, 0.72; 95% CI, 0.68 to 0.78). Patients in the UR group had higher pathologic T stage (pT3 and T4: 86% v 73%; P < .01), higher positive lymph nodes (73% v 48%; P < .01), and higher positive resection margin (24% v 17%; P < .01). Compared with a subset of UR patients who received adjuvant therapy, NAT patients had a better survival (adjusted hazard ratio, 0.83; 95% CI, 0.73 to 0.89). Conclusion NAT followed by resection has a significant survival benefit compared with UR in early-stage, resected pancreatic head adenocarcinoma. These findings support the use of NAT, particularly as a patient selection tool, in the management of resectable pancreatic adenocarcinoma.

Results and limitations: We identified a total of 4639 eligible patients with mRCC. Among the 4202 patients treated with targeted therapy and 437 patients treated with immune checkpoint inhibitors, 2326 (55%) and 234 (54%) patients received upfront CN prior to treatment start. In multivariable analyses, CN was associated with significantly better OS in both the immune checkpoint inhibitor-treated (hazard ratio [HR]: 0.61; 95% confidence interval [CI], 0.41-0.90, p = 0.013) and the targeted therapy treatment (HR: 0.72; 95% CI, 0.67-0.78, p < 0.001) group. There was no difference in OS benefit of CN between the immune checkpoint inhibitor and targeted therapy treatment groups (interaction p = 0.6). Limitations include selection of patients from large academic centers and the retrospective nature of the study.

Upfront App Download

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I always require full payment upfront for video projects. There's one client that I've conducted 3 phone calls (usually it's one call max- I prefer email) and the project is only $350. He refuses to pay upfront and says he will do 1/2 upfront and 1/2 after. He runs a very successful business though and I was hoping to collaborate on more projects. How would you handle this?

Edited to add: I have not responded to that last message about taking business personal. I don't know how to reply. Would y'all just ignore him and drop him as a potentially difficult client? Or would you accept 1/2 payment upfront terms?

Background: Studies comparing upfront surgery with neoadjuvant treatment in pancreatic cancer may report only patients who underwent resection and so survival will be skewed. The aim of this study was to report survival by intention to treat in a comparison of upfront surgery versus neoadjuvant treatment in resectable or borderline resectable pancreatic cancer.

Results: In total, 38 studies were included with 3484 patients, of whom 1738 (499 per cent) had neoadjuvant treatment. The weighted median overall survival by intention to treat was 188 months for neoadjuvant treatment and 148 months for upfront surgery; the difference was larger among patients whose tumours were resected (261 versus 150 months respectively). The overall resection rate was lower with neoadjuvant treatment than with upfront surgery (660 versus 813 per cent; P < 0001), but the R0 rate was higher (868 (95 per cent c.i. 846 to 887) versus 669 (642 to 696) per cent; P < 0001). Reported by intention to treat, the R0 rates were 580 and 549 per cent respectively (P = 0088). The pathological lymph node rate was 438 per cent after neoadjuvant therapy and 648 per cent in the upfront surgery group (P < 0001). Toxicity of at least grade III was reported in up to 64 per cent of the patients.

I just had an unpleasent experience with this new payment feature. Guest reserved a few months in advance for a very sought after perior or time in Fort Lauderdale. He then used the Pay less upfront option. A few days later he cancelled the resrrvation. We have a strict cancellation policy, which should have allowed me to receive 50% of the etire booking, inspead I received 50% of the 50% he already had paid. I feel disapointed and cheated. This is two sour notes in my airbnb experience in the last few months: first the removal of the direct payment to co-hosts and now this...

Me: I just got a call from a guest who rented my place starting 9/1. She wanted to know if I am taking the second payment today. I don't handle payments, you guys do so I directed her to contact you. After getting this call, I found out ABB has some policy called "pay less upfront". How do I opt out of this? I don't want the risk of someone staying without paying or cancelling and expecting a refund and I'm left holding the bag.

ABB: I would like to share with you that the in payless upfront option guest can pay in 2 payments.

First payment is taken at the time of booking and the second after few days, however by any chance the guest fails to pay the second payment the booking gets canceled automatically within a week.

So, even in that case hosts never have to deal with a guest who has paid in half. When a guest checkin they have already paid the full amount.

I asked two different case managers where I could find the information/notification on my account that a guest is using the "pay less upfront" option, and why Airbnb are leading us to believe that we have fully paid up, confirmed bookings when they're nothing of the sort. One told me that a guests' financial dealings are none of the host's business, and the other told me that as a responsible host, it's my duty to respect my guests' privacy! (From anecdotal evidence, it does appear that some multiple-listing commercial property managers are privy to this information, but in most jurisdictions at least, traditional hosts are still not being informed that a guest is utilising the 50% now/50% later facility)

I searched for info on this but could only find an article (not on Airbnb) stating that guests who "pay less upfront" can cancel up to 30 days out and get a full refund, this would nullify the 'strict/grace' policy: full refund only if the guest cancels within 48 hours of booking.

Who has an upfront?

Every big media company in television has at least one upfront event, from NBCUniversal and CBS to ESPN and Turner. All the major TV buyers from brands and agencies show up. Increasingly, the networks are setting up individual meetings with media buyers outside their core upfront presentations (and parties).

Wait, billions of dollars happens at parties?

Well, the upfront presentations are just the opening move in what become lengthy negotiations. The following discussions can take weeks, even months. In 2013, it took ABC 10 weeks to close out the last of its upfront negotiations, during which the network sold around 75 percent of its inventory for roughly $2.35 billion.

I ALLWAYS pay when offer is accepted. But why would anyone need my payment info upfront before making an offer? What if the sellers denies my offer? I provided my payment information to a system that I have no control or visibility over. This does not make any sense at all.

Interest may accrue on outstanding loan balances per the terms of your loan agreement. When your customer pays their invoice through QuickBooks Payments during the first 30 days, the payment will be automatically applied to your Get Paid Upfront balance. You can take advantage of autopay to repay the loan. Each month, the pre-authorized monthly repayment amount will be debited from the same business bank account where your upfront advance was sent.

You can also make manual payments. Sign in to your QuickBooks account and go to Invoices and then select Get Paid Upfront. You can view, manage, and repay your upfront advances.

Yes, if you'd like to buy tickets for your team email shakira@weareupfront.com. Employers such as Nike, Just Eat, Pleo, Onifdo, Co-op, Department for Education, Deeson, Impact Arts, Citizens Advice, and The Big Lottery Fund have funded places for their teams

Boucly and colleagues should be commended on this analysis with relevant implications for patients with newly diagnosed PAH. The study is the largest real-world cohort to support the overall treatment strategy from the 2018 World Symposium (2). It adds to the observational evidence for upfront combination therapy including a parenteral prostacyclin for high-risk patients. Notably, it provides the first evidence for the potential role of earlier triple combination therapy with a parenteral prostacyclin for intermediate-risk disease.

So, should all patients with newly diagnosed PAH be treated with upfront triple combination therapy? Perhaps not all; however, this work compels us to look closely at the intermediate-risk group. The majority of patients, 70% in the current study, fall into this broad category. Unfortunately, current risk assessment tools cannot differentiate responders or those likely to progress among this group regardless of treatment strategy. More precise risk stratification, potentially including parameters of right ventricular function, might inform more personalized treatment decisions. Until this becomes available, the evidence suggests that perhaps we should be more ambitious than AMBITION. 17dc91bb1f